Almonertinib (mesylate)_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (mesylate) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (mesylate)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.201006
FNDC3B fibronectin type III domain containing 3B 0.145902
NAV2 neuron navigator 2 0.121465
RPS3 ribosomal protein S3 0.0943543
MSN moesin 0.0739171
ICAM1 intercellular adhesion molecule 1 0.0675605
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0601227
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0591939
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0582995
LDHA lactate dehydrogenase A 0.0573294
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0562082
RPL35A ribosomal protein L35a 0.0554993
CD59 CD59 molecule, complement regulatory protein 0.0511487
ENO1 enolase 1, (alpha) 0.0480013
SMAD3 SMAD family member 3 0.0477684
RPL3 ribosomal protein L3 0.0462139
HMGA1 high mobility group AT-hook 1 0.0461473
FLNA filamin A, alpha 0.0457633
RPL23 ribosomal protein L23 0.0433664
ANLN anillin, actin binding protein 0.0396454
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0382259
CSDE1 cold shock domain containing E1, RNA-binding 0.0379049
SLC39A11 solute carrier family 39, member 11 0.0378006
PTK2 protein tyrosine kinase 2 0.037562
RPS12 ribosomal protein S12 0.0368776
RPLP2 ribosomal protein, large, P2 0.0362332
RPS8 ribosomal protein S8 0.0355989
TRIO trio Rho guanine nucleotide exchange factor 0.0355896
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0351563
CTTN cortactin 0.0346858
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0336969
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0335411
MKI67 marker of proliferation Ki-67 0.033356
FAM219A family with sequence similarity 219, member A 0.0333359
FMNL2 formin-like 2 0.0332968
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0332468
CORO1C coronin, actin binding protein, 1C 0.0327433
TPM3 tropomyosin 3 0.0321764
HSPA8 heat shock 70kDa protein 8 0.0319068
ZNF292 zinc finger protein 292 0.0318503
MFSD12 major facilitator superfamily domain containing 12 0.0318177
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0314807
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0312732
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0306934
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0301773
AFDN afadin, adherens junction formation factor 0.0296792
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.029492
HMG20B high mobility group 20B 0.0294565
AKAP12 A kinase (PRKA) anchor protein 12 0.0293268
ATXN1 ataxin 1 0.0290316
HLA-B major histocompatibility complex, class I, B 0.0288996
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.0283921
ANKRD11 ankyrin repeat domain 11 0.0283554
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0280291
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0280136
CLEC2D C-type lectin domain family 2, member D 0.0279794
POTEF POTE ankyrin domain family, member F 0.0277759
TM4SF1 transmembrane 4 L six family member 1 0.0277149
MYH9 myosin, heavy chain 9, non-muscle 0.0275887
RPS27 ribosomal protein S27 0.0267855
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0267627
PRKCSH protein kinase C substrate 80K-H 0.0267305
IL1RAP interleukin 1 receptor accessory protein 0.026388
ATXN7 ataxin 7 0.0263207
SOX10 SRY (sex determining region Y)-box 10 0.0261773
MT1X metallothionein 1X 0.0259679
RPL13A ribosomal protein L13a 0.0259572
NDRG1 N-myc downstream regulated 1 0.0255866
BACE2 beta-site APP-cleaving enzyme 2 0.0254243
CEP70 centrosomal protein 70kDa 0.0253582
ACTN1 actinin, alpha 1 0.0252642
PXYLP1 2-phosphoxylose phosphatase 1 0.0252271
RPS21 ribosomal protein S21 0.0251614
MT2A metallothionein 2A 0.02496
TPT1 tumor protein, translationally-controlled 1 0.0248471
NOTCH2 notch 2 0.0248056
EIF4H eukaryotic translation initiation factor 4H 0.0247212
S100A9 S100 calcium binding protein A9 0.0245533
IFI6 interferon, alpha-inducible protein 6 0.02447
KLF6 Kruppel-like factor 6 0.0243535
RPL11 ribosomal protein L11 0.0240749
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0238075
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0237889
RPS19 ribosomal protein S19 0.0236537
NCKAP1 NCK-associated protein 1 0.0233054
RPS13 ribosomal protein S13 0.0231841
RPL37 ribosomal protein L37 0.0231187
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0230466
CTSD cathepsin D 0.0230175
CD44 CD44 molecule (Indian blood group) 0.0228487
TMED9 transmembrane emp24 protein transport domain containing 9 0.0227358
RAB17 RAB17, member RAS oncogene family 0.022706
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.022607
ZNF875 zinc finger protein 875 0.0225635
RPL5 ribosomal protein L5 0.0225075
ITGB5 integrin, beta 5 0.0221844
CADM1 cell adhesion molecule 1 0.0221565
PTPRF protein tyrosine phosphatase, receptor type, F 0.0221059
RPL34 ribosomal protein L34 0.0220221
UCN2 urocortin 2 0.0217047

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.137504
NLGN1 neuroligin 1 -0.131732
NRG3 neuregulin 3 -0.109984
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0861253
FRMD4A FERM domain containing 4A -0.0706923
CCND1 cyclin D1 -0.0690191
PKM pyruvate kinase, muscle -0.0637512
EIF1 eukaryotic translation initiation factor 1 -0.0571932
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0529161
UBC ubiquitin C -0.0525822
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0525586
ZBTB20 zinc finger and BTB domain containing 20 -0.0495073
PDE4D phosphodiesterase 4D, cAMP-specific -0.046947
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0460503
CANX calnexin -0.0457609
VDAC1 voltage-dependent anion channel 1 -0.0431909
LSAMP limbic system-associated membrane protein -0.0428179
RRBP1 ribosome binding protein 1 -0.0417812
SP100 SP100 nuclear antigen -0.0407926
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.040205
MAP4 microtubule-associated protein 4 -0.0401614
SETD5 SET domain containing 5 -0.038549
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0375616
RAD51B RAD51 paralog B -0.0366361
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.03591
BICD1 bicaudal D homolog 1 (Drosophila) -0.0355885
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0350603
CNIH3 cornichon family AMPA receptor auxiliary protein 3 -0.0350228
ARHGAP5 Rho GTPase activating protein 5 -0.0347254
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -0.0343641
ZC3H11A zinc finger CCCH-type containing 11A -0.033894
IFI44L interferon-induced protein 44-like -0.0337958
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.033085
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0330149
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0324923
MAN1A2 mannosidase, alpha, class 1A, member 2 -0.0323694
XPO1 exportin 1 -0.0323558
OXSR1 oxidative stress responsive 1 -0.0321951
CLIC4 chloride intracellular channel 4 -0.0320881
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0311002
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0307878
AEBP2 AE binding protein 2 -0.0301583
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0295511
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0294596
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0294293
AFF4 AF4/FMR2 family, member 4 -0.0292364
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0290834
ZNF638 zinc finger protein 638 -0.028844
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0287255
ASPH aspartate beta-hydroxylase -0.0285657
DIAPH2 diaphanous-related formin 2 -0.0285324
TBC1D22A TBC1 domain family, member 22A -0.0282046
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0281884
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.02817
BTG1 B-cell translocation gene 1, anti-proliferative -0.027903
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0276241
MBNL1 muscleblind-like splicing regulator 1 -0.0276136
DLG1 discs, large homolog 1 (Drosophila) -0.0275613
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.0273994
STAG2 stromal antigen 2 -0.027311
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0273013
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0271795
DNAH14 dynein, axonemal, heavy chain 14 -0.0270461
TOP1 topoisomerase (DNA) I -0.0267854
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0267664
SPDYA speedy/RINGO cell cycle regulator family member A -0.0265302
AHNAK AHNAK nucleoprotein -0.0264854
NAP1L1 nucleosome assembly protein 1-like 1 -0.0264691
LOC112694756 uncharaterized LOC112694756 -0.0263398
TJP1 tight junction protein 1 -0.026302
PDIA3 protein disulfide isomerase family A, member 3 -0.026235
POGZ pogo transposable element with ZNF domain -0.0261518
CELF2 CUGBP, Elav-like family member 2 -0.0258125
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0258106
SERINC1 serine incorporator 1 -0.0256877
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0254983
CDK13 cyclin-dependent kinase 13 -0.0253913
RIGI RNA sensor RIG-I -0.0253313
LAMP2 lysosomal-associated membrane protein 2 -0.0252237
SRRM2 serine/arginine repetitive matrix 2 -0.0251569
INTS6 integrator complex subunit 6 -0.0251541
LINC02798 long intergenic non-protein coding RNA 2798 -0.0250428
COMMD10 COMM domain containing 10 -0.0248085
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0248007
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 -0.0247014
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0245657
GATAD2A GATA zinc finger domain containing 2A -0.024532
CSNK1A1 casein kinase 1, alpha 1 -0.0243094
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0242222
IFIH1 interferon induced with helicase C domain 1 -0.0240966
NAV1 neuron navigator 1 -0.0240144
RHOBTB3 Rho-related BTB domain containing 3 -0.0238403
PNISR PNN-interacting serine/arginine-rich protein -0.0238179
KIF5B kinesin family member 5B -0.0237912
PHF3 PHD finger protein 3 -0.0234101
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0234
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.023398
PAIP2 poly(A) binding protein interacting protein 2 -0.0232117
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0231511
SEPTIN7 septin 7 -0.0231362