| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (mesylate) perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (mesylate)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.173545 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.165522 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.1069 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.102032 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0994863 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0976943 |
| FN1 | fibronectin 1 | 0.097094 |
| RPS12 | ribosomal protein S12 | 0.0957344 |
| RPS8 | ribosomal protein S8 | 0.083182 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0811666 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0804789 |
| ZNF292 | zinc finger protein 292 | 0.0801511 |
| ENO1 | enolase 1, (alpha) | 0.0801087 |
| RPL23 | ribosomal protein L23 | 0.0775366 |
| RPL26 | ribosomal protein L26 | 0.0753949 |
| RPS3 | ribosomal protein S3 | 0.0745903 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0700104 |
| HMGA1 | high mobility group AT-hook 1 | 0.0650422 |
| CALR | calreticulin | 0.0603369 |
| RPS6 | ribosomal protein S6 | 0.0601654 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0576795 |
| TPM3 | tropomyosin 3 | 0.0572301 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0570062 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0568887 |
| RPL5 | ribosomal protein L5 | 0.0568232 |
| CANX | calnexin | 0.0567741 |
| PRELID2 | PRELI domain containing 2 | 0.0567558 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0544924 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0541078 |
| GOLGA4 | golgin A4 | 0.0532258 |
| COL5A1 | collagen, type V, alpha 1 | 0.052292 |
| NDRG1 | N-myc downstream regulated 1 | 0.0502998 |
| RPLP2 | ribosomal protein, large, P2 | 0.0498146 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0496035 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0495833 |
| YBX1 | Y box binding protein 1 | 0.0489532 |
| RPL13A | ribosomal protein L13a | 0.0476502 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0455929 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0454869 |
| RPL37A | ribosomal protein L37a | 0.0445741 |
| RPS2 | ribosomal protein S2 | 0.0440655 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0438618 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0436357 |
| POTEF | POTE ankyrin domain family, member F | 0.0435277 |
| ARRDC3 | arrestin domain containing 3 | 0.0431341 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0414946 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0412284 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0398534 |
| SEPTIN9 | septin 9 | 0.0397934 |
| RPL6 | ribosomal protein L6 | 0.0395453 |
| RPL35 | ribosomal protein L35 | 0.0392349 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0390389 |
| FLNA | filamin A, alpha | 0.0390185 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0389836 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0389437 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0385872 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0383584 |
| TPM4 | tropomyosin 4 | 0.0382572 |
| RPS19 | ribosomal protein S19 | 0.0381567 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.038065 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0379032 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0368702 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0368549 |
| CEP250 | centrosomal protein 250kDa | 0.0363928 |
| RPS13 | ribosomal protein S13 | 0.0360236 |
| HLA-B | major histocompatibility complex, class I, B | 0.0355629 |
| VEGFA | vascular endothelial growth factor A | 0.0354165 |
| FOSL1 | FOS-like antigen 1 | 0.0350245 |
| FLNB | filamin B, beta | 0.0350123 |
| PCBP2 | poly(rC) binding protein 2 | 0.0349732 |
| MT2A | metallothionein 2A | 0.0347055 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0338666 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0333765 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0332756 |
| RPL12 | ribosomal protein L12 | 0.0321373 |
| YEATS2 | YEATS domain containing 2 | 0.0320284 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0316152 |
| RPL7A | ribosomal protein L7a | 0.0315504 |
| RPL36A | ribosomal protein L36a | 0.0315309 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0314424 |
| TPD52 | tumor protein D52 | 0.0308894 |
| RPL19 | ribosomal protein L19 | 0.0307914 |
| RPL7 | ribosomal protein L7 | 0.0307266 |
| CDK19 | cyclin-dependent kinase 19 | 0.0306788 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0305255 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.029482 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0291791 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0289816 |
| CTSB | cathepsin B | 0.0289312 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0288615 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0288347 |
| WDR45B | WD repeat domain 45B | 0.028444 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0284212 |
| MSN | moesin | 0.0282814 |
| RAI1 | retinoic acid induced 1 | 0.0279507 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0278981 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0278555 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | 0.0275817 |
| SFRP1 | secreted frizzled-related protein 1 | 0.0275432 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0267323 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VCL | vinculin | -0.176995 |
| VIM | vimentin | -0.151222 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.117538 |
| BICC1 | BicC family RNA binding protein 1 | -0.110981 |
| KYNU | kynureninase | -0.0886549 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0824055 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0816765 |
| HDAC9 | histone deacetylase 9 | -0.0754402 |
| IER3 | immediate early response 3 | -0.0741598 |
| PALLD | palladin, cytoskeletal associated protein | -0.0690351 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.066023 |
| RIGI | RNA sensor RIG-I | -0.0651427 |
| PLIN2 | perilipin 2 | -0.063997 |
| NABP1 | nucleic acid binding protein 1 | -0.0606622 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0584046 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0563795 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0543788 |
| FTL | ferritin, light polypeptide | -0.0542985 |
| INTS6 | integrator complex subunit 6 | -0.0533007 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.051721 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0515629 |
| ADM | adrenomedullin | -0.0495178 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0478113 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0466065 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0443384 |
| SP100 | SP100 nuclear antigen | -0.0432897 |
| CLIC4 | chloride intracellular channel 4 | -0.042709 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0418839 |
| MAP1B | microtubule-associated protein 1B | -0.0418598 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0406656 |
| CD44 | CD44 molecule (Indian blood group) | -0.0406527 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0387747 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0381907 |
| CENPF | centromere protein F, 350/400kDa | -0.0381198 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0380945 |
| OSMR | oncostatin M receptor | -0.0380781 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0368025 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0366725 |
| PMP22 | peripheral myelin protein 22 | -0.0349179 |
| PDLIM5 | PDZ and LIM domain 5 | -0.034883 |
| ERBIN | erbb2 interacting protein | -0.0348499 |
| TMSB10 | thymosin beta 10 | -0.0342107 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0339698 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0339344 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0338005 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0337242 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0334314 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0331614 |
| TLE4 | transducin-like enhancer of split 4 | -0.0330306 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.032734 |
| HLA-E | major histocompatibility complex, class I, E | -0.0326784 |
| PLSCR1 | phospholipid scramblase 1 | -0.0314703 |
| GOLGB1 | golgin B1 | -0.0313116 |
| C6ORF62 | chromosome 6 open reading frame 62 | -0.0312653 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0312642 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0311962 |
| DIAPH2 | diaphanous-related formin 2 | -0.0310145 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0302733 |
| GOPC | golgi-associated PDZ and coiled-coil motif containing | -0.0302375 |
| KIF4A | kinesin family member 4A | -0.0292303 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0290687 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0290388 |
| RPLP1 | ribosomal protein, large, P1 | -0.0289321 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0286821 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0283295 |
| NTN4 | netrin 4 | -0.0280168 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0280062 |
| SMAD2 | SMAD family member 2 | -0.0278788 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0274424 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0271798 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0271781 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0270168 |
| REEP3 | receptor accessory protein 3 | -0.0269488 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0268447 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0266295 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0261203 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0261173 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0260516 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0260382 |
| RND3 | Rho family GTPase 3 | -0.0259719 |
| JMJD1C | jumonji domain containing 1C | -0.0254448 |
| MX2 | MX dynamin-like GTPase 2 | -0.0254447 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0252002 |
| TOP1 | topoisomerase (DNA) I | -0.0249834 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0249781 |
| SYNJ2 | synaptojanin 2 | -0.0249237 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0248659 |
| TRIM55 | tripartite motif containing 55 | -0.0247734 |
| PITPNB | phosphatidylinositol transfer protein, beta | -0.0246289 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0243156 |
| ZNF644 | zinc finger protein 644 | -0.0241857 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0239271 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.023891 |
| GLIS3 | GLIS family zinc finger 3 | -0.0237962 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0237582 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0236891 |
| GPC6 | glypican 6 | -0.0236282 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.0235476 |
| FILIP1L | filamin A interacting protein 1-like | -0.0230747 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0228508 |
