Almonertinib (mesylate)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (mesylate) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (mesylate)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.139734
RAD51B RAD51 paralog B 0.113796
NPAS3 neuronal PAS domain protein 3 0.101718
TOX thymocyte selection-associated high mobility group box 0.0888862
EFNA5 ephrin-A5 0.0746243
SOX5 SRY (sex determining region Y)-box 5 0.0710709
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0704212
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0703064
DST dystonin 0.0667603
ZNF292 zinc finger protein 292 0.0632445
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0631227
PARD3 par-3 family cell polarity regulator 0.0614573
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.061243
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0605248
PNN pinin, desmosome associated protein 0.059461
EEF1G eukaryotic translation elongation factor 1 gamma 0.0594315
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0584507
RPL13A ribosomal protein L13a 0.0558488
RPL23 ribosomal protein L23 0.0545671
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0537638
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0537395
GRID2 glutamate receptor, ionotropic, delta 2 0.0515969
RPS3 ribosomal protein S3 0.0508725
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0496334
WSB1 WD repeat and SOCS box containing 1 0.0486778
NEBL nebulette 0.0484167
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0474047
RPS13 ribosomal protein S13 0.0457286
RPL3 ribosomal protein L3 0.0452623
RPS8 ribosomal protein S8 0.0448188
KMT2C lysine (K)-specific methyltransferase 2C 0.044431
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0435036
CAMTA1 calmodulin binding transcription activator 1 0.041769
RPL26 ribosomal protein L26 0.0415629
SLF1 SMC5-SMC6 complex localization factor 1 0.041065
KTN1 kinectin 1 (kinesin receptor) 0.0401837
DSCAM Down syndrome cell adhesion molecule 0.0397636
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 0.039175
PTK2 protein tyrosine kinase 2 0.0384872
RPL37A ribosomal protein L37a 0.0370571
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0364208
YEATS2 YEATS domain containing 2 0.0363251
PTCH1 patched 1 0.0362226
NGLY1 N-glycanase 1 0.0358546
ZNF160 zinc finger protein 160 0.0355835
TTC28 tetratricopeptide repeat domain 28 0.0353325
RPS11 ribosomal protein S11 0.0348915
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0344977
ZFP36L1 ZFP36 ring finger protein-like 1 0.034471
TBL1X transducin (beta)-like 1X-linked 0.0343789
EIF4B eukaryotic translation initiation factor 4B 0.0341468
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0341021
LDHA lactate dehydrogenase A 0.0338397
ATRN attractin 0.0336037
ANKRD36 ankyrin repeat domain 36 0.0334066
SFPQ splicing factor proline/glutamine-rich 0.032891
RPS29 ribosomal protein S29 0.0327779
RPL9 ribosomal protein L9 0.0327494
RBM25 RNA binding motif protein 25 0.032625
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.032335
CABIN1 calcineurin binding protein 1 0.032198
CHSY1 chondroitin sulfate synthase 1 0.0315922
AUTS2 autism susceptibility candidate 2 0.0312612
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0310955
RPL18 ribosomal protein L18 0.0310332
AKAP13 A kinase (PRKA) anchor protein 13 0.0302253
ARB2A ARB2 cotranscriptional regulator A 0.0293321
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0291047
UBC ubiquitin C 0.0290081
PRKCE protein kinase C, epsilon 0.0289922
PCBP2 poly(rC) binding protein 2 0.0288825
HMGA1 high mobility group AT-hook 1 0.0288823
KDM4B lysine (K)-specific demethylase 4B 0.0288594
TENM2 teneurin transmembrane protein 2 0.0281917
NFIA nuclear factor I/A 0.0276948
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0273822
RPL21 ribosomal protein L21 0.0273688
RFLNA refilin A 0.0272912
GSE1 Gse1 coiled-coil protein 0.0271862
TET1 tet methylcytosine dioxygenase 1 0.0269556
RPS12 ribosomal protein S12 0.0266888
RPL36A ribosomal protein L36a 0.0266128
RNF220 ring finger protein 220 0.0266071
CSDE1 cold shock domain containing E1, RNA-binding 0.026521
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0264661
RPS25 ribosomal protein S25 0.0261561
NUP58 nucleoporin 58 0.0261458
PGK1 phosphoglycerate kinase 1 0.0261136
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0260306
VEGFC vascular endothelial growth factor C 0.0260052
ATP11A ATPase, class VI, type 11A 0.0256172
PFN1 profilin 1 0.0256066
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0253643
RPL5 ribosomal protein L5 0.0251947
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 0.0248643
DDHD1 DDHD domain containing 1 0.0248197
DIDO1 death inducer-obliterator 1 0.0246944
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0246812
SRPK2 SRSF protein kinase 2 0.0246372
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0244408

decreased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.144046
GNAS GNAS complex locus -0.0793901
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0780487
ACTG1 actin gamma 1 -0.0764038
MATR3 matrin 3 -0.0634593
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0615729
RPLP1 ribosomal protein, large, P1 -0.0610993
LOC112694756 uncharaterized LOC112694756 -0.0579466
PDE4D phosphodiesterase 4D, cAMP-specific -0.0577551
RIGI RNA sensor RIG-I -0.0544188
KDM3A lysine (K)-specific demethylase 3A -0.0527853
VDAC1 voltage-dependent anion channel 1 -0.0527562
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0473115
SOX4 SRY (sex determining region Y)-box 4 -0.0443419
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0421952
FBXO11 F-box protein 11 -0.042045
GJA1 gap junction protein, alpha 1, 43kDa -0.0415748
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0405768
ZFAND3 zinc finger, AN1-type domain 3 -0.0396218
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0394534
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0392362
TMSB10 thymosin beta 10 -0.0389296
RHOA ras homolog family member A -0.0389179
IARS1 isoleucyl-tRNA synthetase 1 -0.0388972
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0388152
VCL vinculin -0.0384935
NF1 neurofibromin 1 -0.0374953
RPLP0 ribosomal protein, large, P0 -0.0367451
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0364703
DNAH14 dynein, axonemal, heavy chain 14 -0.0362187
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0360752
STAT1 signal transducer and activator of transcription 1, 91kDa -0.035993
CELF2 CUGBP, Elav-like family member 2 -0.0351412
ARHGAP32 Rho GTPase activating protein 32 -0.0342871
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0338626
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0337246
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0330447
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0324399
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.031865
SLIT2 slit homolog 2 (Drosophila) -0.0308334
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0307598
IPO7 importin 7 -0.0302562
TMEM41B transmembrane protein 41B -0.0302077
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0301551
FNBP1L formin binding protein 1-like -0.0296208
HMGB1 high mobility group box 1 -0.0291218
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0289054
RPS28 ribosomal protein S28 -0.028852
RBM28 RNA binding motif protein 28 -0.0284886
RPS4X ribosomal protein S4, X-linked -0.027365
DCDC2 doublecortin domain containing 2 -0.0272209
ADGRG6 adhesion G protein-coupled receptor G6 -0.027186
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0270672
SETX senataxin -0.0269336
HDLBP high density lipoprotein binding protein -0.0269194
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0266795
BLTP2 bridge-like lipid transfer protein family member 2 -0.0265717
KPNB1 karyopherin (importin) beta 1 -0.0262962
BZW1 basic leucine zipper and W2 domains 1 -0.0259372
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0259189
CCDC47 coiled-coil domain containing 47 -0.0256225
CDC73 cell division cycle 73 -0.0255767
MCTP1 multiple C2 domains, transmembrane 1 -0.02521
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0249415
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0249161
ZNF33A zinc finger protein 33A -0.0246371
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0244367
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0242482
RBM39 RNA binding motif protein 39 -0.0242478
KNL1 kinetochore scaffold 1 -0.023986
SETD5 SET domain containing 5 -0.0239703
LARS1 leucyl-tRNA synthetase 1 -0.0238792
RPS20 ribosomal protein S20 -0.0231511
SPIDR scaffolding protein involved in DNA repair -0.023124
TMEM123 transmembrane protein 123 -0.02302
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0230089
TMX3 thioredoxin-related transmembrane protein 3 -0.0229428
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0228616
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0228109
PPHLN1 periphilin 1 -0.0226497
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0224078
TUBB tubulin, beta class I -0.0223866
ANKHD1 ankyrin repeat and KH domain containing 1 -0.022368
CCDC88A coiled-coil domain containing 88A -0.0223604
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0223151
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0218938
RPL31 ribosomal protein L31 -0.0217009
MAPK8 mitogen-activated protein kinase 8 -0.0215778
MED13 mediator complex subunit 13 -0.0215362
RSRC1 arginine/serine-rich coiled-coil 1 -0.0214752
TXNRD1 thioredoxin reductase 1 -0.0214235
KMT2A lysine (K)-specific methyltransferase 2A -0.0212877
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0212375
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0211944
KIAA0319L KIAA0319-like -0.02094
CANX calnexin -0.0209251
RAB10 RAB10, member RAS oncogene family -0.02089
PUM2 pumilio RNA-binding family member 2 -0.0208828
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0207531
E2F3 E2F transcription factor 3 -0.0206768