| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (mesylate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (mesylate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.197381 |
| VIM | vimentin | 0.111284 |
| LDHA | lactate dehydrogenase A | 0.0981151 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0968801 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0957884 |
| MT2A | metallothionein 2A | 0.0919674 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0916613 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.082938 |
| MCL1 | myeloid cell leukemia 1 | 0.0808768 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0789287 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0784838 |
| IGF2 | insulin-like growth factor 2 | 0.0758041 |
| CMIP | c-Maf inducing protein | 0.0743166 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0733289 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0724371 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0702605 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0677018 |
| CALR | calreticulin | 0.0674776 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0658792 |
| FAM168A | family with sequence similarity 168, member A | 0.061629 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0605388 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.057127 |
| RPL23 | ribosomal protein L23 | 0.0571012 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0565719 |
| VMP1 | vacuole membrane protein 1 | 0.0555219 |
| NUP58 | nucleoporin 58 | 0.0528695 |
| PYGL | phosphorylase, glycogen, liver | 0.0520104 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0517449 |
| KLF6 | Kruppel-like factor 6 | 0.0515072 |
| PTK2 | protein tyrosine kinase 2 | 0.0506116 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0504486 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0496744 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0490659 |
| ACTN1 | actinin, alpha 1 | 0.0485085 |
| TPD52 | tumor protein D52 | 0.0479713 |
| ZNF292 | zinc finger protein 292 | 0.0465158 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0458949 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0454957 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0448214 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0444519 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0443923 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0429061 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0424752 |
| HMGA1 | high mobility group AT-hook 1 | 0.0417015 |
| FDPS | farnesyl diphosphate synthase | 0.0417004 |
| FLNA | filamin A, alpha | 0.0414515 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0411853 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0408662 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0407101 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0401396 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0389157 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0387397 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0380706 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.037891 |
| CHN1 | chimerin 1 | 0.0373649 |
| ASPH | aspartate beta-hydroxylase | 0.0373576 |
| APP | amyloid beta (A4) precursor protein | 0.0372976 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0371332 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0369928 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0369806 |
| AHNAK | AHNAK nucleoprotein | 0.0366594 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0363354 |
| CALU | calumenin | 0.0359158 |
| USP3 | ubiquitin specific peptidase 3 | 0.0353112 |
| FLNB | filamin B, beta | 0.0351941 |
| ITGB5 | integrin, beta 5 | 0.0351813 |
| GANAB | glucosidase, alpha; neutral AB | 0.0345989 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0328637 |
| S100A10 | S100 calcium binding protein A10 | 0.0328343 |
| PFKP | phosphofructokinase, platelet | 0.0327452 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0321881 |
| THBS1 | thrombospondin 1 | 0.0321267 |
| RPS7 | ribosomal protein S7 | 0.0319588 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0318285 |
| CFDP1 | craniofacial development protein 1 | 0.0318023 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0316827 |
| PDE8A | phosphodiesterase 8A | 0.0316796 |
| TPM4 | tropomyosin 4 | 0.0316676 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0310968 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0309118 |
| MKI67 | marker of proliferation Ki-67 | 0.030778 |
| HLA-B | major histocompatibility complex, class I, B | 0.0305973 |
| SPAG5 | sperm associated antigen 5 | 0.0305948 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0304986 |
| ECT2 | epithelial cell transforming 2 | 0.030455 |
| YME1L1 | YME1-like 1 ATPase | 0.0304448 |
| EIF4A3 | eukaryotic translation initiation factor 4A3 | 0.0303307 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0302693 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 0.0296861 |
| IST1 | increased sodium tolerance 1 homolog (yeast) | 0.0293974 |
| WDR43 | WD repeat domain 43 | 0.0293619 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0291371 |
| FKBP10 | FK506 binding protein 10, 65 kDa | 0.0290418 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0290204 |
| TPM3 | tropomyosin 3 | 0.0290184 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0289688 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.028822 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0288156 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0287813 |
| TFG | TRK-fused gene | 0.0286756 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FTL | ferritin, light polypeptide | -0.261097 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.181199 |
| PM20D1 | peptidase M20 domain containing 1 | -0.161094 |
| TMSB10 | thymosin beta 10 | -0.104338 |
| RPS2 | ribosomal protein S2 | -0.0929067 |
| RPLP1 | ribosomal protein, large, P1 | -0.0850457 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0788752 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0780881 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0723627 |
| RPL19 | ribosomal protein L19 | -0.071203 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0656897 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0627318 |
| FGB | fibrinogen beta chain | -0.0626279 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0595424 |
| RPS6 | ribosomal protein S6 | -0.0589573 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0575429 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0548378 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.051298 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0415691 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0411598 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0409984 |
| JMJD1C | jumonji domain containing 1C | -0.0407739 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0407287 |
| RPL4 | ribosomal protein L4 | -0.038446 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.035002 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0345076 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0344503 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0323769 |
| RPS5 | ribosomal protein S5 | -0.0319908 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0315893 |
| TXNRD1 | thioredoxin reductase 1 | -0.0315224 |
| RPL12 | ribosomal protein L12 | -0.0313493 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0309194 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0304763 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0301035 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0296213 |
| RPS12 | ribosomal protein S12 | -0.0291922 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0290951 |
| GNAS | GNAS complex locus | -0.0290178 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0283753 |
| PTMA | prothymosin, alpha | -0.0282536 |
| MATR3 | matrin 3 | -0.0280746 |
| POTEF | POTE ankyrin domain family, member F | -0.0279707 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0277444 |
| GOLGB1 | golgin B1 | -0.0277146 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0276398 |
| DST | dystonin | -0.0275226 |
| USP34 | ubiquitin specific peptidase 34 | -0.0275059 |
| FBXO11 | F-box protein 11 | -0.0274196 |
| BICC1 | BicC family RNA binding protein 1 | -0.02739 |
| BRD2 | bromodomain containing 2 | -0.0269783 |
| HBP1 | HMG-box transcription factor 1 | -0.0267699 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0265339 |
| UBB | ubiquitin B | -0.0263508 |
| ATAD2B | ATPase family, AAA domain containing 2B | -0.0260982 |
| GLG1 | golgi glycoprotein 1 | -0.0260631 |
| CDK6 | cyclin-dependent kinase 6 | -0.0258124 |
| ATF4 | activating transcription factor 4 | -0.0257429 |
| KANSL1L | KAT8 regulatory NSL complex subunit 1-like | -0.0257306 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0256541 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0254376 |
| RPS25 | ribosomal protein S25 | -0.025152 |
| TKT | transketolase | -0.0250874 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0247237 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.024531 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0238797 |
| GPHN | gephyrin | -0.0237301 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.023559 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | -0.0235383 |
| UBXN4 | UBX domain protein 4 | -0.0235224 |
| HDLBP | high density lipoprotein binding protein | -0.023164 |
| SRRM1 | serine/arginine repetitive matrix 1 | -0.0229575 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0226585 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0223013 |
| RAB10 | RAB10, member RAS oncogene family | -0.022292 |
| RPS19 | ribosomal protein S19 | -0.0221959 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0218912 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0217717 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0217322 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0216035 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0215686 |
| STAG2 | stromal antigen 2 | -0.0214126 |
| MORF4L2 | mortality factor 4 like 2 | -0.0212075 |
| NCOA2 | nuclear receptor coactivator 2 | -0.0210888 |
| CCT3 | chaperonin containing TCP1, subunit 3 (gamma) | -0.0209443 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0209348 |
| ASTN2 | astrotactin 2 | -0.0209334 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0208119 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0207078 |
| RDX | radixin | -0.0206581 |
| PHF3 | PHD finger protein 3 | -0.020623 |
| FGG | fibrinogen gamma chain | -0.0206173 |
| MTDH | metadherin | -0.0203803 |
| RPLP0 | ribosomal protein, large, P0 | -0.0203141 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0202857 |
| EIF3J | eukaryotic translation initiation factor 3, subunit J | -0.0202284 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0200161 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0197862 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0197733 |
| TOP1 | topoisomerase (DNA) I | -0.0197227 |
