Almonertinib (mesylate)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (mesylate) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (mesylate)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
P4HB prolyl 4-hydroxylase, beta polypeptide 0.138282
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0913355
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0843435
PCBP2 poly(rC) binding protein 2 0.0839367
NAV2 neuron navigator 2 0.0830999
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0760388
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0749177
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0735108
GRB10 growth factor receptor-bound protein 10 0.0704532
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0668422
SMAD3 SMAD family member 3 0.0611348
VEGFA vascular endothelial growth factor A 0.0597484
IGFBP3 insulin-like growth factor binding protein 3 0.0588609
HMGA1 high mobility group AT-hook 1 0.0505181
FAM13A family with sequence similarity 13, member A 0.049331
FLNB filamin B, beta 0.0489873
RPL13A ribosomal protein L13a 0.0475243
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0452695
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0446738
TRIO trio Rho guanine nucleotide exchange factor 0.0442198
MAP2K1 mitogen-activated protein kinase kinase 1 0.0426643
EEF2 eukaryotic translation elongation factor 2 0.0422639
FAM20C family with sequence similarity 20, member C 0.0420737
DOCK5 dedicator of cytokinesis 5 0.0413921
PRELID2 PRELI domain containing 2 0.0412654
RPS12 ribosomal protein S12 0.0407638
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0401355
ENO1 enolase 1, (alpha) 0.0387101
RPS3 ribosomal protein S3 0.0383808
BACE2 beta-site APP-cleaving enzyme 2 0.0378882
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0373665
RPL5 ribosomal protein L5 0.0371145
DSCAM Down syndrome cell adhesion molecule 0.0369941
SIK3 SIK family kinase 3 0.0368436
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0365366
CALR calreticulin 0.0362545
YEATS2 YEATS domain containing 2 0.0356112
ZNF292 zinc finger protein 292 0.035497
RUNX1 runt-related transcription factor 1 0.035238
RPL3 ribosomal protein L3 0.0351831
RPL37A ribosomal protein L37a 0.0331814
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0330969
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0326509
OPTN optineurin 0.0323777
NGLY1 N-glycanase 1 0.0321012
CALU calumenin 0.031962
ANGPTL4 angiopoietin-like 4 0.0318055
EEF1G eukaryotic translation elongation factor 1 gamma 0.0317479
MYH9 myosin, heavy chain 9, non-muscle 0.0316609
RPL23 ribosomal protein L23 0.0316375
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.03151
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0310767
ZMIZ1 zinc finger, MIZ-type containing 1 0.0307987
ZFP36L1 ZFP36 ring finger protein-like 1 0.030794
RPS2 ribosomal protein S2 0.0302072
CEP250 centrosomal protein 250kDa 0.0294442
GANAB glucosidase, alpha; neutral AB 0.0292954
GYS1 glycogen synthase 1 (muscle) 0.0286455
EGFR epidermal growth factor receptor 0.0284699
PFN1 profilin 1 0.0279368
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0267593
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0266079
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0265951
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0265618
SDK1 sidekick cell adhesion molecule 1 0.0263661
NDRG1 N-myc downstream regulated 1 0.0261731
NCOR2 nuclear receptor corepressor 2 0.0260729
CDK19 cyclin-dependent kinase 19 0.0255664
TPM3 tropomyosin 3 0.0255124
CNOT12 CCR4-NOT transcription complex subunit 12 0.0254866
SLC43A3 solute carrier family 43, member 3 0.025383
ARRDC3 arrestin domain containing 3 0.0253628
MLPH melanophilin 0.0252181
POM121 POM121 transmembrane nucleoporin 0.0251793
APLP2 amyloid beta (A4) precursor-like protein 2 0.0248779
PFKP phosphofructokinase, platelet 0.024839
LIMS1 LIM and senescent cell antigen-like domains 1 0.0246565
TP53BP1 tumor protein p53 binding protein 1 0.0246384
KTN1 kinectin 1 (kinesin receptor) 0.0245525
NBAS neuroblastoma amplified sequence 0.0245418
MRPS6 mitochondrial ribosomal protein S6 0.0243706
SHB Src homology 2 domain containing adaptor protein B 0.024364
RPS29 ribosomal protein S29 0.0242028
ANKRD11 ankyrin repeat domain 11 0.0238052
SEPTIN9 septin 9 0.0236502
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0236192
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0235183
ANKRD36 ankyrin repeat domain 36 0.0234094
MACF1 microtubule-actin crosslinking factor 1 0.0232926
POTEF POTE ankyrin domain family, member F 0.0232086
HSPA8 heat shock 70kDa protein 8 0.0231965
MCL1 myeloid cell leukemia 1 0.0230104
ATXN1 ataxin 1 0.0229362
RPL18 ribosomal protein L18 0.0222473
AMPD3 adenosine monophosphate deaminase 3 0.0220757
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 0.0219319
RPL6 ribosomal protein L6 0.0218648
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0218317
UBE2O ubiquitin-conjugating enzyme E2O 0.0216913
RPS8 ribosomal protein S8 0.0216758

decreased expression

Symbol Name Standardized Value
CD44 CD44 molecule (Indian blood group) -0.203951
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.154171
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.137662
FTL ferritin, light polypeptide -0.136888
GLCCI1 glucocorticoid induced 1 -0.130633
CXCL8 chemokine (C-X-C motif) ligand 8 -0.112768
NRG1 neuregulin 1 -0.0947989
OSMR oncostatin M receptor -0.0853805
NCOA7 nuclear receptor coactivator 7 -0.0843525
PTMA prothymosin, alpha -0.0831836
PDE4D phosphodiesterase 4D, cAMP-specific -0.0733044
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0704921
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0688369
LMAN1 lectin, mannose-binding, 1 -0.0681787
RAP1B RAP1B, member of RAS oncogene family -0.0674597
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0661743
RBM39 RNA binding motif protein 39 -0.0638713
NTN4 netrin 4 -0.0636677
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0600871
IER3 immediate early response 3 -0.0594012
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0590417
RPLP1 ribosomal protein, large, P1 -0.0572644
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0569596
STC1 stanniocalcin 1 -0.0565834
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0564166
BTG1 B-cell translocation gene 1, anti-proliferative -0.0559104
BZW1 basic leucine zipper and W2 domains 1 -0.0554518
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0554424
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0554156
PSD3 pleckstrin and Sec7 domain containing 3 -0.0542376
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0524868
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0519445
EIF1 eukaryotic translation initiation factor 1 -0.0519035
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.05088
H1-0 H1.0 linker histone -0.0507323
ARHGAP5 Rho GTPase activating protein 5 -0.0506069
RPLP0 ribosomal protein, large, P0 -0.0494094
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0489153
VIM vimentin -0.0486598
KYNU kynureninase -0.0476753
KDM3A lysine (K)-specific demethylase 3A -0.0475184
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0473522
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0470833
VRK2 vaccinia related kinase 2 -0.0467554
TMSB10 thymosin beta 10 -0.0453955
HMGA2 high mobility group AT-hook 2 -0.044137
NFE2L2 nuclear factor, erythroid 2-like 2 -0.044058
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.043847
VDAC1 voltage-dependent anion channel 1 -0.0427443
TMEM263 transmembrane protein 263 -0.0423532
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.040992
JMJD1C jumonji domain containing 1C -0.0408566
AHNAK AHNAK nucleoprotein -0.040704
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0406883
ELL2 elongation factor, RNA polymerase II, 2 -0.0399868
SP100 SP100 nuclear antigen -0.0393256
OXSR1 oxidative stress responsive 1 -0.0389619
ZC3H12C zinc finger CCCH-type containing 12C -0.0386553
HDLBP high density lipoprotein binding protein -0.0385752
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0380817
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0379864
COPA coatomer protein complex, subunit alpha -0.0376508
RPS24 ribosomal protein S24 -0.0370529
SAMD9 sterile alpha motif domain containing 9 -0.0365044
STRN3 striatin, calmodulin binding protein 3 -0.0362562
VCL vinculin -0.0357635
SOD2 superoxide dismutase 2, mitochondrial -0.0349436
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0347073
TJP1 tight junction protein 1 -0.0336827
TFPI2 tissue factor pathway inhibitor 2 -0.0333026
RAB1A RAB1A, member RAS oncogene family -0.0331478
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0331282
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0321887
PDLIM5 PDZ and LIM domain 5 -0.0321612
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0318475
NUMB numb homolog (Drosophila) -0.0317472
GNAS GNAS complex locus -0.0313736
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0313538
AADAC arylacetamide deacetylase -0.0311205
FBXO11 F-box protein 11 -0.0309298
CLIC4 chloride intracellular channel 4 -0.0308971
CDK6 cyclin-dependent kinase 6 -0.0305599
ANKRD28 ankyrin repeat domain 28 -0.0298561
KSR1 kinase suppressor of ras 1 -0.0293927
PTBP3 polypyrimidine tract binding protein 3 -0.0292294
MSRB3 methionine sulfoxide reductase B3 -0.0290961
COL12A1 collagen, type XII, alpha 1 -0.0289384
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0287595
RNF24 ring finger protein 24 -0.0286479
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0284645
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0283451
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.0278975
STAU1 staufen double-stranded RNA binding protein 1 -0.0276606
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0275452
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0275361
CANX calnexin -0.0275193
NF1 neurofibromin 1 -0.0273358
PLIN2 perilipin 2 -0.0271433
NPEPPS aminopeptidase puromycin sensitive -0.0270369
ZBTB38 zinc finger and BTB domain containing 38 -0.0270313