| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (mesylate) perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (mesylate)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0922677 |
| MB21D2 | Mab-21 domain containing 2 | 0.0637048 |
| SPAG9 | sperm associated antigen 9 | 0.055187 |
| CALR | calreticulin | 0.0522301 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0500508 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0492209 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 0.0469646 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0460988 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0454181 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0425976 |
| MED13L | mediator complex subunit 13-like | 0.0403713 |
| PFN1 | profilin 1 | 0.0398165 |
| TMSB10 | thymosin beta 10 | 0.0383938 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.037434 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0373642 |
| SP3 | Sp3 transcription factor | 0.0372796 |
| RREB1 | ras responsive element binding protein 1 | 0.0372451 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0367784 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0365032 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0360691 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0360592 |
| USP12 | ubiquitin specific peptidase 12 | 0.0358112 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0350402 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0349175 |
| WDR43 | WD repeat domain 43 | 0.0345953 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0336326 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0333987 |
| TRAK1 | trafficking protein, kinesin binding 1 | 0.0331779 |
| MTF2 | metal response element binding transcription factor 2 | 0.0327864 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0327401 |
| FBXO11 | F-box protein 11 | 0.0324941 |
| FAM168A | family with sequence similarity 168, member A | 0.0317777 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0317439 |
| RPL5 | ribosomal protein L5 | 0.0317428 |
| RYBP | RING1 and YY1 binding protein | 0.0316425 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0315527 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0303323 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0302325 |
| TNRC6A | trinucleotide repeat containing 6A | 0.030189 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.02994 |
| PLS3 | plastin 3 | 0.0299027 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0298343 |
| ECT2 | epithelial cell transforming 2 | 0.029693 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0295435 |
| SMG6 | SMG6 nonsense mediated mRNA decay factor | 0.0288824 |
| MBIP | MAP3K12 binding inhibitory protein 1 | 0.0287457 |
| RPL23 | ribosomal protein L23 | 0.0286627 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0283527 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.0283136 |
| ZNF292 | zinc finger protein 292 | 0.0281341 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0280617 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0275287 |
| TBC1D12 | TBC1 domain family, member 12 | 0.0271466 |
| USP3 | ubiquitin specific peptidase 3 | 0.0267983 |
| GAB2 | GRB2-associated binding protein 2 | 0.0267058 |
| RBM33 | RNA binding motif protein 33 | 0.0266651 |
| CORO1C | coronin, actin binding protein, 1C | 0.0263362 |
| VMP1 | vacuole membrane protein 1 | 0.0262905 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0262081 |
| B2M | beta-2-microglobulin | 0.0260724 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.02595 |
| ACTN4 | actinin, alpha 4 | 0.0257766 |
| NFIB | nuclear factor I/B | 0.0253944 |
| CNIH4 | cornichon family AMPA receptor auxiliary protein 4 | 0.0253636 |
| FN1 | fibronectin 1 | 0.0251844 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0250897 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.024955 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0245844 |
| TP53BP1 | tumor protein p53 binding protein 1 | 0.0245305 |
| RASAL2 | RAS protein activator like 2 | 0.0243975 |
| UPP1 | uridine phosphorylase 1 | 0.0242874 |
| NAA16 | N(alpha)-acetyltransferase 16, NatA auxiliary subunit | 0.0240505 |
| CERT1 | ceramide transporter 1 | 0.0239745 |
| ORC4 | origin recognition complex, subunit 4 | 0.0239424 |
| DR1 | down-regulator of transcription 1, TBP-binding (negative cofactor 2) | 0.0237397 |
| RIGI | RNA sensor RIG-I | 0.023197 |
| ATXN1 | ataxin 1 | 0.0231359 |
| TSC22D2 | TSC22 domain family, member 2 | 0.022895 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0227613 |
| LRRC4C | leucine rich repeat containing 4C | 0.0224795 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0224643 |
| CCN2 | cellular communication network factor 2 | 0.0224051 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.022403 |
| ACTN1 | actinin, alpha 1 | 0.0222838 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | 0.0222241 |
| TAB2 | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | 0.0220024 |
| ABI1 | abl-interactor 1 | 0.021884 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0216068 |
| S100A10 | S100 calcium binding protein A10 | 0.0214453 |
| EWSR1 | EWS RNA-binding protein 1 | 0.0213888 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0213326 |
| SARNP | SAP domain containing ribonucleoprotein | 0.0211995 |
| COL5A2 | collagen, type V, alpha 2 | 0.0211724 |
| THBS1 | thrombospondin 1 | 0.0211109 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.021107 |
| CDC73 | cell division cycle 73 | 0.0208705 |
| DENND4A | DENN/MADD domain containing 4A | 0.0207379 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0207204 |
| B3GALNT2 | beta-1,3-N-acetylgalactosaminyltransferase 2 | 0.0206581 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0206214 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.179775 |
| SNX6 | sorting nexin 6 | -0.114122 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.111909 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.108415 |
| NTM | neurotrimin | -0.0965809 |
| RPS2 | ribosomal protein S2 | -0.0928341 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0917557 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0885502 |
| VIM | vimentin | -0.0858966 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0826552 |
| HDAC9 | histone deacetylase 9 | -0.081336 |
| TMSB4X | thymosin beta 4, X-linked | -0.0705921 |
| POTEF | POTE ankyrin domain family, member F | -0.0687392 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0647639 |
| H1-4 | H1.4 linker histone, cluster member | -0.0644087 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0632002 |
| CLTC | clathrin, heavy chain (Hc) | -0.0623065 |
| CADM2 | cell adhesion molecule 2 | -0.0599221 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0594459 |
| ACTG1 | actin gamma 1 | -0.0591141 |
| SRP54 | signal recognition particle 54kDa | -0.0586262 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0586162 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0579571 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0577039 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.05454 |
| SFRP4 | secreted frizzled-related protein 4 | -0.0543083 |
| GPC3 | glypican 3 | -0.0537306 |
| GNAS | GNAS complex locus | -0.0528637 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0513982 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0512537 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0512337 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.050527 |
| SOX2 | SRY (sex determining region Y)-box 2 | -0.0505213 |
| CENPF | centromere protein F, 350/400kDa | -0.050136 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0494033 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.04846 |
| PRKD1 | protein kinase D1 | -0.0483447 |
| TXNRD1 | thioredoxin reductase 1 | -0.0480547 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0479293 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0467353 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0460791 |
| COL11A1 | collagen, type XI, alpha 1 | -0.0458463 |
| LIN28B | lin-28 homolog B (C. elegans) | -0.0454372 |
| MEIS2 | Meis homeobox 2 | -0.0424571 |
| PCDH9 | protocadherin 9 | -0.0416757 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0407115 |
| RFPL4B | ret finger protein-like 4B | -0.0406301 |
| RDX | radixin | -0.0401867 |
| RPS6 | ribosomal protein S6 | -0.0399606 |
| MAP4 | microtubule-associated protein 4 | -0.0398217 |
| NKTR | natural killer cell triggering receptor | -0.0386706 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0380681 |
| H1-5 | H1.5 linker histone, cluster member | -0.0379946 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0379136 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0378632 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0375638 |
| RPS12 | ribosomal protein S12 | -0.0371728 |
| RTN3 | reticulon 3 | -0.0369137 |
| COL3A1 | collagen, type III, alpha 1 | -0.0368512 |
| ZFR | zinc finger RNA binding protein | -0.0363686 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0360743 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0356483 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0352388 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0346466 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0346176 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0342361 |
| PDGFC | platelet derived growth factor C | -0.0340729 |
| MMS22L | MMS22-like, DNA repair protein | -0.0340681 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.033981 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0338798 |
| TARS1 | threonyl-tRNA synthetase 1 | -0.0338135 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0337917 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0337771 |
| TPX2 | TPX2, microtubule-associated | -0.0334105 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0332501 |
| TPR | translocated promoter region, nuclear basket protein | -0.033195 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0331585 |
| XPO1 | exportin 1 | -0.0328751 |
| OGA | O-GlcNAcase | -0.0324761 |
| GPATCH8 | G patch domain containing 8 | -0.0324303 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0323658 |
| ARHGAP15 | Rho GTPase activating protein 15 | -0.032208 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0320498 |
| HMGB1 | high mobility group box 1 | -0.0315169 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0313902 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.0313326 |
| RPLP0 | ribosomal protein, large, P0 | -0.0310466 |
| STAG2 | stromal antigen 2 | -0.0309677 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0308678 |
| CLASP2 | cytoplasmic linker associated protein 2 | -0.0307726 |
| CDH19 | cadherin 19, type 2 | -0.030749 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0307101 |
| USP53 | ubiquitin specific peptidase 53 | -0.0306882 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.030566 |
| VCL | vinculin | -0.0305526 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0304651 |
| RPS16 | ribosomal protein S16 | -0.0304574 |
| ANXA1 | annexin A1 | -0.0303724 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.0303045 |
| IPO9 | importin 9 | -0.0302737 |
