Almonertinib (mesylate)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (mesylate) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (mesylate)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AREG amphiregulin 0.173208
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.103236
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.084338
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0828027
RPL26 ribosomal protein L26 0.0725854
RPS12 ribosomal protein S12 0.0715988
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0715913
RPL37A ribosomal protein L37a 0.0710003
RPS8 ribosomal protein S8 0.0701354
EPHA2 EPH receptor A2 0.0697328
HMGA1 high mobility group AT-hook 1 0.068519
ANXA1 annexin A1 0.0665293
RUNX2 runt-related transcription factor 2 0.0663416
RPS3 ribosomal protein S3 0.0662274
HSPA8 heat shock 70kDa protein 8 0.0644171
CD36 CD36 molecule (thrombospondin receptor) 0.0629394
EEF1G eukaryotic translation elongation factor 1 gamma 0.0611057
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0609594
RPL13A ribosomal protein L13a 0.05952
ANLN anillin, actin binding protein 0.058093
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0548635
LDHA lactate dehydrogenase A 0.053238
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.052329
MKI67 marker of proliferation Ki-67 0.0497179
NDRG1 N-myc downstream regulated 1 0.046601
FLOT1 flotillin 1 0.046432
RPL35A ribosomal protein L35a 0.0453938
RPL6 ribosomal protein L6 0.0453766
ANKRD11 ankyrin repeat domain 11 0.0440159
FOSL1 FOS-like antigen 1 0.0423841
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0400814
GCLC glutamate-cysteine ligase, catalytic subunit 0.0395236
GOLGA4 golgin A4 0.0394121
EEF2 eukaryotic translation elongation factor 2 0.0371867
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0370073
RPS13 ribosomal protein S13 0.0359311
RPL23 ribosomal protein L23 0.0358343
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0358341
FAT1 FAT atypical cadherin 1 0.0357217
RPS29 ribosomal protein S29 0.0353681
TXNRD1 thioredoxin reductase 1 0.0350162
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0349256
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 0.0348037
RPS2 ribosomal protein S2 0.0339568
CARS1 cysteinyl-tRNA synthetase 1 0.0337135
ENO1 enolase 1, (alpha) 0.0334568
ACTN4 actinin, alpha 4 0.0331543
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0330414
EGR1 early growth response 1 0.0329504
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.031949
RPL5 ribosomal protein L5 0.0306758
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0300507
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0289567
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0287126
ITGB4 integrin, beta 4 0.0282345
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.028231
EDAR ectodysplasin A receptor 0.0280998
NCKAP1 NCK-associated protein 1 0.0280544
RPL3 ribosomal protein L3 0.0275781
SBF2 SET binding factor 2 0.0273541
CENPF centromere protein F, 350/400kDa 0.0268996
PNN pinin, desmosome associated protein 0.0268686
SREBF2 sterol regulatory element binding transcription factor 2 0.0268358
LGALS3 lectin, galactoside-binding, soluble, 3 0.0266045
RPLP2 ribosomal protein, large, P2 0.0258689
RPS27A ribosomal protein S27a 0.0258261
TBCD tubulin folding cofactor D 0.0257048
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.0255577
GNPDA1 glucosamine-6-phosphate deaminase 1 0.025315
CD9 CD9 molecule 0.0251183
YEATS2 YEATS domain containing 2 0.0250107
DDIT4 DNA-damage-inducible transcript 4 0.024967
MSI2 musashi RNA-binding protein 2 0.0248577
KDM4B lysine (K)-specific demethylase 4B 0.024847
LAMC2 laminin, gamma 2 0.0248108
RPL38 ribosomal protein L38 0.0247947
RAB6A RAB6A, member RAS oncogene family 0.0247563
PSAT1 phosphoserine aminotransferase 1 0.0246868
KLF6 Kruppel-like factor 6 0.0246713
P4HB prolyl 4-hydroxylase, beta polypeptide 0.024543
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0244459
RPS21 ribosomal protein S21 0.0242534
DBF4 DBF4 zinc finger 0.0241793
RPS23 ribosomal protein S23 0.0240937
SQSTM1 sequestosome 1 0.0240839
RPL21 ribosomal protein L21 0.0240262
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0239704
EIF4B eukaryotic translation initiation factor 4B 0.0238928
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.023703
PTPRF protein tyrosine phosphatase, receptor type, F 0.0236768
HLA-B major histocompatibility complex, class I, B 0.0235782
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.0232469
TNIP1 TNFAIP3 interacting protein 1 0.0230951
RPL35 ribosomal protein L35 0.0228919
BRD4 bromodomain containing 4 0.022308
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.0220392
PCBP2 poly(rC) binding protein 2 0.0220126
RPS15 ribosomal protein S15 0.0219878
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0218083
PLAUR plasminogen activator, urokinase receptor 0.0217743

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.24051
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.160192
PTMA prothymosin, alpha -0.127489
HMGA2 high mobility group AT-hook 2 -0.109374
IER3 immediate early response 3 -0.0981466
RPLP1 ribosomal protein, large, P1 -0.0744805
LMO7 LIM domain 7 -0.0730654
RAD51B RAD51 paralog B -0.0679952
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0626139
RPS24 ribosomal protein S24 -0.0619655
RBM25 RNA binding motif protein 25 -0.0603887
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0602332
RAB10 RAB10, member RAS oncogene family -0.0595158
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0517335
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0516021
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0515923
VCL vinculin -0.0506607
RPS4X ribosomal protein S4, X-linked -0.0498261
EZR ezrin -0.0496729
TMSB10 thymosin beta 10 -0.0491782
RPLP0 ribosomal protein, large, P0 -0.0487029
KITLG KIT ligand -0.048259
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.047733
RCOR1 REST corepressor 1 -0.0461741
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0456866
RSL1D1 ribosomal L1 domain containing 1 -0.0456138
PKM pyruvate kinase, muscle -0.0447074
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0435213
NCEH1 neutral cholesterol ester hydrolase 1 -0.0433228
OXR1 oxidation resistance 1 -0.0418635
JMJD1C jumonji domain containing 1C -0.0417684
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0404455
RPS6 ribosomal protein S6 -0.0393709
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0392498
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0390532
PHF3 PHD finger protein 3 -0.0379019
MTAP methylthioadenosine phosphorylase -0.0376446
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.037578
CDK13 cyclin-dependent kinase 13 -0.0373962
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0372158
S100A10 S100 calcium binding protein A10 -0.0368406
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0354342
GPHN gephyrin -0.0350346
DOCK5 dedicator of cytokinesis 5 -0.0350214
MED13 mediator complex subunit 13 -0.0348899
SETD5 SET domain containing 5 -0.0346835
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0345249
FAF1 Fas (TNFRSF6) associated factor 1 -0.0341785
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0337181
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0334634
USP9X ubiquitin specific peptidase 9, X-linked -0.0331148
TRA2A transformer 2 alpha homolog (Drosophila) -0.0328428
HDAC2 histone deacetylase 2 -0.0328203
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0316604
PDLIM5 PDZ and LIM domain 5 -0.0314314
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0311093
TJP1 tight junction protein 1 -0.0310722
SGPP2 sphingosine-1-phosphate phosphatase 2 -0.0307487
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0305193
XPO1 exportin 1 -0.0304396
PHF14 PHD finger protein 14 -0.0303976
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0295883
PDIA3 protein disulfide isomerase family A, member 3 -0.029392
TENM3 teneurin transmembrane protein 3 -0.0291342
EGFR epidermal growth factor receptor -0.0291144
OXSR1 oxidative stress responsive 1 -0.028951
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0287151
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0285993
SERINC5 serine incorporator 5 -0.0285702
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0276034
ALCAM activated leukocyte cell adhesion molecule -0.0275827
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0275109
GNAS GNAS complex locus -0.0274663
GLG1 golgi glycoprotein 1 -0.0273859
TNS3 tensin 3 -0.0273751
FHIT fragile histidine triad -0.027245
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.026939
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0269378
TUT4 terminal uridylyl transferase 4 -0.0268579
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0265312
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0257514
RBM6 RNA binding motif protein 6 -0.0253145
ZNF207 zinc finger protein 207 -0.0253017
SMAD3 SMAD family member 3 -0.0252463
VWA8 von Willebrand factor A domain containing 8 -0.0247239
GARS1 glycyl-tRNA synthetase 1 -0.0246241
TNPO1 transportin 1 -0.0245891
SKAP1 src kinase associated phosphoprotein 1 -0.0243654
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0241442
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0241426
SEPTIN11 septin 11 -0.0241134
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0238138
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.023698
ZFC3H1 zinc finger, C3H1-type containing -0.0234015
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.023345
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0232704
BICD1 bicaudal D homolog 1 (Drosophila) -0.0232684
MATR3 matrin 3 -0.0232277
ANKRD17 ankyrin repeat domain 17 -0.0231396
IPO7 importin 7 -0.0231355