| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Alpelisib perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Alpelisib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.148553 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.133344 |
| FAT1 | FAT atypical cadherin 1 | 0.100854 |
| EXT1 | exostosin glycosyltransferase 1 | 0.089933 |
| NEBL | nebulette | 0.070034 |
| MYO1E | myosin IE | 0.0666394 |
| LMO7 | LIM domain 7 | 0.0662724 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0527824 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0522493 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0498498 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0495051 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0468389 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0388197 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0371534 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0363708 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0363209 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.0360037 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 0.0358799 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0352169 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.034802 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.034438 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0306806 |
| AREG | amphiregulin | 0.0304636 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0297209 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0289905 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0288252 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.0286274 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.0284756 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0283883 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0283392 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0281128 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0277041 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0271741 |
| EGFR | epidermal growth factor receptor | 0.0256441 |
| PCBP2 | poly(rC) binding protein 2 | 0.0249073 |
| KRT18 | keratin 18, type I | 0.023536 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0233287 |
| WHRN | whirlin | 0.0232184 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0231917 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0230306 |
| WWOX | WW domain containing oxidoreductase | 0.0228747 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0228307 |
| RPS18 | ribosomal protein S18 | 0.0227478 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0224536 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0218487 |
| SIK3 | SIK family kinase 3 | 0.0217484 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.0216331 |
| SEPTIN9 | septin 9 | 0.0213853 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0212656 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0212184 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0209873 |
| CALR | calreticulin | 0.0208396 |
| PDE10A | phosphodiesterase 10A | 0.0205112 |
| KRT19 | keratin 19, type I | 0.0204116 |
| TRIM2 | tripartite motif containing 2 | 0.0198039 |
| MT2A | metallothionein 2A | 0.019765 |
| ATXN1 | ataxin 1 | 0.0196962 |
| SMAD2 | SMAD family member 2 | 0.0196065 |
| SGMS2 | sphingomyelin synthase 2 | 0.0194653 |
| CRY1 | cryptochrome circadian clock 1 | 0.0193188 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0192477 |
| TJP1 | tight junction protein 1 | 0.018311 |
| INTS6 | integrator complex subunit 6 | 0.0180781 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.018067 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0177647 |
| SAMD5 | sterile alpha motif domain containing 5 | 0.017534 |
| UBN2 | ubinuclein 2 | 0.0172517 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0169918 |
| SQSTM1 | sequestosome 1 | 0.0168963 |
| RPLP0 | ribosomal protein, large, P0 | 0.016861 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0168165 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.01662 |
| PDZD8 | PDZ domain containing 8 | 0.0164325 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0163854 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0163325 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0163003 |
| FAM107B | family with sequence similarity 107, member B | 0.0162128 |
| RPL21 | ribosomal protein L21 | 0.0160184 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | 0.0159521 |
| FHIT | fragile histidine triad | 0.0159368 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0158504 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0158306 |
| QSOX1 | quiescin Q6 sulfhydryl oxidase 1 | 0.0156482 |
| CADPS2 | Ca++-dependent secretion activator 2 | 0.0152686 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0152226 |
| TUBA1C | tubulin, alpha 1c | 0.0150794 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0150327 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0150181 |
| CANX | calnexin | 0.0150004 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0148195 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0147831 |
| HYOU1 | hypoxia up-regulated 1 | 0.0147276 |
| KIZ | kizuna centrosomal protein | 0.0145313 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0142256 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0140217 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0139397 |
| TUBA1B | tubulin, alpha 1b | 0.0139209 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0138587 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0137306 |
| B2M | beta-2-microglobulin | 0.0136853 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NPSR1 | neuropeptide S receptor 1 | -0.217188 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.159993 |
| TMSB10 | thymosin beta 10 | -0.135283 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.114473 |
| PTMA | prothymosin, alpha | -0.107799 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0916103 |
| GPHN | gephyrin | -0.0905783 |
| ANXA2 | annexin A2 | -0.0793828 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0767799 |
| AHNAK | AHNAK nucleoprotein | -0.0714258 |
| FLNB | filamin B, beta | -0.0634419 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0626855 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0624441 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.05743 |
| RPS6 | ribosomal protein S6 | -0.0567254 |
| PRSS3 | protease, serine, 3 | -0.0566471 |
| EPCAM | epithelial cell adhesion molecule | -0.056232 |
| NDRG1 | N-myc downstream regulated 1 | -0.0535736 |
| RNF43 | ring finger protein 43 | -0.0531363 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0511841 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0509951 |
| ITGA6 | integrin, alpha 6 | -0.049964 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0483828 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0476653 |
| EHBP1 | EH domain binding protein 1 | -0.0469005 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0466633 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.04488 |
| FERMT1 | fermitin family member 1 | -0.0442939 |
| CALB1 | calbindin 1, 28kDa | -0.0439178 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0434799 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.043446 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0430984 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.042952 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0429034 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0427991 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0412625 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0409668 |
| FNBP1L | formin binding protein 1-like | -0.0406838 |
| EZR | ezrin | -0.0405643 |
| SERINC5 | serine incorporator 5 | -0.0392775 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0388161 |
| GOLGA4 | golgin A4 | -0.0381558 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0378237 |
| RPL32 | ribosomal protein L32 | -0.037338 |
| MED13L | mediator complex subunit 13-like | -0.0367169 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0361633 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0360209 |
| KRT8 | keratin 8, type II | -0.0358958 |
| RPLP1 | ribosomal protein, large, P1 | -0.0355198 |
| PKM | pyruvate kinase, muscle | -0.0355032 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0353565 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0347955 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0342898 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.034154 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0340487 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0339765 |
| CADPS | Ca++-dependent secretion activator | -0.0336051 |
| RBM39 | RNA binding motif protein 39 | -0.0334171 |
| LYZ | lysozyme | -0.0330856 |
| FAM13A | family with sequence similarity 13, member A | -0.0329 |
| GDF15 | growth differentiation factor 15 | -0.0327792 |
| H1-0 | H1.0 linker histone | -0.032763 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0325471 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.0319931 |
| MSI2 | musashi RNA-binding protein 2 | -0.0319384 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0319232 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -0.0315643 |
| SETD5 | SET domain containing 5 | -0.0313421 |
| MAP4 | microtubule-associated protein 4 | -0.0312486 |
| ITGB4 | integrin, beta 4 | -0.0310512 |
| WDR45B | WD repeat domain 45B | -0.0308925 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0307232 |
| ZNF292 | zinc finger protein 292 | -0.0307101 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0307094 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0305594 |
| ONECUT3 | one cut homeobox 3 | -0.0305488 |
| USP3 | ubiquitin specific peptidase 3 | -0.0304623 |
| INSIG1 | insulin induced gene 1 | -0.0302819 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0301741 |
| PCDHB16 | protocadherin beta 16 | -0.0299817 |
| RIN2 | Ras and Rab interactor 2 | -0.0299597 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0299283 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.029909 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0296604 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0296219 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0294909 |
| RPS19 | ribosomal protein S19 | -0.0294301 |
| TNS4 | tensin 4 | -0.0294116 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0293729 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0292909 |
| NF1 | neurofibromin 1 | -0.0292313 |
| RPS29 | ribosomal protein S29 | -0.0290359 |
| RNF145 | ring finger protein 145 | -0.0289588 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0287041 |
| EXOC1 | exocyst complex component 1 | -0.0285124 |
| S100P | S100 calcium binding protein P | -0.0282165 |
| GLG1 | golgi glycoprotein 1 | -0.0282164 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0279543 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0269757 |
| RPS3 | ribosomal protein S3 | -0.0269372 |
