| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Alpelisib perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Alpelisib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.255061 |
| DSPP | dentin sialophosphoprotein | 0.186444 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.157443 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.155664 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.143429 |
| SVIL | supervillin | 0.114905 |
| ENO1 | enolase 1, (alpha) | 0.104577 |
| GPC6 | glypican 6 | 0.0989741 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.098945 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0971284 |
| FAM107B | family with sequence similarity 107, member B | 0.0969285 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0954719 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.091961 |
| PDLIM5 | PDZ and LIM domain 5 | 0.086748 |
| FAT1 | FAT atypical cadherin 1 | 0.0847916 |
| PEG3 | paternally expressed 3 | 0.0842108 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0811868 |
| TF | transferrin | 0.0803168 |
| SLC38A2 | solute carrier family 38, member 2 | 0.079706 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0766845 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0765865 |
| FOXP1 | forkhead box P1 | 0.0745692 |
| DST | dystonin | 0.0735998 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0731593 |
| ATXN1 | ataxin 1 | 0.0716458 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0679119 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0646507 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.06444 |
| ITGAV | integrin, alpha V | 0.0641623 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0633242 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.063091 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0627642 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0617227 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0605772 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0556476 |
| C3 | complement component 3 | 0.0554245 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0550912 |
| VCL | vinculin | 0.053034 |
| EHBP1 | EH domain binding protein 1 | 0.0520675 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0515714 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.048903 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0482162 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0479762 |
| CANX | calnexin | 0.0467627 |
| KYNU | kynureninase | 0.0465037 |
| CTSB | cathepsin B | 0.046484 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0457492 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0457358 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0456608 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0448893 |
| SMAD3 | SMAD family member 3 | 0.0443209 |
| DNAH17 | dynein, axonemal, heavy chain 17 | 0.044047 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0422577 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0416491 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0416217 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.041598 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.0413086 |
| TPM4 | tropomyosin 4 | 0.0411834 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0411748 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0408652 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0407576 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0397637 |
| GK | glycerol kinase | 0.0389303 |
| SEPTIN9 | septin 9 | 0.0386859 |
| TNS3 | tensin 3 | 0.037568 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0374833 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.036795 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0365407 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0360488 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | 0.0359369 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0357946 |
| TNS1 | tensin 1 | 0.0354064 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0349917 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.034975 |
| CRY1 | cryptochrome circadian clock 1 | 0.0340351 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0339141 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0335335 |
| KIAA1217 | KIAA1217 | 0.032953 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0328204 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0327097 |
| ENAH | enabled homolog (Drosophila) | 0.0326858 |
| DSTN | destrin (actin depolymerizing factor) | 0.0323321 |
| ASPH | aspartate beta-hydroxylase | 0.0318378 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0310415 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0310077 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0309772 |
| PCBP2 | poly(rC) binding protein 2 | 0.030579 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0304752 |
| RASA2 | RAS p21 protein activator 2 | 0.0303566 |
| CMIP | c-Maf inducing protein | 0.0303107 |
| JMJD1C | jumonji domain containing 1C | 0.0301102 |
| BPTF | bromodomain PHD finger transcription factor | 0.0298523 |
| AFDN | afadin, adherens junction formation factor | 0.0298289 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0296249 |
| FRMD5 | FERM domain containing 5 | 0.02962 |
| AHR | aryl hydrocarbon receptor | 0.0295674 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.0295509 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0294437 |
| RPS8 | ribosomal protein S8 | 0.0294236 |
| TPM1 | tropomyosin 1 (alpha) | 0.0291406 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.388145 |
| MT2A | metallothionein 2A | -0.0875942 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0651214 |
| RPL35A | ribosomal protein L35a | -0.0471804 |
| FTL | ferritin, light polypeptide | -0.0471132 |
| TMSB10 | thymosin beta 10 | -0.042447 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0411011 |
| RPS19 | ribosomal protein S19 | -0.0402555 |
| GPC3 | glypican 3 | -0.0376726 |
| APOA2 | apolipoprotein A-II | -0.0299176 |
| RPS24 | ribosomal protein S24 | -0.0294462 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0287542 |
| TRIM26 | tripartite motif containing 26 | -0.0284372 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0266668 |
| APOE | apolipoprotein E | -0.0256527 |
| RBM25 | RNA binding motif protein 25 | -0.0250531 |
| GNAS | GNAS complex locus | -0.0239444 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0238322 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0221225 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0205054 |
| MT1X | metallothionein 1X | -0.0193834 |
| NPR2 | natriuretic peptide receptor 2 | -0.0174426 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0170251 |
| NDRG1 | N-myc downstream regulated 1 | -0.0165334 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0164552 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0163287 |
| RPLP1 | ribosomal protein, large, P1 | -0.0159981 |
| ZNF292 | zinc finger protein 292 | -0.0153664 |
| RPL4 | ribosomal protein L4 | -0.0153308 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0148604 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.014199 |
| CST3 | cystatin C | -0.0141946 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0135821 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0133654 |
| RPL31 | ribosomal protein L31 | -0.0131873 |
| TFRC | transferrin receptor | -0.0129989 |
| CRLS1 | cardiolipin synthase 1 | -0.0128962 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0127754 |
| RPL32 | ribosomal protein L32 | -0.0123762 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0122416 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0121714 |
| WDR45B | WD repeat domain 45B | -0.0121117 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0120938 |
| CEP95 | centrosomal protein 95kDa | -0.011943 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0118403 |
| RPL28 | ribosomal protein L28 | -0.0117981 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0117941 |
| CCNL1 | cyclin L1 | -0.0116681 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0115925 |
| LYZ | lysozyme | -0.0114735 |
| APOH | apolipoprotein H (beta-2-glycoprotein I) | -0.0113332 |
| TUT4 | terminal uridylyl transferase 4 | -0.0112539 |
| SDC4 | syndecan 4 | -0.0111849 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.010947 |
| RPL36A | ribosomal protein L36a | -0.010896 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0107338 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | -0.0105859 |
| DDX18 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 | -0.0104209 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -0.0102344 |
| ZNF518A | zinc finger protein 518A | -0.0101591 |
| UBB | ubiquitin B | -0.00987176 |
| NEK7 | NIMA-related kinase 7 | -0.00978178 |
| RPLP2 | ribosomal protein, large, P2 | -0.0097809 |
| AGXT | alanine-glyoxylate aminotransferase | -0.00973913 |
| MALT1 | MALT1 paracaspase | -0.00971836 |
| RPS4X | ribosomal protein S4, X-linked | -0.00955177 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | -0.00955092 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.00941738 |
| ICAM1 | intercellular adhesion molecule 1 | -0.00940388 |
| RPL38 | ribosomal protein L38 | -0.0093657 |
| GDF15 | growth differentiation factor 15 | -0.00931821 |
| MBNL3 | muscleblind-like splicing regulator 3 | -0.00927865 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.00927504 |
| IER3 | immediate early response 3 | -0.00925648 |
| RNF145 | ring finger protein 145 | -0.00924773 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.00921271 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.00897384 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.00884822 |
| RPS5 | ribosomal protein S5 | -0.00873281 |
| TCEA2 | transcription elongation factor A (SII), 2 | -0.00870001 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.00867383 |
| RPL34 | ribosomal protein L34 | -0.00866592 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.00866119 |
| PDS5B | PDS5 cohesin associated factor B | -0.00864816 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.00863828 |
| LCN2 | lipocalin 2 | -0.00852017 |
| RPL22 | ribosomal protein L22 | -0.00846216 |
| CNOT6L | CCR4-NOT transcription complex, subunit 6-like | -0.00845033 |
| MKI67 | marker of proliferation Ki-67 | -0.00836231 |
| LLGL2 | lethal giant larvae homolog 2 (Drosophila) | -0.00834044 |
| METTL9 | methyltransferase like 9 | -0.00833052 |
| FOXK2 | forkhead box K2 | -0.00828773 |
| ANGPTL8 | angiopoietin like 8 | -0.00823693 |
| LMBRD1 | LMBR1 domain containing 1 | -0.0082357 |
| LAPTM4B | lysosomal protein transmembrane 4 beta | -0.00812566 |
| BPIFB2 | BPI fold containing family B, member 2 | -0.00805901 |
| CRLF1 | cytokine receptor-like factor 1 | -0.00802571 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.00789147 |
| ARF1 | ADP-ribosylation factor 1 | -0.00786536 |
| TMEM51 | transmembrane protein 51 | -0.00781206 |
