| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (mesylate) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Almonertinib (mesylate)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.300914 |
| COL6A3 | collagen, type VI, alpha 3 | 0.138819 |
| ATP13A3 | ATPase type 13A3 | 0.0946479 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0774574 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0722375 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0719901 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0683814 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0632903 |
| POSTN | periostin, osteoblast specific factor | 0.0569267 |
| SMAD3 | SMAD family member 3 | 0.0498892 |
| FOSL1 | FOS-like antigen 1 | 0.0497398 |
| PDE10A | phosphodiesterase 10A | 0.0494391 |
| HMGA1 | high mobility group AT-hook 1 | 0.0479016 |
| RASA2 | RAS p21 protein activator 2 | 0.0478617 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0468964 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0458063 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0441022 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0436782 |
| MT2A | metallothionein 2A | 0.0433874 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0432603 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0412593 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0408391 |
| PFN1 | profilin 1 | 0.0401171 |
| NAV2 | neuron navigator 2 | 0.0392076 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0386233 |
| ARRDC3 | arrestin domain containing 3 | 0.0378076 |
| RPL3 | ribosomal protein L3 | 0.0372792 |
| COL5A1 | collagen, type V, alpha 1 | 0.0363812 |
| SBF2 | SET binding factor 2 | 0.035946 |
| ADAM12 | ADAM metallopeptidase domain 12 | 0.0359394 |
| FLNB | filamin B, beta | 0.0356672 |
| MYO9B | myosin IXB | 0.0355107 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0351651 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0348897 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.034835 |
| FMNL2 | formin-like 2 | 0.0344087 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0340997 |
| RUNX1 | runt-related transcription factor 1 | 0.0337702 |
| VEGFA | vascular endothelial growth factor A | 0.0334427 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0329109 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0314033 |
| MSN | moesin | 0.0311096 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0308101 |
| PTK2 | protein tyrosine kinase 2 | 0.0307127 |
| TNS1 | tensin 1 | 0.030159 |
| RPL13A | ribosomal protein L13a | 0.0300447 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0291694 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0288421 |
| KLF6 | Kruppel-like factor 6 | 0.0277065 |
| ZNF292 | zinc finger protein 292 | 0.0277046 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0269847 |
| VASP | vasodilator-stimulated phosphoprotein | 0.026849 |
| GANAB | glucosidase, alpha; neutral AB | 0.026655 |
| S100A9 | S100 calcium binding protein A9 | 0.0266403 |
| SEPTIN9 | septin 9 | 0.0263513 |
| RPL26 | ribosomal protein L26 | 0.0260551 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0260123 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0258457 |
| PDE8A | phosphodiesterase 8A | 0.0256273 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0254131 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0252481 |
| MKI67 | marker of proliferation Ki-67 | 0.0249318 |
| CALR | calreticulin | 0.0248059 |
| RPL5 | ribosomal protein L5 | 0.0245179 |
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | 0.0244993 |
| TPM2 | tropomyosin 2 (beta) | 0.0242546 |
| STC1 | stanniocalcin 1 | 0.0240875 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0240761 |
| COL1A2 | collagen, type I, alpha 2 | 0.0236064 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.0235575 |
| WDR45B | WD repeat domain 45B | 0.0234306 |
| TMEM65 | transmembrane protein 65 | 0.0234077 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0229334 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0228979 |
| NCOR2 | nuclear receptor corepressor 2 | 0.02281 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0227034 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0225349 |
| TMEM165 | transmembrane protein 165 | 0.0225139 |
| NCKAP1 | NCK-associated protein 1 | 0.0222632 |
| TPM3 | tropomyosin 3 | 0.0219313 |
| ITGA11 | integrin, alpha 11 | 0.0217016 |
| FOXJ3 | forkhead box J3 | 0.0211241 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0211132 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0210793 |
| RPL23 | ribosomal protein L23 | 0.0209659 |
| AXL | AXL receptor tyrosine kinase | 0.0208578 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0205423 |
| POTEF | POTE ankyrin domain family, member F | 0.0204336 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0203096 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0202341 |
| COL1A1 | collagen, type I, alpha 1 | 0.0202285 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0199473 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.0199467 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0196806 |
| ECE1 | endothelin converting enzyme 1 | 0.0196179 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0195894 |
| ZNF148 | zinc finger protein 148 | 0.0195349 |
| GOLGA4 | golgin A4 | 0.0194302 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0193475 |
| SMG6 | SMG6 nonsense mediated mRNA decay factor | 0.0193155 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.247787 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.186944 |
| FN1 | fibronectin 1 | -0.17893 |
| VIM | vimentin | -0.173962 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.130999 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.11462 |
| CD44 | CD44 molecule (Indian blood group) | -0.10857 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0955482 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0846644 |
| FBN1 | fibrillin 1 | -0.0831232 |
| CLIC4 | chloride intracellular channel 4 | -0.0787762 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0783504 |
| IL6ST | interleukin 6 signal transducer | -0.0767669 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0716414 |
| AHNAK | AHNAK nucleoprotein | -0.0708685 |
| GOLGB1 | golgin B1 | -0.070373 |
| TMSB10 | thymosin beta 10 | -0.0694991 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0668889 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0663574 |
| CANX | calnexin | -0.0620483 |
| IER3 | immediate early response 3 | -0.0615178 |
| VCL | vinculin | -0.0603254 |
| CDH13 | cadherin 13 | -0.0597982 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0565069 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.056494 |
| HDLBP | high density lipoprotein binding protein | -0.056334 |
| FTL | ferritin, light polypeptide | -0.0531982 |
| ENO1 | enolase 1, (alpha) | -0.0515419 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0513871 |
| OSMR | oncostatin M receptor | -0.0484011 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0461327 |
| RPLP1 | ribosomal protein, large, P1 | -0.046093 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0456234 |
| ASPH | aspartate beta-hydroxylase | -0.0453447 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0450811 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0448808 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0446474 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0443337 |
| SP100 | SP100 nuclear antigen | -0.0425851 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0418261 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0410248 |
| RPS20 | ribosomal protein S20 | -0.0409988 |
| ANXA2 | annexin A2 | -0.0405249 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0400999 |
| MTDH | metadherin | -0.0399409 |
| PALLD | palladin, cytoskeletal associated protein | -0.0394718 |
| UBC | ubiquitin C | -0.038931 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0387439 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0387273 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0385414 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0384204 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0383998 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0380278 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.037882 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0376512 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0375952 |
| RPLP0 | ribosomal protein, large, P0 | -0.0372154 |
| SQSTM1 | sequestosome 1 | -0.0368572 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0368307 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0366607 |
| RRBP1 | ribosome binding protein 1 | -0.0364587 |
| CAVIN1 | caveolae associated protein 1 | -0.0363448 |
| RPS6 | ribosomal protein S6 | -0.0354408 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0354176 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0342816 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.034215 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0339739 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0339422 |
| ATF4 | activating transcription factor 4 | -0.0332106 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0328681 |
| NABP1 | nucleic acid binding protein 1 | -0.0321459 |
| SEC24D | SEC24 family member D | -0.0318618 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0316377 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0310779 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0305248 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0301559 |
| ZNF644 | zinc finger protein 644 | -0.0299777 |
| RPL30 | ribosomal protein L30 | -0.029911 |
| NEK10 | NIMA-related kinase 10 | -0.0298705 |
| RHOA | ras homolog family member A | -0.0298444 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0297519 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0295979 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.029528 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0293263 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.029094 |
| AHR | aryl hydrocarbon receptor | -0.0289366 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.0287049 |
| INTS6 | integrator complex subunit 6 | -0.0286987 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0284037 |
| RPS5 | ribosomal protein S5 | -0.0283286 |
| GNAS | GNAS complex locus | -0.0282071 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0282047 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0279149 |
| TMEM263 | transmembrane protein 263 | -0.0278982 |
| RTN3 | reticulon 3 | -0.0277698 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0275583 |
| TMSB4X | thymosin beta 4, X-linked | -0.0274003 |
| RIGI | RNA sensor RIG-I | -0.0270921 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0270614 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0268953 |
