| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Alpelisib perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Alpelisib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYOF | myoferlin | 0.127014 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.11626 |
| LMO7 | LIM domain 7 | 0.110326 |
| CD44 | CD44 molecule (Indian blood group) | 0.108315 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0912783 |
| FOXP1 | forkhead box P1 | 0.0891088 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0881847 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0845931 |
| STC1 | stanniocalcin 1 | 0.0801708 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0797269 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0749458 |
| ITGA6 | integrin, alpha 6 | 0.0722646 |
| TGM2 | transglutaminase 2 | 0.0711612 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0703783 |
| PTK2 | protein tyrosine kinase 2 | 0.0658696 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.065005 |
| EXT1 | exostosin glycosyltransferase 1 | 0.063146 |
| MEF2A | myocyte enhancer factor 2A | 0.0622561 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0619738 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0604444 |
| B2M | beta-2-microglobulin | 0.0602806 |
| EMP1 | epithelial membrane protein 1 | 0.0600454 |
| ENO1 | enolase 1, (alpha) | 0.0597849 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0586435 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0577408 |
| ANXA1 | annexin A1 | 0.0576015 |
| CANX | calnexin | 0.0575525 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0568538 |
| ANXA2 | annexin A2 | 0.0554876 |
| LDHA | lactate dehydrogenase A | 0.0519732 |
| RPS8 | ribosomal protein S8 | 0.0519431 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0498007 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0491999 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0463662 |
| PGK1 | phosphoglycerate kinase 1 | 0.0450802 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0448675 |
| EZR | ezrin | 0.0448101 |
| RAI14 | retinoic acid induced 14 | 0.0442687 |
| ASPH | aspartate beta-hydroxylase | 0.0442131 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0441249 |
| AOPEP | aminopeptidase O (putative) | 0.0433938 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.042815 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0412509 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0398607 |
| DST | dystonin | 0.0397826 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0396042 |
| DOK5 | docking protein 5 | 0.038776 |
| EFNA5 | ephrin-A5 | 0.0385441 |
| TXNIP | thioredoxin interacting protein | 0.0383352 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0380559 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.0372999 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0370409 |
| FAM107B | family with sequence similarity 107, member B | 0.0363248 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0361185 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.0356711 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0351868 |
| JMJD1C | jumonji domain containing 1C | 0.0349146 |
| H1-0 | H1.0 linker histone | 0.0347196 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0346981 |
| SMAD3 | SMAD family member 3 | 0.0342969 |
| PTMA | prothymosin, alpha | 0.0342134 |
| YBX3 | Y box binding protein 3 | 0.0328725 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0323892 |
| SEPTIN9 | septin 9 | 0.0322188 |
| YBX1 | Y box binding protein 1 | 0.0321317 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0317041 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0315301 |
| SIK3 | SIK family kinase 3 | 0.0315071 |
| RPLP0 | ribosomal protein, large, P0 | 0.0312749 |
| KIAA1217 | KIAA1217 | 0.0310168 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0308796 |
| ARRDC3 | arrestin domain containing 3 | 0.0307309 |
| PLEC | plectin | 0.0304351 |
| DSTN | destrin (actin depolymerizing factor) | 0.0303253 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0296232 |
| BARX2 | BARX homeobox 2 | 0.0295761 |
| SLK | STE20-like kinase | 0.0293193 |
| HLA-E | major histocompatibility complex, class I, E | 0.0292546 |
| SFTPA2 | surfactant protein A2 | 0.0289832 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0289281 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0287414 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0287158 |
| MTSS1 | metastasis suppressor 1 | 0.028714 |
| IFI44L | interferon-induced protein 44-like | 0.0285761 |
| FOXO1 | forkhead box O1 | 0.0285658 |
| TXNRD1 | thioredoxin reductase 1 | 0.0278221 |
| KRT17 | keratin 17, type I | 0.0277787 |
| STAU1 | staufen double-stranded RNA binding protein 1 | 0.0277477 |
| HDAC9 | histone deacetylase 9 | 0.027289 |
| APP | amyloid beta (A4) precursor protein | 0.0272322 |
| CMIP | c-Maf inducing protein | 0.0271531 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0269572 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0269415 |
| TPR | translocated promoter region, nuclear basket protein | 0.0268584 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.026765 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0266297 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0263079 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0262856 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.026239 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0258801 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0518717 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0301211 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0281372 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0268721 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0266949 |
| LAMA5 | laminin, alpha 5 | -0.0251596 |
| NDRG1 | N-myc downstream regulated 1 | -0.024488 |
| ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 | -0.0241086 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0240976 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0220035 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0200709 |
| EGR1 | early growth response 1 | -0.0196948 |
| LAMC2 | laminin, gamma 2 | -0.0179979 |
| CAPRIN2 | caprin family member 2 | -0.0175834 |
| GBP4 | guanylate binding protein 4 | -0.0174236 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0171046 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0166915 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0164963 |
| THBD | thrombomodulin | -0.0157463 |
| VCL | vinculin | -0.015711 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0156424 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0135105 |
| GBP2 | guanylate binding protein 2, interferon-inducible | -0.0132772 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0130826 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0127595 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0123092 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0122311 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0117092 |
| FOSL1 | FOS-like antigen 1 | -0.0116898 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | -0.0114506 |
| SETX | senataxin | -0.0114439 |
| ACTG1 | actin gamma 1 | -0.0111451 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.0110254 |
| COL4A5 | collagen, type IV, alpha 5 | -0.01102 |
| CLU | clusterin | -0.0109815 |
| LRRC8A | leucine rich repeat containing 8 family, member A | -0.0107428 |
| RGS4 | regulator of G-protein signaling 4 | -0.0107396 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0107115 |
| RNF38 | ring finger protein 38 | -0.0104105 |
| ZRANB2 | zinc finger, RAN-binding domain containing 2 | -0.0103743 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.010227 |
| HMGA2 | high mobility group AT-hook 2 | -0.0102229 |
| MGLL | monoglyceride lipase | -0.0101487 |
| SERTAD2 | SERTA domain containing 2 | -0.0101135 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0100311 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.00994989 |
| HM13 | histocompatibility (minor) 13 | -0.00962429 |
| TMEM165 | transmembrane protein 165 | -0.00959138 |
| DNAJC18 | DnaJ (Hsp40) homolog, subfamily C, member 18 | -0.0095691 |
| NANOS3 | nanos homolog 3 (Drosophila) | -0.00944759 |
| CTSD | cathepsin D | -0.00936043 |
| GBP1 | guanylate binding protein 1, interferon-inducible | -0.00933399 |
| EGFR | epidermal growth factor receptor | -0.00921183 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.00911123 |
| LAMB3 | laminin, beta 3 | -0.00909928 |
| ZMIZ2 | zinc finger, MIZ-type containing 2 | -0.00896962 |
| MNT | MAX network transcriptional repressor | -0.00875297 |
| SYNPO | synaptopodin | -0.0087398 |
| MTAP | methylthioadenosine phosphorylase | -0.00873868 |
| UBAP2 | ubiquitin associated protein 2 | -0.00866491 |
| C1D | C1D nuclear receptor corepressor | -0.00865936 |
| AQP3 | aquaporin 3 (Gill blood group) | -0.00851422 |
| FLNA | filamin A, alpha | -0.00850277 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.00849936 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.00833837 |
| TPTEP2-CSNK1E | TPTEP2-CSNK1E readthrough | -0.0083184 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.00828824 |
| MT1G | metallothionein 1G | -0.0082199 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0080622 |
| FAM120B | family with sequence similarity 120B | -0.00800918 |
| SBF2 | SET binding factor 2 | -0.00795511 |
| FUBP3 | far upstream element (FUSE) binding protein 3 | -0.00790202 |
| RHOJ | ras homolog family member J | -0.00780522 |
| FBXO32 | F-box protein 32 | -0.00778397 |
| SLC44A5 | solute carrier family 44, member 5 | -0.00777812 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.00774939 |
| NPC1 | Niemann-Pick disease, type C1 | -0.00765028 |
| DHFR | dihydrofolate reductase | -0.00762378 |
| ESM1 | endothelial cell-specific molecule 1 | -0.00761112 |
| SLC45A4 | solute carrier family 45, member 4 | -0.00758611 |
| PLXNA3 | plexin A3 | -0.00758603 |
| NABP1 | nucleic acid binding protein 1 | -0.00750729 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.00749726 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.00742126 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.00741975 |
| FRMD4A | FERM domain containing 4A | -0.00740005 |
| SEC16A | SEC16 homolog A (S. cerevisiae) | -0.00737986 |
| NUP188 | nucleoporin 188kDa | -0.0073471 |
| KIAA1328 | KIAA1328 | -0.00732872 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.00731466 |
| DGCR2 | DiGeorge syndrome critical region gene 2 | -0.00717116 |
| NLRP1 | NLR family, pyrin domain containing 1 | -0.0071481 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | -0.00714695 |
| DUSP5 | dual specificity phosphatase 5 | -0.00712984 |
| FRAS1 | Fraser extracellular matrix complex subunit 1 | -0.00712329 |
| COG6 | component of oligomeric golgi complex 6 | -0.00701264 |
| MT1M | metallothionein 1M | -0.00694794 |
| COL5A1 | collagen, type V, alpha 1 | -0.00694382 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.00691431 |
| FSCN1 | fascin actin-bundling protein 1 | -0.00687808 |
