| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (mesylate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (mesylate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GRB10 | growth factor receptor-bound protein 10 | 0.178651 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.153988 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.134348 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.116587 |
| CALR | calreticulin | 0.115307 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.114103 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.108974 |
| G0S2 | G0/G1 switch 2 | 0.107105 |
| VEGFA | vascular endothelial growth factor A | 0.102711 |
| LAMB3 | laminin, beta 3 | 0.10177 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0889742 |
| HMGA1 | high mobility group AT-hook 1 | 0.0751986 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0732432 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0687916 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0655556 |
| CD109 | CD109 molecule | 0.0647015 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0646302 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0642078 |
| RPS3 | ribosomal protein S3 | 0.0612309 |
| FAM13A | family with sequence similarity 13, member A | 0.0598057 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0586727 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.057979 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0561816 |
| RPS29 | ribosomal protein S29 | 0.0559348 |
| ACTG1 | actin gamma 1 | 0.0543276 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0500779 |
| RPL23 | ribosomal protein L23 | 0.0499333 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0494615 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0489618 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0486104 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0477438 |
| MSN | moesin | 0.0473829 |
| FN1 | fibronectin 1 | 0.0463635 |
| MT2A | metallothionein 2A | 0.0462178 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0460925 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0459703 |
| RPS8 | ribosomal protein S8 | 0.0455539 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0454088 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0449265 |
| AREG | amphiregulin | 0.0441253 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0440212 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0437246 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0426698 |
| RPL9 | ribosomal protein L9 | 0.0426507 |
| ARRDC3 | arrestin domain containing 3 | 0.0425706 |
| TOP1 | topoisomerase (DNA) I | 0.0424631 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0413263 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0410656 |
| RACK1 | receptor for activated C kinase 1 | 0.0406612 |
| HLA-A | major histocompatibility complex, class I, A | 0.0399273 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0396264 |
| NDRG1 | N-myc downstream regulated 1 | 0.0394442 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0392317 |
| HLA-B | major histocompatibility complex, class I, B | 0.0392001 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0388491 |
| MXD1 | MAX dimerization protein 1 | 0.0387944 |
| CCNY | cyclin Y | 0.0374082 |
| FOSL1 | FOS-like antigen 1 | 0.0373213 |
| LDHA | lactate dehydrogenase A | 0.0369014 |
| RPL13A | ribosomal protein L13a | 0.0368607 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0366388 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.036444 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0363336 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0362716 |
| CTBP2 | C-terminal binding protein 2 | 0.0358736 |
| HDGF | hepatoma-derived growth factor | 0.0358722 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0358584 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.035718 |
| NUP58 | nucleoporin 58 | 0.0353471 |
| B2M | beta-2-microglobulin | 0.0353058 |
| FLNB | filamin B, beta | 0.0349276 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0348788 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0348641 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0347284 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0344821 |
| S100A10 | S100 calcium binding protein A10 | 0.0343969 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0343481 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0342726 |
| CD47 | CD47 molecule | 0.034231 |
| AHDC1 | AT hook, DNA binding motif, containing 1 | 0.034004 |
| SETD5 | SET domain containing 5 | 0.0325777 |
| ZNF292 | zinc finger protein 292 | 0.0317777 |
| COX6C | cytochrome c oxidase subunit VIc | 0.0316934 |
| RPLP2 | ribosomal protein, large, P2 | 0.0309616 |
| RPL37 | ribosomal protein L37 | 0.0309026 |
| SACK1A | scaffolding CK1 anchoring protein A | 0.0308663 |
| MSI2 | musashi RNA-binding protein 2 | 0.0306511 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0304032 |
| PLAU | plasminogen activator, urokinase | 0.0300873 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0296436 |
| RPS13 | ribosomal protein S13 | 0.0295906 |
| PLEC | plectin | 0.029202 |
| RPS12 | ribosomal protein S12 | 0.029016 |
| QKI | QKI, KH domain containing, RNA binding | 0.0288308 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.02843 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0279905 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.0278972 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0277307 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0275243 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0270846 |
| Symbol | Name | Standardized Value |
|---|---|---|
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.196495 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.142606 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.13461 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.120468 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0926191 |
| TXNRD1 | thioredoxin reductase 1 | -0.0879247 |
| TMSB10 | thymosin beta 10 | -0.0871262 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0676184 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.062207 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0621995 |
| UBC | ubiquitin C | -0.0619102 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0602931 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0596855 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0581283 |
| RPLP0 | ribosomal protein, large, P0 | -0.0570305 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0561731 |
| AHNAK | AHNAK nucleoprotein | -0.0556903 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.049966 |
| CCND1 | cyclin D1 | -0.0490995 |
| RPLP1 | ribosomal protein, large, P1 | -0.0462201 |
| DSG2 | desmoglein 2 | -0.0448445 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0439198 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0437688 |
| RPL4 | ribosomal protein L4 | -0.0434843 |
| FTL | ferritin, light polypeptide | -0.0416591 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0411335 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0407782 |
| MAP4 | microtubule-associated protein 4 | -0.0370643 |
| OSMR | oncostatin M receptor | -0.0367903 |
| POTEF | POTE ankyrin domain family, member F | -0.036053 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0357598 |
| HDLBP | high density lipoprotein binding protein | -0.0350293 |
| ANXA2 | annexin A2 | -0.0347594 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0342265 |
| NEK7 | NIMA-related kinase 7 | -0.0340802 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0340364 |
| GNAS | GNAS complex locus | -0.033949 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.033122 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0329462 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0327619 |
| SGMS2 | sphingomyelin synthase 2 | -0.0327222 |
| MATR3 | matrin 3 | -0.0321398 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0320662 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.032021 |
| SLC34A2 | solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 | -0.031542 |
| MAP1B | microtubule-associated protein 1B | -0.0312801 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0303348 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0302438 |
| USP15 | ubiquitin specific peptidase 15 | -0.0299994 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0298374 |
| TJP1 | tight junction protein 1 | -0.0294572 |
| LMO7 | LIM domain 7 | -0.0289321 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0286614 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0286415 |
| TXNIP | thioredoxin interacting protein | -0.0284234 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | -0.0281798 |
| CENPF | centromere protein F, 350/400kDa | -0.0277671 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.027334 |
| ARF1 | ADP-ribosylation factor 1 | -0.0273022 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.027051 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0268512 |
| TKT | transketolase | -0.0268252 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0266503 |
| RPS5 | ribosomal protein S5 | -0.0266439 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0256138 |
| EGFR | epidermal growth factor receptor | -0.0253231 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0252632 |
| OXSR1 | oxidative stress responsive 1 | -0.0250557 |
| SEPTIN11 | septin 11 | -0.0250347 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | -0.0249539 |
| SEPTIN7 | septin 7 | -0.0248449 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0247841 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | -0.0247531 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0246532 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0240765 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0239 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0237438 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.023712 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0236792 |
| MYO6 | myosin VI | -0.0236387 |
| RYBP | RING1 and YY1 binding protein | -0.0235345 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.023094 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0230875 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.02286 |
| PARD3 | par-3 family cell polarity regulator | -0.0225037 |
| PALLD | palladin, cytoskeletal associated protein | -0.0224555 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0221455 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0221257 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0221008 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0219786 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0219079 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.021878 |
| NKTR | natural killer cell triggering receptor | -0.0218338 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0218218 |
| CCNB1 | cyclin B1 | -0.0217346 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0216763 |
| KIF5B | kinesin family member 5B | -0.0216712 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0215236 |
| SP100 | SP100 nuclear antigen | -0.0214659 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0214545 |
