Almonertinib (mesylate)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (mesylate) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (mesylate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 0.200723
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.114254
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0838977
PYGL phosphorylase, glycogen, liver 0.0705949
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.068483
RPL23 ribosomal protein L23 0.0683634
RPL13A ribosomal protein L13a 0.0546998
RPS8 ribosomal protein S8 0.052961
PDGFA platelet-derived growth factor alpha polypeptide 0.0500823
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0484306
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.048277
DDIT4 DNA-damage-inducible transcript 4 0.0473291
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.047285
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0461624
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0461597
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0434566
ANXA1 annexin A1 0.0430309
RPS19 ribosomal protein S19 0.0424685
RPL35 ribosomal protein L35 0.0419764
RPL18 ribosomal protein L18 0.0413901
RPS27 ribosomal protein S27 0.0413716
PFN1 profilin 1 0.0413575
IGFBP3 insulin-like growth factor binding protein 3 0.0404038
TENM2 teneurin transmembrane protein 2 0.0398789
RPS21 ribosomal protein S21 0.0392648
MCL1 myeloid cell leukemia 1 0.0372978
LIMCH1 LIM and calponin homology domains 1 0.0372159
PPP1R3C protein phosphatase 1, regulatory subunit 3C 0.0371072
STC2 stanniocalcin 2 0.0369047
PRELID2 PRELI domain containing 2 0.036353
RPLP2 ribosomal protein, large, P2 0.0359926
RPL3 ribosomal protein L3 0.0352739
P3H2 prolyl 3-hydroxylase 2 0.0350002
RPS12 ribosomal protein S12 0.0346432
RPL5 ribosomal protein L5 0.0342156
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0340292
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.033868
RPL19 ribosomal protein L19 0.0334688
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0325913
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0313135
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0311268
RPS29 ribosomal protein S29 0.0305547
RPL37 ribosomal protein L37 0.0304901
TRIO trio Rho guanine nucleotide exchange factor 0.0304508
PDE4D phosphodiesterase 4D, cAMP-specific 0.0302556
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0302501
MT2A metallothionein 2A 0.0301801
HMGA1 high mobility group AT-hook 1 0.0301369
RPL36 ribosomal protein L36 0.0299409
RTN4 reticulon 4 0.0297305
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0295518
RBM39 RNA binding motif protein 39 0.0295193
RPL36A ribosomal protein L36a 0.0292044
RPL26 ribosomal protein L26 0.0286224
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0280207
RPL6 ribosomal protein L6 0.02798
CDH13 cadherin 13 0.0277701
PDE10A phosphodiesterase 10A 0.0276098
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0275942
EEF1G eukaryotic translation elongation factor 1 gamma 0.0274841
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0273953
NCOR2 nuclear receptor corepressor 2 0.0270356
ADGRD1 adhesion G protein-coupled receptor D1 0.027004
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0268957
RPS2 ribosomal protein S2 0.0268422
FTL ferritin, light polypeptide 0.0268412
SAMD4A sterile alpha motif domain containing 4A 0.0267758
FOSL1 FOS-like antigen 1 0.0266662
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0266246
MSN moesin 0.026432
RPS3 ribosomal protein S3 0.0262367
S100A10 S100 calcium binding protein A10 0.0261709
PSD3 pleckstrin and Sec7 domain containing 3 0.0261401
TGFBI transforming growth factor, beta-induced, 68kDa 0.02599
CRLF2 cytokine receptor-like factor 2 0.0259585
RPL9 ribosomal protein L9 0.0259446
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 0.0254634
NDRG1 N-myc downstream regulated 1 0.025378
FNDC3B fibronectin type III domain containing 3B 0.0253753
YEATS2 YEATS domain containing 2 0.0250689
RPL7A ribosomal protein L7a 0.0250533
RPS14 ribosomal protein S14 0.024294
INHBA inhibin, beta A 0.0241987
GLRX glutaredoxin (thioltransferase) 0.0238396
RPS23 ribosomal protein S23 0.0237735
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0236276
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0234804
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0230978
ASTN2 astrotactin 2 0.0230049
CEMIP cell migration inducing protein, hyaluronan binding 0.0226831
PABPN1 poly(A) binding protein, nuclear 1 0.0225592
RPL7 ribosomal protein L7 0.0223539
RPL8 ribosomal protein L8 0.0218949
PIAS2 protein inhibitor of activated STAT, 2 0.0217032
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa 0.021648
RTN1 reticulon 1 0.0216042
NCKAP1 NCK-associated protein 1 0.0215196
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0214635
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0213157
GPRIN3 GPRIN family member 3 0.0212109

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.153761
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.153053
EEF2 eukaryotic translation elongation factor 2 -0.117307
VCL vinculin -0.110687
CANX calnexin -0.105521
UBC ubiquitin C -0.0958847
PDIA3 protein disulfide isomerase family A, member 3 -0.0913838
FN1 fibronectin 1 -0.0876013
AHNAK AHNAK nucleoprotein -0.0830197
BZW1 basic leucine zipper and W2 domains 1 -0.0813353
FTH1 ferritin, heavy polypeptide 1 -0.0811929
RPS27A ribosomal protein S27a -0.0783622
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0711655
SMYD3 SET and MYND domain containing 3 -0.0679624
TGFBR1 transforming growth factor, beta receptor 1 -0.0677845
PM20D1 peptidase M20 domain containing 1 -0.0644775
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0632646
LOC112694756 uncharaterized LOC112694756 -0.0629879
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0628733
MATR3 matrin 3 -0.0621797
ENO1 enolase 1, (alpha) -0.0621199
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0609741
ELL2 elongation factor, RNA polymerase II, 2 -0.0594217
VDAC1 voltage-dependent anion channel 1 -0.0564988
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0554013
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0544383
HDLBP high density lipoprotein binding protein -0.0498528
MAP7 microtubule-associated protein 7 -0.0496509
APP amyloid beta (A4) precursor protein -0.0488674
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0485561
TXNRD1 thioredoxin reductase 1 -0.0484245
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0481536
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0468646
PDIA6 protein disulfide isomerase family A, member 6 -0.0464044
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0455499
ASPH aspartate beta-hydroxylase -0.0451337
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0444923
BTG1 B-cell translocation gene 1, anti-proliferative -0.0438395
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0427257
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0420882
TNPO1 transportin 1 -0.0418093
ANXA2 annexin A2 -0.0413232
USP9X ubiquitin specific peptidase 9, X-linked -0.0404454
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0394825
PDLIM5 PDZ and LIM domain 5 -0.0393687
RPS24 ribosomal protein S24 -0.038843
B2M beta-2-microglobulin -0.0384762
PKM pyruvate kinase, muscle -0.0379338
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.037714
COL8A1 collagen, type VIII, alpha 1 -0.037026
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0369633
PTMA prothymosin, alpha -0.035444
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0349279
LAMA1 laminin, alpha 1 -0.0347894
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.034752
IPO7 importin 7 -0.0344285
COPA coatomer protein complex, subunit alpha -0.0341417
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0331275
ITGA6 integrin, alpha 6 -0.0326903
RHOA ras homolog family member A -0.0321784
STC1 stanniocalcin 1 -0.0320371
SRRM2 serine/arginine repetitive matrix 2 -0.0319759
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0319663
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0317134
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0313557
TFPI2 tissue factor pathway inhibitor 2 -0.0311031
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0310866
NCOA7 nuclear receptor coactivator 7 -0.0309125
SRPK2 SRSF protein kinase 2 -0.0309083
RSL1D1 ribosomal L1 domain containing 1 -0.0308289
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0306388
BASP1 brain abundant, membrane attached signal protein 1 -0.0305902
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.0305562
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0300642
FNDC3A fibronectin type III domain containing 3A -0.0300073
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0299064
RNF145 ring finger protein 145 -0.0296588
RAB10 RAB10, member RAS oncogene family -0.0294479
FOXK1 forkhead box K1 -0.0292019
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0291786
TENT5A terminal nucleotidyltransferase 5A -0.0291268
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0290481
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0284318
CLIP1 CAP-GLY domain containing linker protein 1 -0.0283564
LMAN1 lectin, mannose-binding, 1 -0.0283256
PCNX4 pecanex 4 -0.0278781
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0277065
ZC3H11A zinc finger CCCH-type containing 11A -0.027699
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0276717
GNAS GNAS complex locus -0.0273776
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0270329
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -0.0270324
SH3KBP1 SH3-domain kinase binding protein 1 -0.026964
NALF1 NALCN channel auxiliary factor 1 -0.0269399
KMT2C lysine (K)-specific methyltransferase 2C -0.026923
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0269165
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 -0.0269092
PCBP3 poly(rC) binding protein 3 -0.0268517
BLTP2 bridge-like lipid transfer protein family member 2 -0.026704
CTSL cathepsin L -0.0265552