| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (mesylate) perturbation in CFPAC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (mesylate)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LAMB3 | laminin, beta 3 | 0.181047 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.115055 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.107533 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0944507 |
| HLA-B | major histocompatibility complex, class I, B | 0.0933249 |
| MT2A | metallothionein 2A | 0.0854355 |
| FAM13A | family with sequence similarity 13, member A | 0.0803461 |
| CCNY | cyclin Y | 0.0800876 |
| CALR | calreticulin | 0.0792491 |
| ANKRD11 | ankyrin repeat domain 11 | 0.078407 |
| HLA-A | major histocompatibility complex, class I, A | 0.074049 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0739939 |
| FLNB | filamin B, beta | 0.0736114 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0705599 |
| PTMA | prothymosin, alpha | 0.0697525 |
| VEGFA | vascular endothelial growth factor A | 0.0673736 |
| RPL23 | ribosomal protein L23 | 0.0655583 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.064672 |
| G0S2 | G0/G1 switch 2 | 0.0641479 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0614812 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0602995 |
| RPS3 | ribosomal protein S3 | 0.0572137 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0570276 |
| HMGA1 | high mobility group AT-hook 1 | 0.0562844 |
| KLF6 | Kruppel-like factor 6 | 0.0558355 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.054267 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0524663 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0520252 |
| ENO1 | enolase 1, (alpha) | 0.0515965 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0515605 |
| B2M | beta-2-microglobulin | 0.0496706 |
| SMAD3 | SMAD family member 3 | 0.0489372 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0487434 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0476567 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0472064 |
| PLAU | plasminogen activator, urokinase | 0.0453286 |
| ACTN4 | actinin, alpha 4 | 0.0447982 |
| RPS29 | ribosomal protein S29 | 0.0446284 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0439293 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.0430855 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0425959 |
| PGK1 | phosphoglycerate kinase 1 | 0.0423219 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.041526 |
| CIB1 | calcium and integrin binding 1 (calmyrin) | 0.041057 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0407694 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | 0.0406674 |
| RPL35A | ribosomal protein L35a | 0.0398451 |
| MCL1 | myeloid cell leukemia 1 | 0.037683 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.03699 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0366045 |
| PADI1 | peptidyl arginine deiminase, type I | 0.0364379 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0360427 |
| RPS8 | ribosomal protein S8 | 0.035967 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0352861 |
| RPL13A | ribosomal protein L13a | 0.0350939 |
| ITGB4 | integrin, beta 4 | 0.0344701 |
| PLEC | plectin | 0.033715 |
| LMNA | lamin A/C | 0.033667 |
| B4GALT4 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 | 0.0335223 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | 0.0335156 |
| APOL2 | apolipoprotein L, 2 | 0.033373 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0327927 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0325162 |
| GANAB | glucosidase, alpha; neutral AB | 0.0322141 |
| HLA-C | major histocompatibility complex, class I, C | 0.0320131 |
| FAM162A | family with sequence similarity 162, member A | 0.0319507 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0316681 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0315457 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | 0.0314546 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0312572 |
| DTNA | dystrobrevin, alpha | 0.0312218 |
| FDPS | farnesyl diphosphate synthase | 0.0310834 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0304233 |
| CMIP | c-Maf inducing protein | 0.0304226 |
| STC2 | stanniocalcin 2 | 0.030388 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0302535 |
| RPS27A | ribosomal protein S27a | 0.0301449 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0301283 |
| HDGF | hepatoma-derived growth factor | 0.0293098 |
| MUC4 | mucin 4, cell surface associated | 0.0292861 |
| NUP58 | nucleoporin 58 | 0.0290385 |
| MCU | mitochondrial calcium uniporter | 0.0289984 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0285194 |
| RPL26 | ribosomal protein L26 | 0.0283815 |
| RPS21 | ribosomal protein S21 | 0.0283598 |
| HELZ | helicase with zinc finger | 0.0282111 |
| RPL37A | ribosomal protein L37a | 0.0280478 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0279109 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0277923 |
| CD47 | CD47 molecule | 0.0275602 |
| HSPG2 | heparan sulfate proteoglycan 2 | 0.0271549 |
| OBSCN | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | 0.0268396 |
| FLNA | filamin A, alpha | 0.0268311 |
| WDR45B | WD repeat domain 45B | 0.0265017 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0261245 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0260487 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0259822 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.0259107 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0258781 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0253259 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.201233 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.107424 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.100325 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0977361 |
| EFNA5 | ephrin-A5 | -0.0911178 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0894885 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0843029 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0783473 |
| FTL | ferritin, light polypeptide | -0.0769932 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0723419 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0710749 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0710131 |
| OSMR | oncostatin M receptor | -0.0705391 |
| CDCP1 | CUB domain containing protein 1 | -0.0655723 |
| KRT19 | keratin 19, type I | -0.0644317 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0633285 |
| RPLP1 | ribosomal protein, large, P1 | -0.0611993 |
| FAM3C | family with sequence similarity 3, member C | -0.060923 |
| BICC1 | BicC family RNA binding protein 1 | -0.0595853 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0595249 |
| CD2AP | CD2-associated protein | -0.0572708 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0569028 |
| TXNIP | thioredoxin interacting protein | -0.0564361 |
| NRP1 | neuropilin 1 | -0.0542456 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.054156 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0533755 |
| MX1 | MX dynamin-like GTPase 1 | -0.053331 |
| DSG2 | desmoglein 2 | -0.0525293 |
| RTN4 | reticulon 4 | -0.0523476 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0508201 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0507095 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0501238 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0497083 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0464455 |
| AHR | aryl hydrocarbon receptor | -0.0460167 |
| RPS2 | ribosomal protein S2 | -0.0459099 |
| ANXA2 | annexin A2 | -0.0450891 |
| RPLP0 | ribosomal protein, large, P0 | -0.0449547 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0439757 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0439443 |
| PKM | pyruvate kinase, muscle | -0.0437557 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0436172 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0428303 |
| POTEF | POTE ankyrin domain family, member F | -0.0424727 |
| MYO1E | myosin IE | -0.0423869 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.041993 |
| SP100 | SP100 nuclear antigen | -0.0415323 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0414944 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0398465 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0393541 |
| PHF3 | PHD finger protein 3 | -0.0391119 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0381301 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.037957 |
| TJP1 | tight junction protein 1 | -0.0369338 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0362882 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0361763 |
| IL6ST | interleukin 6 signal transducer | -0.036083 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0358756 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0358128 |
| SGMS2 | sphingomyelin synthase 2 | -0.0357103 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0356066 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0354572 |
| NABP1 | nucleic acid binding protein 1 | -0.0353981 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0353879 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0340946 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0340412 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0335764 |
| TGM2 | transglutaminase 2 | -0.0332894 |
| NRG3 | neuregulin 3 | -0.0328305 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0326006 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0325475 |
| MX2 | MX dynamin-like GTPase 2 | -0.0322333 |
| ITGA6 | integrin, alpha 6 | -0.0316711 |
| RAB10 | RAB10, member RAS oncogene family | -0.0316056 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.0315414 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0313718 |
| JMJD1C | jumonji domain containing 1C | -0.0311342 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0303695 |
| TES | testin LIM domain protein | -0.030133 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0298393 |
| CDC42SE2 | CDC42 small effector 2 | -0.0295153 |
| GNAS | GNAS complex locus | -0.0288845 |
| EGR1 | early growth response 1 | -0.028635 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0283508 |
| GOLM2 | golgi membrane protein 2 | -0.0280309 |
| MMP7 | matrix metallopeptidase 7 | -0.0279954 |
| LCN2 | lipocalin 2 | -0.0278622 |
| RPS6 | ribosomal protein S6 | -0.0277028 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | -0.0276881 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0274428 |
| CLTC | clathrin, heavy chain (Hc) | -0.0273327 |
| MATR3 | matrin 3 | -0.0273061 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0270904 |
| RPS24 | ribosomal protein S24 | -0.0269401 |
| TMEM263 | transmembrane protein 263 | -0.0267632 |
| RPS5 | ribosomal protein S5 | -0.0266362 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0264783 |
| MAP1B | microtubule-associated protein 1B | -0.0264653 |
| AREG | amphiregulin | -0.0263001 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0260234 |
