Almonertinib (mesylate)_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (mesylate) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (mesylate)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.1727
PTMA prothymosin, alpha 0.142582
RPS8 ribosomal protein S8 0.100645
RAI1 retinoic acid induced 1 0.0786141
TXNRD1 thioredoxin reductase 1 0.0680392
RPL23 ribosomal protein L23 0.0650438
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0647662
RPS19 ribosomal protein S19 0.0622397
RPL26 ribosomal protein L26 0.0607715
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0590061
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0589863
YEATS2 YEATS domain containing 2 0.0555949
RPS29 ribosomal protein S29 0.0546387
RPL5 ribosomal protein L5 0.0531433
RPL37A ribosomal protein L37a 0.0519238
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0480066
CENPF centromere protein F, 350/400kDa 0.0473781
ANKRD11 ankyrin repeat domain 11 0.046517
RPL13A ribosomal protein L13a 0.0459425
RPS27 ribosomal protein S27 0.0458683
SLC38A2 solute carrier family 38, member 2 0.0455365
RPS6 ribosomal protein S6 0.0452658
HMGA1 high mobility group AT-hook 1 0.0432719
RPS3 ribosomal protein S3 0.0431879
MKI67 marker of proliferation Ki-67 0.0427352
RPL35 ribosomal protein L35 0.0409595
EEF1G eukaryotic translation elongation factor 1 gamma 0.0408992
RPL12 ribosomal protein L12 0.0405019
RPL35A ribosomal protein L35a 0.0395793
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0391443
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0386268
RPS13 ribosomal protein S13 0.0385311
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.0380345
CALR calreticulin 0.0379979
RPL18 ribosomal protein L18 0.0376916
RPL37 ribosomal protein L37 0.0375364
RPLP2 ribosomal protein, large, P2 0.0373892
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0369695
RPS23 ribosomal protein S23 0.0360951
RPL3 ribosomal protein L3 0.0357133
ANXA1 annexin A1 0.0356532
SRGN serglycin 0.0340082
MSN moesin 0.0329675
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0329158
DLG1 discs, large homolog 1 (Drosophila) 0.032787
RPL19 ribosomal protein L19 0.0325063
RPL34 ribosomal protein L34 0.0320297
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0314457
UPP1 uridine phosphorylase 1 0.0312829
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0309255
MACF1 microtubule-actin crosslinking factor 1 0.0289238
RPL9 ribosomal protein L9 0.0288365
TPT1 tumor protein, translationally-controlled 1 0.0286467
BRD4 bromodomain containing 4 0.028283
RPL36 ribosomal protein L36 0.0279785
DPYSL2 dihydropyrimidinase-like 2 0.0276606
ANLN anillin, actin binding protein 0.0274745
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0272423
CSDE1 cold shock domain containing E1, RNA-binding 0.0270507
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0270355
S100A9 S100 calcium binding protein A9 0.0268899
FOSL1 FOS-like antigen 1 0.0267311
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0265443
SET SET nuclear proto-oncogene 0.0265037
DIAPH3 diaphanous-related formin 3 0.0264688
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0261355
RPL31 ribosomal protein L31 0.0260089
ACTG1 actin gamma 1 0.0259301
RPS11 ribosomal protein S11 0.025659
NAV2 neuron navigator 2 0.0256051
PFN1 profilin 1 0.0254653
RPL32 ribosomal protein L32 0.0249325
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0248738
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0247349
ZNF146 zinc finger protein 146 0.024655
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.024619
RPS12 ribosomal protein S12 0.0244029
RPL38 ribosomal protein L38 0.0241699
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0237942
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0237504
AK2 adenylate kinase 2 0.0237002
RPL6 ribosomal protein L6 0.0235356
RPL8 ribosomal protein L8 0.0235265
PYGL phosphorylase, glycogen, liver 0.0233788
TRA2B transformer 2 beta homolog (Drosophila) 0.0232542
AMBRA1 autophagy/beclin-1 regulator 1 0.0232471
HDGF hepatoma-derived growth factor 0.0232074
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0231455
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0231322
ZNF121 zinc finger protein 121 0.0225875
VASP vasodilator-stimulated phosphoprotein 0.0225142
CDK19 cyclin-dependent kinase 19 0.0224953
TMSB10 thymosin beta 10 0.022494
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0224571
APLP2 amyloid beta (A4) precursor-like protein 2 0.0220386
RPL27 ribosomal protein L27 0.0218759
PYGB phosphorylase, glycogen; brain 0.0215171
POTEF POTE ankyrin domain family, member F 0.021416
ANKRD36 ankyrin repeat domain 36 0.0213909
RPS15 ribosomal protein S15 0.0209181

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.17161
CD44 CD44 molecule (Indian blood group) -0.149351
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.134534
TP63 tumor protein p63 -0.130808
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.103364
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0904339
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0901593
AHNAK AHNAK nucleoprotein -0.0828686
JUN jun proto-oncogene -0.0776747
PSD3 pleckstrin and Sec7 domain containing 3 -0.0731412
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0678618
LOC112694756 uncharaterized LOC112694756 -0.0651079
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0614449
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0613706
FBXO11 F-box protein 11 -0.0566563
FTH1 ferritin, heavy polypeptide 1 -0.0561826
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0560626
ARHGAP5 Rho GTPase activating protein 5 -0.0558368
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0547245
BZW1 basic leucine zipper and W2 domains 1 -0.0530754
TXNIP thioredoxin interacting protein -0.0526741
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0520813
EREG epiregulin -0.0497476
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.047036
SP100 SP100 nuclear antigen -0.0466753
CADM2 cell adhesion molecule 2 -0.0460385
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0448806
EEF2 eukaryotic translation elongation factor 2 -0.0442949
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0439379
MYOF myoferlin -0.0401795
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0401572
DST dystonin -0.0400602
CANX calnexin -0.0397969
RIGI RNA sensor RIG-I -0.0384652
UBC ubiquitin C -0.0378881
NT5E 5'-nucleotidase, ecto (CD73) -0.0378716
BIRC3 baculoviral IAP repeat containing 3 -0.0367291
MATR3 matrin 3 -0.0355803
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0350271
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0345497
BRWD1 bromodomain and WD repeat domain containing 1 -0.0344863
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0341513
ANXA2 annexin A2 -0.0334094
FMNL2 formin-like 2 -0.0328873
VDAC1 voltage-dependent anion channel 1 -0.0327933
GNAS GNAS complex locus -0.0327519
DPYD dihydropyrimidine dehydrogenase -0.0323094
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0308835
CAPRIN2 caprin family member 2 -0.0308614
RUNX1 runt-related transcription factor 1 -0.0308344
XPO1 exportin 1 -0.0307785
VMP1 vacuole membrane protein 1 -0.0307528
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0305686
ZBTB38 zinc finger and BTB domain containing 38 -0.0302801
CDK6 cyclin-dependent kinase 6 -0.0298361
APP amyloid beta (A4) precursor protein -0.0294724
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0294373
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0292262
WARS1 tryptophanyl-tRNA synthetase 1 -0.0291335
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0283179
PLIN2 perilipin 2 -0.0281266
GLG1 golgi glycoprotein 1 -0.0276967
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0276636
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0276353
IFIH1 interferon induced with helicase C domain 1 -0.0273384
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0271159
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.026613
EPHA4 EPH receptor A4 -0.0263998
CLIP2 CAP-GLY domain containing linker protein 2 -0.0262263
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0257676
VCL vinculin -0.0256538
TGM2 transglutaminase 2 -0.0255868
AHNAK2 AHNAK nucleoprotein 2 -0.0255202
BICD1 bicaudal D homolog 1 (Drosophila) -0.0252966
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0252172
EMP1 epithelial membrane protein 1 -0.0243591
H1-0 H1.0 linker histone -0.0243196
PLSCR1 phospholipid scramblase 1 -0.0241709
ADGRG6 adhesion G protein-coupled receptor G6 -0.0237243
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0236804
SENP5 SUMO1/sentrin specific peptidase 5 -0.0235487
SMYD3 SET and MYND domain containing 3 -0.0235373
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.023489
PLK2 polo-like kinase 2 -0.023439
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0234297
NPAS2 neuronal PAS domain protein 2 -0.0233584
CFLAR CASP8 and FADD-like apoptosis regulator -0.0228128
NCEH1 neutral cholesterol ester hydrolase 1 -0.0227243
ZC3H11A zinc finger CCCH-type containing 11A -0.0226993
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0226621
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0226068
USP9X ubiquitin specific peptidase 9, X-linked -0.0224498
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -0.0224496
RAB27B RAB27B, member RAS oncogene family -0.0224381
TOP1 topoisomerase (DNA) I -0.0223002
DNAH14 dynein, axonemal, heavy chain 14 -0.0221834
INTS6 integrator complex subunit 6 -0.0219185
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 -0.0217792
KLHL24 kelch-like family member 24 -0.0217586
HLA-B major histocompatibility complex, class I, B -0.0217126