| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (mesylate) perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Almonertinib (mesylate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.22443 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.14062 |
| NDRG1 | N-myc downstream regulated 1 | 0.137017 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.114462 |
| ENO1 | enolase 1, (alpha) | 0.0875785 |
| PTMA | prothymosin, alpha | 0.085502 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0766613 |
| RPL35A | ribosomal protein L35a | 0.068808 |
| RPL23 | ribosomal protein L23 | 0.0685539 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0654275 |
| RPS8 | ribosomal protein S8 | 0.0594842 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0592584 |
| RPL26 | ribosomal protein L26 | 0.0589517 |
| GANAB | glucosidase, alpha; neutral AB | 0.0586762 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0581722 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0581445 |
| RPL37A | ribosomal protein L37a | 0.0569345 |
| HMGA1 | high mobility group AT-hook 1 | 0.0565589 |
| RPS3 | ribosomal protein S3 | 0.0565452 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0559503 |
| VEGFA | vascular endothelial growth factor A | 0.0540845 |
| TMSB10 | thymosin beta 10 | 0.0532146 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0528133 |
| MT2A | metallothionein 2A | 0.0509778 |
| RPL13A | ribosomal protein L13a | 0.0492622 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0483683 |
| CALR | calreticulin | 0.046327 |
| KRT8 | keratin 8, type II | 0.0462536 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0434859 |
| ZNF292 | zinc finger protein 292 | 0.0426909 |
| OBSCN | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | 0.0420996 |
| GOLGA2 | golgin A2 | 0.0417418 |
| ZNF511 | zinc finger protein 511 | 0.0402125 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | 0.0401002 |
| RPL18 | ribosomal protein L18 | 0.0395644 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0391304 |
| WDR45B | WD repeat domain 45B | 0.0385907 |
| RPS19 | ribosomal protein S19 | 0.0381117 |
| NUP58 | nucleoporin 58 | 0.03775 |
| CTBP2 | C-terminal binding protein 2 | 0.035512 |
| PRELID2 | PRELI domain containing 2 | 0.0353125 |
| RPLP2 | ribosomal protein, large, P2 | 0.0350958 |
| RPS29 | ribosomal protein S29 | 0.0348724 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0341726 |
| MKI67 | marker of proliferation Ki-67 | 0.0339339 |
| HMBOX1 | homeobox containing 1 | 0.033374 |
| RPS12 | ribosomal protein S12 | 0.0329957 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0329498 |
| RPL36 | ribosomal protein L36 | 0.0329327 |
| RAD51B | RAD51 paralog B | 0.0328903 |
| TPM3 | tropomyosin 3 | 0.0326692 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0323566 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0322287 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0320874 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0320712 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0319742 |
| HPCAL1 | hippocalcin-like 1 | 0.031729 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.031582 |
| RPS21 | ribosomal protein S21 | 0.0307693 |
| RPS13 | ribosomal protein S13 | 0.0307497 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0306837 |
| PLEC | plectin | 0.0306386 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.0299076 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0298936 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0298004 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0295626 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0295393 |
| PMM2 | phosphomannomutase 2 | 0.0294045 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0292594 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0289699 |
| RPL5 | ribosomal protein L5 | 0.0287102 |
| PDXK | pyridoxal (pyridoxine, vitamin B6) kinase | 0.0278142 |
| BRD4 | bromodomain containing 4 | 0.0277078 |
| SCFD1 | sec1 family domain containing 1 | 0.0276975 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0275797 |
| YEATS2 | YEATS domain containing 2 | 0.027564 |
| RPS11 | ribosomal protein S11 | 0.0274928 |
| GOLGA3 | golgin A3 | 0.0274776 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0273033 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0270634 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0270384 |
| HM13 | histocompatibility (minor) 13 | 0.0268506 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0267966 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0267562 |
| CALU | calumenin | 0.0267124 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0262962 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0262789 |
| FAM162A | family with sequence similarity 162, member A | 0.0262669 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 0.0261922 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0260303 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0259538 |
| BMS1 | BMS1 ribosome biogenesis factor | 0.025778 |
| GOLGA4 | golgin A4 | 0.0256475 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0254856 |
| PGM3 | phosphoglucomutase 3 | 0.0254488 |
| RPL11 | ribosomal protein L11 | 0.0250423 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0250381 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0249649 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0247447 |
| TMEM59 | transmembrane protein 59 | 0.0245495 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.145092 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.116605 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0834474 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0718046 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0709375 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0686235 |
| VCL | vinculin | -0.0660841 |
| FHIT | fragile histidine triad | -0.0557612 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0555377 |
| TPM4 | tropomyosin 4 | -0.0543666 |
| NF1 | neurofibromin 1 | -0.0536461 |
| GPHN | gephyrin | -0.0527083 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0511126 |
| FTL | ferritin, light polypeptide | -0.04956 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.047801 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0460535 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0456226 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.0456108 |
| XPO1 | exportin 1 | -0.0454147 |
| AHNAK | AHNAK nucleoprotein | -0.0447223 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0446045 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0441479 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0433387 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0422018 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0417417 |
| CLTC | clathrin, heavy chain (Hc) | -0.0412022 |
| LCOR | ligand dependent nuclear receptor corepressor | -0.0411634 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0407576 |
| USP34 | ubiquitin specific peptidase 34 | -0.0403673 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0399881 |
| TENM3 | teneurin transmembrane protein 3 | -0.0398406 |
| IPO7 | importin 7 | -0.0375575 |
| RPLP0 | ribosomal protein, large, P0 | -0.0373483 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0372219 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0366454 |
| PKM | pyruvate kinase, muscle | -0.0359506 |
| FAT1 | FAT atypical cadherin 1 | -0.0354134 |
| RPL4 | ribosomal protein L4 | -0.0353631 |
| KLF12 | Kruppel-like factor 12 | -0.0346287 |
| JMJD1C | jumonji domain containing 1C | -0.0343486 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0336537 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0335066 |
| CENPF | centromere protein F, 350/400kDa | -0.0335034 |
| TNPO1 | transportin 1 | -0.0333958 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0329004 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0328722 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0327647 |
| TJP1 | tight junction protein 1 | -0.0326699 |
| TAOK1 | TAO kinase 1 | -0.0326295 |
| SKP1 | S-phase kinase-associated protein 1 | -0.0323401 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0317673 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0313142 |
| UBXN4 | UBX domain protein 4 | -0.0312118 |
| RPS2 | ribosomal protein S2 | -0.0310677 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0310319 |
| PHIP | pleckstrin homology domain interacting protein | -0.0310127 |
| GOLM2 | golgi membrane protein 2 | -0.0307274 |
| PERP | PERP, TP53 apoptosis effector | -0.0305287 |
| SETX | senataxin | -0.0305208 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0303273 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0302517 |
| PCM1 | pericentriolar material 1 | -0.0302501 |
| MACROD2 | MACRO domain containing 2 | -0.0302117 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0297008 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0295386 |
| MATR3 | matrin 3 | -0.0292654 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0291502 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0289954 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | -0.0289675 |
| INTS6 | integrator complex subunit 6 | -0.0288388 |
| DSPP | dentin sialophosphoprotein | -0.0288264 |
| TASOR2 | transcription activation suppressor family member 2 | -0.0287354 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0285945 |
| DIAPH2 | diaphanous-related formin 2 | -0.0285831 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0283469 |
| RAB10 | RAB10, member RAS oncogene family | -0.0283427 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0281385 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0281161 |
| BBX | bobby sox homolog (Drosophila) | -0.0280451 |
| ZNF644 | zinc finger protein 644 | -0.0280277 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0279893 |
| MYO6 | myosin VI | -0.027939 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0278881 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0277465 |
| RYBP | RING1 and YY1 binding protein | -0.0275046 |
| PCBP2 | poly(rC) binding protein 2 | -0.0271141 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0269012 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0267855 |
| DNAJB14 | DnaJ (Hsp40) homolog, subfamily B, member 14 | -0.0267457 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0266276 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0265601 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0264796 |
| IL6ST | interleukin 6 signal transducer | -0.0263579 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0261695 |
| PKP4 | plakophilin 4 | -0.0259695 |
| DENND4C | DENN/MADD domain containing 4C | -0.0256898 |
| PTK2 | protein tyrosine kinase 2 | -0.0256509 |
| PAPOLA | poly(A) polymerase alpha | -0.0255333 |
| RPLP1 | ribosomal protein, large, P1 | -0.0251494 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | -0.0250024 |
