Almonertinib (mesylate)_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (mesylate) perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (mesylate)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 0.145052
FN1 fibronectin 1 0.116499
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0817223
HLA-B major histocompatibility complex, class I, B 0.0814517
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0805067
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0743379
NAMPT nicotinamide phosphoribosyltransferase 0.0613649
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0607786
ZNF841 zinc finger protein 841 0.057545
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0554298
FOSL1 FOS-like antigen 1 0.0552254
TPM3 tropomyosin 3 0.0532236
PFN1 profilin 1 0.05219
RPL23 ribosomal protein L23 0.0506377
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0494508
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0483753
FLNB filamin B, beta 0.0482605
HMGA1 high mobility group AT-hook 1 0.0477979
LDHA lactate dehydrogenase A 0.0469633
EEF1G eukaryotic translation elongation factor 1 gamma 0.0467986
MYH9 myosin, heavy chain 9, non-muscle 0.0453368
ANXA1 annexin A1 0.0447723
RPL26 ribosomal protein L26 0.0445277
COL5A1 collagen, type V, alpha 1 0.0430762
MT1X metallothionein 1X 0.0426131
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0414806
HMGB2 high mobility group box 2 0.0414205
RND3 Rho family GTPase 3 0.0413618
RPL13A ribosomal protein L13a 0.0404296
FLNA filamin A, alpha 0.0391846
HLA-C major histocompatibility complex, class I, C 0.0388014
SMAD3 SMAD family member 3 0.0386657
CALR calreticulin 0.0379429
SFPQ splicing factor proline/glutamine-rich 0.0367866
CD59 CD59 molecule, complement regulatory protein 0.0354612
IFI6 interferon, alpha-inducible protein 6 0.034522
RPL5 ribosomal protein L5 0.034053
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.033881
GANAB glucosidase, alpha; neutral AB 0.0337113
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0330516
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0327369
KLF6 Kruppel-like factor 6 0.0325794
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.032415
RPL35 ribosomal protein L35 0.032227
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0315412
RPL12 ribosomal protein L12 0.0311556
UBC ubiquitin C 0.0309486
RPL6 ribosomal protein L6 0.0307804
STC2 stanniocalcin 2 0.0307239
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0305076
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.030268
COL4A2 collagen, type IV, alpha 2 0.0295669
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0292433
NCKAP1 NCK-associated protein 1 0.0287128
RPS8 ribosomal protein S8 0.0287025
PLEC plectin 0.0282031
RPS3 ribosomal protein S3 0.0279508
NUP58 nucleoporin 58 0.0278854
RPS21 ribosomal protein S21 0.0277744
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0274641
PCBP2 poly(rC) binding protein 2 0.0274599
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0272149
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0271877
MCL1 myeloid cell leukemia 1 0.0271516
TPT1 tumor protein, translationally-controlled 1 0.0257069
FAM219A family with sequence similarity 219, member A 0.025683
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0253391
VASP vasodilator-stimulated phosphoprotein 0.0253388
PHACTR1 phosphatase and actin regulator 1 0.0252938
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0243884
RPLP2 ribosomal protein, large, P2 0.0243558
SDC4 syndecan 4 0.0242553
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0239242
HLA-A major histocompatibility complex, class I, A 0.0237353
TXNRD1 thioredoxin reductase 1 0.0236824
RPL36A ribosomal protein L36a 0.0235997
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0234137
CTSD cathepsin D 0.0233421
YBX1 Y box binding protein 1 0.0232972
CCBE1 collagen and calcium binding EGF domains 1 0.0230748
RPL18 ribosomal protein L18 0.0229465
IFITM1 interferon induced transmembrane protein 1 0.0228927
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0227525
THSD4 thrombospondin, type I, domain containing 4 0.0227408
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0227108
RPL37A ribosomal protein L37a 0.0223664
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0220614
MPRIP myosin phosphatase Rho interacting protein 0.0220157
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0219195
RASA2 RAS p21 protein activator 2 0.0217382
KRT8 keratin 8, type II 0.0217145
PTK2 protein tyrosine kinase 2 0.0216511
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0216265
FOXJ3 forkhead box J3 0.0212009
RPS19 ribosomal protein S19 0.0211584
CFB complement factor B 0.0210525
GATA2 GATA binding protein 2 0.0209519
ACTN4 actinin, alpha 4 0.0209062
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0208509
CALU calumenin 0.0206756

decreased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 -0.17606
FTL ferritin, light polypeptide -0.143816
TRIO trio Rho guanine nucleotide exchange factor -0.131934
NALF1 NALCN channel auxiliary factor 1 -0.12569
AKAP12 A kinase (PRKA) anchor protein 12 -0.114801
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0952374
PLIN2 perilipin 2 -0.0869054
DLG1 discs, large homolog 1 (Drosophila) -0.0790661
ARF4 ADP-ribosylation factor 4 -0.0744364
B2M beta-2-microglobulin -0.0733387
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0722176
F3 coagulation factor III (thromboplastin, tissue factor) -0.0719667
COPA coatomer protein complex, subunit alpha -0.0677891
VEGFA vascular endothelial growth factor A -0.0667244
GLIS3 GLIS family zinc finger 3 -0.0642616
INTS6 integrator complex subunit 6 -0.0630165
BTG1 B-cell translocation gene 1, anti-proliferative -0.0593076
PDIA3 protein disulfide isomerase family A, member 3 -0.0555492
PTBP3 polypyrimidine tract binding protein 3 -0.0541612
SLC12A8 solute carrier family 12, member 8 -0.053731
PTMA prothymosin, alpha -0.0508669
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.050438
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0500314
CD44 CD44 molecule (Indian blood group) -0.0489215
COPB1 coatomer protein complex, subunit beta 1 -0.0477033
CANX calnexin -0.0466455
VIM vimentin -0.0447725
BZW1 basic leucine zipper and W2 domains 1 -0.0444814
ZBTB20 zinc finger and BTB domain containing 20 -0.0419341
RHOA ras homolog family member A -0.0418397
DIAPH3 diaphanous-related formin 3 -0.0414091
CLIC4 chloride intracellular channel 4 -0.0403048
GOLGB1 golgin B1 -0.0394037
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0393195
TMEM165 transmembrane protein 165 -0.0388643
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0387641
CENPF centromere protein F, 350/400kDa -0.0385557
SDK1 sidekick cell adhesion molecule 1 -0.0374374
OSMR oncostatin M receptor -0.0373764
UGCG UDP-glucose ceramide glucosyltransferase -0.0372112
SETX senataxin -0.0366101
LMAN1 lectin, mannose-binding, 1 -0.0364271
SULF1 sulfatase 1 -0.0359957
ZMYM2 zinc finger, MYM-type 2 -0.0354719
SRRM2 serine/arginine repetitive matrix 2 -0.0350596
PKM pyruvate kinase, muscle -0.0348944
VDAC1 voltage-dependent anion channel 1 -0.0348681
ADM adrenomedullin -0.0347688
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0346693
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0344478
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0344162
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0342263
ENO2 enolase 2 (gamma, neuronal) -0.0340069
MYOF myoferlin -0.0339355
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0334566
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.033153
TPM4 tropomyosin 4 -0.0325901
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0324112
KPNB1 karyopherin (importin) beta 1 -0.0322971
TRPC4 transient receptor potential cation channel, subfamily C, member 4 -0.0315503
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.0307805
RAP1B RAP1B, member of RAS oncogene family -0.0307162
VCL vinculin -0.0305099
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0299853
SLIT2 slit homolog 2 (Drosophila) -0.029823
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0294728
ZCCHC7 zinc finger, CCHC domain containing 7 -0.029351
LOC112694756 uncharaterized LOC112694756 -0.0286065
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0285372
TGFB2 transforming growth factor, beta 2 -0.0284628
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.0284587
HPS3 Hermansky-Pudlak syndrome 3 -0.0276349
PARD3B par-3 family cell polarity regulator beta -0.0275929
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0275272
GDI2 GDP dissociation inhibitor 2 -0.0273062
PBX3 pre-B-cell leukemia homeobox 3 -0.0272231
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0271745
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0271276
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0270706
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0268346
RHOBTB3 Rho-related BTB domain containing 3 -0.026752
THOC2 THO complex 2 -0.0266555
NFE2L2 nuclear factor, erythroid 2-like 2 -0.026639
ECPAS Ecm29 proteasome adaptor and scaffold -0.0264813
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0264283
DEK DEK proto-oncogene -0.0263356
MATR3 matrin 3 -0.026099
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0259425
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0258598
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0258343
MMP12 matrix metallopeptidase 12 -0.0257754
CLIP1 CAP-GLY domain containing linker protein 1 -0.0256391
SSR1 signal sequence receptor, alpha -0.025502
SENP5 SUMO1/sentrin specific peptidase 5 -0.025079
SNX14 sorting nexin 14 -0.0247826
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0247169
RB1 retinoblastoma 1 -0.0245017
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0244882
SUCO SUN domain containing ossification factor -0.0243973
GOSR1 golgi SNAP receptor complex member 1 -0.024093