| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (mesylate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (mesylate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.30315 |
| C3 | complement component 3 | 0.249038 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.119829 |
| IGF2 | insulin-like growth factor 2 | 0.114818 |
| APOB | apolipoprotein B | 0.109444 |
| FNDC3B | fibronectin type III domain containing 3B | 0.10834 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.100793 |
| VEGFA | vascular endothelial growth factor A | 0.0970657 |
| RPS12 | ribosomal protein S12 | 0.0963784 |
| FN1 | fibronectin 1 | 0.0807915 |
| CFB | complement factor B | 0.0794184 |
| AFDN | afadin, adherens junction formation factor | 0.0783278 |
| TNS1 | tensin 1 | 0.0695559 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0638812 |
| RPL3 | ribosomal protein L3 | 0.0622722 |
| TF | transferrin | 0.0616369 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0598346 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0586754 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0584768 |
| RPL26 | ribosomal protein L26 | 0.0547247 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0522825 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0520279 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0506402 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0491916 |
| SDC4 | syndecan 4 | 0.0471519 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0465743 |
| SMAD3 | SMAD family member 3 | 0.0463761 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0450176 |
| IQSEC1 | IQ motif and Sec7 domain 1 | 0.0444141 |
| CCNY | cyclin Y | 0.0439201 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0429446 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0423364 |
| PEG10 | paternally expressed 10 | 0.0401436 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.039132 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0388188 |
| RPL6 | ribosomal protein L6 | 0.0382923 |
| JAG1 | jagged 1 | 0.0373142 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0362831 |
| MT2A | metallothionein 2A | 0.0353235 |
| NCKAP1 | NCK-associated protein 1 | 0.034821 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0346803 |
| MTSS1 | metastasis suppressor 1 | 0.0346545 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.034214 |
| HLF | hepatic leukemia factor | 0.0342059 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0338063 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.033564 |
| RPL37A | ribosomal protein L37a | 0.0333532 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0332847 |
| DSPP | dentin sialophosphoprotein | 0.0331216 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0324125 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0323287 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0319941 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.031224 |
| A2M | alpha-2-macroglobulin | 0.0310309 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0308169 |
| PLEC | plectin | 0.0302761 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0300825 |
| BRD4 | bromodomain containing 4 | 0.0295974 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0295127 |
| RBM33 | RNA binding motif protein 33 | 0.0293668 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0293532 |
| MYO1B | myosin IB | 0.0293078 |
| ENO1 | enolase 1, (alpha) | 0.0289874 |
| FOXN3 | forkhead box N3 | 0.0286025 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.028453 |
| HELZ | helicase with zinc finger | 0.028221 |
| SVIL | supervillin | 0.0281981 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0281646 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0280508 |
| RPL13A | ribosomal protein L13a | 0.0280185 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0277136 |
| FAT1 | FAT atypical cadherin 1 | 0.0274689 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0273891 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.027265 |
| SET | SET nuclear proto-oncogene | 0.0271531 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0263442 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0262093 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0259603 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.025784 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0256941 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0256517 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.025475 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0254731 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0254184 |
| RPS17 | ribosomal protein S17 | 0.0252374 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0251822 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0251023 |
| RPL5 | ribosomal protein L5 | 0.0249752 |
| FLNB | filamin B, beta | 0.024918 |
| MED13L | mediator complex subunit 13-like | 0.0246175 |
| PTK2 | protein tyrosine kinase 2 | 0.024525 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0244254 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0243857 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0241433 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0240044 |
| BCL2L1 | BCL2-like 1 | 0.0237542 |
| YAP1 | Yes-associated protein 1 | 0.023621 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0235683 |
| CALU | calumenin | 0.0231585 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0231418 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.133432 |
| FTL | ferritin, light polypeptide | -0.111573 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.11147 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0970175 |
| APOA2 | apolipoprotein A-II | -0.0807154 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0802654 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0758792 |
| RPS24 | ribosomal protein S24 | -0.0754293 |
| EHBP1 | EH domain binding protein 1 | -0.0689487 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0676176 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0665554 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0660645 |
| PLIN2 | perilipin 2 | -0.0630389 |
| FRMD5 | FERM domain containing 5 | -0.0626835 |
| CP | ceruloplasmin (ferroxidase) | -0.0626403 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0618618 |
| RPLP1 | ribosomal protein, large, P1 | -0.0584808 |
| AHSG | alpha-2-HS-glycoprotein | -0.0582692 |
| VCL | vinculin | -0.0565963 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.056136 |
| GPC6 | glypican 6 | -0.0551001 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0541617 |
| RPLP0 | ribosomal protein, large, P0 | -0.0541603 |
| PERP | PERP, TP53 apoptosis effector | -0.0521707 |
| ASPH | aspartate beta-hydroxylase | -0.0520944 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0509094 |
| H1-0 | H1.0 linker histone | -0.0481301 |
| TMSB10 | thymosin beta 10 | -0.0474383 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0465729 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0461053 |
| APOE | apolipoprotein E | -0.0446783 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.044536 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0443019 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0431478 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0429553 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0426448 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0421389 |
| RPL34 | ribosomal protein L34 | -0.0418535 |
| TPM4 | tropomyosin 4 | -0.0408065 |
| ITGAV | integrin, alpha V | -0.0401213 |
| FMNL2 | formin-like 2 | -0.0391224 |
| TRIM26 | tripartite motif containing 26 | -0.0386526 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0383636 |
| GNAS | GNAS complex locus | -0.0348249 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0346385 |
| RRBP1 | ribosome binding protein 1 | -0.0344899 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0344701 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0340309 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0334722 |
| PKM | pyruvate kinase, muscle | -0.0334662 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0328658 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.032769 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0324007 |
| GPC3 | glypican 3 | -0.0321864 |
| DST | dystonin | -0.0321252 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0318463 |
| RPL31 | ribosomal protein L31 | -0.0308401 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0302735 |
| NDRG1 | N-myc downstream regulated 1 | -0.030042 |
| NPR2 | natriuretic peptide receptor 2 | -0.0298099 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0296946 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0293918 |
| PTCHD4 | patched domain containing 4 | -0.0293771 |
| GDF15 | growth differentiation factor 15 | -0.0293123 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0292333 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0291725 |
| RPL35A | ribosomal protein L35a | -0.0291637 |
| CDK6 | cyclin-dependent kinase 6 | -0.029068 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0286429 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0285888 |
| FAM135A | family with sequence similarity 135, member A | -0.0283037 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0279771 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0279556 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0277048 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0276218 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0275985 |
| KRT18 | keratin 18, type I | -0.0273793 |
| TMEM123 | transmembrane protein 123 | -0.0272018 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0268038 |
| VDAC1 | voltage-dependent anion channel 1 | -0.02657 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0262994 |
| HDLBP | high density lipoprotein binding protein | -0.0256986 |
| RPS19 | ribosomal protein S19 | -0.0253002 |
| INTS6 | integrator complex subunit 6 | -0.0252302 |
| AHNAK | AHNAK nucleoprotein | -0.0250783 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0249967 |
| GK | glycerol kinase | -0.0249627 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0247893 |
| VIM | vimentin | -0.0247892 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0247206 |
| TUT4 | terminal uridylyl transferase 4 | -0.0246321 |
| LMO7 | LIM domain 7 | -0.0244731 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0244532 |
| KIF21A | kinesin family member 21A | -0.0240004 |
| ZNF638 | zinc finger protein 638 | -0.0239709 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | -0.0237463 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0234881 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0233997 |
| ERBIN | erbb2 interacting protein | -0.0233674 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0232954 |
