| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/2099 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Alosetron relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTPRB | protein tyrosine phosphatase, receptor type, B | 1.36 |
| SULF2 | sulfatase 2 | 1.23 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | 1.17 |
| CCDC57 | coiled-coil domain containing 57 | 1.08 |
| NIN | ninein (GSK3B interacting protein) | 0.85 |
| PGK2 | phosphoglycerate kinase 2 | 0.66 |
| NAV2 | neuron navigator 2 | 0.66 |
| UCHL5 | ubiquitin carboxyl-terminal hydrolase L5 | 0.63 |
| FAM185A | family with sequence similarity 185, member A | 0.6 |
| CELSR2 | cadherin, EGF LAG seven-pass G-type receptor 2 | 0.53 |
| PDE7A | phosphodiesterase 7A | 0.51 |
| MAP3K11 | mitogen-activated protein kinase kinase kinase 11 | 0.51 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | 0.49 |
| FSIP2 | fibrous sheath interacting protein 2 | 0.49 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | 0.49 |
| SLC35B1 | solute carrier family 35, member B1 | 0.47 |
| ZNF444 | zinc finger protein 444 | 0.46 |
| ZSCAN32 | zinc finger and SCAN domain containing 32 | 0.45 |
| SERF2 | small EDRK-rich factor 2 | 0.45 |
| GPATCH2L | G patch domain containing 2-like | 0.43 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 0.42 |
| IER3IP1 | immediate early response 3 interacting protein 1 | 0.41 |
| LMBR1 | limb development membrane protein 1 | 0.41 |
| ZNF226 | zinc finger protein 226 | 0.41 |
| N6AMT1 | N-6 adenine-specific DNA methyltransferase 1 (putative) | 0.39 |
| MYBPC1 | myosin binding protein C, slow type | 0.38 |
| ZNF799 | zinc finger protein 799 | 0.36 |
| TMCO6 | transmembrane and coiled-coil domains 6 | 0.36 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.36 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | 0.35 |
| C19ORF47 | chromosome 19 open reading frame 47 | 0.35 |
| FBXW2 | F-box and WD repeat domain containing 2 | 0.35 |
| SMPD1 | sphingomyelin phosphodiesterase 1, acid lysosomal | 0.34 |
| MIIP | migration and invasion inhibitory protein | 0.34 |
| ZXDB | zinc finger, X-linked, duplicated B | 0.34 |
| SCARA3 | scavenger receptor class A, member 3 | 0.33 |
| CLIC6 | chloride intracellular channel 6 | 0.33 |
| SP140 | SP140 nuclear body protein | 0.32 |
| ZBTB17 | zinc finger and BTB domain containing 17 | 0.32 |
| ORC3 | origin recognition complex, subunit 3 | 0.32 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.32 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | 0.32 |
| ATP8B2 | ATPase, aminophospholipid transporter, class I, type 8B, member 2 | 0.31 |
| MKS1 | Meckel syndrome, type 1 | 0.31 |
| ERCC8 | excision repair cross-complementation group 8 | 0.31 |
| C2CD4C | C2 calcium-dependent domain containing 4C | 0.31 |
| RITA1 | RBPJ interacting and tubulin associated 1 | 0.31 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.31 |
| METAP1D | methionyl aminopeptidase type 1D (mitochondrial) | 0.3 |
| ITFG2 | integrin alpha FG-GAP repeat containing 2 | 0.3 |
| MSRB2 | methionine sulfoxide reductase B2 | 0.3 |
| ANKRD20A4 | ankyrin repeat domain 20 family, member A4 | 0.3 |
| SUPT7L | suppressor of Ty 7 (S. cerevisiae)-like | 0.3 |
| CPEB3 | cytoplasmic polyadenylation element binding protein 3 | 0.3 |
| SLC25A26 | solute carrier family 25 (S-adenosylmethionine carrier), member 26 | 0.29 |
| LGALSL | lectin, galactoside-binding-like | 0.29 |
| RARG | retinoic acid receptor, gamma | 0.29 |
| RTN4R | reticulon 4 receptor | 0.29 |
| HOXA9 | homeobox A9 | 0.29 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | 0.29 |
| TNFAIP1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | 0.28 |
| KAT5 | K(lysine) acetyltransferase 5 | 0.28 |
| DCAF10 | DDB1 and CUL4 associated factor 10 | 0.28 |
| SNX24 | sorting nexin 24 | 0.28 |
| VAV1 | vav 1 guanine nucleotide exchange factor | 0.28 |
| SC5D | sterol-C5-desaturase | 0.28 |
| AAMDC | adipogenesis associated, Mth938 domain containing | 0.27 |
| CEP112 | centrosomal protein 112kDa | 0.27 |
| CBLC | Cbl proto-oncogene C, E3 ubiquitin protein ligase | 0.27 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | 0.27 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.27 |
| CDC26 | cell division cycle 26 | 0.27 |
| GPN3 | GPN-loop GTPase 3 | 0.27 |
| COA3 | cytochrome c oxidase assembly factor 3 | 0.27 |
| SPHK2 | sphingosine kinase 2 | 0.27 |
| VAMP8 | vesicle-associated membrane protein 8 | 0.27 |
| RPL10 | ribosomal protein L10 | 0.26 |
| RPGR | retinitis pigmentosa GTPase regulator | 0.26 |
| EWSR1 | EWS RNA-binding protein 1 | 0.26 |
| PPP1R14B | protein phosphatase 1, regulatory (inhibitor) subunit 14B | 0.26 |
| CNKSR1 | connector enhancer of kinase suppressor of Ras 1 | 0.26 |
| ZNF417 | zinc finger protein 417 | 0.26 |
| HAS3 | hyaluronan synthase 3 | 0.26 |
| NKIRAS2 | NFKB inhibitor interacting Ras-like 2 | 0.26 |
| MVB12B | multivesicular body subunit 12B | 0.25 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.25 |
| ZNF195 | zinc finger protein 195 | 0.25 |
| H3C1 | H3 clustered histone 1 | 0.25 |
| C16ORF70 | chromosome 16 open reading frame 70 | 0.25 |
| HAUS7 | HAUS augmin-like complex, subunit 7 | 0.25 |
| NOL12 | nucleolar protein 12 | 0.25 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | 0.25 |
| NEK2 | NIMA-related kinase 2 | 0.25 |
| FAM104A | family with sequence similarity 104, member A | 0.25 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.25 |
| TRANK1 | tetratricopeptide repeat and ankyrin repeat containing 1 | 0.25 |
| MKRN4P | makorin ring finger protein 4, pseudogene | 0.25 |
| ARL14EPL | ADP-ribosylation factor-like 14 effector protein-like | 0.24 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 0.24 |
| Symbol | Name | Standardized Value |
|---|---|---|
| KLHL23 | kelch-like family member 23 | -2.33 |
| PIP | prolactin-induced protein | -2.21 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -2.08 |
| KPNA5 | karyopherin alpha 5 (importin alpha 6) | -1.76 |
| SBSN | suprabasin | -1.28 |
| NCAM1 | neural cell adhesion molecule 1 | -1.04 |
| ECM1 | extracellular matrix protein 1 | -1.0 |
| LRP12 | low density lipoprotein receptor-related protein 12 | -0.79 |
| MARVELD3 | MARVEL domain containing 3 | -0.79 |
| FAM122A | family with sequence similarity 122A | -0.71 |
| PHLDA3 | pleckstrin homology-like domain, family A, member 3 | -0.7 |
| PTGES | prostaglandin E synthase | -0.6 |
| GPANK1 | G patch domain and ankyrin repeats 1 | -0.59 |
| COL17A1 | collagen, type XVII, alpha 1 | -0.59 |
| CLIC3 | chloride intracellular channel 3 | -0.53 |
| BBS1 | Bardet-Biedl syndrome 1 | -0.52 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.52 |
| CCNQ | cyclin Q | -0.51 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.51 |
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma | -0.5 |
| PLEKHH1 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 | -0.5 |
| CASZ1 | castor zinc finger 1 | -0.5 |
| SPPL3 | signal peptide peptidase like 3 | -0.5 |
| TMEM192 | transmembrane protein 192 | -0.48 |
| PRKCH | protein kinase C, eta | -0.48 |
| CCDC112 | coiled-coil domain containing 112 | -0.48 |
| HAL | histidine ammonia-lyase | -0.47 |
| SESTD1 | SEC14 and spectrin domains 1 | -0.47 |
| TMEM94 | transmembrane protein 94 | -0.47 |
| CLASP2 | cytoplasmic linker associated protein 2 | -0.46 |
| CERK | ceramide kinase | -0.45 |
| RGN | regucalcin | -0.44 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | -0.44 |
| CENPJ | centromere protein J | -0.44 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.44 |
| TMEM64 | transmembrane protein 64 | -0.43 |
| DPY19L2 | dpy-19-like 2 (C. elegans) | -0.43 |
| RABEP2 | rabaptin, RAB GTPase binding effector protein 2 | -0.42 |
| PCGF3 | polycomb group ring finger 3 | -0.41 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.41 |
| ZNF250 | zinc finger protein 250 | -0.4 |
| ZNF446 | zinc finger protein 446 | -0.4 |
| HNF4A | hepatocyte nuclear factor 4, alpha | -0.39 |
| NUDT18 | nudix (nucleoside diphosphate linked moiety X)-type motif 18 | -0.39 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.39 |
| CRYBG2 | crystallin beta-gamma domain containing 2 | -0.39 |
| OPHN1 | oligophrenin 1 | -0.38 |
| COBL | cordon-bleu WH2 repeat protein | -0.38 |
| HAUS1 | HAUS augmin-like complex, subunit 1 | -0.37 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.37 |
| TIMM10B | translocase of inner mitochondrial membrane 10 homolog B (yeast) | -0.37 |
| BMPR1B | bone morphogenetic protein receptor, type IB | -0.36 |
| SERINC3 | serine incorporator 3 | -0.36 |
| ZNF264 | zinc finger protein 264 | -0.36 |
| TRERF1 | transcriptional regulating factor 1 | -0.35 |
| GJB3 | gap junction protein, beta 3, 31kDa | -0.35 |
| GPBP1L1 | GC-rich promoter binding protein 1-like 1 | -0.35 |
| FER1L5 | fer-1-like family member 5 | -0.34 |
| DMWD | dystrophia myotonica, WD repeat containing | -0.34 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | -0.34 |
| ZNF320 | zinc finger protein 320 | -0.34 |
| IFT52 | intraflagellar transport 52 | -0.34 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.34 |
| BSN | bassoon presynaptic cytomatrix protein | -0.34 |
| SEC11C | SEC11 homolog C (S. cerevisiae) | -0.34 |
| ZNF611 | zinc finger protein 611 | -0.33 |
| KPTN | kaptin (actin binding protein) | -0.33 |
| MYH7B | myosin, heavy chain 7B, cardiac muscle, beta | -0.32 |
| SLC43A3 | solute carrier family 43, member 3 | -0.32 |
| ETV6 | ets variant 6 | -0.32 |
| FBXW4 | F-box and WD repeat domain containing 4 | -0.32 |
| RCAN3 | RCAN family member 3 | -0.32 |
| ZNF808 | zinc finger protein 808 | -0.32 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.32 |
| ATE1 | arginyltransferase 1 | -0.31 |
| CYB561 | cytochrome b561 | -0.31 |
| CES2 | carboxylesterase 2 | -0.31 |
| PPM1L | protein phosphatase, Mg2+/Mn2+ dependent, 1L | -0.3 |
| KIAA0100 | KIAA0100 | -0.3 |
| ZNF397 | zinc finger protein 397 | -0.3 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.3 |
| TMEM120B | transmembrane protein 120B | -0.3 |
| MTF1 | metal-regulatory transcription factor 1 | -0.3 |
| ARL6IP6 | ADP-ribosylation factor-like 6 interacting protein 6 | -0.29 |
| TM2D3 | TM2 domain containing 3 | -0.29 |
| ZNF100 | zinc finger protein 100 | -0.29 |
| CENPK | centromere protein K | -0.29 |
| S100A14 | S100 calcium binding protein A14 | -0.29 |
| NR2C1 | nuclear receptor subfamily 2, group C, member 1 | -0.29 |
| SLC26A6 | solute carrier family 26 (anion exchanger), member 6 | -0.29 |
| SPIN2B | spindlin family, member 2B | -0.29 |
| SLC39A4 | solute carrier family 39 (zinc transporter), member 4 | -0.29 |
| ARNTL | aryl hydrocarbon receptor nuclear translocator-like | -0.29 |
| PET100 | PET100 homolog (S. cerevisiae) | -0.29 |
| PRUNE2 | prune homolog 2 (Drosophila) | -0.29 |
| ABCB4 | ATP-binding cassette, sub-family B (MDR/TAP), member 4 | -0.28 |
| EXT1 | exostosin glycosyltransferase 1 | -0.28 |
| PML | promyelocytic leukemia | -0.28 |
| BMT2 | base methyltransferase of 25S rRNA 2 homolog | -0.28 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.28 |
