| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Alpelisib perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Alpelisib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TLE4 | transducin-like enhancer of split 4 | 0.121893 |
| VCL | vinculin | 0.105808 |
| FMN1 | formin 1 | 0.0751017 |
| MEIS2 | Meis homeobox 2 | 0.071954 |
| LSAMP | limbic system-associated membrane protein | 0.0629331 |
| RNF213 | ring finger protein 213 | 0.0617683 |
| PLPP1 | phospholipid phosphatase 1 | 0.0616102 |
| SYT1 | synaptotagmin I | 0.0609717 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0573072 |
| TPST1 | tyrosylprotein sulfotransferase 1 | 0.0510448 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0510009 |
| DST | dystonin | 0.0506629 |
| NCAM2 | neural cell adhesion molecule 2 | 0.0498266 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0497079 |
| BPTF | bromodomain PHD finger transcription factor | 0.0494538 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.048543 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0462668 |
| THBS1 | thrombospondin 1 | 0.045122 |
| RIGI | RNA sensor RIG-I | 0.0449628 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0431531 |
| INTS6 | integrator complex subunit 6 | 0.0397023 |
| PRKCA | protein kinase C, alpha | 0.0392564 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0391727 |
| SLITRK6 | SLIT and NTRK-like family, member 6 | 0.0383803 |
| LPIN1 | lipin 1 | 0.038026 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0378527 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0374133 |
| AUTS2 | autism susceptibility candidate 2 | 0.0368879 |
| ITGA1 | integrin, alpha 1 | 0.0367148 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | 0.0357041 |
| VMP1 | vacuole membrane protein 1 | 0.0349848 |
| MYO6 | myosin VI | 0.0342077 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0340058 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0336675 |
| SEPTIN9 | septin 9 | 0.0331615 |
| AOPEP | aminopeptidase O (putative) | 0.0321131 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0316918 |
| TPM1 | tropomyosin 1 (alpha) | 0.0315227 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0309027 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0299197 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0297323 |
| RUNX1T1 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | 0.0293864 |
| GLCCI1 | glucocorticoid induced 1 | 0.0285832 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0281577 |
| AHNAK | AHNAK nucleoprotein | 0.0278148 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0277168 |
| AEBP2 | AE binding protein 2 | 0.0276922 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0276533 |
| RALYL | RALY RNA binding protein-like | 0.0274285 |
| ATXN1 | ataxin 1 | 0.0273926 |
| SYNPO2 | synaptopodin 2 | 0.0273403 |
| FERMT2 | fermitin family member 2 | 0.0271734 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0271561 |
| FAM107B | family with sequence similarity 107, member B | 0.0267779 |
| MRTFA | myocardin related transcription factor A | 0.0267482 |
| GLI3 | GLI family zinc finger 3 | 0.0266499 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.0263689 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0262235 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0260781 |
| PDE10A | phosphodiesterase 10A | 0.0257595 |
| HOMER1 | homer scaffolding protein 1 | 0.0255458 |
| EXOC4 | exocyst complex component 4 | 0.0254038 |
| UNC5C | unc-5 homolog C (C. elegans) | 0.0249119 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0244226 |
| APP | amyloid beta (A4) precursor protein | 0.0243903 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | 0.0242385 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0238166 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | 0.0234253 |
| TRIB2 | tribbles pseudokinase 2 | 0.0229075 |
| FOXP1 | forkhead box P1 | 0.0228837 |
| DKK2 | dickkopf WNT signaling pathway inhibitor 2 | 0.0228672 |
| STK38L | serine/threonine kinase 38 like | 0.0228262 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0227003 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0225659 |
| SPAG9 | sperm associated antigen 9 | 0.0221392 |
| PCBP2 | poly(rC) binding protein 2 | 0.0221354 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0219132 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0218903 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0216462 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0214463 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0212709 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0212447 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0210435 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.021022 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0209642 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0209482 |
| GRK5 | G protein-coupled receptor kinase 5 | 0.0208017 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0205303 |
| MBTD1 | mbt domain containing 1 | 0.0203947 |
| MYO1E | myosin IE | 0.0203277 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0202619 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0202421 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0200441 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0199759 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0199428 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0198075 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0197996 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0197005 |
| HMBOX1 | homeobox containing 1 | 0.0195674 |
| PMP22 | peripheral myelin protein 22 | 0.0195623 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.46964 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -0.141892 |
| VIM | vimentin | -0.0812896 |
| COL1A1 | collagen, type I, alpha 1 | -0.0720781 |
| PTMA | prothymosin, alpha | -0.0675154 |
| RPL35A | ribosomal protein L35a | -0.0611169 |
| TMSB10 | thymosin beta 10 | -0.0548789 |
| RPL23 | ribosomal protein L23 | -0.0440991 |
| RPS6 | ribosomal protein S6 | -0.0429839 |
| ACTG1 | actin gamma 1 | -0.0423917 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0421149 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0417854 |
| RPS19 | ribosomal protein S19 | -0.0400169 |
| RPS3 | ribosomal protein S3 | -0.0387365 |
| RPL31 | ribosomal protein L31 | -0.0343958 |
| FTL | ferritin, light polypeptide | -0.0335528 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0314642 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0314095 |
| RPL37A | ribosomal protein L37a | -0.0307115 |
| RPL34 | ribosomal protein L34 | -0.0304696 |
| NRG1 | neuregulin 1 | -0.0298193 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0296697 |
| RPL7A | ribosomal protein L7a | -0.0292027 |
| HIP1 | huntingtin interacting protein 1 | -0.0290248 |
| HMGA2 | high mobility group AT-hook 2 | -0.0287118 |
| RPL32 | ribosomal protein L32 | -0.028387 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0276938 |
| IER3 | immediate early response 3 | -0.0275362 |
| RPS14 | ribosomal protein S14 | -0.0274448 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | -0.0274119 |
| RPS24 | ribosomal protein S24 | -0.0267227 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0266511 |
| CBX3 | chromobox homolog 3 | -0.026436 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.0262481 |
| RPS17 | ribosomal protein S17 | -0.0261787 |
| RPS23 | ribosomal protein S23 | -0.0255524 |
| CDH13 | cadherin 13 | -0.025369 |
| SCG2 | secretogranin II | -0.0246848 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.024411 |
| RPLP1 | ribosomal protein, large, P1 | -0.0242707 |
| GPC6 | glypican 6 | -0.0241677 |
| RPS5 | ribosomal protein S5 | -0.0241024 |
| S100A6 | S100 calcium binding protein A6 | -0.0230763 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.0229955 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0224571 |
| RPL38 | ribosomal protein L38 | -0.0219633 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0217447 |
| RPS29 | ribosomal protein S29 | -0.0216279 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0215475 |
| NDRG1 | N-myc downstream regulated 1 | -0.021349 |
| CRH | corticotropin releasing hormone | -0.0210093 |
| COL18A1 | collagen, type XVIII, alpha 1 | -0.0203588 |
| DTNA | dystrobrevin, alpha | -0.0203263 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0202136 |
| RPS12 | ribosomal protein S12 | -0.0201392 |
| POTEF | POTE ankyrin domain family, member F | -0.0200671 |
| GOLGA4 | golgin A4 | -0.0197301 |
| RPS27A | ribosomal protein S27a | -0.0195814 |
| RPLP2 | ribosomal protein, large, P2 | -0.0190928 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0190506 |
| PFN1 | profilin 1 | -0.0190399 |
| RPL5 | ribosomal protein L5 | -0.0188305 |
| MEF2A | myocyte enhancer factor 2A | -0.0188252 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.018635 |
| RPS25 | ribosomal protein S25 | -0.0185982 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0184408 |
| RPS21 | ribosomal protein S21 | -0.0181557 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0179103 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0178332 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0178138 |
| CCND1 | cyclin D1 | -0.0175803 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0174417 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0174046 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0171866 |
| PKM | pyruvate kinase, muscle | -0.0171432 |
| RPS16 | ribosomal protein S16 | -0.0171174 |
| CA12 | carbonic anhydrase XII | -0.0169521 |
| DSTN | destrin (actin depolymerizing factor) | -0.0169473 |
| RPL26 | ribosomal protein L26 | -0.0169354 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0169045 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0168927 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0167708 |
| RPS15 | ribosomal protein S15 | -0.0167559 |
| NREP | neuronal regeneration related protein | -0.0166548 |
| RPL10A | ribosomal protein L10a | -0.016501 |
| XPR1 | xenotropic and polytropic retrovirus receptor 1 | -0.016422 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0161829 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0160179 |
| RPS10 | ribosomal protein S10 | -0.0160068 |
| RPL36A | ribosomal protein L36a | -0.0159462 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0158321 |
| RAI14 | retinoic acid induced 14 | -0.0157764 |
| WDR45B | WD repeat domain 45B | -0.0157082 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0154386 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0153753 |
| RPLP0 | ribosomal protein, large, P0 | -0.0152502 |
| RHOA | ras homolog family member A | -0.015246 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0152437 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0152043 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0151736 |
