Almonertinib (mesylate)_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (mesylate) perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (mesylate)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MUC6 mucin 6, oligomeric mucus/gel-forming 0.158364
VEGFA vascular endothelial growth factor A 0.145521
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0794845
RPL3 ribosomal protein L3 0.0699469
RPS12 ribosomal protein S12 0.0679252
RPL23 ribosomal protein L23 0.0657514
ANKRD11 ankyrin repeat domain 11 0.0615991
RPL37A ribosomal protein L37a 0.0593166
CCNY cyclin Y 0.0552207
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0521151
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0513484
RPS8 ribosomal protein S8 0.0492331
RPL26 ribosomal protein L26 0.0466527
DNM2 dynamin 2 0.0466404
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0449103
RPL13A ribosomal protein L13a 0.0442024
S100P S100 calcium binding protein P 0.0440603
TPM3 tropomyosin 3 0.0437719
AREG amphiregulin 0.0418935
RPS3 ribosomal protein S3 0.0402267
RPLP2 ribosomal protein, large, P2 0.0396869
TNS4 tensin 4 0.0394134
EEF1G eukaryotic translation elongation factor 1 gamma 0.0393789
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0392203
RPS29 ribosomal protein S29 0.0380517
RPS27 ribosomal protein S27 0.0377462
LPP LIM domain containing preferred translocation partner in lipoma 0.036756
NCOR1 nuclear receptor corepressor 1 0.0352428
MPRIP myosin phosphatase Rho interacting protein 0.0347
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0344894
ASPH aspartate beta-hydroxylase 0.0343468
APLP2 amyloid beta (A4) precursor-like protein 2 0.0343378
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.033891
PTMA prothymosin, alpha 0.0338756
RPL9 ribosomal protein L9 0.0336501
KDM2A lysine (K)-specific demethylase 2A 0.0333679
MYO5B myosin VB 0.0321056
FLNB filamin B, beta 0.0320094
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0316822
ACIN1 apoptotic chromatin condensation inducer 1 0.0316269
CMIP c-Maf inducing protein 0.0315421
SLC38A2 solute carrier family 38, member 2 0.0313123
TBC1D22A TBC1 domain family, member 22A 0.0312018
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0306296
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0306275
CALR calreticulin 0.0299348
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0293407
CEMIP cell migration inducing protein, hyaluronan binding 0.029242
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0290162
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0289023
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0288653
FTH1 ferritin, heavy polypeptide 1 0.0287498
RPL5 ribosomal protein L5 0.0286444
ENO1 enolase 1, (alpha) 0.0284806
RPL36 ribosomal protein L36 0.028431
POTEF POTE ankyrin domain family, member F 0.0278916
MYH9 myosin, heavy chain 9, non-muscle 0.0276946
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.027607
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0274342
HSPA8 heat shock 70kDa protein 8 0.027413
CD47 CD47 molecule 0.0262297
YTHDC1 YTH domain containing 1 0.0259831
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0259538
RPS18 ribosomal protein S18 0.0258896
EIF4B eukaryotic translation initiation factor 4B 0.0257748
NUPR1 nuclear protein, transcriptional regulator, 1 0.0253274
RPL6 ribosomal protein L6 0.0252036
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0251644
CD9 CD9 molecule 0.0251377
GANAB glucosidase, alpha; neutral AB 0.0250895
INSIG1 insulin induced gene 1 0.0249966
GMDS GDP-mannose 4,6-dehydratase 0.0247986
KIAA1671 KIAA1671 0.0247577
NCOR2 nuclear receptor corepressor 2 0.0247334
ATXN1 ataxin 1 0.0246693
PTK2 protein tyrosine kinase 2 0.0243291
COX6C cytochrome c oxidase subunit VIc 0.0241447
RPS2 ribosomal protein S2 0.0240624
EPHA2 EPH receptor A2 0.0240299
FNIP1 folliculin interacting protein 1 0.0239002
AFDN afadin, adherens junction formation factor 0.0235733
RPL21 ribosomal protein L21 0.0233301
SEPTIN9 septin 9 0.0232913
DSPP dentin sialophosphoprotein 0.0229496
USP34 ubiquitin specific peptidase 34 0.0228489
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0227321
VASP vasodilator-stimulated phosphoprotein 0.0227019
VMP1 vacuole membrane protein 1 0.0226818
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.022248
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0220858
PICALM phosphatidylinositol binding clathrin assembly protein 0.0217838
GSK3B glycogen synthase kinase 3 beta 0.0216265
PTPRF protein tyrosine phosphatase, receptor type, F 0.0215832
ZFAND3 zinc finger, AN1-type domain 3 0.0215593
SNX9 sorting nexin 9 0.0214439
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.021424
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.0214174
NCKAP1 NCK-associated protein 1 0.0212037
RPS27A ribosomal protein S27a 0.0211998
FDPS farnesyl diphosphate synthase 0.0207679

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.249995
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.13837
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.124559
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.118035
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0957739
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0759878
H1-0 H1.0 linker histone -0.0675944
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0668926
LOC112694756 uncharaterized LOC112694756 -0.0660545
AHNAK AHNAK nucleoprotein -0.0627627
ANXA2 annexin A2 -0.0595093
TXNIP thioredoxin interacting protein -0.0580716
EIF1 eukaryotic translation initiation factor 1 -0.0569219
BTG1 B-cell translocation gene 1, anti-proliferative -0.0563361
KRT18 keratin 18, type I -0.055771
ALCAM activated leukocyte cell adhesion molecule -0.0491919
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0462472
PRSS3 protease, serine, 3 -0.0461037
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0449276
RPS6 ribosomal protein S6 -0.0447449
CCND1 cyclin D1 -0.0443684
RPLP0 ribosomal protein, large, P0 -0.044124
KIF5B kinesin family member 5B -0.0435286
LDHA lactate dehydrogenase A -0.0428822
ABLIM1 actin binding LIM protein 1 -0.0418113
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0392599
AGR2 anterior gradient 2 -0.0389736
HDLBP high density lipoprotein binding protein -0.038967
NPSR1 neuropeptide S receptor 1 -0.0388676
EREG epiregulin -0.0387741
BZW1 basic leucine zipper and W2 domains 1 -0.0387141
EPCAM epithelial cell adhesion molecule -0.0385662
ARHGAP5 Rho GTPase activating protein 5 -0.0375479
RPS20 ribosomal protein S20 -0.0372993
DSG2 desmoglein 2 -0.0370947
ARF1 ADP-ribosylation factor 1 -0.036346
KLF5 Kruppel-like factor 5 (intestinal) -0.0357885
CLTC clathrin, heavy chain (Hc) -0.0355192
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0353018
COPB1 coatomer protein complex, subunit beta 1 -0.0349674
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0342904
POF1B premature ovarian failure, 1B -0.0339879
RRBP1 ribosome binding protein 1 -0.0331368
RAB10 RAB10, member RAS oncogene family -0.032155
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0320255
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0319507
FTL ferritin, light polypeptide -0.0315436
TTC3 tetratricopeptide repeat domain 3 -0.0314852
LOC102724023 ES1 protein homolog, mitochondrial -0.0312043
MED13 mediator complex subunit 13 -0.0312007
PPARG peroxisome proliferator-activated receptor gamma -0.0310908
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0299249
CD44 CD44 molecule (Indian blood group) -0.0299204
KDM7A lysine (K)-specific demethylase 7A -0.0298829
PCNP PEST proteolytic signal containing nuclear protein -0.0295726
CDK6 cyclin-dependent kinase 6 -0.0291799
SCAF11 SR-related CTD-associated factor 11 -0.0286165
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0284037
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0282853
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0279581
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0279384
PKM pyruvate kinase, muscle -0.0278848
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0276746
FNDC3A fibronectin type III domain containing 3A -0.0275712
JUN jun proto-oncogene -0.0274163
NKTR natural killer cell triggering receptor -0.0271512
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0271066
CCNI cyclin I -0.0259416
RPL30 ribosomal protein L30 -0.0259336
GOLM2 golgi membrane protein 2 -0.0257467
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0255953
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0255624
PGK1 phosphoglycerate kinase 1 -0.0252437
NRN1 neuritin 1 -0.0252029
TUBB4B tubulin, beta 4B class IVb -0.0251385
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) -0.0249508
RAB2A RAB2A, member RAS oncogene family -0.0249127
RESF1 retroelement silencing factor 1 -0.0249086
RPS24 ribosomal protein S24 -0.0247535
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0243309
JMJD1C jumonji domain containing 1C -0.024064
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0238199
H3-3B H3.3 histone B -0.0236189
FOXO1 forkhead box O1 -0.0235242
KPNB1 karyopherin (importin) beta 1 -0.0233455
CBX3 chromobox homolog 3 -0.0233077
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0227912
IARS1 isoleucyl-tRNA synthetase 1 -0.0227723
PDIA3 protein disulfide isomerase family A, member 3 -0.0226602
LAMA4 laminin, alpha 4 -0.0223229
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0218523
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0218278
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0218162
FHL2 four and a half LIM domains 2 -0.0217061
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0216052
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.0214814
GLG1 golgi glycoprotein 1 -0.0214557
ISG15 ISG15 ubiquitin-like modifier -0.0214458
ATP5F1B ATP synthase F1 subunit beta -0.0213458
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0213037