| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Alpelisib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Alpelisib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.112921 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0941199 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.077978 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0767153 |
| CANX | calnexin | 0.0730255 |
| AHNAK | AHNAK nucleoprotein | 0.0729468 |
| HDAC9 | histone deacetylase 9 | 0.0718857 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0665112 |
| SQSTM1 | sequestosome 1 | 0.0663786 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0660435 |
| ANXA2 | annexin A2 | 0.0587766 |
| DST | dystonin | 0.0582342 |
| LDHA | lactate dehydrogenase A | 0.0520774 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0501964 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0482645 |
| FNDC3B | fibronectin type III domain containing 3B | 0.047331 |
| FLNA | filamin A, alpha | 0.0428225 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0418361 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.04021 |
| FLNB | filamin B, beta | 0.0393417 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.038938 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0388946 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0387567 |
| SEPTIN9 | septin 9 | 0.038245 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0380504 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0370456 |
| CDH13 | cadherin 13 | 0.0369344 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0361853 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0347283 |
| NAV2 | neuron navigator 2 | 0.0344587 |
| CENPF | centromere protein F, 350/400kDa | 0.0336703 |
| TPM4 | tropomyosin 4 | 0.0335881 |
| FSTL1 | follistatin-like 1 | 0.0316231 |
| MYOF | myoferlin | 0.0306169 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0300537 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0298699 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0297826 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0284635 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0281053 |
| DSPP | dentin sialophosphoprotein | 0.0280301 |
| PLEC | plectin | 0.0273095 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | 0.026854 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0267924 |
| CALR | calreticulin | 0.0266183 |
| MB21D2 | Mab-21 domain containing 2 | 0.0265824 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0264183 |
| TPM3 | tropomyosin 3 | 0.0262789 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0262488 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0261599 |
| APP | amyloid beta (A4) precursor protein | 0.0258253 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0256223 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0249718 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0249136 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0241867 |
| RNF213 | ring finger protein 213 | 0.0240785 |
| RUNX1 | runt-related transcription factor 1 | 0.0233892 |
| SMAD3 | SMAD family member 3 | 0.0232165 |
| SP100 | SP100 nuclear antigen | 0.023205 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0227478 |
| ENO1 | enolase 1, (alpha) | 0.0225478 |
| CD44 | CD44 molecule (Indian blood group) | 0.0224489 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0222902 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0222189 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0221587 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0215433 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0213826 |
| EGFR | epidermal growth factor receptor | 0.0213004 |
| FAT1 | FAT atypical cadherin 1 | 0.0211411 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0211017 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0206662 |
| PRELID2 | PRELI domain containing 2 | 0.0206536 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0206443 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.020623 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0206041 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0205662 |
| RND3 | Rho family GTPase 3 | 0.0205432 |
| RPS2 | ribosomal protein S2 | 0.0205296 |
| SMYD3 | SET and MYND domain containing 3 | 0.0204223 |
| SFTPA2 | surfactant protein A2 | 0.0200934 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0198887 |
| NCKAP1 | NCK-associated protein 1 | 0.0194778 |
| VCL | vinculin | 0.0192669 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.019259 |
| ATXN1 | ataxin 1 | 0.019259 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.019171 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0191645 |
| ASPH | aspartate beta-hydroxylase | 0.018625 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0184596 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0184414 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0184279 |
| ADAR | adenosine deaminase, RNA-specific | 0.018319 |
| SET | SET nuclear proto-oncogene | 0.0181613 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0181373 |
| TLE4 | transducin-like enhancer of split 4 | 0.0178354 |
| ERBIN | erbb2 interacting protein | 0.0177302 |
| THBS2 | thrombospondin 2 | 0.0176851 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0176481 |
| FAM107B | family with sequence similarity 107, member B | 0.0176306 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0175944 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0175663 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.288202 |
| TMSB10 | thymosin beta 10 | -0.266547 |
| VIM | vimentin | -0.246626 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.183694 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.134689 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.101974 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0816803 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0708309 |
| LOX | lysyl oxidase | -0.0695822 |
| PLAT | plasminogen activator, tissue | -0.0670334 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.054406 |
| COL1A2 | collagen, type I, alpha 2 | -0.0500042 |
| MT2A | metallothionein 2A | -0.0479249 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0464668 |
| NDRG1 | N-myc downstream regulated 1 | -0.045667 |
| S100A6 | S100 calcium binding protein A6 | -0.0418943 |
| SUCNR1 | succinate receptor 1 | -0.0404604 |
| MT1X | metallothionein 1X | -0.0379468 |
| FBN1 | fibrillin 1 | -0.0375123 |
| PRSS23 | protease, serine, 23 | -0.0367312 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.03314 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0321569 |
| FN1 | fibronectin 1 | -0.0313666 |
| LMNA | lamin A/C | -0.0310239 |
| S100A4 | S100 calcium binding protein A4 | -0.0295981 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0285024 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0281294 |
| HLA-B | major histocompatibility complex, class I, B | -0.0276507 |
| S100A10 | S100 calcium binding protein A10 | -0.0269991 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0261354 |
| TAGLN2 | transgelin 2 | -0.026024 |
| FTL | ferritin, light polypeptide | -0.0250581 |
| FRMD4A | FERM domain containing 4A | -0.0244675 |
| PFN1 | profilin 1 | -0.0236991 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0230129 |
| LOXL2 | lysyl oxidase-like 2 | -0.0225058 |
| MYADM | myeloid-associated differentiation marker | -0.0219042 |
| PODXL | podocalyxin-like | -0.0215099 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0213671 |
| CD99 | CD99 molecule | -0.0207378 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0207289 |
| GNAS | GNAS complex locus | -0.0201355 |
| RPL35A | ribosomal protein L35a | -0.019794 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0196434 |
| JAZF1 | JAZF zinc finger 1 | -0.0194381 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0192105 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0189926 |
| CSTB | cystatin B (stefin B) | -0.0186476 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0186458 |
| SEC61G | Sec61 gamma subunit | -0.0184018 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0183985 |
| RPS19 | ribosomal protein S19 | -0.0175937 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0175657 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0171235 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0163516 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0162375 |
| PRRX1 | paired related homeobox 1 | -0.0162201 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0161414 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0160294 |
| COL1A1 | collagen, type I, alpha 1 | -0.0159004 |
| KRT81 | keratin 81, type II | -0.0157302 |
| BSG | basigin (Ok blood group) | -0.015085 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0150549 |
| CBX3 | chromobox homolog 3 | -0.0145629 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0145154 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0140808 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0140345 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0139396 |
| S100A9 | S100 calcium binding protein A9 | -0.013789 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0137177 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0135815 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0131616 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0130977 |
| IGFBP6 | insulin-like growth factor binding protein 6 | -0.0130678 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0130478 |
| FRMD5 | FERM domain containing 5 | -0.0128917 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.0127566 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.012656 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0125705 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0125134 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0124578 |
| S100A11 | S100 calcium binding protein A11 | -0.0123428 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0121255 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0120398 |
| SRPK2 | SRSF protein kinase 2 | -0.0119902 |
| TMEM165 | transmembrane protein 165 | -0.0119591 |
| CST3 | cystatin C | -0.011915 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0119035 |
| COL5A1 | collagen, type V, alpha 1 | -0.0114973 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0114824 |
| CD151 | CD151 molecule (Raph blood group) | -0.0111959 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0111329 |
| RBM25 | RNA binding motif protein 25 | -0.0109481 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0108975 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0104219 |
| IL7R | interleukin 7 receptor | -0.0103554 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0103231 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0102099 |
| MRC2 | mannose receptor, C type 2 | -0.0102066 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0101437 |
