Almonertinib (mesylate)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (mesylate) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (mesylate)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.145938
PEG10 paternally expressed 10 0.12521
ENO1 enolase 1, (alpha) 0.123245
NDRG1 N-myc downstream regulated 1 0.110523
CALCA calcitonin-related polypeptide alpha 0.0943578
GRB10 growth factor receptor-bound protein 10 0.0839048
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.083752
ZNF292 zinc finger protein 292 0.08149
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0771612
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0760156
RPS3 ribosomal protein S3 0.0706587
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0667982
CHGB chromogranin B 0.0638384
NALF1 NALCN channel auxiliary factor 1 0.0624325
RPL26 ribosomal protein L26 0.0608994
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0588437
JAM3 junctional adhesion molecule 3 0.0560529
HMGB3 high mobility group box 3 0.0549148
P4HB prolyl 4-hydroxylase, beta polypeptide 0.052915
VEGFA vascular endothelial growth factor A 0.0526309
DTNA dystrobrevin, alpha 0.0525038
CADM1 cell adhesion molecule 1 0.0521459
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.0508903
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.0507895
IGFBP5 insulin-like growth factor binding protein 5 0.0501506
CHD7 chromodomain helicase DNA binding protein 7 0.0499359
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0499018
FAM13A family with sequence similarity 13, member A 0.0494405
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0486557
FKBP9 FK506 binding protein 9, 63 kDa 0.0481825
CCNY cyclin Y 0.047923
TPM3 tropomyosin 3 0.0475967
CA8 carbonic anhydrase VIII 0.046466
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.0459086
SINHCAF SIN3-HDAC complex associated factor 0.0452098
PDIA6 protein disulfide isomerase family A, member 6 0.0446344
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0443308
TPD52 tumor protein D52 0.0441193
WDR45B WD repeat domain 45B 0.0436294
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0430878
RORA RAR-related orphan receptor A 0.0428966
RPL23 ribosomal protein L23 0.0427601
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0427274
MT2A metallothionein 2A 0.0415797
RPL8 ribosomal protein L8 0.0408905
JAZF1 JAZF zinc finger 1 0.0408417
FAM162A family with sequence similarity 162, member A 0.0408064
EEF1G eukaryotic translation elongation factor 1 gamma 0.0402846
PGK1 phosphoglycerate kinase 1 0.04002
RPL37A ribosomal protein L37a 0.0394361
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0394185
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 0.0393462
NCAM1 neural cell adhesion molecule 1 0.0391847
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0391812
MYH9 myosin, heavy chain 9, non-muscle 0.0389353
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0388653
RPS8 ribosomal protein S8 0.0387629
GSE1 Gse1 coiled-coil protein 0.0386583
SET SET nuclear proto-oncogene 0.0383892
NAP1L1 nucleosome assembly protein 1-like 1 0.0380639
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.0380207
IQSEC1 IQ motif and Sec7 domain 1 0.0377278
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0372882
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.0369001
SMC1A structural maintenance of chromosomes 1A 0.0365738
CALR calreticulin 0.0364704
RPS12 ribosomal protein S12 0.0352204
MSI2 musashi RNA-binding protein 2 0.0350645
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0349548
RPS27A ribosomal protein S27a 0.0344938
RPS27 ribosomal protein S27 0.0343883
BHLHE40 basic helix-loop-helix family, member e40 0.0340357
RPL5 ribosomal protein L5 0.0337455
RPS21 ribosomal protein S21 0.0335575
RTN4 reticulon 4 0.0335147
FOXC1 forkhead box C1 0.0332206
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.033139
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0327369
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0327241
FTH1 ferritin, heavy polypeptide 1 0.0326554
DENND1A DENN/MADD domain containing 1A 0.0325342
EEF2 eukaryotic translation elongation factor 2 0.0321634
RPL37 ribosomal protein L37 0.0319585
PFN1 profilin 1 0.0318733
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0317883
NUP58 nucleoporin 58 0.0317867
YBX1 Y box binding protein 1 0.0316796
SCG2 secretogranin II 0.0307878
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0307717
ZNF395 zinc finger protein 395 0.0304448
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 0.0301312
AFF1 AF4/FMR2 family, member 1 0.0301071
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0299461
MED13L mediator complex subunit 13-like 0.0296221
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0295845
NAMPT nicotinamide phosphoribosyltransferase 0.0295213
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.029479
EYA2 EYA transcriptional coactivator and phosphatase 2 0.0291652
NFIA nuclear factor I/A 0.029122
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0290853

decreased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A -0.214527
TENM1 teneurin transmembrane protein 1 -0.114389
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0779187
SNAP25 synaptosomal-associated protein, 25kDa -0.076201
RIMS2 regulating synaptic membrane exocytosis 2 -0.0742938
PDE4D phosphodiesterase 4D, cAMP-specific -0.0677559
PTCHD4 patched domain containing 4 -0.0622697
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0605781
TENT5A terminal nucleotidyltransferase 5A -0.0595237
FNDC3A fibronectin type III domain containing 3A -0.0592888
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0573552
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0531946
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0500222
SIK2 salt-inducible kinase 2 -0.0499833
NBEA neurobeachin -0.0476324
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0464202
GDAP1 ganglioside induced differentiation associated protein 1 -0.0458458
CNTNAP2 contactin associated protein-like 2 -0.044779
PCSK1 proprotein convertase subtilisin/kexin type 1 -0.0425544
DOCK5 dedicator of cytokinesis 5 -0.0415566
SETX senataxin -0.0407998
SNTG1 syntrophin, gamma 1 -0.0385296
AHR aryl hydrocarbon receptor -0.0382936
STXBP5L syntaxin binding protein 5-like -0.0378491
TXNRD1 thioredoxin reductase 1 -0.0370926
SMOC1 SPARC related modular calcium binding 1 -0.0367772
FGF14 fibroblast growth factor 14 -0.0359161
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0344467
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0333725
CDH12 cadherin 12, type 2 (N-cadherin 2) -0.0333227
ASPH aspartate beta-hydroxylase -0.0331666
SCFD2 sec1 family domain containing 2 -0.0326885
MCL1 myeloid cell leukemia 1 -0.0323906
NOVA1 neuro-oncological ventral antigen 1 -0.0316681
ZNF804A zinc finger protein 804A -0.031035
TUSC3 tumor suppressor candidate 3 -0.0303006
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0302169
PHF14 PHD finger protein 14 -0.0299521
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0296164
PBX3 pre-B-cell leukemia homeobox 3 -0.0293345
CLTC clathrin, heavy chain (Hc) -0.0290004
FBXL17 F-box and leucine-rich repeat protein 17 -0.0285954
ZC3H12B zinc finger CCCH-type containing 12B -0.0284712
STC1 stanniocalcin 1 -0.0277454
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0275496
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0274592
PDK4 pyruvate dehydrogenase kinase, isozyme 4 -0.0272976
CDK13 cyclin-dependent kinase 13 -0.0272523
FTL ferritin, light polypeptide -0.0267073
LOC112694756 uncharaterized LOC112694756 -0.0265833
EXT1 exostosin glycosyltransferase 1 -0.0254975
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0253238
EFNA5 ephrin-A5 -0.025091
THSD7A thrombospondin, type I, domain containing 7A -0.0250702
ERBIN erbb2 interacting protein -0.0248157
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0246052
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0244414
SLC38A2 solute carrier family 38, member 2 -0.0243286
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) -0.0242314
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.0240598
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0240433
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0239091
POU6F2 POU class 6 homeobox 2 -0.0238667
TAS2R14 taste receptor, type 2, member 14 -0.0238493
PLSCR1 phospholipid scramblase 1 -0.0237903
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0236781
SP100 SP100 nuclear antigen -0.0235224
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0234215
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0233633
CENPF centromere protein F, 350/400kDa -0.0233391
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0233153
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0232008
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0229577
GPATCH2 G patch domain containing 2 -0.0229017
STAU2 staufen double-stranded RNA binding protein 2 -0.0227668
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma -0.0226412
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0225544
IARS1 isoleucyl-tRNA synthetase 1 -0.0225071
RSRC1 arginine/serine-rich coiled-coil 1 -0.0225055
TTC19 tetratricopeptide repeat domain 19 -0.0224976
SMC5 structural maintenance of chromosomes 5 -0.0224938
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.022385
AURKA aurora kinase A -0.0223804
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha -0.0223195
AGBL4 ATP/GTP binding protein-like 4 -0.0219863
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0219307
RABGAP1 RAB GTPase activating protein 1 -0.0217483
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0216656
ATP5F1B ATP synthase F1 subunit beta -0.0213172
PCLO piccolo presynaptic cytomatrix protein -0.0212754
GPATCH2L G patch domain containing 2-like -0.0212723
BPTF bromodomain PHD finger transcription factor -0.021059
LCOR ligand dependent nuclear receptor corepressor -0.0209989
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -0.0209945
FAF1 Fas (TNFRSF6) associated factor 1 -0.0208844
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like -0.0208772
GPC5 glypican 5 -0.0207082
ACBD6 acyl-CoA binding domain containing 6 -0.0205949
ARMH4 armadillo like helical domain containing 4 -0.0205707
RABGAP1L RAB GTPase activating protein 1-like -0.0205678