Almonertinib (mesylate)_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (mesylate) perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (mesylate)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.165321
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.146643
GRB10 growth factor receptor-bound protein 10 0.113062
SPTBN1 spectrin, beta, non-erythrocytic 1 0.107608
PTPRJ protein tyrosine phosphatase, receptor type, J 0.103348
FLNB filamin B, beta 0.103327
ANKRD11 ankyrin repeat domain 11 0.101953
MCL1 myeloid cell leukemia 1 0.0914642
CA12 carbonic anhydrase XII 0.082616
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0813277
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0724362
NAV2 neuron navigator 2 0.070191
CMIP c-Maf inducing protein 0.0674285
OGA O-GlcNAcase 0.0669688
ACTN4 actinin, alpha 4 0.0660362
MYH9 myosin, heavy chain 9, non-muscle 0.0660079
TRIO trio Rho guanine nucleotide exchange factor 0.0657226
FMNL2 formin-like 2 0.0628024
PLEC plectin 0.0617769
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0617177
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0572219
PABPC1 poly(A) binding protein, cytoplasmic 1 0.057092
RPL23 ribosomal protein L23 0.056113
MACF1 microtubule-actin crosslinking factor 1 0.0547132
TNIP1 TNFAIP3 interacting protein 1 0.0545453
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0540766
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0531525
SMAD3 SMAD family member 3 0.0527957
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0523069
DAPK1 death-associated protein kinase 1 0.0507415
SHB Src homology 2 domain containing adaptor protein B 0.0500479
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0498432
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.048463
FLNA filamin A, alpha 0.047564
IGFBP4 insulin-like growth factor binding protein 4 0.0467812
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0467692
TNS1 tensin 1 0.0461513
PRELID2 PRELI domain containing 2 0.0446379
ESYT2 extended synaptotagmin-like protein 2 0.0445238
NUP58 nucleoporin 58 0.0444834
KIRREL3 kin of IRRE like 3 (Drosophila) 0.0439535
NDRG1 N-myc downstream regulated 1 0.0439171
C1D C1D nuclear receptor corepressor 0.0431445
AUTS2 autism susceptibility candidate 2 0.0423899
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0417042
PYGL phosphorylase, glycogen, liver 0.0409537
CTBP2 C-terminal binding protein 2 0.0404477
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0399579
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0398935
RB1CC1 RB1-inducible coiled-coil 1 0.0398543
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0396485
TBC1D22A TBC1 domain family, member 22A 0.0393796
LTBP4 latent transforming growth factor beta binding protein 4 0.0392029
SRRM2 serine/arginine repetitive matrix 2 0.0391013
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0385539
ZNF292 zinc finger protein 292 0.0383985
RPL13A ribosomal protein L13a 0.0383798
ZFAND3 zinc finger, AN1-type domain 3 0.0378548
PFKP phosphofructokinase, platelet 0.0370994
ADAM17 ADAM metallopeptidase domain 17 0.0369223
PTMA prothymosin, alpha 0.0368887
HMGA1 high mobility group AT-hook 1 0.036849
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0366413
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0360583
USP34 ubiquitin specific peptidase 34 0.0359958
DENND1A DENN/MADD domain containing 1A 0.0357657
FAM13A family with sequence similarity 13, member A 0.0354461
NGLY1 N-glycanase 1 0.0353815
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0353037
SETD5 SET domain containing 5 0.0348803
VIM vimentin 0.0347404
YEATS2 YEATS domain containing 2 0.0346506
BACE2 beta-site APP-cleaving enzyme 2 0.0346308
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0345729
EEF1G eukaryotic translation elongation factor 1 gamma 0.0344395
MSI2 musashi RNA-binding protein 2 0.0340717
ZFHX3 zinc finger homeobox 3 0.0337734
PGK1 phosphoglycerate kinase 1 0.0337254
RPL26 ribosomal protein L26 0.0337243
DENND5A DENN/MADD domain containing 5A 0.0335609
AHNAK AHNAK nucleoprotein 0.0332932
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 0.0329811
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.0329513
WSB1 WD repeat and SOCS box containing 1 0.0322317
IGF1R insulin-like growth factor 1 receptor 0.0321463
BHLHE40 basic helix-loop-helix family, member e40 0.0316506
PMM2 phosphomannomutase 2 0.0313818
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.03128
ABTB3 ankyrin repeat and BTB domain containing 3 0.0312026
RNF213 ring finger protein 213 0.0311864
RPLP2 ribosomal protein, large, P2 0.0311858
RPL7A ribosomal protein L7a 0.0310378
MSN moesin 0.0308611
RAB1A RAB1A, member RAS oncogene family 0.0307143
CALR calreticulin 0.0306441
NPAS2 neuronal PAS domain protein 2 0.0306003
CTTN cortactin 0.0305949
MYO1E myosin IE 0.0305125
LDHA lactate dehydrogenase A 0.0303992
RPS7 ribosomal protein S7 0.0301102

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.174398
KYNU kynureninase -0.168248
FTL ferritin, light polypeptide -0.161809
PDE4D phosphodiesterase 4D, cAMP-specific -0.158777
STC1 stanniocalcin 1 -0.111783
RPS2 ribosomal protein S2 -0.0976777
AKAP12 A kinase (PRKA) anchor protein 12 -0.0957085
TXNRD1 thioredoxin reductase 1 -0.0924984
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0740746
OSMR oncostatin M receptor -0.0724312
RPLP1 ribosomal protein, large, P1 -0.0720105
RPS6 ribosomal protein S6 -0.0708873
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0707854
ELL2 elongation factor, RNA polymerase II, 2 -0.0640302
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0608606
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0598198
FTH1 ferritin, heavy polypeptide 1 -0.0575088
TM4SF1 transmembrane 4 L six family member 1 -0.0571729
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0549916
POTEF POTE ankyrin domain family, member F -0.0532084
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0512604
RPL12 ribosomal protein L12 -0.049537
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0486088
RPLP0 ribosomal protein, large, P0 -0.0483671
PNRC1 proline-rich nuclear receptor coactivator 1 -0.048113
TKT transketolase -0.0478792
PDE10A phosphodiesterase 10A -0.0475384
VCL vinculin -0.0475356
LOC112694756 uncharaterized LOC112694756 -0.0472867
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0469466
ARHGAP26 Rho GTPase activating protein 26 -0.0469078
NCOA7 nuclear receptor coactivator 7 -0.0465582
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0452012
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0448906
EXT1 exostosin glycosyltransferase 1 -0.0438724
NAMPT nicotinamide phosphoribosyltransferase -0.0429656
ASPH aspartate beta-hydroxylase -0.042115
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0410039
GRAMD1B GRAM domain containing 1B -0.0408068
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0405982
ALCAM activated leukocyte cell adhesion molecule -0.0395225
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0392337
MT1X metallothionein 1X -0.0391024
ZBTB20 zinc finger and BTB domain containing 20 -0.0375442
RPS5 ribosomal protein S5 -0.0366383
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0365175
BICC1 BicC family RNA binding protein 1 -0.0363351
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0360837
GLIS3 GLIS family zinc finger 3 -0.0359308
CD44 CD44 molecule (Indian blood group) -0.0338769
RSPO3 R-spondin 3 -0.0338714
TGM2 transglutaminase 2 -0.0336842
C15ORF48 chromosome 15 open reading frame 48 -0.0325447
EREG epiregulin -0.0323706
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0320438
CA8 carbonic anhydrase VIII -0.0317726
VDAC1 voltage-dependent anion channel 1 -0.0307535
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0307236
SH3KBP1 SH3-domain kinase binding protein 1 -0.0306378
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0304924
MBNL1 muscleblind-like splicing regulator 1 -0.0301914
WWC1 WW and C2 domain containing 1 -0.0301867
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0300726
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0298341
MT2A metallothionein 2A -0.0293697
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0293218
MAP1B microtubule-associated protein 1B -0.0292953
DOCK4 dedicator of cytokinesis 4 -0.0288177
BMAL2 basic helix-loop-helix ARNT like 2 -0.0285685
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0283231
CENPF centromere protein F, 350/400kDa -0.0281644
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0280902
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.02799
PTBP3 polypyrimidine tract binding protein 3 -0.0272236
CXCL5 chemokine (C-X-C motif) ligand 5 -0.0271561
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 -0.0271512
RAI14 retinoic acid induced 14 -0.0270559
NCEH1 neutral cholesterol ester hydrolase 1 -0.0264035
RIGI RNA sensor RIG-I -0.0261206
RPS24 ribosomal protein S24 -0.0258517
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0256979
FAM107B family with sequence similarity 107, member B -0.0256084
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0246715
RNF145 ring finger protein 145 -0.024619
GPRIN3 GPRIN family member 3 -0.0245933
BIRC3 baculoviral IAP repeat containing 3 -0.0245525
NABP1 nucleic acid binding protein 1 -0.0244785
CDK6 cyclin-dependent kinase 6 -0.0244467
BTG1 B-cell translocation gene 1, anti-proliferative -0.0244209
ZC3H12C zinc finger CCCH-type containing 12C -0.0242847
FOXP1 forkhead box P1 -0.0239375
FNDC3A fibronectin type III domain containing 3A -0.0238225
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0236644
VEZT vezatin, adherens junctions transmembrane protein -0.0234371
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0232169
ATF4 activating transcription factor 4 -0.0229438
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0227508
YBX3 Y box binding protein 3 -0.0226032
UGCG UDP-glucose ceramide glucosyltransferase -0.0223808
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0223726