| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (mesylate) perturbation in AN3 CA cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (mesylate)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MEST | mesoderm specific transcript | 0.130244 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0876941 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0755889 |
| NFIB | nuclear factor I/B | 0.0711623 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0651359 |
| GSE1 | Gse1 coiled-coil protein | 0.059266 |
| CALR | calreticulin | 0.0572252 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0548697 |
| HOXA3 | homeobox A3 | 0.0505551 |
| PRELID2 | PRELI domain containing 2 | 0.0467956 |
| MKI67 | marker of proliferation Ki-67 | 0.0437864 |
| PTMA | prothymosin, alpha | 0.0428769 |
| TPM3 | tropomyosin 3 | 0.0412686 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0381386 |
| MED13L | mediator complex subunit 13-like | 0.0377498 |
| RPS12 | ribosomal protein S12 | 0.0365077 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | 0.0336211 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0331184 |
| RPL13A | ribosomal protein L13a | 0.0329127 |
| LMNB1 | lamin B1 | 0.0328319 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0328025 |
| YEATS2 | YEATS domain containing 2 | 0.0327016 |
| CNN3 | calponin 3, acidic | 0.0323643 |
| UBC | ubiquitin C | 0.0323474 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0318272 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0314182 |
| DST | dystonin | 0.0302694 |
| ZNF292 | zinc finger protein 292 | 0.030232 |
| VEGFA | vascular endothelial growth factor A | 0.0302208 |
| ZFHX3 | zinc finger homeobox 3 | 0.0301407 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | 0.0300792 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0300475 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.029893 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0295753 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0294571 |
| SH3PXD2A | SH3 and PX domains 2A | 0.0291532 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0284723 |
| SPAG5 | sperm associated antigen 5 | 0.0283018 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.0279589 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.02795 |
| NAV2 | neuron navigator 2 | 0.0277177 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0274826 |
| FLNA | filamin A, alpha | 0.027406 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0272224 |
| HDGF | hepatoma-derived growth factor | 0.0269493 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0268694 |
| SEC61G | Sec61 gamma subunit | 0.0268234 |
| UBE3A | ubiquitin protein ligase E3A | 0.0268046 |
| MT2A | metallothionein 2A | 0.0267356 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0266228 |
| HOXC6 | homeobox C6 | 0.0264174 |
| HMGB2 | high mobility group box 2 | 0.0263955 |
| FAM219A | family with sequence similarity 219, member A | 0.0263599 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0263524 |
| RPL3 | ribosomal protein L3 | 0.0262715 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | 0.0261325 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0260334 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0256138 |
| WDR43 | WD repeat domain 43 | 0.0248505 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0246803 |
| CEP70 | centrosomal protein 70kDa | 0.0243887 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.0241115 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.0240147 |
| SEPTIN9 | septin 9 | 0.0237704 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0236963 |
| USP13 | ubiquitin specific peptidase 13 (isopeptidase T-3) | 0.0233077 |
| MGP | matrix Gla protein | 0.0231872 |
| VGLL4 | vestigial-like family member 4 | 0.0229523 |
| GPR107 | G protein-coupled receptor 107 | 0.0227659 |
| HOXC4 | homeobox C4 | 0.0227408 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0224836 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0224554 |
| GANAB | glucosidase, alpha; neutral AB | 0.0223625 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0220795 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0218326 |
| BRD2 | bromodomain containing 2 | 0.0217629 |
| ADD1 | adducin 1 (alpha) | 0.0217532 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0217287 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0216235 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0215996 |
| EFNA5 | ephrin-A5 | 0.0215794 |
| CCNL1 | cyclin L1 | 0.0215548 |
| EPC1 | enhancer of polycomb homolog 1 (Drosophila) | 0.0213139 |
| RPS3 | ribosomal protein S3 | 0.0211404 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0209663 |
| TMSB4X | thymosin beta 4, X-linked | 0.0209162 |
| SUCO | SUN domain containing ossification factor | 0.0208944 |
| FGFR2 | fibroblast growth factor receptor 2 | 0.0208613 |
| BCL2L1 | BCL2-like 1 | 0.0206842 |
| TSHZ2 | teashirt zinc finger homeobox 2 | 0.0206265 |
| KHSRP | KH-type splicing regulatory protein | 0.0206124 |
| CEP170 | centrosomal protein 170kDa | 0.0205837 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.020572 |
| MED17 | mediator complex subunit 17 | 0.0205617 |
| WTAP | Wilms tumor 1 associated protein | 0.0205605 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.0204296 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0204074 |
| MSI2 | musashi RNA-binding protein 2 | 0.0203556 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.020318 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.020299 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CADM2 | cell adhesion molecule 2 | -0.12344 |
| VIM | vimentin | -0.0943234 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0932138 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0882985 |
| JMJD1C | jumonji domain containing 1C | -0.084917 |
| FBXO11 | F-box protein 11 | -0.0766442 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0710623 |
| HMGA2 | high mobility group AT-hook 2 | -0.070769 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0692721 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0687925 |
| IER3 | immediate early response 3 | -0.0610806 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.058499 |
| BCOR | BCL6 corepressor | -0.0566464 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.055601 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.0553497 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0550314 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0538424 |
| RANBP17 | RAN binding protein 17 | -0.0531418 |
| RPS6 | ribosomal protein S6 | -0.0529117 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0505345 |
| RPLP1 | ribosomal protein, large, P1 | -0.0493775 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0489761 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0479479 |
| TCF12 | transcription factor 12 | -0.0466753 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0457457 |
| FTL | ferritin, light polypeptide | -0.0457449 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.044611 |
| RFX7 | regulatory factor X, 7 | -0.0444442 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.044375 |
| CANX | calnexin | -0.0438804 |
| RPS24 | ribosomal protein S24 | -0.0438064 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0433895 |
| IGF2R | insulin-like growth factor 2 receptor | -0.0426841 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.042138 |
| TUT4 | terminal uridylyl transferase 4 | -0.0420458 |
| NDRG1 | N-myc downstream regulated 1 | -0.0415041 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0412258 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0410613 |
| DOCK3 | dedicator of cytokinesis 3 | -0.0402431 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0401327 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0395912 |
| KLHL24 | kelch-like family member 24 | -0.0391731 |
| MEOX2 | mesenchyme homeobox 2 | -0.0388508 |
| LOC112694756 | uncharaterized LOC112694756 | -0.038812 |
| SEPTIN11 | septin 11 | -0.0386303 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0385979 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0384398 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0382963 |
| PHF3 | PHD finger protein 3 | -0.0381461 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.037746 |
| PCDH7 | protocadherin 7 | -0.0376769 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0371868 |
| NBEA | neurobeachin | -0.0364489 |
| TULP4 | tubby like protein 4 | -0.0363283 |
| MAP1B | microtubule-associated protein 1B | -0.0363056 |
| VCL | vinculin | -0.0362671 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0357528 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0348462 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0347887 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0343423 |
| ACTG1 | actin gamma 1 | -0.0340236 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0334763 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0327991 |
| SHISA3 | shisa family member 3 | -0.0327281 |
| SLC19A1 | solute carrier family 19 (folate transporter), member 1 | -0.0327076 |
| USP15 | ubiquitin specific peptidase 15 | -0.0326641 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0325304 |
| GOLM2 | golgi membrane protein 2 | -0.0324194 |
| MATR3 | matrin 3 | -0.03212 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0320777 |
| RNF130 | ring finger protein 130 | -0.0320474 |
| CTBP2 | C-terminal binding protein 2 | -0.0317879 |
| SHOC2 | soc-2 suppressor of clear homolog (C. elegans) | -0.0317153 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0314035 |
| UBXN4 | UBX domain protein 4 | -0.0310638 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0308824 |
| PARD3 | par-3 family cell polarity regulator | -0.0304909 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.0301143 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0300147 |
| POU2F1 | POU class 2 homeobox 1 | -0.0299164 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0298768 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0298508 |
| NSD3 | nuclear receptor binding SET domain protein 3 | -0.0295464 |
| TOP1 | topoisomerase (DNA) I | -0.0293471 |
| ANKRD11 | ankyrin repeat domain 11 | -0.029231 |
| NEK7 | NIMA-related kinase 7 | -0.0289815 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0289468 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0289243 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.028871 |
| RBM5 | RNA binding motif protein 5 | -0.0288105 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0286677 |
| TBCA | tubulin folding cofactor A | -0.0286653 |
| HDLBP | high density lipoprotein binding protein | -0.0286331 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0284101 |
| ERBIN | erbb2 interacting protein | -0.0280828 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0279949 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0278797 |
| RPL12 | ribosomal protein L12 | -0.027672 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0276679 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.027661 |
