| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (mesylate) perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (mesylate)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.120343 |
| MT2A | metallothionein 2A | 0.1126 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.101549 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.101334 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0985867 |
| COL5A1 | collagen, type V, alpha 1 | 0.0929495 |
| MSN | moesin | 0.0878987 |
| CALU | calumenin | 0.0830074 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0778402 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0767094 |
| POTEF | POTE ankyrin domain family, member F | 0.0746284 |
| CALR | calreticulin | 0.0714849 |
| HLA-B | major histocompatibility complex, class I, B | 0.0700097 |
| COL1A1 | collagen, type I, alpha 1 | 0.0682871 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0647976 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.064638 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0642724 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.059548 |
| GOLGA4 | golgin A4 | 0.0591221 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0578241 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0570693 |
| COL1A2 | collagen, type I, alpha 2 | 0.0545485 |
| HMGA1 | high mobility group AT-hook 1 | 0.054268 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0529532 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0522511 |
| FOSL1 | FOS-like antigen 1 | 0.0498995 |
| RPL13A | ribosomal protein L13a | 0.0478738 |
| FMNL2 | formin-like 2 | 0.0469588 |
| ZNF292 | zinc finger protein 292 | 0.0464834 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0461515 |
| PFN1 | profilin 1 | 0.0460138 |
| ANLN | anillin, actin binding protein | 0.045177 |
| LMNA | lamin A/C | 0.0443971 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0439522 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0435185 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0434285 |
| RPL23 | ribosomal protein L23 | 0.042964 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0429242 |
| RPS12 | ribosomal protein S12 | 0.0423699 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.041309 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0412329 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0409881 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0409758 |
| GANAB | glucosidase, alpha; neutral AB | 0.0409753 |
| FLNA | filamin A, alpha | 0.0407692 |
| NDRG1 | N-myc downstream regulated 1 | 0.0407053 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0399991 |
| TMF1 | TATA element modulatory factor 1 | 0.0387609 |
| ARRDC3 | arrestin domain containing 3 | 0.0386109 |
| NUP58 | nucleoporin 58 | 0.0377258 |
| TPM3 | tropomyosin 3 | 0.0374004 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0373647 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0369426 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0368136 |
| ENO1 | enolase 1, (alpha) | 0.0361453 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0358414 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0357104 |
| PCBP2 | poly(rC) binding protein 2 | 0.0356954 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0355617 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | 0.0350646 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0343894 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0342892 |
| RPS8 | ribosomal protein S8 | 0.0337937 |
| RPS3 | ribosomal protein S3 | 0.0334752 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0329164 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0326993 |
| FAM168A | family with sequence similarity 168, member A | 0.0323053 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0322389 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0320245 |
| RPL37A | ribosomal protein L37a | 0.0319319 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0314978 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.030767 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0307616 |
| RPL35A | ribosomal protein L35a | 0.0306727 |
| HDGF | hepatoma-derived growth factor | 0.0305818 |
| FAM20C | family with sequence similarity 20, member C | 0.0305429 |
| BRD2 | bromodomain containing 2 | 0.0303271 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0299096 |
| MYO9B | myosin IXB | 0.0297397 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0293932 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0293274 |
| FAM162A | family with sequence similarity 162, member A | 0.0292482 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0289882 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0289069 |
| BPNT2 | 3'(2'), 5'-bisphosphate nucleotidase 2 | 0.0288657 |
| VASP | vasodilator-stimulated phosphoprotein | 0.0287991 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0281617 |
| ZNF12 | zinc finger protein 12 | 0.0281029 |
| ACTN1 | actinin, alpha 1 | 0.0280229 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.027997 |
| RPL5 | ribosomal protein L5 | 0.0278433 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0278378 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0278337 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0278119 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0277855 |
| RBM39 | RNA binding motif protein 39 | 0.0276392 |
| HLA-A | major histocompatibility complex, class I, A | 0.027148 |
| FLNB | filamin B, beta | 0.0269062 |
| NPTN | neuroplastin | 0.0267517 |
| STAT2 | signal transducer and activator of transcription 2, 113kDa | 0.0267186 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.164637 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.143844 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.107579 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0925645 |
| FTL | ferritin, light polypeptide | -0.0908287 |
| PGK1 | phosphoglycerate kinase 1 | -0.0838785 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0736021 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0696716 |
| CD44 | CD44 molecule (Indian blood group) | -0.0679786 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0672112 |
| H1-0 | H1.0 linker histone | -0.0621091 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0574884 |
| RPLP1 | ribosomal protein, large, P1 | -0.0571459 |
| RRBP1 | ribosome binding protein 1 | -0.0503392 |
| STC1 | stanniocalcin 1 | -0.0493382 |
| HDLBP | high density lipoprotein binding protein | -0.0482428 |
| AHNAK | AHNAK nucleoprotein | -0.0480213 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0479496 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0465671 |
| IER3 | immediate early response 3 | -0.0459796 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0457532 |
| FHIT | fragile histidine triad | -0.0454623 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0452187 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0449949 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0430422 |
| TPM1 | tropomyosin 1 (alpha) | -0.0421108 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0404745 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0400653 |
| FRMD4A | FERM domain containing 4A | -0.0397072 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0394973 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0388651 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0386521 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0384921 |
| CDCP1 | CUB domain containing protein 1 | -0.0384645 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0380458 |
| PKM | pyruvate kinase, muscle | -0.0377734 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0374912 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0373887 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0368798 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0364865 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0363504 |
| PLIN2 | perilipin 2 | -0.0360374 |
| ANXA2 | annexin A2 | -0.0360304 |
| CLIC4 | chloride intracellular channel 4 | -0.0350387 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0350197 |
| GNAS | GNAS complex locus | -0.0349036 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0346934 |
| BPTF | bromodomain PHD finger transcription factor | -0.0345489 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.034463 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0344104 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0343258 |
| ARF1 | ADP-ribosylation factor 1 | -0.0342567 |
| CENPF | centromere protein F, 350/400kDa | -0.033842 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0334883 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0333892 |
| SP100 | SP100 nuclear antigen | -0.0327878 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0321821 |
| TUBB | tubulin, beta class I | -0.0318005 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0313017 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0309131 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0301258 |
| OSMR | oncostatin M receptor | -0.0299243 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.029663 |
| MAP1B | microtubule-associated protein 1B | -0.0293162 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0290331 |
| TMSB10 | thymosin beta 10 | -0.0289492 |
| ASPH | aspartate beta-hydroxylase | -0.0289462 |
| FBXO11 | F-box protein 11 | -0.0288514 |
| GOLGB1 | golgin B1 | -0.0278573 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0278089 |
| B2M | beta-2-microglobulin | -0.0276397 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0275378 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0272479 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.027032 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0268565 |
| MATR3 | matrin 3 | -0.0268109 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0266799 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0265492 |
| TP63 | tumor protein p63 | -0.0261191 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0260566 |
| SHISA5 | shisa family member 5 | -0.0259067 |
| SMYD3 | SET and MYND domain containing 3 | -0.0258687 |
| RPL4 | ribosomal protein L4 | -0.0258593 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0257629 |
| ATM | ATM serine/threonine kinase | -0.0256972 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.025457 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0253046 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0252881 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0251298 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | -0.0244877 |
| SVIL | supervillin | -0.0243888 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0242845 |
| LYST | lysosomal trafficking regulator | -0.0242745 |
| RPS24 | ribosomal protein S24 | -0.0242675 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0239666 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0239313 |
| PHF14 | PHD finger protein 14 | -0.0235396 |
| MAP4 | microtubule-associated protein 4 | -0.0235286 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0233913 |
| NSD3 | nuclear receptor binding SET domain protein 3 | -0.0233664 |
