Almonertinib (mesylate)_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (mesylate) perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (mesylate)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.258464
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.183044
PTMA prothymosin, alpha 0.167076
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.133408
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0949138
VEGFA vascular endothelial growth factor A 0.0920896
FAM13A family with sequence similarity 13, member A 0.0788197
VIM vimentin 0.0773059
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0654682
RPS8 ribosomal protein S8 0.0644075
IGF2 insulin-like growth factor 2 0.0613434
TPT1 tumor protein, translationally-controlled 1 0.0594523
RPL26 ribosomal protein L26 0.0568836
RPS3 ribosomal protein S3 0.0551354
RPL23 ribosomal protein L23 0.053519
RPS12 ribosomal protein S12 0.0521433
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0491838
UBA6 ubiquitin-like modifier activating enzyme 6 0.0487802
WDR45B WD repeat domain 45B 0.048723
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0482176
PDIA6 protein disulfide isomerase family A, member 6 0.047912
MT2A metallothionein 2A 0.04756
RPL35A ribosomal protein L35a 0.0455272
G0S2 G0/G1 switch 2 0.0441984
MYH9 myosin, heavy chain 9, non-muscle 0.0425788
EEF1G eukaryotic translation elongation factor 1 gamma 0.0417949
DDIT4 DNA-damage-inducible transcript 4 0.041453
CALR calreticulin 0.0413634
NGLY1 N-glycanase 1 0.0407675
RPLP2 ribosomal protein, large, P2 0.039975
ANKRD11 ankyrin repeat domain 11 0.0398799
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0391285
RPL12 ribosomal protein L12 0.0387064
RPL37A ribosomal protein L37a 0.0384271
RPS27A ribosomal protein S27a 0.0373268
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0369886
TNS1 tensin 1 0.0369364
AKAP12 A kinase (PRKA) anchor protein 12 0.0363937
RNMT RNA (guanine-7-) methyltransferase 0.0362205
ADM adrenomedullin 0.0361955
OGA O-GlcNAcase 0.0361903
CANX calnexin 0.0358683
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0357537
PDIA4 protein disulfide isomerase family A, member 4 0.0335042
NAP1L1 nucleosome assembly protein 1-like 1 0.0333378
SPAG9 sperm associated antigen 9 0.0323259
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0321568
FOSL1 FOS-like antigen 1 0.0319795
ELL2 elongation factor, RNA polymerase II, 2 0.0316815
RPS13 ribosomal protein S13 0.0310984
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0310298
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0304902
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0302755
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0302132
IRS2 insulin receptor substrate 2 0.0300077
RASA3 RAS p21 protein activator 3 0.0296988
KLF6 Kruppel-like factor 6 0.0296794
RPL13A ribosomal protein L13a 0.0293492
RPL6 ribosomal protein L6 0.0292166
RPL11 ribosomal protein L11 0.0288305
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0286084
VASP vasodilator-stimulated phosphoprotein 0.0283834
SEC24A SEC24 family member A 0.028363
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0282233
TPM3 tropomyosin 3 0.0281444
SEPTIN9 septin 9 0.0280825
FAM162A family with sequence similarity 162, member A 0.0279002
UBC ubiquitin C 0.0276785
GOLGA4 golgin A4 0.0267204
RPL34 ribosomal protein L34 0.0266597
TAC4 tachykinin 4 (hemokinin) 0.0262236
RPS29 ribosomal protein S29 0.0262132
HILPDA hypoxia inducible lipid droplet-associated 0.0259721
RPL3 ribosomal protein L3 0.0251746
NAMPT nicotinamide phosphoribosyltransferase 0.0245976
RPS6 ribosomal protein S6 0.023935
RPL5 ribosomal protein L5 0.023872
RPS17 ribosomal protein S17 0.023866
RPS19 ribosomal protein S19 0.0237605
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0236483
SET SET nuclear proto-oncogene 0.0236436
SETD5 SET domain containing 5 0.0236113
HPCAL1 hippocalcin-like 1 0.0232284
CLEC1B C-type lectin domain family 1, member B 0.0231424
FGFR1 fibroblast growth factor receptor 1 0.023045
PTPRF protein tyrosine phosphatase, receptor type, F 0.0229364
RPS27 ribosomal protein S27 0.0227206
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0226348
AKAP10 A kinase (PRKA) anchor protein 10 0.0226113
RPL9 ribosomal protein L9 0.0224853
USP3 ubiquitin specific peptidase 3 0.0221427
TM4SF1 transmembrane 4 L six family member 1 0.0220136
RPS2 ribosomal protein S2 0.021883
RPL36A ribosomal protein L36a 0.0213107
COL7A1 collagen, type VII, alpha 1 0.0211416
WSB1 WD repeat and SOCS box containing 1 0.0210584
ENO1 enolase 1, (alpha) 0.021049
TMED9 transmembrane emp24 protein transport domain containing 9 0.0209844
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.0207037
GANAB glucosidase, alpha; neutral AB 0.0206047

decreased expression

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 -0.146334
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.131736
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.11092
EXT1 exostosin glycosyltransferase 1 -0.109291
GLIS3 GLIS family zinc finger 3 -0.104766
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.096773
CD44 CD44 molecule (Indian blood group) -0.0935599
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0863562
TRIO trio Rho guanine nucleotide exchange factor -0.0857617
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0829118
NALF1 NALCN channel auxiliary factor 1 -0.0724475
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0706053
DST dystonin -0.0696142
COL6A3 collagen, type VI, alpha 3 -0.0689955
BICD1 bicaudal D homolog 1 (Drosophila) -0.0689841
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0639465
CCND1 cyclin D1 -0.0628869
AHNAK AHNAK nucleoprotein -0.0602472
ASPH aspartate beta-hydroxylase -0.0586736
NDRG1 N-myc downstream regulated 1 -0.0572556
ZBTB20 zinc finger and BTB domain containing 20 -0.0568087
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0546643
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0517347
TAS2R14 taste receptor, type 2, member 14 -0.0517209
FTL ferritin, light polypeptide -0.0512244
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0507785
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0498341
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0491927
CDH13 cadherin 13 -0.0485453
ZBTB38 zinc finger and BTB domain containing 38 -0.0478376
NAV1 neuron navigator 1 -0.0470832
SMYD3 SET and MYND domain containing 3 -0.0469742
MYO10 myosin X -0.0447442
MAP1B microtubule-associated protein 1B -0.0442343
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.044043
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0419996
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0415681
ANXA2 annexin A2 -0.0413527
FMN1 formin 1 -0.0413023
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0408562
PGK1 phosphoglycerate kinase 1 -0.0399464
LOC112694756 uncharaterized LOC112694756 -0.0392349
VDAC1 voltage-dependent anion channel 1 -0.0388499
VCL vinculin -0.0381113
TBC1D5 TBC1 domain family, member 5 -0.0375132
CCDC91 coiled-coil domain containing 91 -0.0371274
ETV6 ets variant 6 -0.0365072
OSMR oncostatin M receptor -0.0356357
F3 coagulation factor III (thromboplastin, tissue factor) -0.0352066
DIAPH2 diaphanous-related formin 2 -0.0350644
SMAD3 SMAD family member 3 -0.0343959
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0341159
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0340488
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0338168
RAI14 retinoic acid induced 14 -0.0337454
ANKRD12 ankyrin repeat domain 12 -0.0337416
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0336358
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0335454
TXNRD1 thioredoxin reductase 1 -0.0335377
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0334354
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0329457
RAD51B RAD51 paralog B -0.0319609
CDK6 cyclin-dependent kinase 6 -0.0318838
WNK1 WNK lysine deficient protein kinase 1 -0.0317668
ANKRD28 ankyrin repeat domain 28 -0.0317612
FNDC3B fibronectin type III domain containing 3B -0.0314645
PRKCA protein kinase C, alpha -0.0314126
ANTXR1 anthrax toxin receptor 1 -0.0312485
CLIC4 chloride intracellular channel 4 -0.0310594
FN1 fibronectin 1 -0.0300876
NF1 neurofibromin 1 -0.0300692
ATXN1 ataxin 1 -0.0300433
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0298886
NAV3 neuron navigator 3 -0.0291434
TMSB10 thymosin beta 10 -0.0289896
MBD5 methyl-CpG binding domain protein 5 -0.0285487
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0285221
FBXL7 F-box and leucine-rich repeat protein 7 -0.0283878
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0283823
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0283521
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0283246
FER fer (fps/fes related) tyrosine kinase -0.0281482
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0272614
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0271911
WWOX WW domain containing oxidoreductase -0.0269651
FOXP1 forkhead box P1 -0.0266311
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0262224
KLF12 Kruppel-like factor 12 -0.0261348
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0259248
ARF1 ADP-ribosylation factor 1 -0.0258764
CAPN2 calpain 2, (m/II) large subunit -0.0258718
TENM2 teneurin transmembrane protein 2 -0.0258264
LPP LIM domain containing preferred translocation partner in lipoma -0.0257677
CD82 CD82 molecule -0.0256633
LRMDA leucine rich melanocyte differentiation associated -0.0255552
PRSS23 protease, serine, 23 -0.0255097
GLS2 glutaminase 2 (liver, mitochondrial) -0.0253893
EGFR epidermal growth factor receptor -0.0253774
TPM1 tropomyosin 1 (alpha) -0.0252471
CAVIN1 caveolae associated protein 1 -0.0250921