Alopecia Gene Set

Dataset DISEASES Experimental Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A hypotrichosis that is characterized by a loss of hair from the head or body. (Human Disease Ontology, DOID_987)
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Genes

146 genes associated with the disease Alopecia in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
HDAC9 histone deacetylase 9 2.046
EXOSC10 exosome component 10 2.04
SRM spermidine synthase 2.04
C1ORF127 chromosome 1 open reading frame 127 2.04
MASP2 mannan-binding lectin serine peptidase 2 2.04
TARDBP TAR DNA binding protein 2.04
MAPT microtubule-associated protein tau 2.009
HLA-C major histocompatibility complex, class I, C 2.008
HLA-B major histocompatibility complex, class I, B 2.008
SLC14A2 solute carrier family 14 (urea transporter), member 2 2.003
SETBP1 SET binding protein 1 2.003
HLA-A major histocompatibility complex, class I, A 2.0
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 2.0
RNF39 ring finger protein 39 2.0
EBF1 early B-cell factor 1 1.989
KANSL1 KAT8 regulatory NSL complex subunit 1 1.979
FGF5 fibroblast growth factor 5 1.973
CFAP299 cilia and flagella associated protein 299 1.973
STH saitohin 1.95
PRDM8 PR domain containing 8 1.942
TWIST2 twist family bHLH transcription factor 2 1.941
EIF3E eukaryotic translation initiation factor 3, subunit E 1.914
DUSP22 dual specificity phosphatase 22 1.914
IRF4 interferon regulatory factor 4 1.914
EXOC2 exocyst complex component 2 1.914
SYF2 SYF2 pre-mRNA-splicing factor 1.906
WNT6 wingless-type MMTV integration site family, member 6 1.895
WNT10A wingless-type MMTV integration site family, member 10A 1.895
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 1.895
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit 1.895
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 1.895
FEV FEV (ETS oncogene family) 1.895
TRIM31 tripartite motif containing 31 1.888
OPHN1 oligophrenin 1 1.86
EEF1AKMT2 EEF1A lysine methyltransferase 2 1.853
FAM53B family with sequence similarity 53, member B 1.853
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase 1.853
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 1.836
SSPN sarcospan 1.836
BHLHE41 basic helix-loop-helix family, member e41 1.836
MRPS22 mitochondrial ribosomal protein S22 1.833
SPAST spastin 1.814
DPY30 dpy-30 homolog (C. elegans) 1.814
MEMO1 mediator of cell motility 1 1.814
LRMDA leucine rich melanocyte differentiation associated 1.805
EMC2 ER membrane protein complex subunit 2 1.801
TMEM74 transmembrane protein 74 1.801
MSI2 musashi RNA-binding protein 2 1.796
AKAP1 A kinase (PRKA) anchor protein 1 1.796
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 1.781
RSRP1 arginine/serine-rich protein 1 1.772
GORAB golgin, RAB6-interacting 1.752
PRRX1 paired related homeobox 1 1.752
SUCNR1 succinate receptor 1 1.75
CRYBA2 crystallin, beta A2 1.743
RUNX1 runt-related transcription factor 1 1.739
TBX15 T-box 15 1.735
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial 1.735
RSPO2 R-spondin 2 1.669
LRRC37A leucine rich repeat containing 37A 1.653
LRRC37A2 leucine rich repeat containing 37, member A2 1.653
ARL17B ADP-ribosylation factor-like 17B 1.653
HOXD1 homeobox D1 1.583
EVX2 even-skipped homeobox 2 1.583
HOXD8 homeobox D8 1.583
HOXD9 homeobox D9 1.583
HOXD4 homeobox D4 1.583
HOXD11 homeobox D11 1.583
HOXD3 homeobox D3 1.583
HOXD12 homeobox D12 1.583
HOXD10 homeobox D10 1.583
HOXD13 homeobox D13 1.583
XDH xanthine dehydrogenase 1.512
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 1.512
KLF15 Kruppel-like factor 15 1.491
CFAP100 cilia and flagella associated protein 100 1.487
ZXDC ZXD family zinc finger C 1.487
DMRTA2 DMRT-like family A2 1.482
FAF1 Fas (TNFRSF6) associated factor 1 1.482
EDAR ectodysplasin A receptor 1.476
RANBP2 RAN binding protein 2 1.476
CCDC138 coiled-coil domain containing 138 1.476
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.43
RMDN2 regulator of microtubule dynamics 2 1.43
AR androgen receptor 1.41
CRHR1 corticotropin releasing hormone receptor 1 1.327
SPPL2C signal peptide peptidase like 2C 1.327
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 1.274
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 1.274
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 1.248
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 1.248
NGRN neugrin, neurite outgrowth associated 1.248
CIB1 calcium and integrin binding 1 (calmyrin) 1.248
GDPGP1 GDP-D-glucose phosphorylase 1 1.248
MRTFB myocardin related transcription factor B 1.22
MYOCD myocardin 1.143
MAP2K4 mitogen-activated protein kinase kinase 4 1.143
HOXC6 homeobox C6 1.106
HOXC4 homeobox C4 1.106
HOXC5 homeobox C5 1.106
HOXC9 homeobox C9 1.106
HOXC13 homeobox C13 1.106
HOXC12 homeobox C12 1.106
HOXC10 homeobox C10 1.106
HOXC11 homeobox C11 1.106
HOXC8 homeobox C8 1.106
DKK2 dickkopf WNT signaling pathway inhibitor 2 1.078
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 1.059
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 1.054
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.054
RUNDC3B RUN domain containing 3B 1.054
BMP3 bone morphogenetic protein 3 1.045
FOXL2NB FOXL2 neighbor 0.984
FOXL2 forkhead box L2 0.984
PRR23C proline rich 23C 0.984
PRR23A proline rich 23A 0.984
PRR23B proline rich 23B 0.984
RUNX3 runt-related transcription factor 3 0.983
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.95
PODXL podocalyxin-like 0.95
ALX4 ALX homeobox 4 0.93
CENPW centromere protein W 0.894
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) 0.894
THADA thyroid adenoma associated 0.871
ZXDA zinc finger, X-linked, duplicated A 0.867
KLF8 Kruppel-like factor 8 0.775
RRAGB Ras-related GTP binding B 0.775
FZD10 frizzled class receptor 10 0.732
CCDC91 coiled-coil domain containing 91 0.73
FAR2 fatty acyl CoA reductase 2 0.73
FAM9B family with sequence similarity 9, member B 0.702
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 0.671
FOXD2 forkhead box D2 0.671
FOXE3 forkhead box E3 0.671
PAGE2B P antigen family, member 2B 0.638
ALAS2 5'-aminolevulinate synthase 2 0.638
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 0.638
PAGE2 P antigen family, member 2 (prostate associated) 0.638
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 0.617
ATF1 activating transcription factor 1 0.568
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.568
TMPRSS12 transmembrane (C-terminal) protease, serine 12 0.568
RSPO3 R-spondin 3 0.551
KATNAL1 katanin p60 subunit A-like 1 0.544
CDC5L cell division cycle 5-like 0.519
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.519