Almonertinib (mesylate)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (mesylate) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (mesylate)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.173537
BAIAP2L1 BAI1-associated protein 2-like 1 0.1371
LAMB3 laminin, beta 3 0.108441
IGFBP3 insulin-like growth factor binding protein 3 0.105572
HMGA1 high mobility group AT-hook 1 0.101783
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0852063
NDRG1 N-myc downstream regulated 1 0.0673238
PLEC plectin 0.0667566
FOSL1 FOS-like antigen 1 0.0620622
TPM3 tropomyosin 3 0.0616293
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0614856
LMTK2 lemur tyrosine kinase 2 0.0592854
MCL1 myeloid cell leukemia 1 0.059068
MUC17 mucin 17, cell surface associated 0.0582893
RPS3 ribosomal protein S3 0.0571485
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0532129
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0523073
DSCAM Down syndrome cell adhesion molecule 0.0503668
UBC ubiquitin C 0.0502081
MPRIP myosin phosphatase Rho interacting protein 0.050003
MYH9 myosin, heavy chain 9, non-muscle 0.0494807
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0456184
SPTBN1 spectrin, beta, non-erythrocytic 1 0.045516
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.045402
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.044974
GRB10 growth factor receptor-bound protein 10 0.044736
POTEF POTE ankyrin domain family, member F 0.044133
PCBP2 poly(rC) binding protein 2 0.0422802
RPL37A ribosomal protein L37a 0.0413247
NCOR2 nuclear receptor corepressor 2 0.0413172
VASP vasodilator-stimulated phosphoprotein 0.0407087
RPS12 ribosomal protein S12 0.0406355
RPS2 ribosomal protein S2 0.040286
MSN moesin 0.0394881
EEF1G eukaryotic translation elongation factor 1 gamma 0.0385525
TNIP1 TNFAIP3 interacting protein 1 0.0377691
HSPA8 heat shock 70kDa protein 8 0.0377012
YTHDC1 YTH domain containing 1 0.0366358
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0357677
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.0357255
ITGB4 integrin, beta 4 0.0351428
RPL13A ribosomal protein L13a 0.0342525
AKAP13 A kinase (PRKA) anchor protein 13 0.0341778
RPS8 ribosomal protein S8 0.0340477
MXD1 MAX dimerization protein 1 0.0338826
UPP1 uridine phosphorylase 1 0.0336741
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0333372
TRRAP transformation/transcription domain-associated protein 0.0315972
SMAD3 SMAD family member 3 0.0315514
UBA6 ubiquitin-like modifier activating enzyme 6 0.0312014
CAPRIN2 caprin family member 2 0.0309907
EPHA2 EPH receptor A2 0.0308757
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0305975
SLK STE20-like kinase 0.0304822
RPS13 ribosomal protein S13 0.0296477
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.0289182
HDGF hepatoma-derived growth factor 0.0285054
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0275704
PRRC2C proline-rich coiled-coil 2C 0.0275344
CCNY cyclin Y 0.026738
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0266388
RPS29 ribosomal protein S29 0.0264267
CHMP4B charged multivesicular body protein 4B 0.0263737
RPL5 ribosomal protein L5 0.0256682
OSBP2 oxysterol binding protein 2 0.0253406
OPTN optineurin 0.025195
RPL36A ribosomal protein L36a 0.0249323
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0249274
SET SET nuclear proto-oncogene 0.0248748
RPL23 ribosomal protein L23 0.0244251
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0244023
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0240743
RPL9 ribosomal protein L9 0.0239112
ARRDC3 arrestin domain containing 3 0.0238331
PTPRF protein tyrosine phosphatase, receptor type, F 0.0235889
RPS7 ribosomal protein S7 0.0234538
ACTN4 actinin, alpha 4 0.0234435
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0234122
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0233943
NACA nascent polypeptide-associated complex alpha subunit 0.0232135
RPLP2 ribosomal protein, large, P2 0.0231675
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0230488
CUL3 cullin 3 0.0229506
ANKRD11 ankyrin repeat domain 11 0.0229391
KLK10 kallikrein-related peptidase 10 0.0228272
RASA3 RAS p21 protein activator 3 0.0227425
EEF2 eukaryotic translation elongation factor 2 0.0227083
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0226501
CD59 CD59 molecule, complement regulatory protein 0.0225449
LAMC2 laminin, gamma 2 0.0218969
PFN1 profilin 1 0.0217646
LDHA lactate dehydrogenase A 0.0217308
ACVR1 activin A receptor, type I 0.0215493
NDEL1 nudE neurodevelopment protein 1-like 1 0.0212942
NPAS2 neuronal PAS domain protein 2 0.0212942
RPS27 ribosomal protein S27 0.0212611
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0212444
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0210542
FA2H fatty acid 2-hydroxylase 0.0208387
ZMIZ1 zinc finger, MIZ-type containing 1 0.0207077

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.132737
VCAN versican -0.126469
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.121136
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.10649
AHNAK AHNAK nucleoprotein -0.103119
BZW1 basic leucine zipper and W2 domains 1 -0.0839892
S100A10 S100 calcium binding protein A10 -0.071892
PTMA prothymosin, alpha -0.0706594
LOC112694756 uncharaterized LOC112694756 -0.0692626
LMO7 LIM domain 7 -0.0652847
DSG2 desmoglein 2 -0.0616493
VIM vimentin -0.0604355
VCL vinculin -0.0598648
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0594692
ANXA2 annexin A2 -0.0579806
F3 coagulation factor III (thromboplastin, tissue factor) -0.0569444
RRBP1 ribosome binding protein 1 -0.0561537
MYOF myoferlin -0.0554832
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0489381
CD2AP CD2-associated protein -0.0481846
HDLBP high density lipoprotein binding protein -0.0479839
AKAP12 A kinase (PRKA) anchor protein 12 -0.0464589
ZBTB20 zinc finger and BTB domain containing 20 -0.0463779
SP100 SP100 nuclear antigen -0.0460201
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0455646
RPS24 ribosomal protein S24 -0.0443579
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0440059
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0438279
PTPRR protein tyrosine phosphatase, receptor type, R -0.0430404
RPLP1 ribosomal protein, large, P1 -0.0423994
HMGA2 high mobility group AT-hook 2 -0.0421942
TXNIP thioredoxin interacting protein -0.0414297
FBXO11 F-box protein 11 -0.0399793
RPLP0 ribosomal protein, large, P0 -0.0394807
SAMD9 sterile alpha motif domain containing 9 -0.0390022
STAU1 staufen double-stranded RNA binding protein 1 -0.0388708
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0387174
SERINC5 serine incorporator 5 -0.0382387
FTL ferritin, light polypeptide -0.037195
RASAL2 RAS protein activator like 2 -0.0368756
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0368609
EHBP1 EH domain binding protein 1 -0.0366369
PDLIM5 PDZ and LIM domain 5 -0.0365795
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0360958
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0353646
ITPRID2 ITPR interacting domain containing 2 -0.0352055
RSL1D1 ribosomal L1 domain containing 1 -0.0343506
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0339409
KDM3A lysine (K)-specific demethylase 3A -0.0337977
NPSR1 neuropeptide S receptor 1 -0.0329917
H1-0 H1.0 linker histone -0.0327448
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0323848
DIAPH2 diaphanous-related formin 2 -0.0319922
FNDC3B fibronectin type III domain containing 3B -0.0316756
RESF1 retroelement silencing factor 1 -0.0313697
SLC35F3 solute carrier family 35, member F3 -0.0307464
IER3 immediate early response 3 -0.0306658
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0305509
ZMYND8 zinc finger, MYND-type containing 8 -0.0303818
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0303069
PERP PERP, TP53 apoptosis effector -0.0302239
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0299487
TMEM263 transmembrane protein 263 -0.0299383
RNF213 ring finger protein 213 -0.0299131
RIGI RNA sensor RIG-I -0.0297986
RAD21 RAD21 homolog (S. pombe) -0.0297806
RAP1B RAP1B, member of RAS oncogene family -0.0294744
SLC38A2 solute carrier family 38, member 2 -0.0293655
ARF1 ADP-ribosylation factor 1 -0.0293651
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0292017
ARHGAP5 Rho GTPase activating protein 5 -0.0287081
NT5C2 5'-nucleotidase, cytosolic II -0.0286169
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0280466
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0277829
CANX calnexin -0.0277829
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0274563
RAB10 RAB10, member RAS oncogene family -0.0271469
PDE4D phosphodiesterase 4D, cAMP-specific -0.0271109
CDK6 cyclin-dependent kinase 6 -0.0267151
ZC3H11A zinc finger CCCH-type containing 11A -0.0267054
KRT18 keratin 18, type I -0.0266797
VDAC1 voltage-dependent anion channel 1 -0.0265522
MBD5 methyl-CpG binding domain protein 5 -0.0264081
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0257803
ARF4 ADP-ribosylation factor 4 -0.0256455
S100A4 S100 calcium binding protein A4 -0.0256293
PTPRK protein tyrosine phosphatase, receptor type, K -0.0254317
MAML2 mastermind-like 2 (Drosophila) -0.0251912
ASPH aspartate beta-hydroxylase -0.0250732
LAMA4 laminin, alpha 4 -0.025007
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.024992
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0249837
PNRC1 proline-rich nuclear receptor coactivator 1 -0.024909
NBEAL1 neurobeachin-like 1 -0.0248109
RABGAP1L RAB GTPase activating protein 1-like -0.0248096
GREB1L growth regulation by estrogen in breast cancer-like -0.0247498
IFI16 interferon, gamma-inducible protein 16 -0.024268
TM4SF1 transmembrane 4 L six family member 1 -0.0242673
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0241635
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.024158