| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (mesylate) perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (mesylate)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.138735 |
| COL6A3 | collagen, type VI, alpha 3 | 0.122967 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.101189 |
| FAM13A | family with sequence similarity 13, member A | 0.0965458 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.087737 |
| NDRG1 | N-myc downstream regulated 1 | 0.0847336 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0810725 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0796861 |
| VIM | vimentin | 0.0785796 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0651615 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0637255 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0614636 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0608232 |
| CD109 | CD109 molecule | 0.0593827 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.058657 |
| HELZ | helicase with zinc finger | 0.0583857 |
| ARRDC3 | arrestin domain containing 3 | 0.0579599 |
| ATP13A3 | ATPase type 13A3 | 0.0534285 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0529102 |
| TMSB10 | thymosin beta 10 | 0.0516989 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0510541 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0502313 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0491033 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.047825 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.046416 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0447364 |
| FLNB | filamin B, beta | 0.0442097 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0432673 |
| LOX | lysyl oxidase | 0.0431702 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0424117 |
| SPAG9 | sperm associated antigen 9 | 0.0420442 |
| INSIG1 | insulin induced gene 1 | 0.0418018 |
| ENO1 | enolase 1, (alpha) | 0.0417251 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0410234 |
| ANXA2 | annexin A2 | 0.040301 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0402722 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0402708 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0394573 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0390776 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0388942 |
| IL6 | interleukin 6 | 0.0387596 |
| HAPSTR1 | HUWE1 associated protein modifying stress responses | 0.0382534 |
| ANXA1 | annexin A1 | 0.0377899 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0376108 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0372557 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0368122 |
| YME1L1 | YME1-like 1 ATPase | 0.0361866 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0361282 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0359836 |
| RNF145 | ring finger protein 145 | 0.0358542 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0356957 |
| RND3 | Rho family GTPase 3 | 0.0354457 |
| UBC | ubiquitin C | 0.035005 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0349997 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0345437 |
| SQSTM1 | sequestosome 1 | 0.0344375 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0342135 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0341985 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0340484 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0335945 |
| ZNF292 | zinc finger protein 292 | 0.0334642 |
| COPA | coatomer protein complex, subunit alpha | 0.0334404 |
| PCBP2 | poly(rC) binding protein 2 | 0.0333278 |
| FLNA | filamin A, alpha | 0.0322379 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0321986 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0321767 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0321488 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0318632 |
| PLAUR | plasminogen activator, urokinase receptor | 0.031813 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0314589 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0313886 |
| RPL5 | ribosomal protein L5 | 0.031181 |
| FMNL2 | formin-like 2 | 0.0306499 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0304623 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0304514 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0303711 |
| COLEC11 | collectin sub-family member 11 | 0.0303316 |
| COL1A2 | collagen, type I, alpha 2 | 0.0301426 |
| FNBP1L | formin binding protein 1-like | 0.0301388 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0300842 |
| WASF2 | WAS protein family, member 2 | 0.0298738 |
| APOL2 | apolipoprotein L, 2 | 0.0290825 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0284097 |
| CLEC1B | C-type lectin domain family 1, member B | 0.0282905 |
| S100A9 | S100 calcium binding protein A9 | 0.0280898 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0277358 |
| ORC4 | origin recognition complex, subunit 4 | 0.0276356 |
| STK10 | serine/threonine kinase 10 | 0.0276009 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0275453 |
| ADM | adrenomedullin | 0.0273525 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0270576 |
| NUS1 | nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) | 0.0267223 |
| USP3 | ubiquitin specific peptidase 3 | 0.0266824 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0266418 |
| SRP54 | signal recognition particle 54kDa | 0.0265428 |
| EHBP1 | EH domain binding protein 1 | 0.0262811 |
| PGK1 | phosphoglycerate kinase 1 | 0.0261398 |
| COL5A2 | collagen, type V, alpha 2 | 0.0261327 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0261238 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0260056 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.111731 |
| VCL | vinculin | -0.0929023 |
| B2M | beta-2-microglobulin | -0.0787544 |
| GLIS3 | GLIS family zinc finger 3 | -0.0721216 |
| CALD1 | caldesmon 1 | -0.0703068 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0690905 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0681074 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0661606 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0642687 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.0638839 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0623449 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0614695 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0606303 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0599168 |
| SMYD3 | SET and MYND domain containing 3 | -0.0596448 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0573189 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0569842 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0557674 |
| SEC24D | SEC24 family member D | -0.0550213 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.051711 |
| TPM4 | tropomyosin 4 | -0.0483027 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0480089 |
| RPL11 | ribosomal protein L11 | -0.0459833 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0454028 |
| RAI14 | retinoic acid induced 14 | -0.0451209 |
| STC1 | stanniocalcin 1 | -0.0450482 |
| PRKCA | protein kinase C, alpha | -0.0436813 |
| HDLBP | high density lipoprotein binding protein | -0.0428657 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0428217 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0427279 |
| PTMA | prothymosin, alpha | -0.0426492 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.042602 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0418621 |
| CD44 | CD44 molecule (Indian blood group) | -0.0417705 |
| RAD51B | RAD51 paralog B | -0.0415716 |
| PKM | pyruvate kinase, muscle | -0.041222 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0405952 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | -0.0400079 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0395438 |
| AHNAK | AHNAK nucleoprotein | -0.0386727 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0384421 |
| TOP1 | topoisomerase (DNA) I | -0.0379768 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0376375 |
| H3-3B | H3.3 histone B | -0.0374518 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0373076 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0372896 |
| PTGES2 | prostaglandin E synthase 2 | -0.0361664 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0359627 |
| ACTG1 | actin gamma 1 | -0.0356622 |
| MORF4L2 | mortality factor 4 like 2 | -0.0353947 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0350525 |
| PRSS23 | protease, serine, 23 | -0.034842 |
| CCDC88A | coiled-coil domain containing 88A | -0.0347872 |
| CLIC4 | chloride intracellular channel 4 | -0.0345752 |
| ANLN | anillin, actin binding protein | -0.0344892 |
| MEF2A | myocyte enhancer factor 2A | -0.0332611 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0331151 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0329431 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0328837 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0328108 |
| MAP4 | microtubule-associated protein 4 | -0.0324172 |
| TNS3 | tensin 3 | -0.0321807 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0320848 |
| MYOF | myoferlin | -0.0319909 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0316066 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0315809 |
| RBM6 | RNA binding motif protein 6 | -0.0312662 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0311845 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0309856 |
| CDK6 | cyclin-dependent kinase 6 | -0.0307036 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0306638 |
| FBXO11 | F-box protein 11 | -0.0306636 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.030465 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0303478 |
| SRPK2 | SRSF protein kinase 2 | -0.0303383 |
| MAP1B | microtubule-associated protein 1B | -0.0302982 |
| RASAL2 | RAS protein activator like 2 | -0.0300023 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | -0.0300016 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0299612 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0299203 |
| SETD5 | SET domain containing 5 | -0.0299172 |
| GLG1 | golgi glycoprotein 1 | -0.0297299 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.02939 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0293565 |
| CDR2 | cerebellar degeneration-related protein 2, 62kDa | -0.029005 |
| LNPK | lunapark, ER junction formation factor | -0.0288454 |
| KIF5B | kinesin family member 5B | -0.0286956 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0284841 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0283673 |
| RPS2 | ribosomal protein S2 | -0.0283199 |
| MRTFA | myocardin related transcription factor A | -0.0281081 |
| PRELID2 | PRELI domain containing 2 | -0.0279934 |
| ATXN1 | ataxin 1 | -0.027982 |
| UBAP2 | ubiquitin associated protein 2 | -0.0276699 |
| DOCK7 | dedicator of cytokinesis 7 | -0.0276441 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0276434 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.027559 |
| PHF21A | PHD finger protein 21A | -0.027163 |
| RNF24 | ring finger protein 24 | -0.0271423 |
| MTPN | myotrophin | -0.0271201 |
