| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (mesylate) perturbation in C32 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (mesylate)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.104591 |
| ASPH | aspartate beta-hydroxylase | 0.0993973 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0911725 |
| ENO1 | enolase 1, (alpha) | 0.0791053 |
| CALU | calumenin | 0.0742698 |
| NAV2 | neuron navigator 2 | 0.0711838 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.070746 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0704528 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | 0.062466 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.061367 |
| NUP58 | nucleoporin 58 | 0.0583203 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0578615 |
| CABIN1 | calcineurin binding protein 1 | 0.0564177 |
| MT2A | metallothionein 2A | 0.0561236 |
| NBAS | neuroblastoma amplified sequence | 0.055559 |
| FOSL1 | FOS-like antigen 1 | 0.0554107 |
| PRELID2 | PRELI domain containing 2 | 0.0553493 |
| PARVB | parvin, beta | 0.0535472 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0524295 |
| HLA-B | major histocompatibility complex, class I, B | 0.0506737 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0486017 |
| BPNT2 | 3'(2'), 5'-bisphosphate nucleotidase 2 | 0.0480485 |
| GANAB | glucosidase, alpha; neutral AB | 0.0468375 |
| SETBP1 | SET binding protein 1 | 0.0466892 |
| CD109 | CD109 molecule | 0.046572 |
| TMEM255B | transmembrane protein 255B | 0.0450058 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.044787 |
| NAV1 | neuron navigator 1 | 0.0442408 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0441223 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0438914 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0435172 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0419661 |
| SETD5 | SET domain containing 5 | 0.0418981 |
| RPS12 | ribosomal protein S12 | 0.0412999 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0411408 |
| SEPTIN9 | septin 9 | 0.0406594 |
| CDK19 | cyclin-dependent kinase 19 | 0.0402168 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0401672 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0400135 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0395246 |
| ZYX | zyxin | 0.0393958 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0380365 |
| RPL37A | ribosomal protein L37a | 0.0378428 |
| DDX41 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 | 0.0378329 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0371623 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0367323 |
| PFN1 | profilin 1 | 0.0365014 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0357335 |
| ACTN1 | actinin, alpha 1 | 0.0353645 |
| CENPF | centromere protein F, 350/400kDa | 0.0353473 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0348331 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0342034 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.0341935 |
| SRPK2 | SRSF protein kinase 2 | 0.0337457 |
| RAD51B | RAD51 paralog B | 0.0336059 |
| ATXN1 | ataxin 1 | 0.033574 |
| HMGA1 | high mobility group AT-hook 1 | 0.033126 |
| FBXO7 | F-box protein 7 | 0.033048 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.032987 |
| MKI67 | marker of proliferation Ki-67 | 0.0326857 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0315465 |
| RPS8 | ribosomal protein S8 | 0.0314372 |
| CTTNBP2 | cortactin binding protein 2 | 0.0312571 |
| MCL1 | myeloid cell leukemia 1 | 0.0312129 |
| RNASE12 | ribonuclease, RNase A family, 12 (non-active) | 0.0311248 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0310709 |
| CHSY1 | chondroitin sulfate synthase 1 | 0.030939 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0305857 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 0.0302488 |
| HDGF | hepatoma-derived growth factor | 0.0298707 |
| S100A9 | S100 calcium binding protein A9 | 0.0298565 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0297054 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0296887 |
| TPR | translocated promoter region, nuclear basket protein | 0.0293379 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0282465 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0279712 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0277409 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0277395 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0274355 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0273553 |
| CALR | calreticulin | 0.0270903 |
| UBE3C | ubiquitin protein ligase E3C | 0.0267041 |
| EXOC4 | exocyst complex component 4 | 0.0266706 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0263889 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0262236 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | 0.0261293 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0260047 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | 0.0259437 |
| OXR1 | oxidation resistance 1 | 0.0259206 |
| PTK2 | protein tyrosine kinase 2 | 0.0258425 |
| RPL3 | ribosomal protein L3 | 0.0257952 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0256625 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0254655 |
| HMG20B | high mobility group 20B | 0.0254018 |
| MSN | moesin | 0.0252482 |
| HLA-A | major histocompatibility complex, class I, A | 0.0249389 |
| RPL13A | ribosomal protein L13a | 0.0247179 |
| LDHA | lactate dehydrogenase A | 0.0240667 |
| XPO6 | exportin 6 | 0.0237253 |
| RPS3 | ribosomal protein S3 | 0.0234915 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.161215 |
| VIM | vimentin | -0.137207 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.135943 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.103094 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0952287 |
| FN1 | fibronectin 1 | -0.0872086 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0818571 |
| NPR2 | natriuretic peptide receptor 2 | -0.0800638 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0682013 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.064694 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | -0.0634257 |
| RPLP1 | ribosomal protein, large, P1 | -0.060898 |
| IER3 | immediate early response 3 | -0.0591847 |
| IFRD1 | interferon-related developmental regulator 1 | -0.056188 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0551785 |
| GDF15 | growth differentiation factor 15 | -0.0522693 |
| VCL | vinculin | -0.0521133 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0518338 |
| LEF1 | lymphoid enhancer-binding factor 1 | -0.0510514 |
| GNAS | GNAS complex locus | -0.0508342 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.050427 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0492875 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0492047 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0490804 |
| VGF | VGF nerve growth factor inducible | -0.048862 |
| INSIG1 | insulin induced gene 1 | -0.0471321 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0456606 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0453534 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0433726 |
| HBP1 | HMG-box transcription factor 1 | -0.0427532 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.042633 |
| FMN1 | formin 1 | -0.0423181 |
| AHNAK | AHNAK nucleoprotein | -0.0421111 |
| CANX | calnexin | -0.0413822 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.040923 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0408491 |
| RLF | rearranged L-myc fusion | -0.0407949 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0406872 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0406326 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0401572 |
| FTL | ferritin, light polypeptide | -0.0389063 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0381762 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0379206 |
| RRBP1 | ribosome binding protein 1 | -0.0371038 |
| SFTPA2 | surfactant protein A2 | -0.0370862 |
| MACROD2 | MACRO domain containing 2 | -0.0368945 |
| RPLP0 | ribosomal protein, large, P0 | -0.0368648 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0365566 |
| TMEM263 | transmembrane protein 263 | -0.0362872 |
| MATR3 | matrin 3 | -0.0359476 |
| FBXO32 | F-box protein 32 | -0.0357749 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0354665 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0352937 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0352247 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0350997 |
| RTN4 | reticulon 4 | -0.0350613 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0349904 |
| OSMR | oncostatin M receptor | -0.0348927 |
| INPP5F | inositol polyphosphate-5-phosphatase F | -0.0346244 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0345532 |
| SDCBP | syndecan binding protein (syntenin) | -0.034384 |
| GPHN | gephyrin | -0.0341891 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | -0.0341731 |
| RYBP | RING1 and YY1 binding protein | -0.0338118 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0337831 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0328174 |
| FUS | FUS RNA binding protein | -0.0326977 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0322241 |
| COPA | coatomer protein complex, subunit alpha | -0.0321446 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0317552 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0315334 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0312275 |
| CLIC4 | chloride intracellular channel 4 | -0.0308836 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0308806 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0308586 |
| MITF | microphthalmia-associated transcription factor | -0.0306204 |
| HMCN1 | hemicentin 1 | -0.0300177 |
| PLIN2 | perilipin 2 | -0.0297734 |
| FBXO11 | F-box protein 11 | -0.0296442 |
| MEF2A | myocyte enhancer factor 2A | -0.0294715 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0292739 |
| PHF21A | PHD finger protein 21A | -0.0289228 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0288198 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0286902 |
| NEK7 | NIMA-related kinase 7 | -0.0286049 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0284573 |
| AHR | aryl hydrocarbon receptor | -0.0283346 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0283283 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0281167 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0278453 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0277669 |
| GTF2B | general transcription factor IIB | -0.0277607 |
| ANXA2 | annexin A2 | -0.0277436 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0271 |
| COL19A1 | collagen, type XIX, alpha 1 | -0.0270541 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0269164 |
| PNPLA8 | patatin-like phospholipase domain containing 8 | -0.0265211 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0263556 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0259589 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0259491 |
