Almonertinib (mesylate)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (mesylate) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (mesylate)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DTNA dystrobrevin, alpha 0.124431
RPS6 ribosomal protein S6 0.111388
RPS12 ribosomal protein S12 0.0852011
MT2A metallothionein 2A 0.0818896
RPS3 ribosomal protein S3 0.0811414
RPL26 ribosomal protein L26 0.0753346
RPL23 ribosomal protein L23 0.0749732
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0740239
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0717035
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0712389
RPL37A ribosomal protein L37a 0.0702894
RPS8 ribosomal protein S8 0.0682204
NUP58 nucleoporin 58 0.0636108
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0625961
RPL5 ribosomal protein L5 0.0621083
RPL35A ribosomal protein L35a 0.058104
RPS2 ribosomal protein S2 0.0573288
MYH9 myosin, heavy chain 9, non-muscle 0.0560851
RPLP2 ribosomal protein, large, P2 0.0545307
TPT1 tumor protein, translationally-controlled 1 0.0526874
RPS17 ribosomal protein S17 0.0526245
TPM3 tropomyosin 3 0.0515259
PTMA prothymosin, alpha 0.0511758
RPL11 ribosomal protein L11 0.0508457
HMGA1 high mobility group AT-hook 1 0.0495208
YBX1 Y box binding protein 1 0.0472004
MKI67 marker of proliferation Ki-67 0.0471773
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0468311
HSPA8 heat shock 70kDa protein 8 0.0459238
RPL12 ribosomal protein L12 0.0445312
ZNF292 zinc finger protein 292 0.0442092
ASPH aspartate beta-hydroxylase 0.0440882
RPL13A ribosomal protein L13a 0.0411247
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0409285
MSN moesin 0.0404924
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0395999
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0394463
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0378881
RPL9 ribosomal protein L9 0.0374949
MCTP1 multiple C2 domains, transmembrane 1 0.0363416
FOSL1 FOS-like antigen 1 0.0353561
RPS19 ribosomal protein S19 0.0350246
RASA2 RAS p21 protein activator 2 0.0347705
RPL35 ribosomal protein L35 0.0338796
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0338448
VEGFA vascular endothelial growth factor A 0.0337779
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.033161
RPS13 ribosomal protein S13 0.0331091
RPS18 ribosomal protein S18 0.0328391
RPS29 ribosomal protein S29 0.0324623
RPL6 ribosomal protein L6 0.0321816
TFRC transferrin receptor 0.0321602
EEF1G eukaryotic translation elongation factor 1 gamma 0.0321365
RPL3 ribosomal protein L3 0.0320128
NAP1L1 nucleosome assembly protein 1-like 1 0.0314562
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.031402
RACK1 receptor for activated C kinase 1 0.0311926
RPL7 ribosomal protein L7 0.0308573
RPL21 ribosomal protein L21 0.0304979
RPS23 ribosomal protein S23 0.0303781
RPL36 ribosomal protein L36 0.0293836
SET SET nuclear proto-oncogene 0.0290804
EEF2 eukaryotic translation elongation factor 2 0.0284964
RPS10 ribosomal protein S10 0.0280912
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0279918
CENPF centromere protein F, 350/400kDa 0.0278786
CORO1C coronin, actin binding protein, 1C 0.0275926
PFN1 profilin 1 0.0274706
RPL7A ribosomal protein L7a 0.0272423
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0267388
KTN1 kinectin 1 (kinesin receptor) 0.0260085
POTEF POTE ankyrin domain family, member F 0.0259533
RPL38 ribosomal protein L38 0.0258767
RPL34 ribosomal protein L34 0.0258335
RPL8 ribosomal protein L8 0.0256435
RTN4 reticulon 4 0.0256395
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0255553
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0252679
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0251319
RPS25 ribosomal protein S25 0.0249594
NCKAP1 NCK-associated protein 1 0.024755
ARGLU1 arginine and glutamate rich 1 0.0247011
TRA2B transformer 2 beta homolog (Drosophila) 0.0246888
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0245745
RPL36A ribosomal protein L36a 0.0243047
FTH1 ferritin, heavy polypeptide 1 0.0238311
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0238064
B2M beta-2-microglobulin 0.0237513
ANKRD11 ankyrin repeat domain 11 0.0235709
TEX10 testis expressed 10 0.0235264
EIF4B eukaryotic translation initiation factor 4B 0.0233218
CUL3 cullin 3 0.0233101
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0232023
SPRED1 sprouty-related, EVH1 domain containing 1 0.0230438
RPS7 ribosomal protein S7 0.0222511
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0222395
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0220943
RRM2 ribonucleotide reductase M2 0.0220575
FLNA filamin A, alpha 0.0218239
RPL28 ribosomal protein L28 0.0216109

decreased expression

Symbol Name Standardized Value
MMP12 matrix metallopeptidase 12 -0.234748
VIM vimentin -0.174883
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.115231
PRKG1 protein kinase, cGMP-dependent, type I -0.109446
LSAMP limbic system-associated membrane protein -0.107941
CD109 CD109 molecule -0.094193
DST dystonin -0.0929548
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0899177
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0784455
EFNA5 ephrin-A5 -0.0761458
GPC6 glypican 6 -0.0751354
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0742543
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0699615
PTCHD4 patched domain containing 4 -0.068654
NF1 neurofibromin 1 -0.0680807
HDAC9 histone deacetylase 9 -0.0680739
EGR1 early growth response 1 -0.0671879
FN1 fibronectin 1 -0.0658217
FOXP1 forkhead box P1 -0.0653586
JMJD1C jumonji domain containing 1C -0.0633758
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0618873
AHNAK AHNAK nucleoprotein -0.0563019
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0561066
SLC38A2 solute carrier family 38, member 2 -0.0547976
USP34 ubiquitin specific peptidase 34 -0.0534574
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0524213
SBF2 SET binding factor 2 -0.0516395
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0514251
ALCAM activated leukocyte cell adhesion molecule -0.0504396
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0499818
TXNIP thioredoxin interacting protein -0.0487637
ERBIN erbb2 interacting protein -0.048715
FRMD6 FERM domain containing 6 -0.0486129
JUN jun proto-oncogene -0.0486123
RUNX1 runt-related transcription factor 1 -0.0483729
BTG1 B-cell translocation gene 1, anti-proliferative -0.0469902
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.046846
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0467273
AKAP12 A kinase (PRKA) anchor protein 12 -0.0461493
MBD5 methyl-CpG binding domain protein 5 -0.0460974
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0457944
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0457899
TXNRD1 thioredoxin reductase 1 -0.0457715
KYNU kynureninase -0.0452807
TRIO trio Rho guanine nucleotide exchange factor -0.0451976
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0440062
NTM neurotrimin -0.0429561
TMPRSS15 transmembrane protease, serine 15 -0.0421293
RAI14 retinoic acid induced 14 -0.0415035
IFI16 interferon, gamma-inducible protein 16 -0.0412
FMNL2 formin-like 2 -0.0411321
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0410083
BPTF bromodomain PHD finger transcription factor -0.0409025
TRPS1 trichorhinophalangeal syndrome I -0.0402791
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0399143
HAS2 hyaluronan synthase 2 -0.039781
ANO6 anoctamin 6 -0.039522
FTL ferritin, light polypeptide -0.0395018
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0391655
CDK6 cyclin-dependent kinase 6 -0.038951
PHACTR1 phosphatase and actin regulator 1 -0.0383693
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0382881
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0377354
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -0.0373267
VDAC1 voltage-dependent anion channel 1 -0.0366697
BIRC6 baculoviral IAP repeat containing 6 -0.0362801
LIMCH1 LIM and calponin homology domains 1 -0.0360461
NABP1 nucleic acid binding protein 1 -0.0359227
FNDC3B fibronectin type III domain containing 3B -0.0356147
MYO9A myosin IXA -0.0355864
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0350283
RCAN1 regulator of calcineurin 1 -0.0348483
UBC ubiquitin C -0.0336749
ANKRD28 ankyrin repeat domain 28 -0.0335925
TLE4 transducin-like enhancer of split 4 -0.0332974
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0332426
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0327197
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0324953
C2CD2 C2 calcium-dependent domain containing 2 -0.0322293
DIAPH2 diaphanous-related formin 2 -0.0321783
SAMD3 sterile alpha motif domain containing 3 -0.0320605
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0318986
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0316936
PTPRK protein tyrosine phosphatase, receptor type, K -0.0315842
MAP4 microtubule-associated protein 4 -0.0314915
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0314418
NPC1 Niemann-Pick disease, type C1 -0.0312447
BRWD1 bromodomain and WD repeat domain containing 1 -0.0309845
EMP1 epithelial membrane protein 1 -0.0308622
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0306553
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.030642
MSR1 macrophage scavenger receptor 1 -0.0305508
MAP3K7CL MAP3K7 C-terminal like -0.0298062
SMG6 SMG6 nonsense mediated mRNA decay factor -0.0296212
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0295586
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0291917
TENM2 teneurin transmembrane protein 2 -0.0290086
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0289985
OSMR oncostatin M receptor -0.0289517
BNC2 basonuclin 2 -0.0288533