Almonertinib (mesylate)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (mesylate) perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (mesylate)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.11932
IGFBP3 insulin-like growth factor binding protein 3 0.106279
CALR calreticulin 0.0714867
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0714066
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0708747
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0646077
ZNF841 zinc finger protein 841 0.0607473
FNIP1 folliculin interacting protein 1 0.0561556
FAM219A family with sequence similarity 219, member A 0.0556239
MT2A metallothionein 2A 0.0534442
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0527191
RPL23 ribosomal protein L23 0.052538
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0505195
ZCCHC7 zinc finger, CCHC domain containing 7 0.0497659
MYH9 myosin, heavy chain 9, non-muscle 0.048636
SEC61G Sec61 gamma subunit 0.0486195
RPL13A ribosomal protein L13a 0.0485088
COL5A1 collagen, type V, alpha 1 0.0457437
GOLGB1 golgin B1 0.0442487
MSN moesin 0.0436178
RPL37A ribosomal protein L37a 0.0434268
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0425499
BACE2 beta-site APP-cleaving enzyme 2 0.0391185
RPLP2 ribosomal protein, large, P2 0.0385614
AKAP9 A kinase (PRKA) anchor protein 9 0.0380777
SBF2 SET binding factor 2 0.0375388
YEATS2 YEATS domain containing 2 0.0368045
METTL15 methyltransferase like 15 0.0356064
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0348285
RPS27A ribosomal protein S27a 0.034771
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0347572
AVL9 AVL9 homolog (S. cerevisiase) 0.0341464
COG5 component of oligomeric golgi complex 5 0.0341152
TNRC18 trinucleotide repeat containing 18 0.034074
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0336625
STC1 stanniocalcin 1 0.0335446
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.033512
ZNF146 zinc finger protein 146 0.0334467
DOCK5 dedicator of cytokinesis 5 0.0331217
NAV2 neuron navigator 2 0.0328703
FLNA filamin A, alpha 0.032551
N4BP2L2 NEDD4 binding protein 2-like 2 0.0325198
HSPA8 heat shock 70kDa protein 8 0.0325063
TPM3 tropomyosin 3 0.032425
CDK19 cyclin-dependent kinase 19 0.0316603
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0313021
EEF1G eukaryotic translation elongation factor 1 gamma 0.0309986
RPL26 ribosomal protein L26 0.0307525
TBC1D22A TBC1 domain family, member 22A 0.0305386
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0303752
GOLGA4 golgin A4 0.0302343
POM121 POM121 transmembrane nucleoporin 0.0301728
RPS12 ribosomal protein S12 0.0301662
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0300411
RPS19 ribosomal protein S19 0.0297435
CEMIP cell migration inducing protein, hyaluronan binding 0.0295427
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0292664
NBEAL1 neurobeachin-like 1 0.0291152
ZNF160 zinc finger protein 160 0.0281565
SHB Src homology 2 domain containing adaptor protein B 0.0281204
DGKD diacylglycerol kinase, delta 130kDa 0.0280363
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 0.0280338
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 0.0275576
RPL7A ribosomal protein L7a 0.0274421
TTC3 tetratricopeptide repeat domain 3 0.0271183
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 0.0270463
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0268691
NFE2L1 nuclear factor, erythroid 2-like 1 0.0267492
RPL3 ribosomal protein L3 0.0264746
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0263649
RPL9 ribosomal protein L9 0.0261152
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0257992
HDGF hepatoma-derived growth factor 0.0256505
HDAC9 histone deacetylase 9 0.0254656
RPS8 ribosomal protein S8 0.0253219
RPS2 ribosomal protein S2 0.0250702
AFF1 AF4/FMR2 family, member 1 0.0250279
SMAD3 SMAD family member 3 0.0249586
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0249138
GPR107 G protein-coupled receptor 107 0.024828
EEF2 eukaryotic translation elongation factor 2 0.0247291
BTBD9 BTB (POZ) domain containing 9 0.0246393
USP36 ubiquitin specific peptidase 36 0.0245547
ZNF451 zinc finger protein 451 0.0245342
GANAB glucosidase, alpha; neutral AB 0.0244435
ACTN4 actinin, alpha 4 0.0243904
POM121C POM121 transmembrane nucleoporin C 0.024333
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0243326
SAMD4A sterile alpha motif domain containing 4A 0.0242852
BRD2 bromodomain containing 2 0.0237298
RPL18 ribosomal protein L18 0.023499
RPS13 ribosomal protein S13 0.0233548
PRELID2 PRELI domain containing 2 0.0232707
ACTN1 actinin, alpha 1 0.0230625
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0229304
NUDCD3 NudC domain containing 3 0.0228957
RPS3 ribosomal protein S3 0.022582
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.0222873
NUP214 nucleoporin 214kDa 0.0222574
ERI3 ERI1 exoribonuclease family member 3 0.0222171

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.269733
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.102127
NALF1 NALCN channel auxiliary factor 1 -0.0964967
FN1 fibronectin 1 -0.0946413
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0905419
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0854723
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0770373
PDIA3 protein disulfide isomerase family A, member 3 -0.0666931
TXNRD1 thioredoxin reductase 1 -0.0643932
GNAS GNAS complex locus -0.0604479
VDAC1 voltage-dependent anion channel 1 -0.0593715
GARS1 glycyl-tRNA synthetase 1 -0.0586395
ANXA2 annexin A2 -0.0560778
CD44 CD44 molecule (Indian blood group) -0.0558453
TPM4 tropomyosin 4 -0.0537555
RPLP1 ribosomal protein, large, P1 -0.0521075
CANX calnexin -0.0520774
MAP1B microtubule-associated protein 1B -0.0517623
NAMPT nicotinamide phosphoribosyltransferase -0.0493896
TRIO trio Rho guanine nucleotide exchange factor -0.0491728
AHNAK AHNAK nucleoprotein -0.0485618
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0477644
PKM pyruvate kinase, muscle -0.0475653
RPLP0 ribosomal protein, large, P0 -0.0470954
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0468366
CDK6 cyclin-dependent kinase 6 -0.046761
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0463577
TIMP3 TIMP metallopeptidase inhibitor 3 -0.045937
RTN4 reticulon 4 -0.0450335
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.044601
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0431216
RLF rearranged L-myc fusion -0.0430355
PDE4D phosphodiesterase 4D, cAMP-specific -0.0428246
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0426085
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0425544
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.042288
SLC38A2 solute carrier family 38, member 2 -0.0418056
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0410262
TUBB tubulin, beta class I -0.0401017
NLGN1 neuroligin 1 -0.0396845
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0395862
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0394761
FTH1 ferritin, heavy polypeptide 1 -0.0390147
CENPF centromere protein F, 350/400kDa -0.0381632
ADM adrenomedullin -0.0380128
SH3KBP1 SH3-domain kinase binding protein 1 -0.0379052
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0375075
RAD21 RAD21 homolog (S. pombe) -0.0372432
MATR3 matrin 3 -0.0370038
PTK2 protein tyrosine kinase 2 -0.0369335
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0366487
CLMP CXADR-like membrane protein -0.0366294
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0363646
NCOA7 nuclear receptor coactivator 7 -0.0356789
JUN jun proto-oncogene -0.0354153
TENM3 teneurin transmembrane protein 3 -0.0344904
JMJD1C jumonji domain containing 1C -0.0343918
GRB10 growth factor receptor-bound protein 10 -0.0342983
USP3 ubiquitin specific peptidase 3 -0.0340619
INHBA inhibin, beta A -0.033891
IGFBP5 insulin-like growth factor binding protein 5 -0.0338723
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0338031
AHR aryl hydrocarbon receptor -0.0329587
SEPTIN7 septin 7 -0.0327201
EGR1 early growth response 1 -0.0319035
CBX3 chromobox homolog 3 -0.0317056
B2M beta-2-microglobulin -0.0315045
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0315033
ZC3H11A zinc finger CCCH-type containing 11A -0.0309921
TNPO1 transportin 1 -0.0309009
TUBA1B tubulin, alpha 1b -0.0303235
VIM vimentin -0.0299092
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0297352
QKI QKI, KH domain containing, RNA binding -0.02956
RAB7A RAB7A, member RAS oncogene family -0.0295244
IER3 immediate early response 3 -0.029371
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0291023
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0290765
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0286988
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0284775
PRSS23 protease, serine, 23 -0.0284146
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0284085
PALS2 protein associated with LIN7 2, MAGUK p55 family member -0.0283579
TXNIP thioredoxin interacting protein -0.0282037
GNG12 guanine nucleotide binding protein (G protein), gamma 12 -0.0277959
TMEM263 transmembrane protein 263 -0.0277071
HIPK2 homeodomain interacting protein kinase 2 -0.0275421
KMT2C lysine (K)-specific methyltransferase 2C -0.0275412
HIP1 huntingtin interacting protein 1 -0.0269236
OSMR oncostatin M receptor -0.0267511
RNF145 ring finger protein 145 -0.0266943
BTG1 B-cell translocation gene 1, anti-proliferative -0.0265022
PXDN peroxidasin -0.0264386
EYA4 EYA transcriptional coactivator and phosphatase 4 -0.0262617
SMC4 structural maintenance of chromosomes 4 -0.0262332
POTEF POTE ankyrin domain family, member F -0.02618
RAB2A RAB2A, member RAS oncogene family -0.0260118
ZFR zinc finger RNA binding protein -0.0259565
GLG1 golgi glycoprotein 1 -0.0259455
SSBP2 single-stranded DNA binding protein 2 -0.0259209