Almonertinib (mesylate)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (mesylate) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (mesylate)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HILPDA hypoxia inducible lipid droplet-associated 0.0960701
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0818422
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0673365
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0602634
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0505907
ANLN anillin, actin binding protein 0.0448653
RPL26 ribosomal protein L26 0.0439717
NUP58 nucleoporin 58 0.0432664
MYH9 myosin, heavy chain 9, non-muscle 0.0395794
ANKRD11 ankyrin repeat domain 11 0.0383908
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0372487
IGFBP3 insulin-like growth factor binding protein 3 0.0367392
ANXA1 annexin A1 0.036031
RPL7A ribosomal protein L7a 0.0359027
FAM13A family with sequence similarity 13, member A 0.035784
GOLGA4 golgin A4 0.0339754
ARF4 ADP-ribosylation factor 4 0.03349
CANX calnexin 0.0330134
NDRG1 N-myc downstream regulated 1 0.0325073
DERA deoxyribose-phosphate aldolase (putative) 0.0319306
EEF1G eukaryotic translation elongation factor 1 gamma 0.0317357
INSIG1 insulin induced gene 1 0.0316442
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0316379
UBAC2 UBA domain containing 2 0.029636
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0296224
DTNA dystrobrevin, alpha 0.0291609
SFXN1 sideroflexin 1 0.0289518
PYGL phosphorylase, glycogen, liver 0.0288367
HMGB2 high mobility group box 2 0.028824
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0283242
FNIP1 folliculin interacting protein 1 0.0280764
RAB6A RAB6A, member RAS oncogene family 0.0280756
ADM adrenomedullin 0.0274614
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0274295
TTC1 tetratricopeptide repeat domain 1 0.0271168
MKI67 marker of proliferation Ki-67 0.0271056
ZNF670 zinc finger protein 670 0.0268338
XPO1 exportin 1 0.0266918
PDGFA platelet-derived growth factor alpha polypeptide 0.026686
RPL36 ribosomal protein L36 0.0266166
ELP2 elongator acetyltransferase complex subunit 2 0.0266094
PFN1 profilin 1 0.0264207
IGF2 insulin-like growth factor 2 0.026185
TFRC transferrin receptor 0.0259438
UBE2O ubiquitin-conjugating enzyme E2O 0.0258642
IARS1 isoleucyl-tRNA synthetase 1 0.0258507
RPL37A ribosomal protein L37a 0.0254983
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0254301
RPL23 ribosomal protein L23 0.0250343
WDR45B WD repeat domain 45B 0.0248928
SEPTIN2 septin 2 0.0247953
GOLGA2 golgin A2 0.0246097
RPL35A ribosomal protein L35a 0.0241831
COLEC11 collectin sub-family member 11 0.0241639
ANXA5 annexin A5 0.0241569
KLF6 Kruppel-like factor 6 0.0240212
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0240172
SGO2 shugoshin 2 0.0239819
UBE3A ubiquitin protein ligase E3A 0.0239089
RPL13A ribosomal protein L13a 0.0237054
ACIN1 apoptotic chromatin condensation inducer 1 0.0234735
SEC61B Sec61 beta subunit 0.0233281
CCNB2 cyclin B2 0.0232551
RPL6 ribosomal protein L6 0.0232198
PHF20 PHD finger protein 20 0.0231037
CEP250 centrosomal protein 250kDa 0.0231028
FN1 fibronectin 1 0.0230907
TM9SF2 transmembrane 9 superfamily member 2 0.0230542
PRPF39 pre-mRNA processing factor 39 0.0229682
TBC1D15 TBC1 domain family, member 15 0.0228727
CEP192 centrosomal protein 192kDa 0.0228581
NAMPT nicotinamide phosphoribosyltransferase 0.0226626
BRD8 bromodomain containing 8 0.0225872
HM13 histocompatibility (minor) 13 0.0225713
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0224029
SQSTM1 sequestosome 1 0.0223743
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G 0.0223398
ZBTB10 zinc finger and BTB domain containing 10 0.0222899
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0221227
TPM3 tropomyosin 3 0.0219852
ARRDC3 arrestin domain containing 3 0.0219021
RPS3 ribosomal protein S3 0.0217805
CIRSR corepressor of RBPJ and splicing regulator 0.0217408
KIF20B kinesin family member 20B 0.0216522
SETD5 SET domain containing 5 0.0216452
IFRD1 interferon-related developmental regulator 1 0.0216267
PUM2 pumilio RNA-binding family member 2 0.0215774
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0215101
MUSK muscle, skeletal, receptor tyrosine kinase 0.0212802
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0212023
RPS23 ribosomal protein S23 0.0211551
RBM33 RNA binding motif protein 33 0.0211313
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0211065
ANKRD37 ankyrin repeat domain 37 0.0210095
RFLNA refilin A 0.0209612
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 0.0209267
HJURP Holliday junction recognition protein 0.0208953
SNX3 sorting nexin 3 0.0206784
SMAD5 SMAD family member 5 0.0206291
CD9 CD9 molecule 0.0205957

decreased expression

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 -0.112033
ZBTB20 zinc finger and BTB domain containing 20 -0.0921091
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0819393
AHNAK AHNAK nucleoprotein -0.079741
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0782729
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0770403
DST dystonin -0.0769567
OSMR oncostatin M receptor -0.0742124
INTS6 integrator complex subunit 6 -0.0720619
PKM pyruvate kinase, muscle -0.0700297
SMYD3 SET and MYND domain containing 3 -0.0693627
CD44 CD44 molecule (Indian blood group) -0.0677718
FNDC3B fibronectin type III domain containing 3B -0.0624408
VCL vinculin -0.0569748
ATM ATM serine/threonine kinase -0.0551555
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0539756
FMNL2 formin-like 2 -0.0527604
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0527527
MBD5 methyl-CpG binding domain protein 5 -0.0522361
TRIO trio Rho guanine nucleotide exchange factor -0.0521767
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0507146
NT5E 5'-nucleotidase, ecto (CD73) -0.0501048
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0494361
PRSS23 protease, serine, 23 -0.0493097
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0487667
NLK nemo-like kinase -0.0485436
SVIL supervillin -0.0485048
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0483535
THSD4 thrombospondin, type I, domain containing 4 -0.0481228
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0468274
PRH1 proline-rich protein HaeIII subfamily 1 -0.0467104
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0454481
MACF1 microtubule-actin crosslinking factor 1 -0.0441971
DPYD dihydropyrimidine dehydrogenase -0.0439453
TMSB10 thymosin beta 10 -0.0436302
RSF1 remodeling and spacing factor 1 -0.0434164
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0434079
PALM2AKAP2 PALM2 and AKAP2 fusion -0.042677
RBM25 RNA binding motif protein 25 -0.041348
EFNA5 ephrin-A5 -0.0412065
PRR16 proline rich 16 -0.0406164
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0405154
FER fer (fps/fes related) tyrosine kinase -0.0401913
RASAL2 RAS protein activator like 2 -0.0400198
PRKCA protein kinase C, alpha -0.0398249
WWTR1 WW domain containing transcription regulator 1 -0.0396923
NAV3 neuron navigator 3 -0.0396043
RAB10 RAB10, member RAS oncogene family -0.03853
BICD1 bicaudal D homolog 1 (Drosophila) -0.0384964
BPTF bromodomain PHD finger transcription factor -0.0382925
SH3KBP1 SH3-domain kinase binding protein 1 -0.0377862
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0375028
TBC1D5 TBC1 domain family, member 5 -0.0367509
ATG10 autophagy related 10 -0.0362263
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0361412
TCF12 transcription factor 12 -0.0359991
RIGI RNA sensor RIG-I -0.0351941
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0345884
GNAS GNAS complex locus -0.0345842
ZC3H12B zinc finger CCCH-type containing 12B -0.0338826
SENP6 SUMO1/sentrin specific peptidase 6 -0.0336787
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 -0.0336693
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0331127
ANKRD28 ankyrin repeat domain 28 -0.0328772
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0327196
BBX bobby sox homolog (Drosophila) -0.0325446
ARB2A ARB2 cotranscriptional regulator A -0.0324187
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0324001
ITPRID2 ITPR interacting domain containing 2 -0.0323688
PRELID2 PRELI domain containing 2 -0.0322816
FBXL7 F-box and leucine-rich repeat protein 7 -0.0322766
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0321847
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0319221
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0319125
GLCCI1 glucocorticoid induced 1 -0.0318882
ERBIN erbb2 interacting protein -0.0317565
ATXN1 ataxin 1 -0.0317041
GLS2 glutaminase 2 (liver, mitochondrial) -0.0312178
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0307449
RABGAP1L RAB GTPase activating protein 1-like -0.0303667
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0300943
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0299265
SLC38A2 solute carrier family 38, member 2 -0.0297619
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0293567
SCAPER S-phase cyclin A-associated protein in the ER -0.029323
AEBP2 AE binding protein 2 -0.0293222
AKAP12 A kinase (PRKA) anchor protein 12 -0.0292883
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4 -0.0291899
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0288194
TAOK3 TAO kinase 3 -0.0286203
TOP1 topoisomerase (DNA) I -0.0285202
ACER3 alkaline ceramidase 3 -0.0282996
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0282938
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0282729
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0282229
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0279278
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0278891
VMP1 vacuole membrane protein 1 -0.0278583
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0278316
NF1 neurofibromin 1 -0.0278032