Almonertinib (mesylate)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (mesylate) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (mesylate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.106466
ANKRD10 ankyrin repeat domain 10 0.0855948
MYH9 myosin, heavy chain 9, non-muscle 0.0834961
SMAD3 SMAD family member 3 0.0830872
APP amyloid beta (A4) precursor protein 0.0771486
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0770393
HMGA1 high mobility group AT-hook 1 0.0761989
ZNF292 zinc finger protein 292 0.0728867
PTK2 protein tyrosine kinase 2 0.0679869
RPL23 ribosomal protein L23 0.0675179
AFDN afadin, adherens junction formation factor 0.0659241
RPL13A ribosomal protein L13a 0.065357
TPT1 tumor protein, translationally-controlled 1 0.0641395
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0620452
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0596752
RPS8 ribosomal protein S8 0.0574867
NCKAP1 NCK-associated protein 1 0.0562177
EEF1G eukaryotic translation elongation factor 1 gamma 0.0552059
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0549838
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0539436
NRIP1 nuclear receptor interacting protein 1 0.051898
PUM1 pumilio RNA-binding family member 1 0.051716
MPRIP myosin phosphatase Rho interacting protein 0.0512355
ACTN4 actinin, alpha 4 0.0510636
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0506715
RPL5 ribosomal protein L5 0.0480532
TXNRD1 thioredoxin reductase 1 0.0472711
LAMB3 laminin, beta 3 0.0472581
TNIP1 TNFAIP3 interacting protein 1 0.0469985
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0468393
RPL9 ribosomal protein L9 0.0466683
FLNA filamin A, alpha 0.0463519
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0458105
TRIM2 tripartite motif containing 2 0.0444632
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0444046
MT2A metallothionein 2A 0.0443211
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0439979
ANKRD28 ankyrin repeat domain 28 0.0437018
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0433723
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0431295
EEF2 eukaryotic translation elongation factor 2 0.0427139
KDM6A lysine (K)-specific demethylase 6A 0.0425572
ARHGAP26 Rho GTPase activating protein 26 0.0422572
USP9X ubiquitin specific peptidase 9, X-linked 0.0422511
ANKRD11 ankyrin repeat domain 11 0.0418911
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.041123
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0403801
ICAM1 intercellular adhesion molecule 1 0.0396727
TRA2B transformer 2 beta homolog (Drosophila) 0.0390864
SFPQ splicing factor proline/glutamine-rich 0.0389683
WAC WW domain containing adaptor with coiled-coil 0.0381324
RPL37A ribosomal protein L37a 0.0375533
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.037425
POTEF POTE ankyrin domain family, member F 0.0368983
CSDE1 cold shock domain containing E1, RNA-binding 0.036613
CAMTA1 calmodulin binding transcription activator 1 0.0362578
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0358793
TNRC6A trinucleotide repeat containing 6A 0.0356126
VASP vasodilator-stimulated phosphoprotein 0.0354984
TMSB10 thymosin beta 10 0.03548
UPP1 uridine phosphorylase 1 0.0353405
UBE3A ubiquitin protein ligase E3A 0.035254
PLEC plectin 0.0349614
RPS19 ribosomal protein S19 0.0348938
TPM3 tropomyosin 3 0.0343405
RPLP2 ribosomal protein, large, P2 0.0342028
RPS12 ribosomal protein S12 0.0341508
CCNL1 cyclin L1 0.0341057
ZFAND3 zinc finger, AN1-type domain 3 0.0340633
RPL26 ribosomal protein L26 0.0340463
FOSL1 FOS-like antigen 1 0.0340028
FAM168B family with sequence similarity 168, member B 0.0339269
WDR43 WD repeat domain 43 0.0338766
PCBP2 poly(rC) binding protein 2 0.0333218
PFN1 profilin 1 0.033224
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0330333
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0329616
MKI67 marker of proliferation Ki-67 0.0329561
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0329174
RPL35A ribosomal protein L35a 0.0327946
RPS3 ribosomal protein S3 0.0325693
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0320499
CELF1 CUGBP, Elav-like family member 1 0.03177
MACF1 microtubule-actin crosslinking factor 1 0.0317492
LMNA lamin A/C 0.0316629
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0314885
KLF6 Kruppel-like factor 6 0.0313053
RPL3 ribosomal protein L3 0.0311401
PARD3 par-3 family cell polarity regulator 0.0307854
FUBP1 far upstream element (FUSE) binding protein 1 0.0307843
S100A9 S100 calcium binding protein A9 0.0307192
RAD23B RAD23 homolog B (S. cerevisiae) 0.0306573
IRF1 interferon regulatory factor 1 0.0306218
RPS13 ribosomal protein S13 0.0305931
SOD2 superoxide dismutase 2, mitochondrial 0.0305462
KRT7 keratin 7, type II 0.0303018
YTHDC1 YTH domain containing 1 0.0301272
TM9SF3 transmembrane 9 superfamily member 3 0.0301172
ATXN7 ataxin 7 0.030104
DNM2 dynamin 2 0.0300419

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.229506
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.103376
ALCAM activated leukocyte cell adhesion molecule -0.101246
AHNAK AHNAK nucleoprotein -0.0964134
CCND1 cyclin D1 -0.0776433
CANX calnexin -0.075399
FTL ferritin, light polypeptide -0.0717425
PRELID2 PRELI domain containing 2 -0.0686592
RAD51B RAD51 paralog B -0.0684928
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0637522
TTC3 tetratricopeptide repeat domain 3 -0.0606618
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.058603
HMGA2 high mobility group AT-hook 2 -0.0571858
FHIT fragile histidine triad -0.0555784
ASPH aspartate beta-hydroxylase -0.0555099
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0505078
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0490811
CREB5 cAMP responsive element binding protein 5 -0.0481487
INTS6 integrator complex subunit 6 -0.0475825
PDIA3 protein disulfide isomerase family A, member 3 -0.0474651
DLC1 DLC1 Rho GTPase activating protein -0.0473576
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.045266
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0435631
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0432013
BPTF bromodomain PHD finger transcription factor -0.0430455
PKM pyruvate kinase, muscle -0.0411745
LMAN1 lectin, mannose-binding, 1 -0.0404832
VCL vinculin -0.0402669
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0393356
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0379882
SNX14 sorting nexin 14 -0.0374472
NDRG1 N-myc downstream regulated 1 -0.0344127
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0342349
RHEX regulator of hemoglobinization and erythroid cell expansion -0.0335339
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0328329
AKAP12 A kinase (PRKA) anchor protein 12 -0.0325332
ECT2 epithelial cell transforming 2 -0.0323562
TPM4 tropomyosin 4 -0.0318968
TBC1D5 TBC1 domain family, member 5 -0.0315195
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0312712
WWOX WW domain containing oxidoreductase -0.0311499
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.03109
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.0310858
CCDC138 coiled-coil domain containing 138 -0.0308056
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0305858
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0301327
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0296024
MYOF myoferlin -0.0293298
INSIG2 insulin induced gene 2 -0.0293222
IARS1 isoleucyl-tRNA synthetase 1 -0.0291018
ZNF638 zinc finger protein 638 -0.0290797
BICD1 bicaudal D homolog 1 (Drosophila) -0.0289024
MBNL1 muscleblind-like splicing regulator 1 -0.0285362
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0285173
ARHGAP29 Rho GTPase activating protein 29 -0.0283887
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0279841
PHF3 PHD finger protein 3 -0.0275421
VDAC1 voltage-dependent anion channel 1 -0.0274429
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0269962
BZW1 basic leucine zipper and W2 domains 1 -0.026654
GOLGB1 golgin B1 -0.0261588
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0259905
GNAS GNAS complex locus -0.0254025
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0251992
MYO1E myosin IE -0.0251223
PAIP2 poly(A) binding protein interacting protein 2 -0.0250668
LOC112694756 uncharaterized LOC112694756 -0.0248428
BBX bobby sox homolog (Drosophila) -0.024539
FNBP1L formin binding protein 1-like -0.0242854
ITGA6 integrin, alpha 6 -0.0242062
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0241111
SUMF1 sulfatase modifying factor 1 -0.0240829
AEBP2 AE binding protein 2 -0.0240624
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0238876
PDIA4 protein disulfide isomerase family A, member 4 -0.0236629
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0235406
DIAPH2 diaphanous-related formin 2 -0.0233347
RFC3 replication factor C (activator 1) 3, 38kDa -0.0233341
BICC1 BicC family RNA binding protein 1 -0.0232522
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0228289
PTPRK protein tyrosine phosphatase, receptor type, K -0.022722
CFAP20DC CFAP20 domain containing -0.0227044
FAM13B family with sequence similarity 13, member B -0.0225851
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0225787
H1-0 H1.0 linker histone -0.0225385
LIMCH1 LIM and calponin homology domains 1 -0.0224956
RAD50 RAD50 homolog (S. cerevisiae) -0.0224527
BBS9 Bardet-Biedl syndrome 9 -0.0223851
DHFR dihydrofolate reductase -0.0222674
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.0222593
TAOK1 TAO kinase 1 -0.0222357
VCAN versican -0.0221037
PICALM phosphatidylinositol binding clathrin assembly protein -0.0220865
ARFGEF3 ARFGEF family member 3 -0.0220836
COPB1 coatomer protein complex, subunit beta 1 -0.0220452
CD44 CD44 molecule (Indian blood group) -0.0220176
RTN3 reticulon 3 -0.0219709
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0219334
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -0.0216561
FNIP1 folliculin interacting protein 1 -0.0216407