| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (mesylate) perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (mesylate)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0833948 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0743404 |
| LAMC2 | laminin, gamma 2 | 0.0685901 |
| FBXO11 | F-box protein 11 | 0.0669036 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.062809 |
| WDR45B | WD repeat domain 45B | 0.0603423 |
| JUN | jun proto-oncogene | 0.060309 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0598699 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0597596 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.0591644 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0588728 |
| MSI2 | musashi RNA-binding protein 2 | 0.0579482 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.057258 |
| H1-0 | H1.0 linker histone | 0.0568383 |
| FNIP1 | folliculin interacting protein 1 | 0.0567662 |
| SCLT1 | sodium channel and clathrin linker 1 | 0.0564046 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0552255 |
| PKM | pyruvate kinase, muscle | 0.0548629 |
| COG5 | component of oligomeric golgi complex 5 | 0.0546474 |
| HDLBP | high density lipoprotein binding protein | 0.0538229 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0536251 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0533132 |
| SNX9 | sorting nexin 9 | 0.0529481 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0518339 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0506468 |
| LARP4B | La ribonucleoprotein domain family, member 4B | 0.0505609 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0504384 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0499602 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0493927 |
| CUL3 | cullin 3 | 0.0492538 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0487163 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0481218 |
| RND3 | Rho family GTPase 3 | 0.047686 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0476809 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0473536 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0472529 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0461549 |
| PGK1 | phosphoglycerate kinase 1 | 0.0461441 |
| ZNF292 | zinc finger protein 292 | 0.0446288 |
| NUP58 | nucleoporin 58 | 0.0446207 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0437693 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0436872 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0435466 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0433431 |
| RBM39 | RNA binding motif protein 39 | 0.0433028 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0429771 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.042652 |
| FAT1 | FAT atypical cadherin 1 | 0.0422837 |
| NDRG1 | N-myc downstream regulated 1 | 0.0421347 |
| TXNIP | thioredoxin interacting protein | 0.0418333 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.041378 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0407041 |
| ADAR | adenosine deaminase, RNA-specific | 0.0401224 |
| RLF | rearranged L-myc fusion | 0.040089 |
| SET | SET nuclear proto-oncogene | 0.0398447 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0395827 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.0394485 |
| IGF2 | insulin-like growth factor 2 | 0.0392787 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0391602 |
| EZR | ezrin | 0.0390989 |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.0390026 |
| CALR | calreticulin | 0.0380183 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0378548 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0377662 |
| BRD4 | bromodomain containing 4 | 0.0374051 |
| FUBP3 | far upstream element (FUSE) binding protein 3 | 0.0368404 |
| B2M | beta-2-microglobulin | 0.036699 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | 0.0366116 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.0364096 |
| GOLGA4 | golgin A4 | 0.0356951 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0355564 |
| TJP1 | tight junction protein 1 | 0.0353686 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0349701 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0348689 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0348137 |
| TMEM41B | transmembrane protein 41B | 0.0347387 |
| SMG6 | SMG6 nonsense mediated mRNA decay factor | 0.034367 |
| LDHA | lactate dehydrogenase A | 0.0340635 |
| ZNF638 | zinc finger protein 638 | 0.0340611 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0338675 |
| PTK2 | protein tyrosine kinase 2 | 0.0338007 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0337811 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0337142 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.0333375 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0328111 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0323237 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0317056 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0315379 |
| SRPK2 | SRSF protein kinase 2 | 0.0315116 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0313919 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0312909 |
| ANXA2 | annexin A2 | 0.0312856 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0312732 |
| RNF115 | ring finger protein 115 | 0.031204 |
| POM121 | POM121 transmembrane nucleoporin | 0.030827 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0307649 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0307383 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0306972 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0305347 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0304876 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.266478 |
| FN1 | fibronectin 1 | -0.226059 |
| EFNA5 | ephrin-A5 | -0.136955 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.132624 |
| ASPH | aspartate beta-hydroxylase | -0.126954 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.11498 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.106916 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.105405 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.100784 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.100419 |
| VIM | vimentin | -0.0927037 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0900867 |
| RPS6 | ribosomal protein S6 | -0.088358 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0882401 |
| VCL | vinculin | -0.0876663 |
| EGFR | epidermal growth factor receptor | -0.0827469 |
| TMSB10 | thymosin beta 10 | -0.0811338 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0752827 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0737762 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0713283 |
| MYO1E | myosin IE | -0.0696698 |
| GPC6 | glypican 6 | -0.0654113 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0645562 |
| CDH13 | cadherin 13 | -0.0638092 |
| FTL | ferritin, light polypeptide | -0.0635003 |
| ATXN1 | ataxin 1 | -0.0613484 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.0568078 |
| ACTG1 | actin gamma 1 | -0.0562382 |
| STC1 | stanniocalcin 1 | -0.0545954 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0517835 |
| RPS27A | ribosomal protein S27a | -0.0504021 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0496565 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0477544 |
| RORA | RAR-related orphan receptor A | -0.0475827 |
| RPL35A | ribosomal protein L35a | -0.0469841 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.046923 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0464206 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0459842 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0453389 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0447758 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0438548 |
| RPL11 | ribosomal protein L11 | -0.0438134 |
| PRKCA | protein kinase C, alpha | -0.0423307 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.04231 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0417909 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0416035 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0413217 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0412389 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0412255 |
| RPL12 | ribosomal protein L12 | -0.040277 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0402682 |
| S100A10 | S100 calcium binding protein A10 | -0.0399296 |
| NHSL1 | NHS-like 1 | -0.0397397 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0397206 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0391912 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0387378 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0383674 |
| CUX1 | cut-like homeobox 1 | -0.0383034 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | -0.0372353 |
| RPLP2 | ribosomal protein, large, P2 | -0.036956 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.036782 |
| RPS16 | ribosomal protein S16 | -0.0367231 |
| HMGA2 | high mobility group AT-hook 2 | -0.0366709 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0359904 |
| CSNK1E | casein kinase 1, epsilon | -0.0352472 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | -0.0351262 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.034863 |
| USP3 | ubiquitin specific peptidase 3 | -0.0348286 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.034741 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0346905 |
| GNAS | GNAS complex locus | -0.0336746 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0334422 |
| RAD51B | RAD51 paralog B | -0.0332597 |
| RACK1 | receptor for activated C kinase 1 | -0.033255 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0324039 |
| JAK1 | Janus kinase 1 | -0.0320179 |
| RPL34 | ribosomal protein L34 | -0.0319618 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0314322 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0314284 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0312769 |
| MT2A | metallothionein 2A | -0.0312644 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0312616 |
| AOPEP | aminopeptidase O (putative) | -0.0306652 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0303195 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0302612 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0300995 |
| RPLP0 | ribosomal protein, large, P0 | -0.0298289 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0295324 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0295228 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0294832 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.029296 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0292302 |
| HDAC8 | histone deacetylase 8 | -0.0291661 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0291199 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0287332 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0285778 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.02848 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0283564 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.0281932 |
| KAT6B | K(lysine) acetyltransferase 6B | -0.0281357 |
