Almonertinib (mesylate)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (mesylate) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (mesylate)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.116597
HMGA1 high mobility group AT-hook 1 0.0916434
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0749339
RPS12 ribosomal protein S12 0.0719511
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0714251
RPL13A ribosomal protein L13a 0.0654809
PTK2 protein tyrosine kinase 2 0.0643295
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0641487
NUP58 nucleoporin 58 0.0634115
HDAC9 histone deacetylase 9 0.0617216
RPL3 ribosomal protein L3 0.0585193
MCL1 myeloid cell leukemia 1 0.0578633
ZFAND3 zinc finger, AN1-type domain 3 0.0572955
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0569664
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0561907
SET SET nuclear proto-oncogene 0.0547903
RPS8 ribosomal protein S8 0.054594
RPS3 ribosomal protein S3 0.0536834
RPL23 ribosomal protein L23 0.0521717
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0520039
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0511709
RPL37A ribosomal protein L37a 0.0505606
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0501629
ANKRD11 ankyrin repeat domain 11 0.0472502
PFN1 profilin 1 0.0468438
SBF2 SET binding factor 2 0.0461264
NCKAP1 NCK-associated protein 1 0.0454255
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0449083
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0437269
UPP1 uridine phosphorylase 1 0.0435964
PRRC2C proline-rich coiled-coil 2C 0.0422682
CCNY cyclin Y 0.0415222
FOSL1 FOS-like antigen 1 0.0399391
FMNL2 formin-like 2 0.0386797
RPL9 ribosomal protein L9 0.0385744
SRSF11 serine/arginine-rich splicing factor 11 0.0385468
SAMD4A sterile alpha motif domain containing 4A 0.0383932
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0383566
PABPN1 poly(A) binding protein, nuclear 1 0.0381726
DGKI diacylglycerol kinase, iota 0.0380746
MCTP1 multiple C2 domains, transmembrane 1 0.0379822
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0379032
TPD52 tumor protein D52 0.0375317
PNN pinin, desmosome associated protein 0.0374459
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0368896
RPL26 ribosomal protein L26 0.0368115
MYH9 myosin, heavy chain 9, non-muscle 0.0364337
YEATS2 YEATS domain containing 2 0.0362664
SHANK1 SH3 and multiple ankyrin repeat domains 1 0.035776
EEF1G eukaryotic translation elongation factor 1 gamma 0.0357337
TM4SF19 transmembrane 4 L six family member 19 0.0355938
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0352466
MAST4 microtubule associated serine/threonine kinase family member 4 0.0352425
ACTN1 actinin, alpha 1 0.0352258
SFPQ splicing factor proline/glutamine-rich 0.0350195
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0346695
PCBP2 poly(rC) binding protein 2 0.0343915
ZNF121 zinc finger protein 121 0.0342853
CUL3 cullin 3 0.033707
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0337019
ZNF292 zinc finger protein 292 0.0336705
RBM39 RNA binding motif protein 39 0.0336609
TNPO3 transportin 3 0.033567
DSCAM Down syndrome cell adhesion molecule 0.0335562
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0333934
KDM6A lysine (K)-specific demethylase 6A 0.0331274
RAB6A RAB6A, member RAS oncogene family 0.0323261
TXNRD1 thioredoxin reductase 1 0.0323214
RPS13 ribosomal protein S13 0.0323161
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0321465
SPAG9 sperm associated antigen 9 0.0321334
ADAM17 ADAM metallopeptidase domain 17 0.0318376
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0317626
YAP1 Yes-associated protein 1 0.0315163
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0314741
FOXO3 forkhead box O3 0.0314581
TOMM34 translocase of outer mitochondrial membrane 34 0.0313658
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0311744
LATS2 large tumor suppressor kinase 2 0.0309679
TRIO trio Rho guanine nucleotide exchange factor 0.0309386
XPO6 exportin 6 0.0307196
OGA O-GlcNAcase 0.0303088
WSB1 WD repeat and SOCS box containing 1 0.0303072
BBX bobby sox homolog (Drosophila) 0.030244
MAP2K1 mitogen-activated protein kinase kinase 1 0.0301069
PUM1 pumilio RNA-binding family member 1 0.0300415
P4HB prolyl 4-hydroxylase, beta polypeptide 0.029859
FLNA filamin A, alpha 0.0298162
RPLP2 ribosomal protein, large, P2 0.0296295
BRD4 bromodomain containing 4 0.0292175
RASA2 RAS p21 protein activator 2 0.0289764
RPL18 ribosomal protein L18 0.0289573
SMG6 SMG6 nonsense mediated mRNA decay factor 0.0289094
PARD3 par-3 family cell polarity regulator 0.0288146
RPS27A ribosomal protein S27a 0.0287561
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0286795
YTHDC1 YTH domain containing 1 0.028677
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.028593
GATAD2B GATA zinc finger domain containing 2B 0.0284439
RPL36 ribosomal protein L36 0.0284389

decreased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.107879
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.107677
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0953521
IFI16 interferon, gamma-inducible protein 16 -0.0918035
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0891239
AHNAK AHNAK nucleoprotein -0.0830493
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0811579
EEF2 eukaryotic translation elongation factor 2 -0.0769759
LOC112694756 uncharaterized LOC112694756 -0.0760216
PDIA3 protein disulfide isomerase family A, member 3 -0.0734188
ZNF438 zinc finger protein 438 -0.0733365
STC1 stanniocalcin 1 -0.072234
RSL1D1 ribosomal L1 domain containing 1 -0.0697271
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0677126
NAV3 neuron navigator 3 -0.0635821
ELL2 elongation factor, RNA polymerase II, 2 -0.0632473
RPLP1 ribosomal protein, large, P1 -0.0595984
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.057905
SLC38A2 solute carrier family 38, member 2 -0.0554809
JMJD1C jumonji domain containing 1C -0.0543689
RRBP1 ribosome binding protein 1 -0.0540617
DLC1 DLC1 Rho GTPase activating protein -0.0534107
HMGA2 high mobility group AT-hook 2 -0.0532659
SP100 SP100 nuclear antigen -0.0523898
FTL ferritin, light polypeptide -0.0512264
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0488574
RPS6 ribosomal protein S6 -0.0482702
BZW1 basic leucine zipper and W2 domains 1 -0.0470031
RPL4 ribosomal protein L4 -0.0466846
RPLP0 ribosomal protein, large, P0 -0.0455367
PCNX4 pecanex 4 -0.0447518
AKAP12 A kinase (PRKA) anchor protein 12 -0.0443273
RPS20 ribosomal protein S20 -0.043503
LARS1 leucyl-tRNA synthetase 1 -0.0432052
RPS24 ribosomal protein S24 -0.0410512
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0409937
TM4SF1 transmembrane 4 L six family member 1 -0.0391549
ZEB1 zinc finger E-box binding homeobox 1 -0.0376477
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0363485
LDHA lactate dehydrogenase A -0.0358238
MATR3 matrin 3 -0.0354216
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0353028
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0352123
CANX calnexin -0.0349956
JUN jun proto-oncogene -0.0349389
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0348881
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0346749
MTAP methylthioadenosine phosphorylase -0.0346028
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0324796
PHF3 PHD finger protein 3 -0.032428
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0320647
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.031744
CAPN2 calpain 2, (m/II) large subunit -0.0317283
RPL34 ribosomal protein L34 -0.0316394
ARF1 ADP-ribosylation factor 1 -0.03141
C2CD2 C2 calcium-dependent domain containing 2 -0.0300824
ANXA2 annexin A2 -0.0298154
PTMA prothymosin, alpha -0.0296907
BPTF bromodomain PHD finger transcription factor -0.0291197
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0289172
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.028779
GNAS GNAS complex locus -0.0285595
TPT1 tumor protein, translationally-controlled 1 -0.0281335
ATF4 activating transcription factor 4 -0.0279894
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0278183
RAB14 RAB14, member RAS oncogene family -0.0277857
RPL19 ribosomal protein L19 -0.0277534
SAMD9 sterile alpha motif domain containing 9 -0.0273509
TMSB10 thymosin beta 10 -0.0272097
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0270893
RPL10A ribosomal protein L10a -0.0270389
RPS4X ribosomal protein S4, X-linked -0.0268925
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0268764
FBXO11 F-box protein 11 -0.0268029
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0266904
SENP5 SUMO1/sentrin specific peptidase 5 -0.0266177
GPHN gephyrin -0.0265577
KPNB1 karyopherin (importin) beta 1 -0.0263369
IARS1 isoleucyl-tRNA synthetase 1 -0.0263184
DST dystonin -0.0263161
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0262392
STAU1 staufen double-stranded RNA binding protein 1 -0.025609
BCL10 B-cell CLL/lymphoma 10 -0.0253087
RPL39 ribosomal protein L39 -0.0251464
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0251038
TCF12 transcription factor 12 -0.0247518
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0245049
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0238675
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0238497
RHOA ras homolog family member A -0.0238038
ZBTB38 zinc finger and BTB domain containing 38 -0.0237452
BZW2 basic leucine zipper and W2 domains 2 -0.0237432
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0237234
ENO1 enolase 1, (alpha) -0.0237091
GDI2 GDP dissociation inhibitor 2 -0.0236171
ABLIM1 actin binding LIM protein 1 -0.0236119
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0236007
TTR transthyretin -0.0235921
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa -0.0234051
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0233903