| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A piperidine that is 3-methyl-2,4-dioxo-3,4-dihydropyrimidine carrying additional 2-cyanobenzyl and 3-aminopiperidin-1-yl groups at positions 1 and 2 respectively (the R-enantiomer). Used in the form of its benzoate salt for treatment of type 2 diabetes. (Chemical Entities of Biological Interest Ontology, CHEBI_72323) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/11450633 |
| Similar Terms | |
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200 proteins with high or low expression in Alogliptin relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| C7 | complement component 7 | 1.49 |
| SRD5A3 | steroid 5 alpha-reductase 3 | 1.37 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.88 |
| NOP10 | NOP10 ribonucleoprotein | 0.73 |
| NCOR1 | nuclear receptor corepressor 1 | 0.72 |
| CETN1 | centrin, EF-hand protein, 1 | 0.71 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | 0.65 |
| TNNC2 | troponin C type 2 (fast) | 0.62 |
| C8ORF76 | chromosome 8 open reading frame 76 | 0.59 |
| CHCHD4 | coiled-coil-helix-coiled-coil-helix domain containing 4 | 0.57 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.54 |
| TAF4B | TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa | 0.49 |
| PKHD1 | polycystic kidney and hepatic disease 1 (autosomal recessive) | 0.48 |
| ZNF580 | zinc finger protein 580 | 0.47 |
| SNRPC | small nuclear ribonucleoprotein polypeptide C | 0.47 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | 0.46 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 0.46 |
| GMCL2 | germ cell-less 2, spermatogenesis associated | 0.45 |
| HIST1H1T | histone cluster 1, H1t | 0.45 |
| MYO18B | myosin XVIIIB | 0.44 |
| RWDD1 | RWD domain containing 1 | 0.44 |
| DSTYK | dual serine/threonine and tyrosine protein kinase | 0.43 |
| RPLP1 | ribosomal protein, large, P1 | 0.43 |
| ADGRL1 | adhesion G protein-coupled receptor L1 | 0.42 |
| ZNF92 | zinc finger protein 92 | 0.41 |
| SNX13 | sorting nexin 13 | 0.4 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.39 |
| ARHGEF40 | Rho guanine nucleotide exchange factor (GEF) 40 | 0.39 |
| ABCA3 | ATP-binding cassette, sub-family A (ABC1), member 3 | 0.38 |
| NFU1 | NFU1 iron-sulfur cluster scaffold | 0.38 |
| HAUS7 | HAUS augmin-like complex, subunit 7 | 0.38 |
| LMBR1 | limb development membrane protein 1 | 0.38 |
| LSM11 | LSM11, U7 small nuclear RNA associated | 0.38 |
| MAGEA12 | melanoma antigen family A12 | 0.37 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.37 |
| C5ORF34 | chromosome 5 open reading frame 34 | 0.36 |
| ATXN2 | ataxin 2 | 0.35 |
| ANKRD2 | ankyrin repeat domain 2 (stretch responsive muscle) | 0.35 |
| METTL6 | methyltransferase like 6 | 0.35 |
| PRR36 | proline rich 36 | 0.35 |
| GATA2 | GATA binding protein 2 | 0.34 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.34 |
| TRIM9 | tripartite motif containing 9 | 0.34 |
| HGH1 | HGH1 homolog (S. cerevisiae) | 0.33 |
| PCDHGA10 | protocadherin gamma subfamily A, 10 | 0.33 |
| CCDC58 | coiled-coil domain containing 58 | 0.33 |
| DUSP22 | dual specificity phosphatase 22 | 0.33 |
| CCNYL1 | cyclin Y-like 1 | 0.33 |
| IQCB1 | IQ motif containing B1 | 0.33 |
| SET | SET nuclear proto-oncogene | 0.33 |
| DNAAF2 | dynein, axonemal, assembly factor 2 | 0.33 |
| GPN1 | GPN-loop GTPase 1 | 0.32 |
| TIGD5 | tigger transposable element derived 5 | 0.32 |
| LRP12 | low density lipoprotein receptor-related protein 12 | 0.32 |
| ZNF8 | zinc finger protein 8 | 0.32 |
| UBE2A | ubiquitin-conjugating enzyme E2A | 0.31 |
| FLII | flightless I homolog (Drosophila) | 0.31 |
| SELENOW | selenoprotein W | 0.31 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.31 |
| PRIMPOL | primase and polymerase (DNA-directed) | 0.31 |
| RPS21 | ribosomal protein S21 | 0.31 |
| SMIM19 | small integral membrane protein 19 | 0.31 |
| HSF2 | heat shock transcription factor 2 | 0.31 |
| TMSB10 | thymosin beta 10 | 0.31 |
| PER2 | period circadian clock 2 | 0.31 |
| SPPL2A | signal peptide peptidase like 2A | 0.3 |
| SDF2L1 | stromal cell-derived factor 2-like 1 | 0.3 |
| EHF | ets homologous factor | 0.3 |
| SMIM26 | small integral membrane protein 26 | 0.3 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.3 |
| NOP16 | NOP16 nucleolar protein | 0.29 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | 0.29 |
| FGF2 | fibroblast growth factor 2 (basic) | 0.29 |
| TRIM23 | tripartite motif containing 23 | 0.29 |
| CAND2 | cullin-associated and neddylation-dissociated 2 (putative) | 0.29 |
| PLK1 | polo-like kinase 1 | 0.29 |
| FAM192A | family with sequence similarity 192, member A | 0.29 |
| NUP62 | nucleoporin 62kDa | 0.29 |
| NAA50 | N(alpha)-acetyltransferase 50, NatE catalytic subunit | 0.28 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | 0.28 |
| METAP1D | methionyl aminopeptidase type 1D (mitochondrial) | 0.28 |
| LRRC28 | leucine rich repeat containing 28 | 0.28 |
| MAD2L1BP | MAD2L1 binding protein | 0.28 |
| USP22 | ubiquitin specific peptidase 22 | 0.28 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.28 |
| ZNF670 | zinc finger protein 670 | 0.28 |
| NR2C1 | nuclear receptor subfamily 2, group C, member 1 | 0.28 |
| ACSL6 | acyl-CoA synthetase long-chain family member 6 | 0.27 |
| COMMD2 | COMM domain containing 2 | 0.27 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.27 |
| FPGT | fucose-1-phosphate guanylyltransferase | 0.27 |
| PPP1R2 | protein phosphatase 1, regulatory (inhibitor) subunit 2 | 0.27 |
| NDUFAF6 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 | 0.27 |
| ELK4 | ELK4, ETS-domain protein (SRF accessory protein 1) | 0.27 |
| PPT2 | palmitoyl-protein thioesterase 2 | 0.27 |
| MSL2 | male-specific lethal 2 homolog (Drosophila) | 0.27 |
| BAIAP2 | BAI1-associated protein 2 | 0.27 |
| PRDM4 | PR domain containing 4 | 0.27 |
| AHDC1 | AT hook, DNA binding motif, containing 1 | 0.27 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | 0.27 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZFYVE1 | zinc finger, FYVE domain containing 1 | -1.08 |
| DAP | death-associated protein | -0.93 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.71 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | -0.68 |
| NRP1 | neuropilin 1 | -0.62 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | -0.59 |
| ALG12 | ALG12, alpha-1,6-mannosyltransferase | -0.58 |
| WWC3 | WWC family member 3 | -0.57 |
| NNT | nicotinamide nucleotide transhydrogenase | -0.52 |
| ATE1 | arginyltransferase 1 | -0.5 |
| PRDM16 | PR domain containing 16 | -0.5 |
| SOX12 | SRY (sex determining region Y)-box 12 | -0.48 |
| TMEM87B | transmembrane protein 87B | -0.47 |
| GLRX | glutaredoxin (thioltransferase) | -0.46 |
| GLI4 | GLI family zinc finger 4 | -0.45 |
| PLPP6 | phospholipid phosphatase 6 | -0.44 |
| CTSL | cathepsin L | -0.44 |
| ANGPTL4 | angiopoietin-like 4 | -0.42 |
| MADD | MAP-kinase activating death domain | -0.42 |
| SGSH | N-sulfoglucosamine sulfohydrolase | -0.41 |
| TRAF3IP2 | TRAF3 interacting protein 2 | -0.41 |
| PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | -0.41 |
| EPHX4 | epoxide hydrolase 4 | -0.39 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.38 |
| RIBC2 | RIB43A domain with coiled-coils 2 | -0.38 |
| RPL26 | ribosomal protein L26 | -0.38 |
| FURIN | furin (paired basic amino acid cleaving enzyme) | -0.38 |
| ATP2A1 | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 | -0.38 |
| NUDT18 | nudix (nucleoside diphosphate linked moiety X)-type motif 18 | -0.38 |
| C18ORF32 | chromosome 18 open reading frame 32 | -0.37 |
| WRB | tryptophan rich basic protein | -0.37 |
| RNF135 | ring finger protein 135 | -0.37 |
| MIB2 | mindbomb E3 ubiquitin protein ligase 2 | -0.37 |
| NOTCH3 | notch 3 | -0.36 |
| ITGB8 | integrin, beta 8 | -0.36 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | -0.36 |
| PACRGL | PARK2 co-regulated-like | -0.35 |
| SLC66A2 | solute carrier family 66 member 2 | -0.35 |
| LIPH | lipase, member H | -0.35 |
| ATP5PF | ATP synthase peripheral stalk subunit F6 | -0.35 |
| CDC26 | cell division cycle 26 | -0.34 |
| AGAP2 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 | -0.34 |
| TSPAN15 | tetraspanin 15 | -0.34 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | -0.34 |
| TSPAN9 | tetraspanin 9 | -0.34 |
| SLC30A3 | solute carrier family 30 (zinc transporter), member 3 | -0.34 |
| LZTS1 | leucine zipper, putative tumor suppressor 1 | -0.34 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | -0.34 |
| IL17RB | interleukin 17 receptor B | -0.33 |
| HSD11B2 | hydroxysteroid (11-beta) dehydrogenase 2 | -0.33 |
| CLTCL1 | clathrin, heavy chain-like 1 | -0.33 |
| DNAH2 | dynein, axonemal, heavy chain 2 | -0.33 |
| ZNF672 | zinc finger protein 672 | -0.33 |
| TCAIM | T cell activation inhibitor, mitochondrial | -0.32 |
| FAAP24 | FA core complex associated protein 24 | -0.32 |
| STARD3NL | STARD3 N-terminal like | -0.32 |
| SIRT3 | sirtuin 3 | -0.31 |
| USP19 | ubiquitin specific peptidase 19 | -0.31 |
| PTK6 | protein tyrosine kinase 6 | -0.31 |
| ARMC7 | armadillo repeat containing 7 | -0.3 |
| SLC49A4 | solute carrier family 49 member 4 | -0.3 |
| SP100 | SP100 nuclear antigen | -0.3 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.3 |
| PDE5A | phosphodiesterase 5A, cGMP-specific | -0.3 |
| GGPS1 | geranylgeranyl diphosphate synthase 1 | -0.3 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.3 |
| CENPT | centromere protein T | -0.3 |
| SYN2 | synapsin II | -0.3 |
| ARL8A | ADP-ribosylation factor-like 8A | -0.3 |
| TSPYL2 | TSPY-like 2 | -0.3 |
| SPEG | SPEG complex locus | -0.3 |
| FAM102B | family with sequence similarity 102, member B | -0.3 |
| YY1AP1 | YY1 associated protein 1 | -0.29 |
| ZC3H6 | zinc finger CCCH-type containing 6 | -0.29 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | -0.29 |
| ADCY6 | adenylate cyclase 6 | -0.29 |
| TMEM160 | transmembrane protein 160 | -0.29 |
| PLEKHB1 | pleckstrin homology domain containing, family B (evectins) member 1 | -0.29 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.29 |
| LACC1 | laccase (multicopper oxidoreductase) domain containing 1 | -0.29 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.28 |
| CES3 | carboxylesterase 3 | -0.28 |
| USP53 | ubiquitin specific peptidase 53 | -0.28 |
| ESPN | espin | -0.28 |
| SGSM3 | small G protein signaling modulator 3 | -0.28 |
| TMEM242 | transmembrane protein 242 | -0.27 |
| RNF139 | ring finger protein 139 | -0.27 |
| MRC2 | mannose receptor, C type 2 | -0.27 |
| OTC | ornithine carbamoyltransferase | -0.27 |
| TM7SF2 | transmembrane 7 superfamily member 2 | -0.27 |
| TESC | tescalcin | -0.27 |
| KDM6B | lysine (K)-specific demethylase 6B | -0.27 |
| INHBA | inhibin, beta A | -0.27 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.27 |
| AREL1 | apoptosis resistant E3 ubiquitin protein ligase 1 | -0.26 |
| DOLPP1 | dolichyldiphosphatase 1 | -0.26 |
| ATP13A2 | ATPase type 13A2 | -0.26 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.26 |
| CYBA | cytochrome b-245, alpha polypeptide | -0.26 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | -0.26 |
