| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (mesylate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (mesylate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.096475 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0800847 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0800343 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0799026 |
| ZNF292 | zinc finger protein 292 | 0.078817 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0718236 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0711392 |
| DTNA | dystrobrevin, alpha | 0.069397 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0688303 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0643924 |
| SMYD3 | SET and MYND domain containing 3 | 0.0620793 |
| FAM13A | family with sequence similarity 13, member A | 0.0619035 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0610538 |
| EGFR | epidermal growth factor receptor | 0.0597191 |
| FLNB | filamin B, beta | 0.0579111 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0557326 |
| RPL26 | ribosomal protein L26 | 0.0556811 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0543142 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0541715 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0538902 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0530736 |
| NGLY1 | N-glycanase 1 | 0.0517908 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0509285 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0508899 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0505025 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0476001 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0474586 |
| RPS25 | ribosomal protein S25 | 0.0448885 |
| SEPTIN9 | septin 9 | 0.0446233 |
| METTL15 | methyltransferase like 15 | 0.0443443 |
| CCNY | cyclin Y | 0.0437683 |
| RNF213 | ring finger protein 213 | 0.0426685 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0418839 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0415339 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0414175 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | 0.0412419 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0408786 |
| RAD51B | RAD51 paralog B | 0.0406219 |
| PCNX4 | pecanex 4 | 0.0404355 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0402047 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0400028 |
| CD47 | CD47 molecule | 0.0398612 |
| EFNA5 | ephrin-A5 | 0.0397531 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0392759 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0391894 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0388879 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.03864 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0374853 |
| SPG7 | spastic paraplegia 7 (pure and complicated autosomal recessive) | 0.0373941 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0371162 |
| ZFHX3 | zinc finger homeobox 3 | 0.036118 |
| NRG1 | neuregulin 1 | 0.0358458 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0357685 |
| ABHD17C | abhydrolase domain containing 17C | 0.0356728 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.035487 |
| PAXBP1 | PAX3 and PAX7 binding protein 1 | 0.0350122 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0348544 |
| SMC3 | structural maintenance of chromosomes 3 | 0.0347124 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0343486 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0340612 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0339737 |
| LATS2 | large tumor suppressor kinase 2 | 0.0339679 |
| KIAA1958 | KIAA1958 | 0.0338902 |
| AHNAK | AHNAK nucleoprotein | 0.0338725 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0337149 |
| TMEM14B | transmembrane protein 14B | 0.0329883 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0329574 |
| AOPEP | aminopeptidase O (putative) | 0.0328044 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0326947 |
| BLTP3B | bridge-like lipid transfer protein family member 3B | 0.0326026 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0325815 |
| PRPF6 | pre-mRNA processing factor 6 | 0.0324609 |
| VEGFA | vascular endothelial growth factor A | 0.0322571 |
| JMJD1C | jumonji domain containing 1C | 0.0321648 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.031852 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0316962 |
| APP | amyloid beta (A4) precursor protein | 0.0316704 |
| HLA-A | major histocompatibility complex, class I, A | 0.0313533 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.031318 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0312814 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.0309266 |
| RASAL2 | RAS protein activator like 2 | 0.0307738 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0304274 |
| USP47 | ubiquitin specific peptidase 47 | 0.0303981 |
| SIL1 | SIL1 nucleotide exchange factor | 0.0301659 |
| EIF5AL1 | eukaryotic translation initiation factor 5A-like 1 | 0.030154 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0300961 |
| NEMF | nuclear export mediator factor | 0.0299863 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0299353 |
| TMF1 | TATA element modulatory factor 1 | 0.0299175 |
| PODXL | podocalyxin-like | 0.0299074 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0299039 |
| ATRN | attractin | 0.0297341 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.0296433 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.029584 |
| STAU2 | staufen double-stranded RNA binding protein 2 | 0.0295657 |
| PLEC | plectin | 0.0295004 |
| VPS13A | vacuolar protein sorting 13 homolog A (S. cerevisiae) | 0.0294886 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0294087 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0292172 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FTL | ferritin, light polypeptide | -0.239797 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.154399 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.134922 |
| TMSB10 | thymosin beta 10 | -0.133836 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.117425 |
| VIM | vimentin | -0.108047 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.093782 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0798101 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0783156 |
| PKM | pyruvate kinase, muscle | -0.0769332 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0747173 |
| LAMB3 | laminin, beta 3 | -0.0737589 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.07232 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0718826 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.071511 |
| RPL35A | ribosomal protein L35a | -0.0693343 |
| ANXA1 | annexin A1 | -0.0679971 |
| SRPK2 | SRSF protein kinase 2 | -0.0645844 |
| ACTG1 | actin gamma 1 | -0.0639311 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0608576 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0604345 |
| RPS19 | ribosomal protein S19 | -0.0596372 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0568436 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0559634 |
| SAR1A | secretion associated, Ras related GTPase 1A | -0.0539598 |
| S100A10 | S100 calcium binding protein A10 | -0.0538736 |
| FOXO3 | forkhead box O3 | -0.0538318 |
| GNAS | GNAS complex locus | -0.0537855 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.053686 |
| RPS6 | ribosomal protein S6 | -0.0526652 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0525422 |
| RPL19 | ribosomal protein L19 | -0.0517713 |
| NPTN | neuroplastin | -0.0515783 |
| PTMA | prothymosin, alpha | -0.0515142 |
| RPS24 | ribosomal protein S24 | -0.0504269 |
| GOLGA4 | golgin A4 | -0.0494175 |
| NKTR | natural killer cell triggering receptor | -0.0478548 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0477346 |
| SNX9 | sorting nexin 9 | -0.0475769 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0475341 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0470914 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0467015 |
| TXNIP | thioredoxin interacting protein | -0.0464481 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0461884 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0457353 |
| RAB8B | RAB8B, member RAS oncogene family | -0.0456688 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0455529 |
| H3-3B | H3.3 histone B | -0.0452097 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0446254 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0446055 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0439198 |
| SUCO | SUN domain containing ossification factor | -0.04366 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0436016 |
| CCDC6 | coiled-coil domain containing 6 | -0.0432304 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0429055 |
| RPL12 | ribosomal protein L12 | -0.0426672 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0418555 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0417793 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.041523 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0414798 |
| RPS11 | ribosomal protein S11 | -0.0413451 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0409302 |
| S100A6 | S100 calcium binding protein A6 | -0.0405874 |
| HBP1 | HMG-box transcription factor 1 | -0.0402615 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0397404 |
| WASF2 | WAS protein family, member 2 | -0.0394055 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0393992 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0393528 |
| MYO6 | myosin VI | -0.0392801 |
| RPS4X | ribosomal protein S4, X-linked | -0.0391208 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0386934 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0386631 |
| MYO1E | myosin IE | -0.0385287 |
| DICER1 | dicer 1, ribonuclease type III | -0.0375853 |
| HMGA1 | high mobility group AT-hook 1 | -0.037439 |
| CCNI | cyclin I | -0.0374151 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0373858 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0373228 |
| FOXP1 | forkhead box P1 | -0.0373014 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0372207 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0370586 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.036985 |
| RPLP0 | ribosomal protein, large, P0 | -0.0369281 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0368078 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0365618 |
| AFAP1 | actin filament associated protein 1 | -0.0359921 |
| RPL21 | ribosomal protein L21 | -0.0356869 |
| FN1 | fibronectin 1 | -0.0355425 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0354751 |
| TNPO1 | transportin 1 | -0.0354169 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0348398 |
| SP100 | SP100 nuclear antigen | -0.0347875 |
| CYTH1 | cytohesin 1 | -0.0346086 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0345024 |
| RPL11 | ribosomal protein L11 | -0.0343894 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0340291 |
| CUL1 | cullin 1 | -0.0338945 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0337995 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0335047 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0333888 |
