| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Alpelisib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Alpelisib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DST | dystonin | 0.146679 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.141689 |
| TP63 | tumor protein p63 | 0.0936975 |
| RUNX1 | runt-related transcription factor 1 | 0.0645765 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0537695 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0468231 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0424985 |
| HDAC9 | histone deacetylase 9 | 0.0406039 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0405667 |
| CANX | calnexin | 0.040116 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0397812 |
| CD44 | CD44 molecule (Indian blood group) | 0.0389961 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0381359 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0376065 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0375625 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0361608 |
| CMIP | c-Maf inducing protein | 0.0353044 |
| MYOF | myoferlin | 0.034535 |
| COL5A2 | collagen, type V, alpha 2 | 0.0338195 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | 0.033613 |
| HOMER1 | homer scaffolding protein 1 | 0.0327054 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0326338 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0325992 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0322087 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0312092 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0299718 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0298073 |
| RPS2 | ribosomal protein S2 | 0.0297934 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0297783 |
| TNS3 | tensin 3 | 0.0292371 |
| GOLGB1 | golgin B1 | 0.0292301 |
| RAD51B | RAD51 paralog B | 0.0289227 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0287317 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0285856 |
| SFTPA2 | surfactant protein A2 | 0.0284558 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0283812 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0283319 |
| MB21D2 | Mab-21 domain containing 2 | 0.0274762 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0268448 |
| TGM2 | transglutaminase 2 | 0.0266456 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0266442 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0264713 |
| DNER | delta/notch-like EGF repeat containing | 0.0263609 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.025738 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0252594 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0251234 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0247024 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.024127 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0240495 |
| ANXA2 | annexin A2 | 0.0235475 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0232607 |
| SQSTM1 | sequestosome 1 | 0.0228552 |
| SPAG9 | sperm associated antigen 9 | 0.0225249 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0224838 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0222676 |
| RCOR1 | REST corepressor 1 | 0.0220963 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0220384 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0220271 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0220176 |
| CAPRIN2 | caprin family member 2 | 0.0219438 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0216615 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0212986 |
| RNF213 | ring finger protein 213 | 0.0212844 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0208505 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0207696 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0204511 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0204272 |
| EREG | epiregulin | 0.0203217 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0200854 |
| VEGFC | vascular endothelial growth factor C | 0.0198059 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0197321 |
| EGFR | epidermal growth factor receptor | 0.0196893 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0195545 |
| RPS18 | ribosomal protein S18 | 0.0195091 |
| LOXL2 | lysyl oxidase-like 2 | 0.0194796 |
| YEATS2 | YEATS domain containing 2 | 0.0191067 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0189974 |
| EPHA4 | EPH receptor A4 | 0.0188786 |
| B2M | beta-2-microglobulin | 0.0188718 |
| HDLBP | high density lipoprotein binding protein | 0.0187772 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0186946 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0186443 |
| LYST | lysosomal trafficking regulator | 0.0185005 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0182327 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.018228 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0181138 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.01784 |
| AHNAK | AHNAK nucleoprotein | 0.0178155 |
| PDE10A | phosphodiesterase 10A | 0.0178001 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | 0.0177193 |
| LDHA | lactate dehydrogenase A | 0.0173953 |
| SGMS2 | sphingomyelin synthase 2 | 0.017317 |
| RCAN1 | regulator of calcineurin 1 | 0.0172897 |
| NEK10 | NIMA-related kinase 10 | 0.0171728 |
| BRD2 | bromodomain containing 2 | 0.0171482 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.01708 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0164827 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0160984 |
| RPL12 | ribosomal protein L12 | 0.0160944 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0159379 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.300388 |
| TMSB10 | thymosin beta 10 | -0.175496 |
| PTMA | prothymosin, alpha | -0.162923 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.130711 |
| RPL35A | ribosomal protein L35a | -0.127402 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0678153 |
| FTL | ferritin, light polypeptide | -0.0675068 |
| RPS6 | ribosomal protein S6 | -0.0670497 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0558877 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0555573 |
| RPS19 | ribosomal protein S19 | -0.0541732 |
| RPS24 | ribosomal protein S24 | -0.0541634 |
| ACTG1 | actin gamma 1 | -0.0520215 |
| CENPF | centromere protein F, 350/400kDa | -0.0500437 |
| RPL31 | ribosomal protein L31 | -0.0487858 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0468713 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0462123 |
| POTEF | POTE ankyrin domain family, member F | -0.045974 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0452423 |
| RPL37A | ribosomal protein L37a | -0.0448236 |
| MT2A | metallothionein 2A | -0.0438212 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0434556 |
| TMSB4X | thymosin beta 4, X-linked | -0.0400426 |
| RPS27A | ribosomal protein S27a | -0.0384433 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0383618 |
| RPL36A | ribosomal protein L36a | -0.037687 |
| RPS23 | ribosomal protein S23 | -0.0376326 |
| RPS12 | ribosomal protein S12 | -0.037458 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0351828 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0336617 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0331356 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0320117 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.031458 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0313292 |
| RPS3 | ribosomal protein S3 | -0.0308665 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0304455 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0304249 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0298351 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0295873 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0278343 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0275455 |
| XPO1 | exportin 1 | -0.0268265 |
| MKI67 | marker of proliferation Ki-67 | -0.0266596 |
| FBXO11 | F-box protein 11 | -0.0263603 |
| RPL34 | ribosomal protein L34 | -0.0261304 |
| RPS14 | ribosomal protein S14 | -0.0260515 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0260455 |
| RPS25 | ribosomal protein S25 | -0.0259121 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0258103 |
| RPL19 | ribosomal protein L19 | -0.0255688 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0253328 |
| EGR1 | early growth response 1 | -0.0253191 |
| S100A10 | S100 calcium binding protein A10 | -0.0252134 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0249053 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0245941 |
| MT1X | metallothionein 1X | -0.0243454 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0241972 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0241657 |
| RPLP2 | ribosomal protein, large, P2 | -0.0239962 |
| RBM25 | RNA binding motif protein 25 | -0.023977 |
| RACK1 | receptor for activated C kinase 1 | -0.0239668 |
| RPL38 | ribosomal protein L38 | -0.0239315 |
| RTN4 | reticulon 4 | -0.0233522 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0232559 |
| WDR45B | WD repeat domain 45B | -0.0226392 |
| RPL11 | ribosomal protein L11 | -0.0223096 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0221761 |
| HMGA1 | high mobility group AT-hook 1 | -0.0221015 |
| RPL37 | ribosomal protein L37 | -0.0218566 |
| THOC2 | THO complex 2 | -0.0217496 |
| RPL28 | ribosomal protein L28 | -0.0216869 |
| SRGN | serglycin | -0.0215973 |
| S100A9 | S100 calcium binding protein A9 | -0.0212961 |
| RPL7A | ribosomal protein L7a | -0.0209852 |
| RPS29 | ribosomal protein S29 | -0.0208359 |
| RPL26 | ribosomal protein L26 | -0.0206156 |
| OGA | O-GlcNAcase | -0.0204073 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.020265 |
| GNAS | GNAS complex locus | -0.0201178 |
| RPLP1 | ribosomal protein, large, P1 | -0.0200851 |
| SNX14 | sorting nexin 14 | -0.0200555 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0200342 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.019912 |
| CBX3 | chromobox homolog 3 | -0.0198665 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0196364 |
| MATR3 | matrin 3 | -0.0192954 |
| RPL5 | ribosomal protein L5 | -0.0191729 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0191517 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.019145 |
| ZNF217 | zinc finger protein 217 | -0.0191399 |
| TNPO1 | transportin 1 | -0.0190258 |
| RPS20 | ribosomal protein S20 | -0.0190136 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0189969 |
| TOP1 | topoisomerase (DNA) I | -0.0189395 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0188748 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0187341 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0186907 |
| SNX3 | sorting nexin 3 | -0.0184982 |
| SBF2 | SET binding factor 2 | -0.018436 |
| SEPTIN7 | septin 7 | -0.0184202 |
