| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (mesylate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (mesylate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.207148 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.114884 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.110483 |
| FAM13A | family with sequence similarity 13, member A | 0.102267 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0825147 |
| RPS3 | ribosomal protein S3 | 0.0747809 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0698233 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0658131 |
| NDRG1 | N-myc downstream regulated 1 | 0.063911 |
| ARRDC3 | arrestin domain containing 3 | 0.0637158 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0627464 |
| HMGA1 | high mobility group AT-hook 1 | 0.062094 |
| MKI67 | marker of proliferation Ki-67 | 0.0608513 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0607607 |
| PCBP2 | poly(rC) binding protein 2 | 0.0566583 |
| SEC61G | Sec61 gamma subunit | 0.0538438 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0535768 |
| RPL37A | ribosomal protein L37a | 0.0472453 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0468119 |
| TMSB10 | thymosin beta 10 | 0.0468019 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0465964 |
| MT2A | metallothionein 2A | 0.0462613 |
| RPS8 | ribosomal protein S8 | 0.0455221 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0438041 |
| RPS12 | ribosomal protein S12 | 0.0426561 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.041855 |
| SMAD3 | SMAD family member 3 | 0.0415982 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0402332 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0401519 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0399733 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0385036 |
| RPL5 | ribosomal protein L5 | 0.0384873 |
| PLEC | plectin | 0.0376641 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0357622 |
| TPD52 | tumor protein D52 | 0.035622 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0356208 |
| RPL7 | ribosomal protein L7 | 0.0351346 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0348284 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0347993 |
| MCL1 | myeloid cell leukemia 1 | 0.0347419 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.03418 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0341426 |
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | 0.0339884 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.033277 |
| S100P | S100 calcium binding protein P | 0.0326201 |
| MXD1 | MAX dimerization protein 1 | 0.0323438 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0320668 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0319671 |
| RNF213 | ring finger protein 213 | 0.0313532 |
| B2M | beta-2-microglobulin | 0.0310716 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0308731 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0305598 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0293129 |
| MSN | moesin | 0.0287724 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0287155 |
| RPL23 | ribosomal protein L23 | 0.0282861 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0279686 |
| RPS29 | ribosomal protein S29 | 0.0273734 |
| RPS27 | ribosomal protein S27 | 0.0271159 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0266297 |
| RPL35A | ribosomal protein L35a | 0.026325 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.026323 |
| KMT5B | lysine methyltransferase 5B | 0.0263055 |
| RPL6 | ribosomal protein L6 | 0.0261809 |
| RUNX1 | runt-related transcription factor 1 | 0.0261269 |
| NCKAP1 | NCK-associated protein 1 | 0.025955 |
| RPS2 | ribosomal protein S2 | 0.0259483 |
| TMEM45B | transmembrane protein 45B | 0.0254733 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0254583 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.025179 |
| ANKRD10 | ankyrin repeat domain 10 | 0.025121 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0248569 |
| SLMAP | sarcolemma associated protein | 0.0247149 |
| GUK1 | guanylate kinase 1 | 0.024643 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.024148 |
| NUP58 | nucleoporin 58 | 0.0237772 |
| RPL13A | ribosomal protein L13a | 0.023638 |
| KDM6B | lysine (K)-specific demethylase 6B | 0.0236222 |
| RPS25 | ribosomal protein S25 | 0.0235634 |
| RPS17 | ribosomal protein S17 | 0.0233421 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0233326 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0232219 |
| FLNB | filamin B, beta | 0.0225387 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0225264 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0225181 |
| KRT7 | keratin 7, type II | 0.0224502 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0223046 |
| MED13L | mediator complex subunit 13-like | 0.0222005 |
| CCNY | cyclin Y | 0.0220639 |
| SQSTM1 | sequestosome 1 | 0.0220147 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0216904 |
| GANAB | glucosidase, alpha; neutral AB | 0.021667 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0216222 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | 0.0215799 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0213707 |
| GPBP1L1 | GC-rich promoter binding protein 1-like 1 | 0.0212612 |
| PFN1 | profilin 1 | 0.0211869 |
| RPL11 | ribosomal protein L11 | 0.0211061 |
| EPHA2 | EPH receptor A2 | 0.0210907 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0210391 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | -0.127429 |
| OSMR | oncostatin M receptor | -0.120506 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.113188 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.108631 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.101011 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0898277 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0857329 |
| HDLBP | high density lipoprotein binding protein | -0.08083 |
| CANX | calnexin | -0.0738818 |
| TOP1 | topoisomerase (DNA) I | -0.0726215 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0725853 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0720749 |
| TES | testin LIM domain protein | -0.0713952 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0659681 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0630576 |
| LAMA4 | laminin, alpha 4 | -0.0628506 |
| GOLGB1 | golgin B1 | -0.0626634 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.060936 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0608864 |
| TXNRD1 | thioredoxin reductase 1 | -0.0601812 |
| PTMA | prothymosin, alpha | -0.0568344 |
| NABP1 | nucleic acid binding protein 1 | -0.0567798 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0535831 |
| H1-0 | H1.0 linker histone | -0.0528694 |
| RPLP1 | ribosomal protein, large, P1 | -0.051875 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0496808 |
| AHNAK | AHNAK nucleoprotein | -0.0492638 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0482732 |
| PKM | pyruvate kinase, muscle | -0.0482006 |
| GM2A | GM2 ganglioside activator | -0.0473703 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0469477 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0466444 |
| VCL | vinculin | -0.0453304 |
| SLTM | SAFB-like, transcription modulator | -0.0445076 |
| PGK1 | phosphoglycerate kinase 1 | -0.044094 |
| GRAMD1B | GRAM domain containing 1B | -0.0429992 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0414608 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0412361 |
| MORF4L2 | mortality factor 4 like 2 | -0.0408376 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0407827 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0406547 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0402596 |
| ABLIM1 | actin binding LIM protein 1 | -0.0401527 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0398711 |
| SP100 | SP100 nuclear antigen | -0.0393958 |
| IER3 | immediate early response 3 | -0.0392048 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0390002 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0387408 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0365803 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0359299 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.035486 |
| MYOF | myoferlin | -0.0354839 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0352765 |
| FBXO11 | F-box protein 11 | -0.0351879 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0350006 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0345237 |
| COPA | coatomer protein complex, subunit alpha | -0.0344828 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0340419 |
| GSK3B | glycogen synthase kinase 3 beta | -0.033744 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0336823 |
| SEC24D | SEC24 family member D | -0.0336072 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0329535 |
| SPAG9 | sperm associated antigen 9 | -0.032749 |
| SRPRA | SRP receptor subunit alpha | -0.0323498 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0321756 |
| SMYD3 | SET and MYND domain containing 3 | -0.0320832 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0320412 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0317841 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.031599 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0311084 |
| LAMC2 | laminin, gamma 2 | -0.0310767 |
| JMJD1C | jumonji domain containing 1C | -0.0309213 |
| RBM39 | RNA binding motif protein 39 | -0.0308753 |
| TJP1 | tight junction protein 1 | -0.0308744 |
| LDHA | lactate dehydrogenase A | -0.0307617 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0307264 |
| TPTEP2-CSNK1E | TPTEP2-CSNK1E readthrough | -0.0306746 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0305641 |
| RPL4 | ribosomal protein L4 | -0.0298202 |
| ZNF638 | zinc finger protein 638 | -0.0297572 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0294877 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.029406 |
| SETX | senataxin | -0.0291204 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0290421 |
| OXSR1 | oxidative stress responsive 1 | -0.0287476 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0283358 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0282848 |
| RPS24 | ribosomal protein S24 | -0.027987 |
| ZRANB2 | zinc finger, RAN-binding domain containing 2 | -0.0279291 |
| CDCP1 | CUB domain containing protein 1 | -0.0278767 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0278519 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0277172 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0275801 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0274895 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0270385 |
| RAB10 | RAB10, member RAS oncogene family | -0.027004 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.026886 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0268224 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0262731 |
| ARCN1 | archain 1 | -0.0258212 |
