| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (mesylate) perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Almonertinib (mesylate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.13154 |
| GRAMD1B | GRAM domain containing 1B | 0.128282 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.122928 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.111251 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0920915 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0867814 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0842424 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0831986 |
| TPM3 | tropomyosin 3 | 0.08129 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.078495 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0746105 |
| MKI67 | marker of proliferation Ki-67 | 0.0737069 |
| PTK2 | protein tyrosine kinase 2 | 0.0702051 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0677097 |
| YBX3 | Y box binding protein 3 | 0.067433 |
| KLF6 | Kruppel-like factor 6 | 0.0662667 |
| ADAR | adenosine deaminase, RNA-specific | 0.0604974 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0592128 |
| CCND2 | cyclin D2 | 0.0571278 |
| RPL13A | ribosomal protein L13a | 0.0560394 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0542643 |
| SMAD3 | SMAD family member 3 | 0.0541476 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.054036 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0513865 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0502063 |
| RPL23 | ribosomal protein L23 | 0.0500717 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0497462 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.049601 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0494687 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0487681 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0487049 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0470627 |
| RPL6 | ribosomal protein L6 | 0.046653 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0461036 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0460359 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0457347 |
| ENO1 | enolase 1, (alpha) | 0.0452022 |
| CTTN | cortactin | 0.0447731 |
| RPS21 | ribosomal protein S21 | 0.0445966 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.043842 |
| FAM168A | family with sequence similarity 168, member A | 0.0432503 |
| RBM33 | RNA binding motif protein 33 | 0.0432078 |
| HMGA1 | high mobility group AT-hook 1 | 0.0429678 |
| AHCYL1 | adenosylhomocysteinase-like 1 | 0.042558 |
| RPL26 | ribosomal protein L26 | 0.042366 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.042128 |
| SPPL3 | signal peptide peptidase like 3 | 0.0418687 |
| RPS3 | ribosomal protein S3 | 0.0417881 |
| RPL5 | ribosomal protein L5 | 0.0414143 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0408582 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0396671 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0390048 |
| PCNX1 | pecanex 1 | 0.0388452 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.038807 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0386994 |
| ACTN1 | actinin, alpha 1 | 0.038551 |
| NCKAP1 | NCK-associated protein 1 | 0.0379714 |
| TRIM33 | tripartite motif containing 33 | 0.0373408 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0369576 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0368124 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0366348 |
| NUP153 | nucleoporin 153kDa | 0.0362085 |
| NUP58 | nucleoporin 58 | 0.0361358 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.035997 |
| TLN1 | talin 1 | 0.0354978 |
| XPO6 | exportin 6 | 0.0352746 |
| UBC | ubiquitin C | 0.0351562 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0348195 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0346592 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0343477 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.0341985 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0341472 |
| RLIM | ring finger protein, LIM domain interacting | 0.0340126 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0338132 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0337398 |
| PCBP2 | poly(rC) binding protein 2 | 0.0335317 |
| NF1 | neurofibromin 1 | 0.0334328 |
| PFN1 | profilin 1 | 0.0332579 |
| TNPO3 | transportin 3 | 0.0331363 |
| GANAB | glucosidase, alpha; neutral AB | 0.0327203 |
| GPBP1L1 | GC-rich promoter binding protein 1-like 1 | 0.0326733 |
| RPL37A | ribosomal protein L37a | 0.0325284 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.032316 |
| WDR45B | WD repeat domain 45B | 0.0322035 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | 0.0319351 |
| ENSA | endosulfine alpha | 0.0318493 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.031678 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.031561 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0311872 |
| ABI2 | abl-interactor 2 | 0.0311345 |
| H1-0 | H1.0 linker histone | 0.0309109 |
| RTN4 | reticulon 4 | 0.0307595 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0307085 |
| OGA | O-GlcNAcase | 0.0305534 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0305021 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0304956 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0303927 |
| SSH2 | slingshot protein phosphatase 2 | 0.0303558 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0299164 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0298596 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.217171 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0984029 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0794955 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0752791 |
| PTMA | prothymosin, alpha | -0.0730167 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0590279 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0558431 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.055162 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0529584 |
| AEBP2 | AE binding protein 2 | -0.0479936 |
| RPLP1 | ribosomal protein, large, P1 | -0.0468474 |
| HMGA2 | high mobility group AT-hook 2 | -0.0449819 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0447695 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0444319 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0412424 |
| PTMS | parathymosin | -0.0401331 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0383532 |
| RNF145 | ring finger protein 145 | -0.036338 |
| RPS6 | ribosomal protein S6 | -0.0358984 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0351288 |
| INTS6 | integrator complex subunit 6 | -0.0342319 |
| PKM | pyruvate kinase, muscle | -0.032858 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0325472 |
| VIM | vimentin | -0.0316231 |
| RPL31 | ribosomal protein L31 | -0.031577 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0308069 |
| GNAS | GNAS complex locus | -0.0301605 |
| RPS24 | ribosomal protein S24 | -0.0300081 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0296668 |
| RBM25 | RNA binding motif protein 25 | -0.0296297 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0289195 |
| MCL1 | myeloid cell leukemia 1 | -0.0276859 |
| GART | phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase | -0.0272314 |
| CBX3 | chromobox homolog 3 | -0.0269319 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0269196 |
| POTEF | POTE ankyrin domain family, member F | -0.0262335 |
| RSF1 | remodeling and spacing factor 1 | -0.0261106 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.02581 |
| COPA | coatomer protein complex, subunit alpha | -0.0257211 |
| SETD5 | SET domain containing 5 | -0.0254583 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0254149 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0253148 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0252828 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0252534 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0250625 |
| PCNX4 | pecanex 4 | -0.0249202 |
| FTL | ferritin, light polypeptide | -0.0248846 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0247591 |
| SNX14 | sorting nexin 14 | -0.0244962 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0244351 |
| ZNF638 | zinc finger protein 638 | -0.0241707 |
| STYK1 | serine/threonine/tyrosine kinase 1 | -0.0236875 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0236553 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0229191 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.022483 |
| DIAPH2 | diaphanous-related formin 2 | -0.0223224 |
| DENND5B | DENN/MADD domain containing 5B | -0.0221052 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0214996 |
| TBCA | tubulin folding cofactor A | -0.0212322 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | -0.0209432 |
| RPS4X | ribosomal protein S4, X-linked | -0.020938 |
| ATM | ATM serine/threonine kinase | -0.0209318 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.0208944 |
| PTEN | phosphatase and tensin homolog | -0.0207664 |
| FBXO11 | F-box protein 11 | -0.0205297 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0203936 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0203714 |
| RAD50 | RAD50 homolog (S. cerevisiae) | -0.0202972 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0196912 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.019555 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | -0.0194232 |
| ATF4 | activating transcription factor 4 | -0.0187932 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0187229 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0185455 |
| CDV3 | CDV3 homolog (mouse) | -0.0185009 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | -0.0184537 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | -0.0183843 |
| GTPBP4 | GTP binding protein 4 | -0.0183018 |
| TUT4 | terminal uridylyl transferase 4 | -0.0181812 |
| TRIM59 | tripartite motif containing 59 | -0.0180725 |
| MATR3 | matrin 3 | -0.0178698 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0178154 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0177604 |
| INTS13 | integrator complex subunit 13 | -0.017669 |
| NEK10 | NIMA-related kinase 10 | -0.0175596 |
| RPS20 | ribosomal protein S20 | -0.0175377 |
| DEK | DEK proto-oncogene | -0.0174977 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | -0.0173162 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0171403 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0171048 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0169951 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | -0.0169496 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0168982 |
| POGZ | pogo transposable element with ZNF domain | -0.0168966 |
| SLC39A10 | solute carrier family 39 (zinc transporter), member 10 | -0.0168686 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.016831 |
| RPL9 | ribosomal protein L9 | -0.0167143 |
| RPL37 | ribosomal protein L37 | -0.0166504 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | -0.0165028 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.0164319 |
