Almonertinib (mesylate)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Almonertinib (mesylate) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Almonertinib (mesylate)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.106492
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.104841
NAV2 neuron navigator 2 0.102439
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0849574
PLEC plectin 0.0847488
HMGA1 high mobility group AT-hook 1 0.08133
MYH9 myosin, heavy chain 9, non-muscle 0.0794035
ITGB4 integrin, beta 4 0.0771132
RPL26 ribosomal protein L26 0.0742682
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0724868
RPL37A ribosomal protein L37a 0.0652104
KRT8 keratin 8, type II 0.0610221
RPS12 ribosomal protein S12 0.0607547
MSN moesin 0.0607137
EEF1G eukaryotic translation elongation factor 1 gamma 0.0594045
RPS3 ribosomal protein S3 0.0583441
HDAC4 histone deacetylase 4 0.0552926
CMIP c-Maf inducing protein 0.0546348
RPL23 ribosomal protein L23 0.052477
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0515324
SFPQ splicing factor proline/glutamine-rich 0.0512805
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0509012
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0498484
RPL13A ribosomal protein L13a 0.0484942
ATXN1 ataxin 1 0.0465012
EFNB2 ephrin-B2 0.0462568
ANO1 anoctamin 1, calcium activated chloride channel 0.0460955
ACTN4 actinin, alpha 4 0.045935
FLNB filamin B, beta 0.0455272
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0455084
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0452549
KIZ kizuna centrosomal protein 0.0441159
P4HB prolyl 4-hydroxylase, beta polypeptide 0.042584
CDH13 cadherin 13 0.0415012
ACTN1 actinin, alpha 1 0.0402123
MACF1 microtubule-actin crosslinking factor 1 0.0393077
RPS7 ribosomal protein S7 0.0392833
YEATS2 YEATS domain containing 2 0.0379267
RPL6 ribosomal protein L6 0.0376627
SEPTIN9 septin 9 0.0374058
MKI67 marker of proliferation Ki-67 0.0370974
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0370617
IGFBP3 insulin-like growth factor binding protein 3 0.0370511
RPS8 ribosomal protein S8 0.0360638
MCL1 myeloid cell leukemia 1 0.0360226
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0359045
NACA nascent polypeptide-associated complex alpha subunit 0.035804
SPTBN1 spectrin, beta, non-erythrocytic 1 0.035604
ZNF292 zinc finger protein 292 0.0355389
SAMD4A sterile alpha motif domain containing 4A 0.0351179
RPL7A ribosomal protein L7a 0.0349813
RPL5 ribosomal protein L5 0.0347023
SDK1 sidekick cell adhesion molecule 1 0.0345549
ANLN anillin, actin binding protein 0.033607
RPL36A ribosomal protein L36a 0.0335741
CD9 CD9 molecule 0.0330222
NCOR2 nuclear receptor corepressor 2 0.0328887
BACE2 beta-site APP-cleaving enzyme 2 0.0323461
FLNA filamin A, alpha 0.0320135
STC2 stanniocalcin 2 0.0317362
VASP vasodilator-stimulated phosphoprotein 0.0313071
TNS4 tensin 4 0.0310568
MXD1 MAX dimerization protein 1 0.0301076
LMNA lamin A/C 0.0300835
KLC1 kinesin light chain 1 0.0298325
IGF2 insulin-like growth factor 2 0.0288768
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0285213
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0284823
AFDN afadin, adherens junction formation factor 0.0284735
TBC1D22A TBC1 domain family, member 22A 0.0282355
TPM3 tropomyosin 3 0.0281758
RPL9 ribosomal protein L9 0.0280746
RPLP2 ribosomal protein, large, P2 0.0280269
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0279406
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0277452
RPH3AL rabphilin 3A-like (without C2 domains) 0.0275082
RPL3 ribosomal protein L3 0.0272579
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0270854
MPRIP myosin phosphatase Rho interacting protein 0.0269348
IRS2 insulin receptor substrate 2 0.0268731
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0268101
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0266617
KTN1 kinectin 1 (kinesin receptor) 0.0264254
SYNE3 spectrin repeat containing, nuclear envelope family member 3 0.0262801
LDHA lactate dehydrogenase A 0.0261243
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0260678
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0260511
GANAB glucosidase, alpha; neutral AB 0.0259616
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0258727
PCBP2 poly(rC) binding protein 2 0.0254796
RPL7 ribosomal protein L7 0.0253984
CDK19 cyclin-dependent kinase 19 0.0251018
RPS29 ribosomal protein S29 0.0248631
RPS13 ribosomal protein S13 0.0248579
PFN1 profilin 1 0.0248162
CEP250 centrosomal protein 250kDa 0.0248152
BRD4 bromodomain containing 4 0.0246799
MINK1 misshapen-like kinase 1 0.0244776
WSB1 WD repeat and SOCS box containing 1 0.0244296
ZBTB20 zinc finger and BTB domain containing 20 0.0240466

decreased expression

Symbol Name Standardized Value
VCL vinculin -0.0859963
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0859174
RPLP1 ribosomal protein, large, P1 -0.0847676
TMSB10 thymosin beta 10 -0.0803255
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0794051
SYT1 synaptotagmin I -0.0776339
RPS24 ribosomal protein S24 -0.0721745
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0646804
IARS1 isoleucyl-tRNA synthetase 1 -0.0614087
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.060292
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0595283
PTMA prothymosin, alpha -0.0554095
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0538229
CDK6 cyclin-dependent kinase 6 -0.0524605
RPLP0 ribosomal protein, large, P0 -0.0512564
SLC38A2 solute carrier family 38, member 2 -0.0509929
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0509146
DLG1 discs, large homolog 1 (Drosophila) -0.0493236
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0493223
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.047709
AHNAK AHNAK nucleoprotein -0.0468155
FTL ferritin, light polypeptide -0.0465719
LOC102724023 ES1 protein homolog, mitochondrial -0.0462749
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0457186
MATR3 matrin 3 -0.0448567
PERP PERP, TP53 apoptosis effector -0.0433404
VDAC1 voltage-dependent anion channel 1 -0.0428967
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0426771
RPL4 ribosomal protein L4 -0.042282
CBX3 chromobox homolog 3 -0.0421512
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0418073
JMJD1C jumonji domain containing 1C -0.0409607
ABLIM1 actin binding LIM protein 1 -0.040053
RPS4X ribosomal protein S4, X-linked -0.0393393
FNDC3A fibronectin type III domain containing 3A -0.0392657
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0391939
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0388792
NPR2 natriuretic peptide receptor 2 -0.0381859
ZMYM2 zinc finger, MYM-type 2 -0.0381652
GPHN gephyrin -0.0373478
GARS1 glycyl-tRNA synthetase 1 -0.0357155
TUBB tubulin, beta class I -0.0355101
GLG1 golgi glycoprotein 1 -0.0354665
TCF12 transcription factor 12 -0.0352152
RBM39 RNA binding motif protein 39 -0.0340654
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0338341
CD46 CD46 molecule, complement regulatory protein -0.0336702
OXR1 oxidation resistance 1 -0.0336632
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0335738
MORF4L2 mortality factor 4 like 2 -0.0335387
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.033338
RPS5 ribosomal protein S5 -0.0333259
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0328951
STAU1 staufen double-stranded RNA binding protein 1 -0.0328806
TNPO1 transportin 1 -0.032857
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.032835
RAD21 RAD21 homolog (S. pombe) -0.0327593
FAF1 Fas (TNFRSF6) associated factor 1 -0.0326677
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0325432
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0324077
ARHGAP5 Rho GTPase activating protein 5 -0.0320733
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) -0.0315147
TES testin LIM domain protein -0.0311124
TUBA1B tubulin, alpha 1b -0.0311042
VIM vimentin -0.0309606
GMDS GDP-mannose 4,6-dehydratase -0.0307763
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0304686
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.0303247
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0302359
SCAF11 SR-related CTD-associated factor 11 -0.0302161
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0299272
ANKRD17 ankyrin repeat domain 17 -0.0297779
IER3 immediate early response 3 -0.0295216
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0291685
FBXO11 F-box protein 11 -0.0290438
TMEM123 transmembrane protein 123 -0.0290028
RPS6 ribosomal protein S6 -0.0289527
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0288522
TARS1 threonyl-tRNA synthetase 1 -0.0287525
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.02856
IPO7 importin 7 -0.0283457
BZW1 basic leucine zipper and W2 domains 1 -0.0283183
CBFB core-binding factor, beta subunit -0.0281165
GNAS GNAS complex locus -0.0280982
SENP5 SUMO1/sentrin specific peptidase 5 -0.028098
TPT1 tumor protein, translationally-controlled 1 -0.0278511
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 -0.0278239
SLC38A1 solute carrier family 38, member 1 -0.0276901
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0276527
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.027556
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0273586
SEC31A SEC31 homolog A (S. cerevisiae) -0.0273106
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0272987
LOC112694756 uncharaterized LOC112694756 -0.0272925
RPL14 ribosomal protein L14 -0.0272123
MIB1 mindbomb E3 ubiquitin protein ligase 1 -0.0269625
AFTPH aftiphilin -0.0268073
TAS2R14 taste receptor, type 2, member 14 -0.0267695
FOXP1 forkhead box P1 -0.0266709
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0266341