| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (mesylate) perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (mesylate)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL23 | ribosomal protein L23 | 0.0758073 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | 0.0610107 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.0512518 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0418319 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.0412896 |
| GSE1 | Gse1 coiled-coil protein | 0.0401619 |
| CFB | complement factor B | 0.0380968 |
| TC2N | tandem C2 domains, nuclear | 0.0363288 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0315516 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0308351 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0308242 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0296066 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.029021 |
| FASN | fatty acid synthase | 0.0287372 |
| ENO1 | enolase 1, (alpha) | 0.0281519 |
| POTEF | POTE ankyrin domain family, member F | 0.0270019 |
| CEP250 | centrosomal protein 250kDa | 0.0254099 |
| S100A8 | S100 calcium binding protein A8 | 0.0253836 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.0250977 |
| RPS3 | ribosomal protein S3 | 0.0236025 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.022654 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0224046 |
| NCAM2 | neural cell adhesion molecule 2 | 0.0223736 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | 0.0220132 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0215334 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0212162 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0209045 |
| RPS12 | ribosomal protein S12 | 0.020041 |
| RPS27 | ribosomal protein S27 | 0.0198711 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.0194214 |
| VEGFA | vascular endothelial growth factor A | 0.0193879 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0191061 |
| RPS8 | ribosomal protein S8 | 0.0190408 |
| TTC6 | tetratricopeptide repeat domain 6 | 0.0185018 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0184409 |
| RALGPS1 | Ral GEF with PH domain and SH3 binding motif 1 | 0.0183243 |
| OSMR | oncostatin M receptor | 0.0181457 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0172914 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0172669 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0171785 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0170744 |
| PCBP2 | poly(rC) binding protein 2 | 0.0168124 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0166629 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.016476 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0163303 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0161975 |
| RPS29 | ribosomal protein S29 | 0.0161299 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0160908 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0159718 |
| PPP1R9B | protein phosphatase 1, regulatory subunit 9B | 0.0158237 |
| RPL35 | ribosomal protein L35 | 0.0156222 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0155189 |
| KAZN | kazrin, periplakin interacting protein | 0.0149513 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0147501 |
| CSNK1D | casein kinase 1, delta | 0.0147264 |
| SPTSSA | serine palmitoyltransferase, small subunit A | 0.0144114 |
| RPL26 | ribosomal protein L26 | 0.0143719 |
| GRB7 | growth factor receptor-bound protein 7 | 0.0142368 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.014046 |
| AUTS2 | autism susceptibility candidate 2 | 0.0139881 |
| PRELID2 | PRELI domain containing 2 | 0.0139732 |
| GPC6 | glypican 6 | 0.0137733 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0136138 |
| EXOC4 | exocyst complex component 4 | 0.0135515 |
| BRD4 | bromodomain containing 4 | 0.0135299 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0132646 |
| NRCAM | neuronal cell adhesion molecule | 0.0129579 |
| RPL13A | ribosomal protein L13a | 0.0128395 |
| RFLNA | refilin A | 0.0128056 |
| MT2A | metallothionein 2A | 0.0127271 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0126494 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0126467 |
| ZNF91 | zinc finger protein 91 | 0.0125961 |
| ARHGEF38 | Rho guanine nucleotide exchange factor (GEF) 38 | 0.0125925 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0125409 |
| TNRC18 | trinucleotide repeat containing 18 | 0.0125016 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0124152 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0124022 |
| RELA | v-rel avian reticuloendotheliosis viral oncogene homolog A | 0.0123166 |
| TMEM165 | transmembrane protein 165 | 0.0122019 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0120677 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0119638 |
| EFNA5 | ephrin-A5 | 0.0119418 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0118851 |
| KIF16B | kinesin family member 16B | 0.0118572 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | 0.0116963 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0116863 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0116805 |
| TPM3 | tropomyosin 3 | 0.01159 |
| RNF213 | ring finger protein 213 | 0.011519 |
| SLC28A3 | solute carrier family 28 (concentrative nucleoside transporter), member 3 | 0.0114252 |
| PPP4R3A | protein phosphatase 4 regulatory subunit 3A | 0.0113884 |
| IL4R | interleukin 4 receptor | 0.0113702 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0112432 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0112266 |
| SEC16A | SEC16 homolog A (S. cerevisiae) | 0.0112153 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0111579 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.011144 |
| ZFHX3 | zinc finger homeobox 3 | 0.01113 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0111213 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL19 | ribosomal protein L19 | -0.113271 |
| NCOA3 | nuclear receptor coactivator 3 | -0.107784 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.105117 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0997603 |
| CCND1 | cyclin D1 | -0.0790429 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.077831 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0712274 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0699011 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0597579 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0563006 |
| SMYD3 | SET and MYND domain containing 3 | -0.0532327 |
| MYOF | myoferlin | -0.0518199 |
| CDK12 | cyclin-dependent kinase 12 | -0.0502096 |
| ZNF217 | zinc finger protein 217 | -0.0483428 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0459633 |
| ANXA2 | annexin A2 | -0.0434228 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0429133 |
| AHNAK | AHNAK nucleoprotein | -0.0401389 |
| PTMA | prothymosin, alpha | -0.0399556 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0398309 |
| ACTG1 | actin gamma 1 | -0.0388652 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0376515 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0363944 |
| PFDN4 | prefoldin subunit 4 | -0.0360325 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0359486 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0347367 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0343681 |
| VCL | vinculin | -0.0332516 |
| IPO7 | importin 7 | -0.033221 |
| RAB22A | RAB22A, member RAS oncogene family | -0.032749 |
| CLTC | clathrin, heavy chain (Hc) | -0.0326511 |
| CCNI | cyclin I | -0.032425 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.032143 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0312118 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | -0.0311232 |
| KRT18 | keratin 18, type I | -0.0309077 |
| ASPH | aspartate beta-hydroxylase | -0.0308114 |
| FNBP1 | formin binding protein 1 | -0.0303511 |
| DSTN | destrin (actin depolymerizing factor) | -0.030257 |
| MBD4 | methyl-CpG binding domain protein 4 | -0.0301258 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0299807 |
| FOXO3 | forkhead box O3 | -0.0288272 |
| SERINC3 | serine incorporator 3 | -0.0282232 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.028074 |
| KIAA1217 | KIAA1217 | -0.0279948 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.027745 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0277292 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.027586 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0272579 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0271556 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0267137 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0267078 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0266295 |
| JMJD1C | jumonji domain containing 1C | -0.0266146 |
| DTNA | dystrobrevin, alpha | -0.0266045 |
| SMIM14 | small integral membrane protein 14 | -0.0260553 |
| MTDH | metadherin | -0.0257242 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0256785 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0252446 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0252141 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0252034 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0250619 |
| TMSB4X | thymosin beta 4, X-linked | -0.0249124 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0248957 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0248647 |
| RESF1 | retroelement silencing factor 1 | -0.0247683 |
| RBM25 | RNA binding motif protein 25 | -0.0247669 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0242903 |
| MYO6 | myosin VI | -0.0242395 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0242189 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0240386 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0239639 |
| FAM13A | family with sequence similarity 13, member A | -0.0238399 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0237249 |
| RRBP1 | ribosome binding protein 1 | -0.0236455 |
| VCP | valosin containing protein | -0.0234154 |
| GLCCI1 | glucocorticoid induced 1 | -0.0233043 |
| PGK1 | phosphoglycerate kinase 1 | -0.02319 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0231743 |
| CWC25 | CWC25 spliceosome-associated protein homolog (S. cerevisiae) | -0.0229272 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0227325 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0227045 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.022611 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0225931 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0224645 |
| OGA | O-GlcNAcase | -0.02243 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.02212 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0220951 |
| HDLBP | high density lipoprotein binding protein | -0.0220948 |
| STK4 | serine/threonine kinase 4 | -0.0220345 |
| RAB14 | RAB14, member RAS oncogene family | -0.0218935 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.0218379 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0218376 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0217623 |
| VMP1 | vacuole membrane protein 1 | -0.0216746 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0216739 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0216731 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0214486 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0213919 |
| RCOR1 | REST corepressor 1 | -0.021383 |
