| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (mesylate) perturbation in SW1417 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (mesylate)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | 0.171103 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.131898 |
| KRT8 | keratin 8, type II | 0.110906 |
| ACTN4 | actinin, alpha 4 | 0.105533 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0999155 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0933559 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0840608 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0726133 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0717509 |
| NDRG1 | N-myc downstream regulated 1 | 0.0562642 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0560187 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0553073 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.054023 |
| FAT1 | FAT atypical cadherin 1 | 0.0523334 |
| CTBP2 | C-terminal binding protein 2 | 0.0515839 |
| ZNRF3 | zinc and ring finger 3 | 0.0505923 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0501435 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0483621 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0481727 |
| RPL13A | ribosomal protein L13a | 0.0467453 |
| CD47 | CD47 molecule | 0.043919 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0437986 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.042997 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0413778 |
| HMGA1 | high mobility group AT-hook 1 | 0.0409401 |
| MYO5B | myosin VB | 0.0401674 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | 0.0401306 |
| CALR | calreticulin | 0.0396597 |
| RPL23 | ribosomal protein L23 | 0.0393999 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | 0.0392007 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.038922 |
| KRT18 | keratin 18, type I | 0.0386803 |
| VASP | vasodilator-stimulated phosphoprotein | 0.0373892 |
| MYO18A | myosin XVIIIA | 0.0363323 |
| HOXB6 | homeobox B6 | 0.0357362 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0352336 |
| NAV2 | neuron navigator 2 | 0.0350701 |
| RPL18 | ribosomal protein L18 | 0.034925 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0338977 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0333981 |
| PGK1 | phosphoglycerate kinase 1 | 0.0333251 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0330977 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0325654 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.0319928 |
| CLDN3 | claudin 3 | 0.031656 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0314802 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0314316 |
| ITGB4 | integrin, beta 4 | 0.0307707 |
| UBC | ubiquitin C | 0.0307545 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0301089 |
| UBE2C | ubiquitin-conjugating enzyme E2C | 0.0301024 |
| RNF43 | ring finger protein 43 | 0.0299198 |
| PRPF38B | pre-mRNA processing factor 38B | 0.0299193 |
| TJP2 | tight junction protein 2 | 0.0297615 |
| ZNF292 | zinc finger protein 292 | 0.0295282 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0295031 |
| MSI2 | musashi RNA-binding protein 2 | 0.029426 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | 0.0288734 |
| B2M | beta-2-microglobulin | 0.0286644 |
| PDE8A | phosphodiesterase 8A | 0.0284566 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0283979 |
| OGA | O-GlcNAcase | 0.028212 |
| KIAA1671 | KIAA1671 | 0.028174 |
| RPL37A | ribosomal protein L37a | 0.0276702 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0273869 |
| ATL2 | atlastin GTPase 2 | 0.0271096 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0266443 |
| JUP | junction plakoglobin | 0.0261454 |
| RPS15A | ribosomal protein S15a | 0.0258426 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0257926 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0257694 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0255872 |
| SP3 | Sp3 transcription factor | 0.025559 |
| MED13L | mediator complex subunit 13-like | 0.0248902 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.0245873 |
| ZYX | zyxin | 0.0243736 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0242865 |
| CTSA | cathepsin A | 0.0241377 |
| RUNX2 | runt-related transcription factor 2 | 0.0240941 |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.0240222 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0238769 |
| LDHA | lactate dehydrogenase A | 0.0238576 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0234685 |
| TPD52L2 | tumor protein D52-like 2 | 0.0234367 |
| VMP1 | vacuole membrane protein 1 | 0.0232423 |
| HDGF | hepatoma-derived growth factor | 0.0229806 |
| MARK4 | MAP/microtubule affinity-regulating kinase 4 | 0.0229133 |
| RPS7 | ribosomal protein S7 | 0.0224941 |
| LRRC59 | leucine rich repeat containing 59 | 0.0224744 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0223936 |
| NUP58 | nucleoporin 58 | 0.0223347 |
| ZFHX3 | zinc finger homeobox 3 | 0.0221526 |
| HLA-A | major histocompatibility complex, class I, A | 0.0221083 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.021864 |
| MYO10 | myosin X | 0.0218046 |
| CAPN1 | calpain 1, (mu/I) large subunit | 0.02179 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.0217627 |
| NUDT4 | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | 0.0216908 |
| MYO1B | myosin IB | 0.0216903 |
| RPS29 | ribosomal protein S29 | 0.0215369 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FTL | ferritin, light polypeptide | -0.130639 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.116259 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0896026 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0885212 |
| RPS2 | ribosomal protein S2 | -0.0778119 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0747707 |
| GOLGB1 | golgin B1 | -0.073815 |
| RPS6 | ribosomal protein S6 | -0.0725924 |
| GNAS | GNAS complex locus | -0.0683602 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0682134 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0680122 |
| RPLP1 | ribosomal protein, large, P1 | -0.067351 |
| DSPP | dentin sialophosphoprotein | -0.0635359 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0633184 |
| RYBP | RING1 and YY1 binding protein | -0.0599743 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0582621 |
| VCL | vinculin | -0.0569442 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0562018 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0557754 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0553605 |
| GOLGA4 | golgin A4 | -0.0552464 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0545142 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0535524 |
| GPHN | gephyrin | -0.0528245 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0518338 |
| HDLBP | high density lipoprotein binding protein | -0.050336 |
| MATR3 | matrin 3 | -0.0503074 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.049394 |
| NKTR | natural killer cell triggering receptor | -0.049056 |
| RBM39 | RNA binding motif protein 39 | -0.0487835 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0487299 |
| NEK7 | NIMA-related kinase 7 | -0.0487039 |
| CST3 | cystatin C | -0.0486896 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0478773 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0477519 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0475768 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0474731 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0472701 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0462614 |
| MYO1E | myosin IE | -0.0461006 |
| RAB10 | RAB10, member RAS oncogene family | -0.0450651 |
| NEBL | nebulette | -0.0449979 |
| SPAG9 | sperm associated antigen 9 | -0.0446422 |
| IPO7 | importin 7 | -0.0443887 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.04382 |
| GLG1 | golgi glycoprotein 1 | -0.0435277 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0425104 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0424406 |
| TARS1 | threonyl-tRNA synthetase 1 | -0.0421498 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0421275 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | -0.0415125 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0414105 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0411437 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | -0.0407597 |
| RPS5 | ribosomal protein S5 | -0.040638 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0401138 |
| FBXO11 | F-box protein 11 | -0.0391349 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0384183 |
| RPLP0 | ribosomal protein, large, P0 | -0.0380874 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0380344 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0380249 |
| MAP4 | microtubule-associated protein 4 | -0.0372679 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.037131 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0369382 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0364982 |
| EGR1 | early growth response 1 | -0.0363456 |
| TXNRD1 | thioredoxin reductase 1 | -0.036092 |
| RIGI | RNA sensor RIG-I | -0.0360885 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0360731 |
| XPO1 | exportin 1 | -0.0360022 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0359292 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0357573 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0353292 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0350233 |
| WWC1 | WW and C2 domain containing 1 | -0.034846 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0344461 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0342252 |
| TMEM263 | transmembrane protein 263 | -0.0339271 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0334093 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | -0.0333065 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0331314 |
| USP15 | ubiquitin specific peptidase 15 | -0.0331158 |
| UBAP2 | ubiquitin associated protein 2 | -0.0329524 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0328229 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.0327994 |
| CCND1 | cyclin D1 | -0.0326788 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0324934 |
| FAM3C | family with sequence similarity 3, member C | -0.0323678 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0319593 |
| PKN2 | protein kinase N2 | -0.0317901 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0315552 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0314785 |
| SF1 | splicing factor 1 | -0.031302 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0311388 |
| UBQLN1 | ubiquilin 1 | -0.0309162 |
| JMJD1C | jumonji domain containing 1C | -0.0307655 |
| TMSB10 | thymosin beta 10 | -0.0305448 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0300365 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0299128 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0298828 |
