| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Almonertinib (mesylate) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Almonertinib (mesylate)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.131382 |
| HLA-B | major histocompatibility complex, class I, B | 0.124538 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.124264 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0934256 |
| HMGA2 | high mobility group AT-hook 2 | 0.0902881 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0863315 |
| VEGFA | vascular endothelial growth factor A | 0.0862954 |
| STC1 | stanniocalcin 1 | 0.0831801 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0779783 |
| RPS12 | ribosomal protein S12 | 0.0683491 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0679281 |
| COL6A1 | collagen, type VI, alpha 1 | 0.067351 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0583118 |
| RPL13A | ribosomal protein L13a | 0.0578391 |
| RPL26 | ribosomal protein L26 | 0.0567046 |
| RPL37A | ribosomal protein L37a | 0.0550618 |
| ENO1 | enolase 1, (alpha) | 0.0545491 |
| RPS8 | ribosomal protein S8 | 0.0539863 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0537218 |
| RPL23 | ribosomal protein L23 | 0.0486666 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.04638 |
| RPS3 | ribosomal protein S3 | 0.0450754 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0425431 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.042125 |
| CALR | calreticulin | 0.0409009 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0403816 |
| STC2 | stanniocalcin 2 | 0.0394602 |
| SEPTIN9 | septin 9 | 0.0391166 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0389576 |
| GANAB | glucosidase, alpha; neutral AB | 0.0371008 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0367 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0361501 |
| HLA-A | major histocompatibility complex, class I, A | 0.0353378 |
| TNS1 | tensin 1 | 0.0351332 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0350681 |
| B2M | beta-2-microglobulin | 0.0340921 |
| IGF2 | insulin-like growth factor 2 | 0.0340483 |
| PRELID2 | PRELI domain containing 2 | 0.0338896 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0333659 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0332169 |
| NDRG1 | N-myc downstream regulated 1 | 0.0331211 |
| RPS6 | ribosomal protein S6 | 0.0330772 |
| INHBA | inhibin, beta A | 0.0330597 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0323347 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0323229 |
| FNIP1 | folliculin interacting protein 1 | 0.032036 |
| RPL5 | ribosomal protein L5 | 0.0319336 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0312143 |
| NGLY1 | N-glycanase 1 | 0.031212 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0307979 |
| MMP12 | matrix metallopeptidase 12 | 0.0302387 |
| RPL3 | ribosomal protein L3 | 0.0298618 |
| HDAC9 | histone deacetylase 9 | 0.0295533 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0293159 |
| TMF1 | TATA element modulatory factor 1 | 0.029168 |
| SET | SET nuclear proto-oncogene | 0.0290074 |
| NAV1 | neuron navigator 1 | 0.0288883 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0287634 |
| G0S2 | G0/G1 switch 2 | 0.0286903 |
| FMNL2 | formin-like 2 | 0.0285037 |
| FOSL1 | FOS-like antigen 1 | 0.0284502 |
| PGM3 | phosphoglucomutase 3 | 0.0283187 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0281923 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0281265 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0280914 |
| HMGA1 | high mobility group AT-hook 1 | 0.0280248 |
| LOXL2 | lysyl oxidase-like 2 | 0.0277776 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.027717 |
| RPS17 | ribosomal protein S17 | 0.0276487 |
| MCL1 | myeloid cell leukemia 1 | 0.0276207 |
| FAM219A | family with sequence similarity 219, member A | 0.0275204 |
| RPL6 | ribosomal protein L6 | 0.0267613 |
| MSN | moesin | 0.0264822 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0263058 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0261824 |
| RPL7 | ribosomal protein L7 | 0.0259532 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0255688 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0250983 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.024766 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0247372 |
| FLNA | filamin A, alpha | 0.0245334 |
| RPL36A | ribosomal protein L36a | 0.0242202 |
| MYO10 | myosin X | 0.023986 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.0238835 |
| CDK19 | cyclin-dependent kinase 19 | 0.0237709 |
| RPL36 | ribosomal protein L36 | 0.0236592 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0236156 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.023202 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0231096 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0230384 |
| TMEM165 | transmembrane protein 165 | 0.0229311 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0227277 |
| GOLGA2 | golgin A2 | 0.0226431 |
| KIAA1217 | KIAA1217 | 0.0225492 |
| YEATS2 | YEATS domain containing 2 | 0.0224262 |
| RPL37 | ribosomal protein L37 | 0.0222853 |
| AHCYL1 | adenosylhomocysteinase-like 1 | 0.0222272 |
| RPS29 | ribosomal protein S29 | 0.0221294 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0218811 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0218563 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.223679 |
| VIM | vimentin | -0.140914 |
| FN1 | fibronectin 1 | -0.140215 |
| FTL | ferritin, light polypeptide | -0.139631 |
| COL1A1 | collagen, type I, alpha 1 | -0.103732 |
| EMP1 | epithelial membrane protein 1 | -0.0895013 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0818304 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0778134 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0732924 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0650777 |
| RPLP1 | ribosomal protein, large, P1 | -0.0645496 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0637214 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0624266 |
| TMSB10 | thymosin beta 10 | -0.0617598 |
| CALD1 | caldesmon 1 | -0.0595162 |
| COL1A2 | collagen, type I, alpha 2 | -0.0575783 |
| USP3 | ubiquitin specific peptidase 3 | -0.0552718 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0547702 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0543618 |
| AHNAK | AHNAK nucleoprotein | -0.0535011 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0497616 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0494533 |
| IER3 | immediate early response 3 | -0.0470191 |
| PKM | pyruvate kinase, muscle | -0.0450537 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0450001 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0444552 |
| CAVIN1 | caveolae associated protein 1 | -0.0441198 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0439509 |
| CD44 | CD44 molecule (Indian blood group) | -0.0427149 |
| CCND1 | cyclin D1 | -0.0412214 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0392459 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0389771 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0389287 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0388465 |
| ASPH | aspartate beta-hydroxylase | -0.0386863 |
| HDLBP | high density lipoprotein binding protein | -0.0384664 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.038278 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0376121 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0376114 |
| TFG | TRK-fused gene | -0.0375031 |
| VCL | vinculin | -0.0372766 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0359195 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0354685 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0348479 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0344718 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0341664 |
| SEPTIN11 | septin 11 | -0.0341432 |
| MORF4L2 | mortality factor 4 like 2 | -0.0340903 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0337641 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0332431 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0329765 |
| RNF145 | ring finger protein 145 | -0.0327475 |
| COPA | coatomer protein complex, subunit alpha | -0.0326591 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0316951 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0314993 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0314617 |
| RTN4 | reticulon 4 | -0.0310062 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0309526 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0305485 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0304131 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0303793 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0303145 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0302985 |
| JAK1 | Janus kinase 1 | -0.0302547 |
| TMEM263 | transmembrane protein 263 | -0.0300483 |
| RPLP0 | ribosomal protein, large, P0 | -0.0299795 |
| RRBP1 | ribosome binding protein 1 | -0.0296812 |
| JMJD1C | jumonji domain containing 1C | -0.0293027 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0292476 |
| RPS24 | ribosomal protein S24 | -0.0292359 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.029232 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0288763 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0287633 |
| TNPO1 | transportin 1 | -0.0282589 |
| H1-0 | H1.0 linker histone | -0.0281924 |
| CCDC102B | coiled-coil domain containing 102B | -0.0280223 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0277576 |
| CCDC47 | coiled-coil domain containing 47 | -0.0276913 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0276444 |
| MED13 | mediator complex subunit 13 | -0.0273965 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0273057 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0272936 |
| QKI | QKI, KH domain containing, RNA binding | -0.0272598 |
| ANXA2 | annexin A2 | -0.0271699 |
| MATR3 | matrin 3 | -0.0271675 |
| SMAD3 | SMAD family member 3 | -0.0270589 |
| SEC24D | SEC24 family member D | -0.0270336 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0269247 |
| OSMR | oncostatin M receptor | -0.0265069 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0264479 |
| TAGLN2 | transgelin 2 | -0.0262363 |
| NEK7 | NIMA-related kinase 7 | -0.0262059 |
| ARF1 | ADP-ribosylation factor 1 | -0.0260751 |
| FOXP1 | forkhead box P1 | -0.0259935 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | -0.0258986 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0258565 |
| CDK6 | cyclin-dependent kinase 6 | -0.0254469 |
| SNX6 | sorting nexin 6 | -0.0253594 |
| PHIP | pleckstrin homology domain interacting protein | -0.0253183 |
| PRSS23 | protease, serine, 23 | -0.0252754 |
