| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (mesylate) perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (mesylate)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.181722 |
| RPL23 | ribosomal protein L23 | 0.115954 |
| FAM13A | family with sequence similarity 13, member A | 0.101141 |
| NDRG1 | N-myc downstream regulated 1 | 0.0927722 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0895346 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0836443 |
| MSI2 | musashi RNA-binding protein 2 | 0.0827596 |
| WDR45B | WD repeat domain 45B | 0.0796997 |
| SEPTIN9 | septin 9 | 0.0717013 |
| VIM | vimentin | 0.0682887 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0650021 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.064157 |
| COL3A1 | collagen, type III, alpha 1 | 0.0621943 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0590478 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0583501 |
| PTMA | prothymosin, alpha | 0.0573219 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0569018 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0563222 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0558175 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0539819 |
| RPS3 | ribosomal protein S3 | 0.0537407 |
| RPS12 | ribosomal protein S12 | 0.0526279 |
| RPL26 | ribosomal protein L26 | 0.0523197 |
| RPL34 | ribosomal protein L34 | 0.0509001 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.05059 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0501172 |
| VEGFA | vascular endothelial growth factor A | 0.0497426 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0494504 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0474136 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | 0.0468023 |
| COL1A1 | collagen, type I, alpha 1 | 0.0464766 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.045192 |
| SSBP3 | single stranded DNA binding protein 3 | 0.0451747 |
| ANTXR1 | anthrax toxin receptor 1 | 0.045064 |
| COL18A1 | collagen, type XVIII, alpha 1 | 0.0443861 |
| ATXN1 | ataxin 1 | 0.0443152 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0440684 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0421819 |
| HELZ | helicase with zinc finger | 0.0412252 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0411193 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0410258 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0405175 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | 0.0399347 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0393427 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.0390906 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0390735 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0389923 |
| RPL36 | ribosomal protein L36 | 0.0388653 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0385859 |
| RPL37A | ribosomal protein L37a | 0.0384798 |
| RPL3 | ribosomal protein L3 | 0.0383026 |
| MTSS2 | MTSS I-BAR domain containing 2 | 0.0379846 |
| RPL35A | ribosomal protein L35a | 0.0379634 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0374079 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.036919 |
| ENO1 | enolase 1, (alpha) | 0.0365276 |
| SETD5 | SET domain containing 5 | 0.0362129 |
| TBX2 | T-box 2 | 0.0359392 |
| MEF2A | myocyte enhancer factor 2A | 0.0357469 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0354559 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0350937 |
| TPM3 | tropomyosin 3 | 0.0344275 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0342691 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0341079 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0340615 |
| COPA | coatomer protein complex, subunit alpha | 0.0335691 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0332558 |
| RPS29 | ribosomal protein S29 | 0.0332137 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0329448 |
| CD36 | CD36 molecule (thrombospondin receptor) | 0.0328763 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | 0.0328676 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0324489 |
| RARA | retinoic acid receptor, alpha | 0.0324288 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0320566 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0319733 |
| IGFBP4 | insulin-like growth factor binding protein 4 | 0.0318374 |
| CALU | calumenin | 0.0315221 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0314587 |
| LDHA | lactate dehydrogenase A | 0.0313461 |
| SMAD3 | SMAD family member 3 | 0.0312314 |
| USP3 | ubiquitin specific peptidase 3 | 0.0310638 |
| RPS13 | ribosomal protein S13 | 0.0306738 |
| RPS27 | ribosomal protein S27 | 0.0306557 |
| CCNY | cyclin Y | 0.0305015 |
| B2M | beta-2-microglobulin | 0.0304909 |
| LAMA5 | laminin, alpha 5 | 0.0303201 |
| RACK1 | receptor for activated C kinase 1 | 0.0302411 |
| EHMT1 | euchromatic histone-lysine N-methyltransferase 1 | 0.0300454 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0299284 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0298909 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0298836 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0297733 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0297421 |
| SBF2 | SET binding factor 2 | 0.029657 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0293819 |
| NUP58 | nucleoporin 58 | 0.0292924 |
| LMNA | lamin A/C | 0.0292798 |
| NBAS | neuroblastoma amplified sequence | 0.0290401 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.029028 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0287244 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VCL | vinculin | -0.135909 |
| SYT1 | synaptotagmin I | -0.0951637 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.087381 |
| FMN1 | formin 1 | -0.0871503 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.0846686 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0659786 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0622026 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0588274 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0573024 |
| ZNF804A | zinc finger protein 804A | -0.0562759 |
| BPTF | bromodomain PHD finger transcription factor | -0.0521794 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0515778 |
| FNDC3A | fibronectin type III domain containing 3A | -0.048947 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0476515 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0471875 |
| GPATCH8 | G patch domain containing 8 | -0.0470135 |
| H3-3B | H3.3 histone B | -0.0452197 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0451594 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0445423 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0438493 |
| CLTC | clathrin, heavy chain (Hc) | -0.0436753 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.042823 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0422608 |
| PLAT | plasminogen activator, tissue | -0.0420365 |
| PCNX4 | pecanex 4 | -0.0411367 |
| UNC5C | unc-5 homolog C (C. elegans) | -0.0407435 |
| TPM1 | tropomyosin 1 (alpha) | -0.0396751 |
| RC3H1 | ring finger and CCCH-type domains 1 | -0.039585 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0390079 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0379546 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0375076 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0366463 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0356524 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0351442 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0349236 |
| LSAMP | limbic system-associated membrane protein | -0.0348886 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0347805 |
| HAND2 | heart and neural crest derivatives expressed 2 | -0.0344319 |
| TLE4 | transducin-like enhancer of split 4 | -0.0339992 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0337426 |
| CCDC47 | coiled-coil domain containing 47 | -0.0332069 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0329597 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0323977 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0323587 |
| GLCCI1 | glucocorticoid induced 1 | -0.0315465 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0313487 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0310332 |
| FERMT2 | fermitin family member 2 | -0.030978 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0308327 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0302928 |
| PHF3 | PHD finger protein 3 | -0.030251 |
| FBXO11 | F-box protein 11 | -0.0286098 |
| SNX14 | sorting nexin 14 | -0.0282371 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0280912 |
| PRR11 | proline rich 11 | -0.0279064 |
| FOXO3 | forkhead box O3 | -0.0277694 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.0275823 |
| DCAF10 | DDB1 and CUL4 associated factor 10 | -0.0267654 |
| IL6ST | interleukin 6 signal transducer | -0.0261713 |
| DGKH | diacylglycerol kinase, eta | -0.0255043 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0252828 |
| HMGA2 | high mobility group AT-hook 2 | -0.0252413 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0250487 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0249891 |
| TCF12 | transcription factor 12 | -0.0249408 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0249306 |
| FAM107B | family with sequence similarity 107, member B | -0.0249038 |
| CEP350 | centrosomal protein 350kDa | -0.0246746 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | -0.0246159 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0241318 |
| INTS6 | integrator complex subunit 6 | -0.0239981 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.023958 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.0239226 |
| RYBP | RING1 and YY1 binding protein | -0.0238014 |
| RPL38 | ribosomal protein L38 | -0.0236775 |
| PPP4R3B | protein phosphatase 4 regulatory subunit 3B | -0.0234307 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | -0.0234244 |
| RBBP6 | retinoblastoma binding protein 6 | -0.0233065 |
| HAS2 | hyaluronan synthase 2 | -0.023304 |
| HDAC8 | histone deacetylase 8 | -0.0232672 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0232434 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0231879 |
| STK38L | serine/threonine kinase 38 like | -0.0231765 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0231609 |
| GOSR1 | golgi SNAP receptor complex member 1 | -0.0230734 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0229451 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0229 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0228666 |
| NEK7 | NIMA-related kinase 7 | -0.0228656 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | -0.0228518 |
| NEK1 | NIMA-related kinase 1 | -0.0228249 |
| JMJD1C | jumonji domain containing 1C | -0.0225467 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.022446 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0224288 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | -0.0223267 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0222992 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0222796 |
| RIGI | RNA sensor RIG-I | -0.0221786 |
| ASPH | aspartate beta-hydroxylase | -0.0220251 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | -0.0219711 |
