Almonertinib (mesylate)_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (mesylate) perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (mesylate)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.146487
RPL23 ribosomal protein L23 0.0895543
RPL13A ribosomal protein L13a 0.0892488
GCLC glutamate-cysteine ligase, catalytic subunit 0.0844183
ATXN1 ataxin 1 0.0832558
RPS3 ribosomal protein S3 0.079728
NAMPT nicotinamide phosphoribosyltransferase 0.0765365
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.073304
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0708623
RPS12 ribosomal protein S12 0.0689135
RPL26 ribosomal protein L26 0.0615087
RPS8 ribosomal protein S8 0.0609528
PTK2 protein tyrosine kinase 2 0.0604899
EXT1 exostosin glycosyltransferase 1 0.0599883
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.058958
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0574809
TPT1 tumor protein, translationally-controlled 1 0.0569246
HMGA1 high mobility group AT-hook 1 0.0544391
RPLP2 ribosomal protein, large, P2 0.054274
ITPKC inositol-trisphosphate 3-kinase C 0.0536778
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0482668
RPS19 ribosomal protein S19 0.0466558
ACTN4 actinin, alpha 4 0.0442302
EEF1G eukaryotic translation elongation factor 1 gamma 0.0441506
RPL18 ribosomal protein L18 0.043492
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0421187
EMP1 epithelial membrane protein 1 0.041483
EXPH5 exophilin 5 0.041096
EZR ezrin 0.0409685
RPL5 ribosomal protein L5 0.0409404
LAMB3 laminin, beta 3 0.0405394
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0405056
RPS13 ribosomal protein S13 0.0403351
RPL37A ribosomal protein L37a 0.0398794
NECTIN2 nectin cell adhesion molecule 2 0.038782
PELI1 pellino E3 ubiquitin protein ligase 1 0.0387793
RPS21 ribosomal protein S21 0.0373478
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0372994
DSCAM Down syndrome cell adhesion molecule 0.0368721
ATAD2 ATPase family, AAA domain containing 2 0.0364884
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0358604
ANXA11 annexin A11 0.0357076
GRB10 growth factor receptor-bound protein 10 0.0352433
SBF2 SET binding factor 2 0.0347311
VASP vasodilator-stimulated phosphoprotein 0.0333662
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0333057
RPL9 ribosomal protein L9 0.0332856
PTPRF protein tyrosine phosphatase, receptor type, F 0.0330748
RPL6 ribosomal protein L6 0.0323241
RPS27A ribosomal protein S27a 0.0319344
MBNL2 muscleblind-like splicing regulator 2 0.0315603
TNIP1 TNFAIP3 interacting protein 1 0.0313777
PATJ PATJ crumbs cell polarity complex component 0.0313513
RPS2 ribosomal protein S2 0.0305705
CNOT12 CCR4-NOT transcription complex subunit 12 0.030443
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0301953
RPL37 ribosomal protein L37 0.0300835
ARHGAP26 Rho GTPase activating protein 26 0.0293996
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0293016
RPS29 ribosomal protein S29 0.0291408
RPL35A ribosomal protein L35a 0.0290214
TPM3 tropomyosin 3 0.0288051
RBM39 RNA binding motif protein 39 0.0285306
ANXA1 annexin A1 0.0280725
NFIA nuclear factor I/A 0.0274976
PRKCE protein kinase C, epsilon 0.02747
KRT17 keratin 17, type I 0.0274537
ZNF292 zinc finger protein 292 0.0274345
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0273181
NCKAP1 NCK-associated protein 1 0.0271587
SAMD12 sterile alpha motif domain containing 12 0.0267279
LSR lipolysis stimulated lipoprotein receptor 0.0263547
LMNA lamin A/C 0.02625
GANAB glucosidase, alpha; neutral AB 0.0261793
PLEC plectin 0.0261657
RND3 Rho family GTPase 3 0.0260821
NCOR2 nuclear receptor corepressor 2 0.0259595
ANKRD10 ankyrin repeat domain 10 0.0258279
AFDN afadin, adherens junction formation factor 0.0255217
RPL21 ribosomal protein L21 0.025365
RPL36 ribosomal protein L36 0.0252838
CAMTA1 calmodulin binding transcription activator 1 0.0248704
RBM33 RNA binding motif protein 33 0.0247607
CMIP c-Maf inducing protein 0.0247336
RPRD1B regulation of nuclear pre-mRNA domain containing 1B 0.0247326
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0244948
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 0.0244473
AHCYL1 adenosylhomocysteinase-like 1 0.0243118
S100P S100 calcium binding protein P 0.0241376
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0240925
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0238479
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.0237096
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0236277
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.023513
KLF6 Kruppel-like factor 6 0.0234873
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0233452
HDGF hepatoma-derived growth factor 0.023273
ARHGAP23 Rho GTPase activating protein 23 0.0232405
RPL12 ribosomal protein L12 0.0232118
PEAK1 pseudopodium-enriched atypical kinase 1 0.0230251

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.128677
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.122611
FTH1 ferritin, heavy polypeptide 1 -0.121643
AHNAK AHNAK nucleoprotein -0.107344
PDIA3 protein disulfide isomerase family A, member 3 -0.104048
FTL ferritin, light polypeptide -0.0968138
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0945836
MYH14 myosin, heavy chain 14, non-muscle -0.0937445
LYZ lysozyme -0.0906093
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.085978
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0789343
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0787023
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -0.0780484
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0701223
KRT18 keratin 18, type I -0.0660202
LAMA4 laminin, alpha 4 -0.0604474
VCL vinculin -0.0591032
KRT20 keratin 20, type I -0.0581912
TJP1 tight junction protein 1 -0.0557116
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0546963
LMO7 LIM domain 7 -0.0546016
PKM pyruvate kinase, muscle -0.054391
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0541464
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0536168
LOC102724023 ES1 protein homolog, mitochondrial -0.050302
PGK1 phosphoglycerate kinase 1 -0.0484527
RPS6 ribosomal protein S6 -0.0478134
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0475642
RTN3 reticulon 3 -0.0461909
DIAPH2 diaphanous-related formin 2 -0.0461743
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0454337
PDE4D phosphodiesterase 4D, cAMP-specific -0.0454052
AGR2 anterior gradient 2 -0.0451791
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.04374
MMP7 matrix metallopeptidase 7 -0.0426448
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0415523
HDLBP high density lipoprotein binding protein -0.0414442
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0409084
SERINC5 serine incorporator 5 -0.040037
COPB1 coatomer protein complex, subunit beta 1 -0.03907
TRIB1 tribbles pseudokinase 1 -0.0390168
VEGFA vascular endothelial growth factor A -0.0381446
TMEM123 transmembrane protein 123 -0.0381243
MYO1E myosin IE -0.0377349
KRT19 keratin 19, type I -0.0365954
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0360062
NTN4 netrin 4 -0.0359618
CANX calnexin -0.0352538
JUN jun proto-oncogene -0.0351977
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0347262
SMAD3 SMAD family member 3 -0.0341904
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0338779
FNDC3B fibronectin type III domain containing 3B -0.0337128
PDIA6 protein disulfide isomerase family A, member 6 -0.0335645
BTG1 B-cell translocation gene 1, anti-proliferative -0.0334401
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0332396
MAGT1 magnesium transporter 1 -0.0331523
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0327784
POF1B premature ovarian failure, 1B -0.0326866
PTPRK protein tyrosine phosphatase, receptor type, K -0.0324155
WASF2 WAS protein family, member 2 -0.0321901
RPLP0 ribosomal protein, large, P0 -0.0314258
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0311628
INSIG1 insulin induced gene 1 -0.0307033
PDLIM5 PDZ and LIM domain 5 -0.0307016
TSC22D1 TSC22 domain family, member 1 -0.0305189
INTS6 integrator complex subunit 6 -0.0295142
HKDC1 hexokinase domain containing 1 -0.0293778
FOS FBJ murine osteosarcoma viral oncogene homolog -0.029066
FAT1 FAT atypical cadherin 1 -0.0289586
DSPP dentin sialophosphoprotein -0.0288082
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0287933
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0287346
SKIL SKI-like proto-oncogene -0.0284715
DGKH diacylglycerol kinase, eta -0.02844
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0278989
SLC38A2 solute carrier family 38, member 2 -0.0277074
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0276752
S100A10 S100 calcium binding protein A10 -0.0274568
PERP PERP, TP53 apoptosis effector -0.0270639
PLK2 polo-like kinase 2 -0.0268496
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0264591
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0261649
EGR1 early growth response 1 -0.0261282
LOC112694756 uncharaterized LOC112694756 -0.0260847
PDIA4 protein disulfide isomerase family A, member 4 -0.0258574
TPM4 tropomyosin 4 -0.0258481
UBXN4 UBX domain protein 4 -0.025845
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0255863
ARHGAP29 Rho GTPase activating protein 29 -0.0255793
ITPRID2 ITPR interacting domain containing 2 -0.0254435
RAD21 RAD21 homolog (S. pombe) -0.0251864
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0249282
LARP1B La ribonucleoprotein domain family, member 1B -0.0248062
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0246813
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0246709
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0246117
FBXO11 F-box protein 11 -0.0245957
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0244603
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0242938