Alpelisib_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Alpelisib perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Alpelisib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.166131
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.137201
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.132502
NLGN1 neuroligin 1 0.121134
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.104675
BIRC3 baculoviral IAP repeat containing 3 0.100233
YAP1 Yes-associated protein 1 0.096017
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0910552
PCDH7 protocadherin 7 0.0879363
AREG amphiregulin 0.0875916
ASPH aspartate beta-hydroxylase 0.0850863
PDE4D phosphodiesterase 4D, cAMP-specific 0.0783916
RRM2 ribonucleotide reductase M2 0.0781507
ANKRD12 ankyrin repeat domain 12 0.0759807
RAB7A RAB7A, member RAS oncogene family 0.0742154
HMGA2 high mobility group AT-hook 2 0.0723134
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0719896
TMEM41B transmembrane protein 41B 0.0677304
NHSL1 NHS-like 1 0.0673309
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0645759
TMSB10 thymosin beta 10 0.0640372
SMC4 structural maintenance of chromosomes 4 0.0614067
MKI67 marker of proliferation Ki-67 0.0601568
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.056864
MMP12 matrix metallopeptidase 12 0.0559538
SPATS2 spermatogenesis associated, serine-rich 2 0.055715
ADIPOR2 adiponectin receptor 2 0.0542106
TAS2R14 taste receptor, type 2, member 14 0.0532038
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0531938
JMJD1C jumonji domain containing 1C 0.0530479
RASAL2 RAS protein activator like 2 0.0530338
IPO7 importin 7 0.0518613
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0499755
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0489812
DST dystonin 0.048703
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0481131
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0475022
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0474289
USP34 ubiquitin specific peptidase 34 0.0471336
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0462468
EDARADD EDAR-associated death domain 0.0450012
VMP1 vacuole membrane protein 1 0.0445304
EHBP1 EH domain binding protein 1 0.0441985
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0435641
TPM3 tropomyosin 3 0.0418201
WWOX WW domain containing oxidoreductase 0.0416357
CANX calnexin 0.0412724
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0408747
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0400971
MARCHF4 membrane associated ring-CH-type finger 4 0.0390489
CLTC clathrin, heavy chain (Hc) 0.0387296
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0386473
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0376968
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.0369593
PRKCE protein kinase C, epsilon 0.0364047
MACF1 microtubule-actin crosslinking factor 1 0.03625
ZFAND3 zinc finger, AN1-type domain 3 0.0361742
RIMS2 regulating synaptic membrane exocytosis 2 0.0358915
NEGR1 neuronal growth regulator 1 0.0353645
TRIO trio Rho guanine nucleotide exchange factor 0.0343738
MTAP methylthioadenosine phosphorylase 0.0341713
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0337927
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0331186
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0326043
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0325911
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0325097
PTK2 protein tyrosine kinase 2 0.0324546
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0324236
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0323551
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0307237
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0305251
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0303005
RABGAP1L RAB GTPase activating protein 1-like 0.0302663
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.0300612
HSPA8 heat shock 70kDa protein 8 0.0298716
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0297677
CMIP c-Maf inducing protein 0.0294208
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0290195
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0289766
ERBIN erbb2 interacting protein 0.0289255
RTN4 reticulon 4 0.0285718
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0285591
TM4SF1 transmembrane 4 L six family member 1 0.0282549
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0282443
RPL23 ribosomal protein L23 0.0278608
FBXL17 F-box and leucine-rich repeat protein 17 0.0275452
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0271549
HSPH1 heat shock 105kDa/110kDa protein 1 0.0268645
GPHN gephyrin 0.0268198
AFF4 AF4/FMR2 family, member 4 0.0266385
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0265625
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0260218
EXOC4 exocyst complex component 4 0.025827
NCAPD2 non-SMC condensin I complex, subunit D2 0.0257125
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0255943
ZNF638 zinc finger protein 638 0.025569
TPX2 TPX2, microtubule-associated 0.0254405
TUBA1B tubulin, alpha 1b 0.0251514
SMYD3 SET and MYND domain containing 3 0.0250889
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.0249003

decreased expression

Symbol Name Standardized Value
CNRIP1 cannabinoid receptor interacting protein 1 -0.0972817
RPS3 ribosomal protein S3 -0.0734714
RPS8 ribosomal protein S8 -0.0725275
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0692255
RPS6 ribosomal protein S6 -0.0558737
SLC38A2 solute carrier family 38, member 2 -0.0529018
HSPB1 heat shock 27kDa protein 1 -0.051901
RPS2 ribosomal protein S2 -0.0445102
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0431145
RPL26 ribosomal protein L26 -0.0382131
RPL9 ribosomal protein L9 -0.0380349
RPL37A ribosomal protein L37a -0.0376473
RPS13 ribosomal protein S13 -0.0374623
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 -0.0344022
RPS27A ribosomal protein S27a -0.0339342
EEF2 eukaryotic translation elongation factor 2 -0.0336661
RPL12 ribosomal protein L12 -0.0320704
RPS12 ribosomal protein S12 -0.0310177
RPS29 ribosomal protein S29 -0.0306594
RPS23 ribosomal protein S23 -0.0306478
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0293375
RPL13A ribosomal protein L13a -0.029217
RPL8 ribosomal protein L8 -0.0282094
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0275279
RPL38 ribosomal protein L38 -0.0264652
RPL11 ribosomal protein L11 -0.0263558
HMGA1 high mobility group AT-hook 1 -0.0261958
S100A10 S100 calcium binding protein A10 -0.0257424
RPS10 ribosomal protein S10 -0.0251045
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0236337
RPS27 ribosomal protein S27 -0.0230713
EEF1G eukaryotic translation elongation factor 1 gamma -0.0220266
CLDN1 claudin 1 -0.0215178
RPL37 ribosomal protein L37 -0.021351
SYT1 synaptotagmin I -0.0212767
RPS15 ribosomal protein S15 -0.0209785
CDK6 cyclin-dependent kinase 6 -0.0205373
RPL7 ribosomal protein L7 -0.0203852
RPS5 ribosomal protein S5 -0.0197491
ANXA1 annexin A1 -0.0195607
RPL36 ribosomal protein L36 -0.0189316
IPMK inositol polyphosphate multikinase -0.0186009
NACA nascent polypeptide-associated complex alpha subunit -0.0185979
KMT2C lysine (K)-specific methyltransferase 2C -0.0185037
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0180249
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0178585
CXADR coxsackie virus and adenovirus receptor -0.0177336
ARHGAP12 Rho GTPase activating protein 12 -0.0176813
RACK1 receptor for activated C kinase 1 -0.0176005
RPS20 ribosomal protein S20 -0.0174311
TPT1 tumor protein, translationally-controlled 1 -0.0170027
RPL28 ribosomal protein L28 -0.0168948
CPOX coproporphyrinogen oxidase -0.0166909
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0166291
PRKCI protein kinase C, iota -0.0165439
FTH1 ferritin, heavy polypeptide 1 -0.0162597
TPI1 triosephosphate isomerase 1 -0.016205
PDCD5 programmed cell death 5 -0.0161847
HLA-B major histocompatibility complex, class I, B -0.0159366
S100A6 S100 calcium binding protein A6 -0.0157537
RPL5 ribosomal protein L5 -0.0154582
TM7SF3 transmembrane 7 superfamily member 3 -0.0152704
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0151511
RPLP0 ribosomal protein, large, P0 -0.0151384
RPL10A ribosomal protein L10a -0.0151318
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0150697
VAT1 vesicle amine transport 1 -0.0149988
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.014973
GPR15 G protein-coupled receptor 15 -0.0149271
PFN1 profilin 1 -0.0148704
FAM177A1 family with sequence similarity 177, member A1 -0.0146545
ATP5F1B ATP synthase F1 subunit beta -0.0144532
LARS1 leucyl-tRNA synthetase 1 -0.0144124
RPS11 ribosomal protein S11 -0.0141731
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0141369
RPS17 ribosomal protein S17 -0.0141235
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0140542
RPL30 ribosomal protein L30 -0.0140426
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 -0.0140325
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0140218
PDK4 pyruvate dehydrogenase kinase, isozyme 4 -0.0138879
CCNG1 cyclin G1 -0.013605
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0135623
ACBD6 acyl-CoA binding domain containing 6 -0.0133983
FSTL5 follistatin-like 5 -0.0133149
RPL15 ribosomal protein L15 -0.0131699
WDR43 WD repeat domain 43 -0.012873
SRRM2 serine/arginine repetitive matrix 2 -0.0127805
GGNBP2 gametogenetin binding protein 2 -0.0127711
AKAP9 A kinase (PRKA) anchor protein 9 -0.0127465
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0127079
LDHB lactate dehydrogenase B -0.0126917
LOC102724023 ES1 protein homolog, mitochondrial -0.0126005
GNAS GNAS complex locus -0.0125944
UGCG UDP-glucose ceramide glucosyltransferase -0.0125902
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0124509
LARP1 La ribonucleoprotein domain family, member 1 -0.0124472
RPS25 ribosomal protein S25 -0.0124261
RPL31 ribosomal protein L31 -0.0124177
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0123986