Alpelisib_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Alpelisib perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Alpelisib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.380742
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.10712
FNDC3B fibronectin type III domain containing 3B 0.0838253
EXT1 exostosin glycosyltransferase 1 0.0738168
CANX calnexin 0.0657728
CDH13 cadherin 13 0.0653647
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0607678
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0603081
COL6A3 collagen, type VI, alpha 3 0.0559417
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0502443
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0466398
PLEC plectin 0.0461892
TRIO trio Rho guanine nucleotide exchange factor 0.0439423
MYH9 myosin, heavy chain 9, non-muscle 0.0436469
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0429037
CALR calreticulin 0.0421888
CXCL8 chemokine (C-X-C motif) ligand 8 0.0418048
ZBTB38 zinc finger and BTB domain containing 38 0.0408856
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0401158
P4HB prolyl 4-hydroxylase, beta polypeptide 0.039555
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.037151
WWTR1 WW domain containing transcription regulator 1 0.0365153
PTK2 protein tyrosine kinase 2 0.036454
SOD2 superoxide dismutase 2, mitochondrial 0.03582
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0354171
FAM107B family with sequence similarity 107, member B 0.0338907
FAT1 FAT atypical cadherin 1 0.0330344
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0309846
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0308226
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0304617
POSTN periostin, osteoblast specific factor 0.0300778
IL6ST interleukin 6 signal transducer 0.0298879
ECE1 endothelin converting enzyme 1 0.0298466
HSPA8 heat shock 70kDa protein 8 0.0287089
SMAD3 SMAD family member 3 0.0284994
NAV2 neuron navigator 2 0.0280282
MYO10 myosin X 0.0278473
RIGI RNA sensor RIG-I 0.0278138
ZSWIM6 zinc finger, SWIM-type containing 6 0.0276338
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0273648
MACF1 microtubule-actin crosslinking factor 1 0.027326
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.027017
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0266597
APP amyloid beta (A4) precursor protein 0.0263908
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.026339
SQSTM1 sequestosome 1 0.0262778
MLF1 myeloid leukemia factor 1 0.0262045
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0258444
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0250242
GOLGB1 golgin B1 0.0244573
SHB Src homology 2 domain containing adaptor protein B 0.0242042
CD44 CD44 molecule (Indian blood group) 0.0239352
VEGFA vascular endothelial growth factor A 0.0238703
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.023568
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0235295
RND3 Rho family GTPase 3 0.0230783
CLIC4 chloride intracellular channel 4 0.0226673
EGFR epidermal growth factor receptor 0.022416
STC1 stanniocalcin 1 0.0223824
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.022344
ICAM1 intercellular adhesion molecule 1 0.022065
NFE2L1 nuclear factor, erythroid 2-like 1 0.021609
VMP1 vacuole membrane protein 1 0.0213304
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0212897
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0211261
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0211247
ATXN1 ataxin 1 0.0210353
CALU calumenin 0.0208227
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0207224
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0205442
SEPTIN9 septin 9 0.0204427
IQGAP1 IQ motif containing GTPase activating protein 1 0.0198961
HDAC9 histone deacetylase 9 0.0198093
ALCAM activated leukocyte cell adhesion molecule 0.0196795
GRB10 growth factor receptor-bound protein 10 0.0192817
YEATS2 YEATS domain containing 2 0.019208
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0191151
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0190366
AHNAK AHNAK nucleoprotein 0.0187594
LDHA lactate dehydrogenase A 0.0185885
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.018449
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0183125
ASPH aspartate beta-hydroxylase 0.0182771
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0181235
AGO2 argonaute RISC catalytic component 2 0.0180998
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0179673
JAG1 jagged 1 0.0177192
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0175953
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0175204
SP100 SP100 nuclear antigen 0.0173162
KIAA1217 KIAA1217 0.0172952
ARRDC3 arrestin domain containing 3 0.0172262
ANXA2 annexin A2 0.0171034
APLP2 amyloid beta (A4) precursor-like protein 2 0.0170209
SVIL supervillin 0.0169126
BRD2 bromodomain containing 2 0.0168893
FTH1 ferritin, heavy polypeptide 1 0.0168601
CLTC clathrin, heavy chain (Hc) 0.0168489
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.016848
SDCBP syndecan binding protein (syntenin) 0.0167716

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.22462
NDRG1 N-myc downstream regulated 1 -0.223859
COL1A1 collagen, type I, alpha 1 -0.210636
VIM vimentin -0.18857
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.145757
TMSB10 thymosin beta 10 -0.139966
IGFBP3 insulin-like growth factor binding protein 3 -0.0996874
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0876028
COL1A2 collagen, type I, alpha 2 -0.0866748
FTL ferritin, light polypeptide -0.0749882
MT2A metallothionein 2A -0.0723516
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0649942
RPL35A ribosomal protein L35a -0.0643928
TGFBI transforming growth factor, beta-induced, 68kDa -0.057625
PSD3 pleckstrin and Sec7 domain containing 3 -0.0500317
IER3 immediate early response 3 -0.0483701
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0483371
ACTG1 actin gamma 1 -0.0425818
HLA-B major histocompatibility complex, class I, B -0.0389485
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0382262
TPT1 tumor protein, translationally-controlled 1 -0.0371696
F3 coagulation factor III (thromboplastin, tissue factor) -0.0358466
CALD1 caldesmon 1 -0.0354058
S100A9 S100 calcium binding protein A9 -0.0343412
EIF1 eukaryotic translation initiation factor 1 -0.0335695
S100A6 S100 calcium binding protein A6 -0.032994
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0324556
RPS6 ribosomal protein S6 -0.0316905
PTMA prothymosin, alpha -0.0309737
RPL28 ribosomal protein L28 -0.0306208
S100A10 S100 calcium binding protein A10 -0.0300992
GARS1 glycyl-tRNA synthetase 1 -0.029379
LOX lysyl oxidase -0.029228
RPS8 ribosomal protein S8 -0.0284569
CADM1 cell adhesion molecule 1 -0.0270737
MT1X metallothionein 1X -0.0270557
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0266132
IFI6 interferon, alpha-inducible protein 6 -0.0254345
CAVIN1 caveolae associated protein 1 -0.0254058
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0235279
RPL37A ribosomal protein L37a -0.0232806
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0231522
ABI3BP ABI family, member 3 (NESH) binding protein -0.0230333
HLA-A major histocompatibility complex, class I, A -0.0229125
RPL11 ribosomal protein L11 -0.0228458
GNAS GNAS complex locus -0.0221575
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0219017
RPS11 ribosomal protein S11 -0.0218689
ENO2 enolase 2 (gamma, neuronal) -0.0217266
RPS24 ribosomal protein S24 -0.0215959
RPS12 ribosomal protein S12 -0.0215048
RPL36 ribosomal protein L36 -0.0213189
RPS27A ribosomal protein S27a -0.0211582
PFN1 profilin 1 -0.0211082
RPS19 ribosomal protein S19 -0.0209892
FAM162A family with sequence similarity 162, member A -0.0209674
RPS13 ribosomal protein S13 -0.0204471
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0201651
RPL31 ribosomal protein L31 -0.0199797
RPLP1 ribosomal protein, large, P1 -0.0198034
SRSF11 serine/arginine-rich splicing factor 11 -0.0196034
RTN4 reticulon 4 -0.0193639
RPLP2 ribosomal protein, large, P2 -0.0191935
LAMB3 laminin, beta 3 -0.0185932
CYB5R3 cytochrome b5 reductase 3 -0.0185614
IFITM3 interferon induced transmembrane protein 3 -0.0185108
LMNA lamin A/C -0.0184822
RPL32 ribosomal protein L32 -0.018402
RPS21 ribosomal protein S21 -0.018353
RPS3 ribosomal protein S3 -0.0181858
TPM4 tropomyosin 4 -0.0174111
RPS14 ribosomal protein S14 -0.0173755
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0172994
RPL8 ribosomal protein L8 -0.0172738
NPEPPS aminopeptidase puromycin sensitive -0.0169687
ATP13A3 ATPase type 13A3 -0.0169194
VDAC1 voltage-dependent anion channel 1 -0.0166776
ATF4 activating transcription factor 4 -0.0166611
RPL37 ribosomal protein L37 -0.0165332
RPS16 ribosomal protein S16 -0.0164966
RPS25 ribosomal protein S25 -0.016191
ZMYND8 zinc finger, MYND-type containing 8 -0.0160679
RPS29 ribosomal protein S29 -0.0159349
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0158738
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.01561
RPS23 ribosomal protein S23 -0.0155536
RPL19 ribosomal protein L19 -0.0153799
RACK1 receptor for activated C kinase 1 -0.0150419
TMEM165 transmembrane protein 165 -0.0150023
POTEF POTE ankyrin domain family, member F -0.0147194
RPL9 ribosomal protein L9 -0.0146418
INHBA inhibin, beta A -0.0146154
RPL26 ribosomal protein L26 -0.0144938
ARL4C ADP-ribosylation factor-like 4C -0.0142883
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0141289
RPS20 ribosomal protein S20 -0.0140598
RPL34 ribosomal protein L34 -0.0139867
OXR1 oxidation resistance 1 -0.0136634
SLC38A2 solute carrier family 38, member 2 -0.013557
PGK1 phosphoglycerate kinase 1 -0.013555